Journal of Toxicology and Environmental Health, Part A最新文献

{"title":"Assessing the disparity: comparative toxicity of Copper in zebrafish larvae exposes alarming consequences of permissible concentrations in Brazil","authors":"Maria Vitória Takemura Mariano, Luana Paganotto Leandro, Karen Kich Gomes, Ana Beatriz dos Santos, Vitor Oliveira de Rosso, Alcir Luiz Dafre, Marcelo Farina, Thaís Posser, Jeferson Luis Franco","doi":"10.1080/15287394.2023.2290630","DOIUrl":"https://doi.org/10.1080/15287394.2023.2290630","url":null,"abstract":"Copper (Cu) is a naturally occurring metal with essential micronutrient properties. However, this metal might also pose increased adverse environmental and health risks due to industrial and agricu...","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tellimagrandin-I and camptothin a exhibit chemopreventive effects in Salmonella enterica serovar Typhimurium strains and human lymphocytes","authors":"Amanda Silva Fernandes, Abel Vieira de Melo Bisneto, Luana Santos Silva, Elisa Flávia Luiz Cardoso Bailão, Clever Gomes Cardoso, Cristiene Costa Carneiro, Suzana da Costa Santos, Lee Chen-Chen","doi":"10.1080/15287394.2023.2290641","DOIUrl":"https://doi.org/10.1080/15287394.2023.2290641","url":null,"abstract":"Tellimagrandin-I (TL) and camptothin A (CA) are ellagitannins widely found in diverse plant species. Numerous studies demonstrated their significant biological activities, which include antitumor, ...","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical analysis of carotenoid profile in Mentha piperita and Artemisia vulgaris: cytotoxicity in tumoral cells and evaluation of plasmid DNA cleavage","authors":"Altevir Rossato Viana, James Eduardo Lago Londero, Pricila Nass Pinheiro, Patricia Acosta, Larissa Duailibe Silva, Eduardo Jacob-Lopes, Aline Ferreira Ourique, Leila Queiroz Zepka, Cristiano Rodrigo Bohn Rhoden, André Passaglia Schuch, Camila Franco","doi":"10.1080/15287394.2023.2291513","DOIUrl":"https://doi.org/10.1080/15287394.2023.2291513","url":null,"abstract":"Several medicinal plants have been administered to cancer patients attributed to their anticarcinogenic and chemoprotective properties, in addition to lower toxicity compared to traditional therapi...","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":"195 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138567651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact Of Obstructive Lung Diseases (Asthma and COPD) due to indoor air pollution and poor room ventilation quality in Medina (Senegal)","authors":"Salimata Thiam, Mahammadou Lamine Daffe, K. Thiam, Awa Ndong, A. Faye, M. Diaw, Mathilde Cabral Ndior, F. Bah, N. O. Touré, M. Fall","doi":"10.7243/2056-3779-10-1","DOIUrl":"https://doi.org/10.7243/2056-3779-10-1","url":null,"abstract":"","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76342080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid communication: effects of cadmium exposure on the growth-related genes of <i>Daphnia magna</i>.","authors":"Mauricio Fernández","doi":"10.1080/15287394.2022.2034688","DOIUrl":"https://doi.org/10.1080/15287394.2022.2034688","url":null,"abstract":"<p><p>Few data are available regarding the effects of gene expression on growth in <i>Daphnia magna</i>. The aim of this study was to determine the influence of cadmium (Cd) exposure on global gene transcription and growth-related genes in <i>D. magna</i> using RNASeq generated data. Our results demonstrated that Cd exposure decreased gene expression, but did not adversely affect the expression of growth-related genes, suggesting differential allocation of resources to growth avoids the deleterious effect of the toxicant on this trait.</p>","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":" ","pages":"457-460"},"PeriodicalIF":2.6,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39885269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity evaluation of traditional and organic yerba mate (<i>Ilex paraguariensis</i> A. St.-Hil.) extracts.","authors":"Lian da Costa Abrão,&nbsp;Dennis Guilherme Costa-Silva,&nbsp;Michele Goulart Dos Santos,&nbsp;Maristela Barnes Rodrigues Cerqueira,&nbsp;Eliana Badiale-Furlong,&nbsp;Ana Luiza Muccillo-Baisch,&nbsp;Mariana Appel Hort","doi":"10.1080/15287394.2022.2035873","DOIUrl":"https://doi.org/10.1080/15287394.2022.2035873","url":null,"abstract":"<p><p>Yerba mate (<i>Ilex paraguariensis</i> A. St.-Hil.) is an important source of biologically active compounds with pharmacological potential. The aim of this study was to examine the toxicity of different extracts obtained from either traditional or organic cultivated yerba mate <i>in vitro</i> and <i>in vivo</i>. Aqueous, ethanolic and methanolic extracts were obtained from commercial samples of yerba mate and total phenolic content was determined employing Folin-Ciocalteau reagent. The aqueous extracts presented higher content of total phenols, compared to ethanolic and methanolic extracts, and also demonstrated lower cytotoxicity, which is the basis for testing were carried out only using aqueous extracts. The main phenolic acids found in traditional aqueous (TA) extract were chlorogenic, gallic and protocatechuic acids. Gallic and hydroxybenzoic acids were detected in aqueous cultivated organic (OA) extract. Pretreatment with OA extract (100 µg/ml, 1 hr) was cytoprotective against rotenone-induced toxicity (1 µM). For <i>in vivo</i> toxicity assay, zebrafish embryos were exposed to OA or TA extracts (10-160 µg/ml) at 4 hr post fertilization. TA extract decreased embryos survival in a concentration-dependent manner, reduced the hatching rate at 40 µg/ml, increased edema frequency at 80 µg/ml and altered body curvature at 120 µg/ml. Further, TA extract produced locomotor disorders at concentrations equal to or greater than 10 µg/ml. In contrast, OA extract exhibited no apparent toxic effect on organogenesis and behavior up to 100 µg/ml. In summary, the OA cultivated extract showed the lowest cytotoxicity <i>in vitro</i>, enhanced reduction in rotenone-induced toxicity, and produced less toxicity in zebrafish embryos compared to the TA extract.</p>","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":" ","pages":"461-479"},"PeriodicalIF":2.6,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39942837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In vivo</i> effects of 1,4-dioxane on genotoxic parameters and behavioral alterations in <i>Drosophila melanogaster</i>.","authors":"Fatma Turna Demir","doi":"10.1080/15287394.2022.2027832","DOIUrl":"https://doi.org/10.1080/15287394.2022.2027832","url":null,"abstract":"<p><p>1,4-Dioxane (DXN) is used as solvent in different consumer products including cosmetics, paints, surfactants, and waxes. In addition, DXN is released as an unwanted contaminating by-product as a result of some reactions including ethoxylation of alcohols, which occurs with in personal care products. Consequently, DXN pollution was detected in drinking water and is considered as an environmental problem. At present, the genotoxicity effects attributed to DXN are controversial. The present study using an <i>in vivo</i> model organism <i>Drosophila melanogaster</i> aimed to determine the toxic/genotoxic, mutagenic/recombinogenic, oxidative damage as evidenced by ROS production, phenotypic alterations as well as behavioral and developmental alterations that are closely related to neuronal functions. Data demonstrated that nontoxic DXN concentration (0.1, 0.25, 0.5, or 1%) induced mutagenic (1%) and recombinogenic (0.1, 0.25, or 0.5%) effects in wing spot test and genotoxicity in hemocytes using comet assay. The nontoxic concentrations of DXN (0.1, 0.25, 0.5, or 1%) significantly increased oxidative stress, climbing behavior, thermal sensivity and abnormal phenotypic alterations. Our findings show that in contrast to <i>in vitro</i> exposure, DXN using an <i>in vivo</i> model <i>Drosophila melanogaster</i> this compound exerts toxic and genotoxic effects. Data suggest that additional studies using other <i>in vivo</i> models are thus warranted.</p>","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":" ","pages":"414-430"},"PeriodicalIF":2.6,"publicationDate":"2022-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pedunculagin isolated from <i>Plinia cauliflora</i> seeds exhibits genotoxic, antigenotoxic and cytotoxic effects in bacteria and human lymphocytes.","authors":"Amanda Silva Fernandes,&nbsp;Jefferson Hollanda Véras,&nbsp;Luana Santos Silva,&nbsp;Sara Cristina Puga,&nbsp;Elisa Flávia Luiz Cardoso Bailão,&nbsp;Matheus Gabriel de Oliveira,&nbsp;Clever Gomes Cardoso,&nbsp;Cristiene Costa Carneiro,&nbsp;Suzana Da Costa Santos,&nbsp;Lee Chen-Chen","doi":"10.1080/15287394.2021.2009947","DOIUrl":"https://doi.org/10.1080/15287394.2021.2009947","url":null,"abstract":"<p><p>Pedunculagin (PD), an ellagitannin found in different plant species, possesses several pharmaceutical properties, including antitumor, antioxidant, gastroprotective, hepatoprotective, and anti-inflammatory properties. However, the effects of PD alone on DNA remain to be determined. The aim of this study was to investigate the potential cytotoxic, genotoxic, and antigenotoxic activities of PD isolated from <i>Plinia cauliflora</i> seeds using <i>in silico</i> and <i>in vitro</i> assays. To elucidate the biological activities of PD, <i>in silico</i> tools indicative of antioxidant, antineoplastic, and chemopreventive activities of PD were used. Subsequently, the mutagenic/antimutagenic effects of PD were later assessed using bacteria with the Ames test, and the cytotoxic, genotoxic, and antigenotoxic effects utilizing human lymphocytes as evidenced by trypan blue exclusion test and CometChip assay. <i>In silico</i> analysis indicated potential antioxidant, chemopreventive, free radical scavenger, and cytostatic activities of PD. In the Ames test, PD was found to be not mutagenic; however, this plant component protected DNA against damage-mediated by mutagens 4-nitroquinoline-1-oxide and sodium azide. Regarding human lymphocytes, PD alone was cytotoxic and genotoxic; however, it also reduced DNA damage induced by doxorubicin at co- and post-treatment. In conclusion, PD showed genotoxic, antigenotoxic and cytotoxic effects in human lymphocytes and antimutagenic effects in bacteria.</p>","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":" ","pages":"353-363"},"PeriodicalIF":2.6,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39577748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidden toxins: bathtubs as a potential source of lead exposure in children.","authors":"Joanna Balza","doi":"10.1080/15287394.2021.2022053","DOIUrl":"https://doi.org/10.1080/15287394.2021.2022053","url":null,"abstract":"<p><p>Exposure to lead (Pb) remains a serious health concern for children in the United States, particularly those residing in deteriorating housing. While some sources of Pb such as deteriorating paint and lead waterworks are relatively well understood and widely known, other sources remain hidden. One potential hidden source is bathtubs. In this experiment, water resting in a leaded bathtub was tested over a course of 60 min to determine the extent of metal leaching from the tub to the water. Lead levels in the water increased from 6.8 μg/L at baseline to 13 μg/L after resting in the tub for 60 min. Further research is needed to understand if this is typical, the contributing factors, and clinical significance of this finding.</p>","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":" ","pages":"376-380"},"PeriodicalIF":2.6,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39911237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Four new cycloartane-type triterpenoids from the leaves of <i>Combretum mellifluum</i> Eichler: assessment of their antioxidant and antileishmanial activities.","authors":"Jaelson Santos Silva,&nbsp;Éverton Leandro França Ferreira,&nbsp;Amanda Maciel Lima,&nbsp;Ruth Raquel Soares de Farias,&nbsp;Bruno Quirino Araújo,&nbsp;José Carlos Quilles Junior,&nbsp;Rodolfo Ritchelle Lima Santos,&nbsp;Fernando Aécio de Amorim Carvalho,&nbsp;Mahendra Rai,&nbsp;Gerardo Magela Vieira Júnior,&nbsp;Mariana Helena Chaves","doi":"10.1080/15287394.2021.2015030","DOIUrl":"https://doi.org/10.1080/15287394.2021.2015030","url":null,"abstract":"<p><p>The beneficial pharmacological actions including antioxidant effects as an antileishmanial, antibacterial, antifungal, antidiabetic, anti-inflammatory, antitumor, antiviral, and analgesic of compounds isolated from <i>Combretum mellifluum</i> Eichler (Combretaceae) are well established. The aim of the present study was to determine the phytochemistry as well as assess the antioxidant and antileishmanial activities of the leaves from <i>Combretum mellifluum</i> Eichler (Combretaceae). Analysis of ethanolic extract resulted in isolation and identification of two epimeric mixtures of four previously unknown cycloartane-type triterpenoids, methyl quadrangularate M and methyl 24-epiquadrangularate M, and 2α,3β,24β-trihydroxy-cycloart-25-ene and 2α, 3β, 24α-trihydroxy-cycloart-25-ene, and eight known compounds. Their structures were using one-dimensional nuclear magnetic resonance (1D NMR), 2D NMR and high-resolution electrospray ionization mass spectroscopy (HRESIMS) analysis. Further, the extract and fractions were tested for antioxidant potential. The ethyl acetate and aqueous fractions demonstrated the highest antioxidant activity against 2,2-dipheny-1-picrylhydrazl (DPPH) free radicals, which correlated directly with total flavonoid content. All extracts and fractions from <i>C. mellifluum</i> Eichler were assessed for antileishmanial activity. The supernatant fraction exhibited highest potential, inhibiting the growth of <i>Leishmania amazonensis</i> with IC₅₀ value 31.29 μg/ml. Our findings provide information on the chemical composition of <i>C. mellifluum</i> and the potential beneficial therapeutic usefulness as an antioxidant agent in various diseases.</p>","PeriodicalId":17418,"journal":{"name":"Journal of Toxicology and Environmental Health, Part A","volume":" ","pages":"364-375"},"PeriodicalIF":2.6,"publicationDate":"2022-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39745335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}