International Journal of Indigenous Herbs and Drugs最新文献

{"title":"A systematic review on wound healing","authors":"A. Md, Bhuvaneshwari J, Roopa C","doi":"10.46956/ijihd.v8i6.514","DOIUrl":"https://doi.org/10.46956/ijihd.v8i6.514","url":null,"abstract":"The body's initial line of defence, the skin protects the inside organs from heat, chemical, and mechanical harm. It has a highly developed immune system that protects the body from harmful illnesses. The body's natural response to tissue damage is wound healing. But wound healing is a complicated process that involves a wide range of cell types, cytokines, mediators, and the vascular system interacting with one another. It is a complex, strictly controlled process that is essential to retaining all other skin functions in addition to the skin's barrier function. Numerous factors, both modifiable and non-modifiable, can impact this process. In order to successfully restore the damaged tissue, wound healing is a dynamic process supported by a variety of cellular processes, including as homeostasis, inflammation, proliferation, and remodelling. These activities must be properly integrated with one another. When there is damage to the skin, bacteria can swiftly infiltrate the tissues behind the skin, leading to life-threatening infections and chronic wounds. Natural phytomedicines with significant pharmacological qualities have been used extensively and successfully to treat wounds and prevent infections. Phytotherapy has been used for millennia to effectively cure skin wounds and delay the formation of infections. This study focuses on cutaneous wound healing and highlights the classical wound healing phases because wound healing occurs in many regions of the human body. Changes in any one of these stages may encourage the development of chronic wounds and hinder their healing. Numerous plants have been shown to aid in wound healing through a variety of processes.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"67 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139279488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indigenous plants as Oral Herbal Contraceptive: an Updated Review","authors":"Durga Priya, M. Gs, Swati Mittal, Sowmya Shree, Mohammad Shaik Sahil, Parashwar Gogoi, Yojana Khariwara","doi":"10.46956/ijihd.v8i4.479","DOIUrl":"https://doi.org/10.46956/ijihd.v8i4.479","url":null,"abstract":"The exponential growth of the human population in a growing nation like India is one of its most serious issues. Contraceptives that are readily available and acceptable are required in many poorer countries to reduce population growth and in all countries to prevent maternal morbidity and mortality arising from unintended pregnancies. Worldwide, women consume contraceptives at a rate of about 90%. Commercially available birth control tablets are deleterious to women's health and occasionally death. Such pills can lead to fat deposition in the liver, kidneys, and uterus, a rupture of the uterus epithelial layer, irregular and unpleasant menstruation, breast cancer, and finally irreversible infertility. They can also impede metabolism and subsequent pregnancy. When considering the treatment of illnesses that often aren't treatable by allopathic medicine, the term \"herbal plants\" became a prevalent one that entered everyone's consciousness. Ancient physicians were cognizant of plants that may be used as contraceptives. Herbs with an anti-fertility effect include herbal contraceptives. Although less effective than pills, herbal contraceptives can be used as a less harmful option. Modern research on contraception has recently turned its attention to the study of natural herbal contraception.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132199602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmids for Efficient Production of Recombinant Proteins in E. coli","authors":"Lekha Arrolla, Deepthi Sri Kanigiri, Azharuddin Mohammed, Venkata Sri Krishna Kona","doi":"10.46956/ijihd.v8i4.469","DOIUrl":"https://doi.org/10.46956/ijihd.v8i4.469","url":null,"abstract":"Plasmids play a crucial role in the transmission of genetic information across different types of bacteria. Plasmids transfer pathogenicity and survival genes to the host bacterium, allowing the bacteria to adapt to new environments and grow. Several plasmids of differing sizes have been recovered from numerous bacterial species. Plasmids may be used to genetically modify bacteria for a variety of reasons, including the generation of recombinant proteins. Escherichia coli is the most often utilised bacterium for the production of recombinant proteins owing to its quick growth rate, low cost, high yield of recombinant proteins, and simple scale-up procedure. To boost the synthesis of heterologous proteins in E. coli, a number of plasmids have been used. Diverse plasmids have been devised and built to address challenges such as protein refolding, E. coli codon use, a lack of post-translational modifications such as glycosylation, and insufficient recovery of functionally viable recombinant proteins. Recent technical advancements that have made it possible for the E. coli expression system to create more complex proteins, such as glycosylated recombinant proteins and therapeutic antibodies.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139351615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotanical Research in the Digital Age: Harnessing Technology for Data Collection and Analysis","authors":"Dileepu Kumar Banisetti, Nagendra Prasad Kosuri","doi":"10.46956/ijihd.v8i4.466","DOIUrl":"https://doi.org/10.46956/ijihd.v8i4.466","url":null,"abstract":"Ethnobotanical research has been transformed by the digital age, as technology offers innovative tools to collect, manage, and analyze data. This review delves into the advancements in digital ethnobotanical research, including the development of databases, mobile applications, social media, Geographic Information Systems (GIS), remote sensing, big data analytics, and machine learning. It also discusses the challenges and ethical considerations that arise with the use of technology in ethnobotanical research. By embracing these technological advancements responsibly, researchers can enhance the scope, efficiency, and cultural sensitivity of ethnobotanical investigations.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130903575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of medicinal plants in rheumatoid arthritis-an updated review","authors":"Ahmed Jafar Talukdar, Rupesh kumar Mani, Ramakantha Malli, Sowmya Shree, Fayazuddin Md","doi":"10.46956/ijihd.v8i3.459","DOIUrl":"https://doi.org/10.46956/ijihd.v8i3.459","url":null,"abstract":"Rheumatoid arthritis (RA) is a debilitating, persistent autoimmune condition that affects by a variety of endogenous and external causes. It is distinguished by cartilage and bone deterioration. The present traditional allopathic treatment is costly and has negative side effects. Recently, some ethnopharmacological research on RA was published, including anti-RA properties and therapeutic targets of various dosage forms of Traditional Herbal Treatments (THMs). Given the increased herbalists' interest medicines among people suffers from rheumatoid arthritis, further research into their safety and efficacy is needed. The goal of this research was to carry out a comprehensive assessment of the evidence based on the use of herbal medications in the treatment of RA Randomised Clinical Trials (RCTs).Different chemical ingredients discovered in various herbal treatments have modest support for lowering pain, sensitive joint count, and stiffness. Herbal remedies were generally considered safe to use. More study is required to evaluate the effectiveness, safety, and potential medication interactions of the numerous herbal remedies advocated for RA.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117062302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic activity and safety evaluation of two Cameroonian medicinal plants in Streptozotocin-rat model: Tetrapleura tetraptera (Fabaceae) and Irvingiagabonensis (Irvingiaceae)","authors":"Denis Zofou, Crispain Stevie Meka Obate, C. Teugwa Mofor, G. Shu, Ebane Ndode Mesue","doi":"10.46956/ijihd.v8i3.455","DOIUrl":"https://doi.org/10.46956/ijihd.v8i3.455","url":null,"abstract":"Background: Irvingia gabonensis and Tetrapleura tetraptera are widely employed by traditional healers of the southern regions of Cameroon to treat diabetes. However. there is only limited or no scientific evidence on the real potential of these two medicinal plants to serve as alternative therapies. The present works thus aimed to evaluate the antidiabetic activity of the barks of I. gabonensis and fruits of T. tetraptera. Methods: The antidiabetic potential of the four extracts was assessed by evaluating the hypoglycaemic activity through the oral glucose tolerance test (OGTT) in male Wistar albino rats and the subacute antidiabetic assay in streptozotocin-induced Wistar rat model. For the later. clinical markers (water and food intake, urine excretion), Fasting Blood Sugar FBS), the effects on some vital organs (liver and kidney), and lipid profile were considered. Safety was evaluated using the in vivo acute toxicity test in mouse model. Results: Out of the four extracts prepared from T. tetraptera and I. gabonensis, and tested for their antidiabetic potential, only the hydroethanol extract of the stem bark of I. gabonensis showed promising hypoglycemic and anti-hyperglycemic activity from preliminary screening. Of the two doses of this extract considered for the subacute antidiabetic assessment, the dose of 500mg/Kg demonstrated the highest activity reflected in significant improvement in both clinical and biochemical markers with a 100% recovery rate after 21 days treatment of the STZ-induced diabetic Wistar rats. At this dose, the I. gabonensis extract was shown to also improve liver and kidney functions as well as mitigating dyslipidemia in diabetic rats. Overall, its pharmacological properties were above those of the reference drug metformin at 10mg/Kg dose. More interestingly, the acute toxicity study revealed a relative safety of this extract in mice. Conclusion: The present work confirms the potential of the hydroethanolic extract of I. gabonensis to serve a source of new antidiabetic drugs. Further investigations are therefore envisaged.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126638992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of different concentrations of green tea on Cryopreservation of German Shepherd dog","authors":"Nagham y Abood, A. S. Aliawy","doi":"10.46956/ijihd.v8i2.447","DOIUrl":"https://doi.org/10.46956/ijihd.v8i2.447","url":null,"abstract":"To investigate the Effect of adding different concentrations of green tea extract as an antioxidant on specific physical semen characteristics of German Shepherd dogs during various steps of frozen semen processing this study was carried out. A total (of 20) good Ejaculate semen samples were collected in a plastic bag from German Shepherd dogs aged 3-4 yearsIn different locations (dog breeding).To achieve the current study's main objectives, two experiments were designed through periods extended from the beginning of December 2021 until the end of May 2022. The investigations included studying the physical properties of raw Semen (ejaculate volume, semen color, consistency, motility percentage, progressive motility percentage, dead sperm percentage, sperm abnormalities percentage, and hypo-osmotic swelling test (HOST). After that, semen samples were diluted with Tris supplemented with antioxidants. The physical properties of Semen were followed after cooling and after freezing (post-thawing). In the experiment, ten ejaculates were collected. Dilution of Semen was performed with Tris supplemented with two T1, T2, and T3) were cooled slowly up to 5C and equilibrated, packed into 0.5 ml straws, and put in vapor nitrogen (-196C) for 5-10  minutes after that, stored for 48and 72 hr in liquid Nitrogen (-196C). Progressive motility percentage, dead sperm percentage, sperm abnormalities percentage, and hypo-osmotic swelling test (HOST) were evaluated after cooling and post-thawing (Submerging the straws in the water bath at 37C for 30 seconds). It can be concluded from the present study that adding green tea extract as an antioxidant to the semen extender improves the ability to freeze, especially in the treatment T3 (0.01 mg/5 ml) and the T2 (0.05 mg/5 ml). This additive can decrease the negative Effect of freezing in liquid Nitrogen compared to the control group.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"120 24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126315909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overall review on annalytical method development and validation of Nilotinib Hydrochloride","authors":"Mohana Vamsi Nuli, Vijay Kumar Rekulapally","doi":"10.46956/ijihd.v8i2.434","DOIUrl":"https://doi.org/10.46956/ijihd.v8i2.434","url":null,"abstract":"In this review, the article determines the different analytical methods for the quantitative establishment of Nilotinib by using HPLC, HPLC-MS, HPLC-UV, and LC-MS/MS. Pharmaceutical analytical method development of Nilotinib requires valid analytical procedures for quantitative and qualitative analysis in Pharmaceuticals dosage formulations and human serum. This assessment explains that the superiority of the HPLC/LC-MS methods reviewed is based on the quantitative analysis of drugs in formulations, (API), and biological fluids such as serum and plasma.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"8 14","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"113954543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature ovarian insufficiency: an augmenting disorder in the growing female population","authors":"Gagana B A, P. G, Sunil Gowda H P, Sagheer Ahmed Syed, R. M, Surabhi H M","doi":"10.46956/ijihd.v8i1.425","DOIUrl":"https://doi.org/10.46956/ijihd.v8i1.425","url":null,"abstract":"A primary ovarian abnormality such as absent menarche (primary amenorrhea) or early depletion of ovarian follicles/arrested folliculogenesis before the age of 40 is described as premature ovarian insufficiency (secondary amenorrhea). Itsprevalence is 1% and 0.1 % in women under 40 and 30 respectively. Common Symptoms include palpitations, excessive sweating, flushes, anxiety, depression, and fatigue. There could be a variety of causes, including chromosomal abnormalities, autoimmune diseases, infections, idiopathic diseases, iatrogenic diseases, and so on. Diagnosis is usually done based on the level of hormones like estradiol, Follicle Stimulating Harmone, and LuteinizingHarmone. Considering the complications of premature ovarian failure, it is necessary to educate the female population about this disorder. Hence, the Present review focuses on the etiology, symptoms, complications, diagnosis, and treatment of premature ovarian failure.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133062964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of antibacterial property of anthyocyanin extracted from brassica oleracea against gram positive and gram negative bacteria by using erythromycin as a standard drug.","authors":"Anil Kumar Tallam, A. Sahithi, Mohana Vamsi Nuli","doi":"10.46956/ijihd.v8i1.415","DOIUrl":"https://doi.org/10.46956/ijihd.v8i1.415","url":null,"abstract":"Anthocyanin was extracted from Brassica oleracea and identified by UV and TLC.The benzene test initially helps us to identify Anthocyanin in residue. Crystals were purified by recrystallization from ether. Acetone –petroleum ether extraction resulted in higher crude Anthocyanin yield than hexane extraction The compounds were tested against two microorganisms namely E. coli (gram-ve) and bacillus (gram+ve) and the compounds showed significant activity against two species. Test sample one Showed significant activity with zone of inhibition (18.21mm). When compared to standard Erythromycin with zone of inhibition (20.83mm) at 100,200,400mg/ml against E. coli organism. Test sample two Showed significant activity with zone of inhibition (15.56mm) when compared to standard Erythromycin with zone of inhibition at (100,200,400mg/ml) against Bacillus.","PeriodicalId":174082,"journal":{"name":"International Journal of Indigenous Herbs and Drugs","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133368556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}