Medicine Updates最新文献

{"title":"Assessment of Secondary Hyperparathyroidism as a ‎Cause of Pulmonary Hypertension among End Stage ‎Renal Disease Patients on Regular Hemodialysis","authors":"Abd El Rahman Badra, Mamdouh El-Nahas, Amir Okeely, Hanzada Elmaghrabi","doi":"10.21608/muj.2024.299843.1173","DOIUrl":"https://doi.org/10.21608/muj.2024.299843.1173","url":null,"abstract":": Background: End-stage renal disease can result in several systemic consequences that pose a significant risk to life, such as cardiovascular disorders. Pulmonary arterial hypertension, characterized by increased blood pressure in the pulmonary artery, poses a significant risk for both morbidity and mortality in individuals with end-stage renal disease (ESRD). Aim‎ of‎ the‎ study: The aim of the current study was to evaluate association between hyperparathyroidism and incidence of pulmonary hypertension among haemodialysis patients. Methods:‎ This study was performed on 100 haemodialysis patients; they were divided according to incidence of pulmonary hypertension into 2 groups: 63 pulmonary hypertension patients and 37 patients without pulmonary hypertension. Results:‎ The most reported leading cause of end-stage renal disease was hypertension (65%), analgesic nephropathy (11%) and diabetic nephropathy (9%). About 27% of patients had residual urine output.The included patients received hemodialysis for about 3.06 ± 1.5 years with average ultrafiltration rate 3.3 ± 1.15 L. About 96% of patients received hemodialysis via A-v fistula and mean A-v fistula flow volume was 1111.7 ± 434.1. Conclusion: Disturbance in parathyroid release significantly affected incidence of pulmonary hypertension. Also, hypoparathyroidism is associated with increased incidence rate of pulmonary hypertension .","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of Leprosy During the Period From 2010 to 2022 in Mansoura, Egypt","authors":"Yasmin Ali Elbosaty, Mohamed Elsayed Mashaly, M. Abdel-gawad, Nesreen Farouk Mohamed Ibrahim, Mohamed Mahmoud Elbaz","doi":"10.21608/muj.2024.293571.1171","DOIUrl":"https://doi.org/10.21608/muj.2024.293571.1171","url":null,"abstract":": ABSTRACT Background: Leprosy is a chronic infection caused by acid-fast rod-shaped bacillus Mycobacterium leprae. It mostly affects the skin and peripheral nerves, triggering a variety of cellular immunological reactions that may have long-term effects, including peripheral neuropathy. WHO categorizes leprosy into two groups: paucibacillary, which has five or less skin lesions, and multibacillary, which has six or more. The disease spectrum is closely correlated with the level of cellular immunity and bacterial load. Objectives: to estimate the annual case detection rate of leprosy in Mansoura dermatology and leprosy hospital, the proportion of lepromatous leprosy and tuberculoid leprosy cases and to assess epidemiological trends of leprosy before and after the start of COVID-19 pandemic in Egypt. Methods: A cross sectional study included 289 patients who were diagnosed and registered as newly detected leprotic patients at leprosy clinic in Mansoura dermatology and leprosy hospital during 2010 and 2022. Results: Annual case detection rate of leprosy in each year estimated by number of reported leprosy cases in relation to the population number in the governorate measured by the central agency for public mobilization and statistics in each year has decreased gradually from 2010 to 2022 with the highest annual case detection rate in 2010 and lowest in 2022. Annual case detection rate of leprosy has been decreased from 4.001/1 million in 2010 to 0.861 /1 million in 2022. Conclusions : The results of this retrospective analysis of leprosy data showed a decrease in the annual case detection rate of new leprotic patients through the study period (289 patients from 2010 to 2022) in comparison with the previous old studies in Egypt . During COVID pandemic, there was significant decrease in average number of recorded leprotic patients/ year, as well as annual case detection rate (0.99 /1 million) of leprosy when compared to their average number/year and annual case detection rate (4.46 /1 million) before COVID pandemic.","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Diffusion MRI Study in Assessment of Colorectal Tumor Response after Chemoradiotherapy","authors":"Khaled Ahmed, Mohamed Elrakhawy, Ahmed El shahat, Omnia Gohar, Waleed S. Abo Shanab","doi":"10.21608/muj.2024.279453.1166","DOIUrl":"https://doi.org/10.21608/muj.2024.279453.1166","url":null,"abstract":"","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"42 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140733844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Botulinum toxin versus 5-flurouracil in the management of keloids and hypertrophic scars","authors":"Fatma Rihan, Mohamedmed Elbaz, Mamdouh Abdel-gawad, Mostafa Ghoneim","doi":"10.21608/muj.2024.273255.1161","DOIUrl":"https://doi.org/10.21608/muj.2024.273255.1161","url":null,"abstract":"","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"71 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140736458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Level and Pregnancy Outcomes among Pregnant Women in Zagazig University Hospitals; Follow-up study","authors":"Al-Zahraa Soliman, Eman Abd el-Sattar, Yosra Osama, Mostafa Salem","doi":"10.21608/muj.2024.273859.1162","DOIUrl":"https://doi.org/10.21608/muj.2024.273859.1162","url":null,"abstract":": Background: Adverse maternal and neonatal outcomes as preterm delivery, preeclampsia, small for gestational age (SGA) and gestational diabetes mellitus have all been accused to be associated with low levels of maternal vitamin D during conception. Objective : to evaluate the relation between maternal and fetal outcomes and levels of maternal vitamin D during pregnancy Patients and methods: In total, 284 third-trimester pregnant women were included in this cohort study at Zagazig University Hospitals' Obstetric and Gynecologic Clinic. They were questioned about their pregnancy and the variables related to their vitamin D levels. Vitamin D level was measured in all participants. The participants were followed till delivery with reporting all adverse maternal, fetal, and neonatal outcomes.","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"1217 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140774486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between calcium and non-calcium-based phosphate binders concerning acid-base status and electrolytes in Hemodialysis patients in ALHYAT hospital.","authors":"Heba Abd El ghany, Mamdouh El Nahas, Amir Okeely, Basma Bader Eldin, Fatima Taha Morsi","doi":"10.21608/muj.2024.274272.1163","DOIUrl":"https://doi.org/10.21608/muj.2024.274272.1163","url":null,"abstract":": Background: End-stage rena1 disease (ESRD) requiring rena1 rep1acement therapy (RRT) has become a major health problem worldwide. Approximately 2.5 million people were estimated to be receiving chronic RRT in 2010. Hyperphosphatemia is one of the major clinical manifestations of decreased kidney function that is more pronounced in CKD stages 3–5. High serum phosphorus is actively involved in soft tissue and vascular calcification with increased cardiovascular disease (CVD) and mortality in these patients. Aim and objectives: To compare calcium-based versus non-calcium-based phosphate binders concerning parameters of acid-base balance and electrolytes in hemodialysis (HD) patients from the Al-Hayah Hospital hemodialysis unit in Port Said Governorate. Patients and methods: This prospective cohort trail was performed on 116 ESRD individuals","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"593 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140776917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of vitamin D status in children admitted to pediatric intensive care unit .","authors":"Walid Mohammed Aboassy, N. M. Handoka, R. E. Badr","doi":"10.21608/muj.2024.278306.1164","DOIUrl":"https://doi.org/10.21608/muj.2024.278306.1164","url":null,"abstract":": Background: Vitamin D has the capability to regulate both the adaptive and innate immune systems, which contributes to its immunological and anti-inflammatory properties further more there is an evidence of significant declines in circulating 25(OH)D concentrations in critical illness. Aim: Our study aimed to evaluate vitamin D status in ill children admitted to pediatric intensive care unit.","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"158 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140760065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of vitamin D level and pediatric risk of mortality III score in critically ill children","authors":"Walid Mohammed Aboassy, N. M. Handoka, R. E. Badr","doi":"10.21608/muj.2024.278496.1165","DOIUrl":"https://doi.org/10.21608/muj.2024.278496.1165","url":null,"abstract":": Background: Twenty-five hydroxy vitamin D is an essential nutrient that is made up of a combination of fat-soluble secosteroids and has a key role in the endocrine system additionally there is evidence that low vitamin d level is associated with increased fatality rate. Aim: Our research aimed to investigate the association amongst critically ill Children`s vitamin 25(OH)D levels and their illness severity measured by PRISM III scores. Patients and methods: This case-control research was performed on 30 children with critical illness admitted to the ICU of Pediatric of El-Salam Port-Said General Hospital in addition to 30 healthy children as the control group. Results: In the patients group (n=30), the PRISM III ranged from 5 to 24, with a median of 9.00, a 95% of the CI of the median of 7.00-15.00, and 25th Percentile –75th Percentile of 6.00-15.00. It was noted no statistically significant variance in PRISM III Score amongst the individuals with different diagnosis (p=0.053). The PRISM III Score was significantly greater in the deceased individuals relative to the discharged individuals (p=0.005),a statistically significant association is noted amongst PRISM III and Serum 25(OH)D (ng/ml) (p<0.001). Conclusion: .low serum 25(OH)D was correlated with higher PRISM III score.","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"501 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140781886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two Shades of Marine Life\"","authors":"Basant Yousef Zaki, Islam Elsaeed, Heba Youssef","doi":"10.21608/muj.2024.257638.1156","DOIUrl":"https://doi.org/10.21608/muj.2024.257638.1156","url":null,"abstract":": Background: Macroalgae, commonly referred to as seaweed, are a diverse group of multicellular photosynthetic organisms that are distributed throughout marine environments across the globe. They are typically classified into three taxonomic groups based on their chemical structure and pigmentation, which include brown algae (Ochrophyta), green algae (Chlorophyta), and red algae (Rhodophyta). However, marine microalgae produce harmful toxins that can cause various syndromes such as shellfish and fish poisonings. These Harmful Algal Blooms (HABs) have increased in frequency, severity, and range, posing significant health risks to those who consume contaminated seafood. HABs are a result of anthropogenic activities and climate change that affect marine planktonic systems.","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140386324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical recovery in Spontaneous lumbar disc resorption may alter the decision of lumbar disc surgery in the future.","authors":"Amr Abu Elfadle, Mohamed Khoudir, Ahmed Soliman, M. Elghareeb, Ebrahim Shamhoot","doi":"10.21608/muj.2024.263776.1160","DOIUrl":"https://doi.org/10.21608/muj.2024.263776.1160","url":null,"abstract":": Background: Different processes have been proposed in the literature to explain the spontaneous resorption of herniated lumbar discs, and numerous studies have found numerous resorption-predictive features. The goal of this study was to assess the clinical improvement and correlation with radiological resorption of lumbar disc herniation (LDH) hence we can decide appropriate time for conservative management. Materials and methods: 18 patients who had LDH on initial magnetic resonance imaging (MRI) were included in this retrospective analysis. The average age was 36.9 ± 7.2 years, with eleven cases predominantly male. A total of 100% of the patients had sciatica, and 55.6% had pain in their lower backs. Since none of the patients underwent surgery, they were all given conservative care. For 8 to 11 months, patients were followed up clinically and radiologically (using an MRI) in the outpatient clinic. Results: 44.4% of patients had L5-S1 disc prolapse whereas 55.6% had L4-5 level affected. Sequestration affected 66.7% while Extruded disc was seen in 33.3%. Conservative management revealed that 66.11 % underwent spontaneous resorption of the ruptured disc in a mean time of 9.2 ± 1.1 months as seen radiologically in the MRI. Clinical improvement occurred in all patients in a mean of 5.9 ± 1.2. Conclusion: Spontaneous resorption of a herniated lumbar disc, which can happen due to retraction, dehydration, or an inflammatory-mediated mechanism, has become a more common event in lumbar disc prolapse. Clinical recovery typically occurred prior to LDH radiological improvement. The clinical resolution of symptoms and the radiological resolution of LDH were not shown to be significantly correlated.","PeriodicalId":174236,"journal":{"name":"Medicine Updates","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140436945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}