The Open Surgery Journal最新文献

Cellular Cardiomyoplasty Using Skeletal Muscle Stem Cells 使用骨骼肌干细胞的细胞心肌成形术

The Open Surgery Journal Pub Date : 2015-02-25 DOI: 10.2174/1874300501509010001

E. Lamb, Grace W. Kao, Chuanful Li, R. Kao

{"title":"Cellular Cardiomyoplasty Using Skeletal Muscle Stem Cells","authors":"E. Lamb, Grace W. Kao, Chuanful Li, R. Kao","doi":"10.2174/1874300501509010001","DOIUrl":"https://doi.org/10.2174/1874300501509010001","url":null,"abstract":"Skeletal muscle satellite cells (myoblasts) are the primary stem cells of skeletal muscle which contribute to growth, maintenance, and repair of the muscle. Satellite cells offer several advantages for cellular cardiomyoplasty: can be easily obtained without affecting one's function, vastly proliferated in culture, have high resistance to ischemic and hypoxic conditions, no identified risk for tumor generation, and more commitment to myogenic differentiation. Cellular cardiomyoplasty is a developing new therapy that use stem cells or progenitor cells for injured heart to improve cardiac function and mitigate heart failure. Since we first published cellular cardiomyoplasty in 1989, this procedure became one of the innovative methods to treat damaged myocardium other than heart transplantation. A significant improvement in cardiac function, metabolism, and perfusion is generally observed in experimental and clinical studies, but the improvement is mild and incomplete. Although safety, feasibility, and efficacy have been well documented for the procedure, the beneficial mechanisms remain unclear and optimization of the procedure requires further study. This paper briefly reviews the skeletal muscle stem cells used for cellular cardiomyoplasty and their clinical outcomes with possible improvements in future studies.","PeriodicalId":174281,"journal":{"name":"The Open Surgery Journal","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121560193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Prevalence and Risk Factors Associated with Post Operative Infections inthe Limbe Regional Hospital of Cameroon 喀麦隆Limbe地区医院手术后感染的流行及相关危险因素

The Open Surgery Journal Pub Date : 2014-01-10 DOI: 10.2174/1874300501408010001

M. NgoweNgowe, A. Touré, Mouafo Tambo Ff, A. Chichom, R. Tchounzou, L. Ako-Egbe, Sosso Ma

{"title":"Prevalence and Risk Factors Associated with Post Operative Infections inthe Limbe Regional Hospital of Cameroon","authors":"M. NgoweNgowe, A. Touré, Mouafo Tambo Ff, A. Chichom, R. Tchounzou, L. Ako-Egbe, Sosso Ma","doi":"10.2174/1874300501408010001","DOIUrl":"https://doi.org/10.2174/1874300501408010001","url":null,"abstract":"Background: Postoperative infections (POIs) contribute to morbidity and mortality of surgical patients. There was no data on the prevalence and associated risk factors of POIs in the Limbe Regional Hospital (RLH). Methods: Selected patients were those who underwent a surgical procedure and were admitted into the surgical or maternity ward of the LRH between January 2009 and August 2012. Data studied included demographic variables, type of surgical procedure performed and postoperative follow-up. Data was analyzed for evidence of POIs using the Chi-square test for categorical variables and test for significance of association between POI and sex, age, procedures performed, hospitalization ward and duration of hospital stay. Results: 848 patients were selected among whom 78.8% were females. 62.1% of the patients were selected from the Obstetric and Gynaecology ward, while 37.9%were from the surgical ward. The mean age of the study subjects was 32.3±12.4 years. 175 patients met the criteria for POI giving a prevalence of 20.6%. The Obstetrics and Gynaecology ward had the highest prevalence of POI (61.7%). Prevalence of POIs was highest (64.3%) among patients in the 0 - 10 years age group. Males (26.7%) were at a higher risk of developing POIs .There was a statistically significant difference between POI and participants' age group (p<0.05). Peritonitis displayed the highest rate of POI (36.6%) while tubal ligation had the lowest (0%). Purulent wound discharge was the most frequent diagnostic criteria for postoperative infection. Conclusion: The prevalence of POIs ranged from 0 - 36.6%. Male sex and patients' age seemed to be associated with a higher risk of POIs. Surgery for acute generalized peritonitis had the highest risk of developing POIs.","PeriodicalId":174281,"journal":{"name":"The Open Surgery Journal","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126079813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Survival after Complete Mesocolic Excision (CME) for Right Sided Colon- cancer Compared to Standard Surgery 右侧结肠癌结肠直肠全切除术(CME)与标准手术的生存率比较

The Open Surgery Journal Pub Date : 2013-09-06 DOI: 10.2174/1874300501307010006

S. Benz

{"title":"Survival after Complete Mesocolic Excision (CME) for Right Sided Colon- cancer Compared to Standard Surgery","authors":"S. Benz","doi":"10.2174/1874300501307010006","DOIUrl":"https://doi.org/10.2174/1874300501307010006","url":null,"abstract":"Purpose: Complete mesocolic excision for right sided colon cancer is a complex operation that might offer a survival benefit. However, studies comparing CME to standard surgery have not been published so far. Methods: One-hundred-seven patients were operated at the discretion of the surgeon either according to principles of complete mesocolic excision (CME-group, n=69) or received a standard right hemicolectomy (non-CME group, n=38). The type of surgery was prospectively recorded. Results: Patients in the non-CME group were significantly older (67,9 vs.78,1 p<0,001) and had fewer adjuvant chemotherapies in stage III (94,7 vs. 60,0% p=0,02). For the combined analysis of stages I-III actuarial 5-year overall-, recurrence free- and tumor specific survival was significantly better for the CME group (OS 89,4% vs. 71,5%, p=0,011; RFS 83,8% vs. 70,3% p=0,035; TSS 93,8% vs. 78,0% p=0,049). Conclusion: The data suggest a survival benefit for complete mesocolic excision in the treatment of right sided colon cancer. However, the data needs to be interpreted with caution because of the uneven distribution of age and number chemotherapies. The results of the large multicentre trial which is currently going on among German certified cancer is expected to further clarify this issue.","PeriodicalId":174281,"journal":{"name":"The Open Surgery Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125531589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Pedunculated Hepatic Hemangiomas often Misdiagnosed Despite Their Typical Findings 带蒂肝血管瘤虽有典型的表现，但常被误诊

The Open Surgery Journal Pub Date : 2013-01-17 DOI: 10.2174/1874300501307010001

Chi D. Ha, S. Kubomoto, Brandi M. Whetstone, S. Parascandola

{"title":"Pedunculated Hepatic Hemangiomas often Misdiagnosed Despite Their Typical Findings","authors":"Chi D. Ha, S. Kubomoto, Brandi M. Whetstone, S. Parascandola","doi":"10.2174/1874300501307010001","DOIUrl":"https://doi.org/10.2174/1874300501307010001","url":null,"abstract":"Background: Hepatic hemangiomas are the most common benign liver tumors which can be often diagnosed radiologically. However despites their typical radiologic findings, giant pedunculated hemangiomas are rare and often misdiagnosed as a supra-renal, retroperitoneal, gastric, or mesenteric mass. Methodology: The authors present a case and the summary of a thorough literature search on this rare disease entity. Results: A 35-year-old male is found to have a 12cm mesenteric mass on computed tomography and undergoes a surgical exploration. Intraoperatively, a large pedunculated hepatic hemangioma from the left lobe of the liver is encountered and removed successfully. A thorough PubMed search reveals a total of 18 publications in English with 24 cases of giant pedunculated hepatic hemangioma, most of which occur in older females, and originate from the left lobe of the liver. These tumors in general retain the typical computed tomography or magnetic resonance imaging findings of an intrahepatic hemangioma. Conclusions: When a peri-hepatic lesion possesses typical radiologic characteristics of a hemangioma, pedunculated hemangioma should be included in the differential diagnosis.","PeriodicalId":174281,"journal":{"name":"The Open Surgery Journal","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131733367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Foudroyant Necrotizing Pancreatitis Caused by Clostridium Perfringens 由产气荚膜梭菌引起的腐殖性坏死性胰腺炎

The Open Surgery Journal Pub Date : 2012-09-07 DOI: 10.2174/1874300501206010001

D. Kaemmerer, B. Kupper, M. Hommann

引用次数: 1

Left Spigelian Hernia in Super-Obese Patient: A Case-Report 超肥胖患者左Spigelian疝1例报告

The Open Surgery Journal Pub Date : 2011-07-13 DOI: 10.2174/1874300501105010024

D. Pagano, G. Echeverri, C. Bartoccelli, C. Ricotta, G. Giuffrida, M. Martino, R. Cavallin, S. Gruttadauria

引用次数: 1

Stump Appendicitis: Does it Occur More Frequently after Laparoscopic or Conventional Appendectomy? - Report of a Case 残端阑尾炎:腹腔镜或常规阑尾切除术后发生的频率更高吗?-个案报告

The Open Surgery Journal Pub Date : 2011-04-20 DOI: 10.2174/1874300501105010019

Gina von Eineme, T. Denecke, C. Grieser, M. Glanemann, A. Andreou

引用次数: 2

Descending Necrotizing Mediastinitis: Review of the Literature and Controversies in Management 下行坏死性纵隔炎:文献综述及治疗争议

The Open Surgery Journal Pub Date : 2011-03-25 DOI: 10.2174/1874300501105010012

C. Foroulis, M. Sileli

{"title":"Descending Necrotizing Mediastinitis: Review of the Literature and Controversies in Management","authors":"C. Foroulis, M. Sileli","doi":"10.2174/1874300501105010012","DOIUrl":"https://doi.org/10.2174/1874300501105010012","url":null,"abstract":"Any deep cervical infection has to be aggressively treated and CT scan of the chest should be performed to exclude the possibility of downward spread of the infection within the mediastinum. Early recognition of DNM is problematic because of its rarity and the non-specific symptoms in its early phase. DNM can rapidly progress to involve the entire mediastinum. Aggressive surgery upon diagnosis has to be performed, usually through a combination of cervicomediastinal and thoracic approach. Cervicomediastinal drainage alone for DNM not extending below the carina level or combined with subxiphoid drainage or anterior mediastinotomies is associated with higher mortality rates. Thoracotomy on the most involved side or bilateral thoracotomies give the best exposure for adequate mediastinal drainage. Median sternotomy or VATS procedures can be performed if one-lung ventilation can be tolerated by the patient. Pleural and pericardial cavities and all mediastinal spaces should be properly drained. Repeat CT scan of the neck and chest should be performed in all patients 48-72 hours after drainage of the infection or even earlier in case of further deterioration of the patient or persistent sepsis. Mortality rate in recent series ranges between 10% and 30%. The development of purulent pericarditis and/or failure of more than two organs before mediastinal drainage are associated with higher risk of fatal outcome. Prolonged ICU and hospital stays are the rule, while re-intervention rate for persistent sepsis exceeds 30%. The re-intervention rate is higher after mediastinal drainage performed through approaches which offer limited exposure to the whole mediastinum.","PeriodicalId":174281,"journal":{"name":"The Open Surgery Journal","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123588888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Gene Expression Profile in Liver Transplantation and the Influence of Gene Dysregulation Occurring in Deceased Donor Grafts 肝移植中的基因表达谱及死亡供体移植物中基因失调的影响

The Open Surgery Journal Pub Date : 2011-02-10 DOI: 10.2174/1874300501105010001

A. Conti, Simona Scala, M. Romano, A. Izzo, Floriana Fabbrini, F. D. Ragione, M. D'Esposito, L. Nitsch, F. Calise, A. Faiella

{"title":"Gene Expression Profile in Liver Transplantation and the Influence of Gene Dysregulation Occurring in Deceased Donor Grafts","authors":"A. Conti, Simona Scala, M. Romano, A. Izzo, Floriana Fabbrini, F. D. Ragione, M. D'Esposito, L. Nitsch, F. Calise, A. Faiella","doi":"10.2174/1874300501105010001","DOIUrl":"https://doi.org/10.2174/1874300501105010001","url":null,"abstract":"Background: Brain dead patients are the main source of organs for transplants. Brain death causes changes in peripheral organs. We define modifications of gene expression in specific pathways occurring in donor livers and their influence on gene expression profile of livers after transplant. Methods: We compared gene expression profile of both deceased donor livers and transplanted livers to gene expression data of liver tissue, retrieved from Array Express database, used as control. All expression data were obtained by microarray analysis. Results: The expression of about 33,000 genes has been compared in liver samples from three groups: deceased donor livers, transplanted livers two hours after reperfusion, and control livers. We found that about 900 genes are dysregulated in deceased donor versus control livers. Up-regulated genes are mainly involved in apoptosis, immune response and inflammation. Down-regulated genes are mostly involved in metabolism and electron transport. We also re-evaluated a group of genes that in a previous study were found dysregulated in transplanted livers when compared to donor livers. Most of these genes, but not all, were dysregulated also when compared to control livers. Moreover 317 additional genes, dysregulated after liver transplant, were identified in this study; they were undetectable in the previous study because they had the same dysregulation both in donor and in transplanted livers. Conclusions: Understanding molecular mechanisms that in the donor compromise graft function is crucial in order to discriminate between basal graft damages and ischemia-reperfusion injuries and therefore to identify therapeutic targets aiming to improve liver transplantation performances.","PeriodicalId":174281,"journal":{"name":"The Open Surgery Journal","volume":"29 8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125696760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Long-Term Survival of a Patient with a Large Unresectable Hepatocellular Carcinoma: Case Report and Review of the Literature~!2010-04-28~!2010-05-29~!2010-07-23~! 不能切除的大肝癌患者的长期生存:1例报告及文献复习2010-04-28 2010-05-29 2010-07-23

The Open Surgery Journal Pub Date : 2010-07-23 DOI: 10.2174/1874300501004010001

T. Karatzas

引用次数: 2