Journal of Thrombosis and Haemostasis最新文献

{"title":"Osteopontin and venous thromboembolism: a new link in the thromboinflammatory axis?","authors":"Maxim E. Shaydakov , Jose A. Diaz","doi":"10.1016/j.jtha.2025.06.022","DOIUrl":"10.1016/j.jtha.2025.06.022","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 9","pages":"Pages 2716-2717"},"PeriodicalIF":5.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on “Arterial thromboembolic events in testicular cancer patients: short- and long-term incidence, risk factors, and impact on mortality”","authors":"Hege S. Haugnes , Torgrim Tandstad","doi":"10.1016/j.jtha.2025.04.013","DOIUrl":"10.1016/j.jtha.2025.04.013","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 9","pages":"Pages 2710-2712"},"PeriodicalIF":5.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Loss of function in protein Z (PROZ) is associated with increased risk of ischemic stroke in the UK Biobank”: reply","authors":"Amelia K. Haj , Pavan K. Bendapudi","doi":"10.1016/j.jtha.2025.05.019","DOIUrl":"10.1016/j.jtha.2025.05.019","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 9","pages":"Pages 3009-3010"},"PeriodicalIF":5.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Alterations in visible light exposure modulate platelet function and regulate thrombus formation”: comment from Fan et al.","authors":"Bingwen Eugene Fan , Leonardo Pasalic , Giuseppe Lippi , Emmanuel J. Favaloro","doi":"10.1016/j.jtha.2025.05.018","DOIUrl":"10.1016/j.jtha.2025.05.018","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 9","pages":"Pages 3011-3013"},"PeriodicalIF":5.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stratifying and managing the risk of antithrombin deficiency in pregnancy","authors":"Shannon M. Bates","doi":"10.1016/j.jtha.2025.05.025","DOIUrl":"10.1016/j.jtha.2025.05.025","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 9","pages":"Pages 2713-2715"},"PeriodicalIF":5.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Loss of function in protein Z is associated with increased risk of ischemic stroke in the United Kingdom biobank”: comment","authors":"Xinmin Zhao, Liting Ma","doi":"10.1016/j.jtha.2025.04.036","DOIUrl":"10.1016/j.jtha.2025.04.036","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 9","pages":"Pages 3007-3008"},"PeriodicalIF":5.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144867274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Home treatment for pulmonary embolism: a step ahead of the new rule","authors":"Maria Cristina Vedovati, Cecilia Becattini","doi":"10.1016/j.jtha.2025.05.028","DOIUrl":"10.1016/j.jtha.2025.05.028","url":null,"abstract":"","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":"23 9","pages":"Pages 2718-2721"},"PeriodicalIF":5.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetic strategies for achieving precise factor VIII control with susoctocog alfa in acquired hemophilia A.","authors":"Justus Heeg, Christiane Dobbelstein, Alfonso Iorio, Heiko Schenk, Benjamin Seeliger, Andreas Tiede","doi":"10.1016/j.jtha.2025.07.033","DOIUrl":"10.1016/j.jtha.2025.07.033","url":null,"abstract":"<p><strong>Background: </strong>Recombinant porcine factor (F)VIII (rpFVIII, susoctocog alfa) is used to treat bleeding in patients with acquired hemophilia A (AHA), yet pharmacokinetic (PK) parameters and dosing needs vary widely.</p><p><strong>Objectives: </strong>To explore the precision of PK-guided bolus dosing and continuous infusion of rpFVIII in AHA.</p><p><strong>Methods: </strong>We enrolled all AHA patients considered for rpFVIII treatment from 2016 to 2023 at our institution. A user-friendly calculation tool was used to estimate noncompartmental PK parameters from 2 measurements after the initial bolus of rpFVIII, projecting FVIII activity levels for different dosing regimens. PK information was used to guide bolus dosing and continuous infusion, and resulting peak and trough levels were recorded during treatment.</p><p><strong>Results: </strong>Out of 22 patients enrolled, 21 received rpFVIII for severe bleeding. After the initial bolus, the median incremental recovery was 1.33 U/dL per U/kg (IQR, 0.73-1.90), with a half-life of 3.8 hours (IQR, 1.9-7.6) and clearance of 0.10 dL/h/kg (IQR, 0.06-0.47). Subsequent PK-guided treatment included bolus dosing (n = 9) or continuous infusion (n = 12), both were clinically effective. Continuous infusion provided stable FVIII levels over time in most patients. PK parameters remained consistent, with a slight increase in half-life over the first 10 days.</p><p><strong>Conclusion: </strong>PK estimates from limited sampling effectively guided rpFVIII bolus and continuous infusion dosing. Continuous infusion provided steady FVIII levels and may offer a practical alternative to bolus dosing.</p>","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel insights into inherited protein C deficiency from an interactive PROC variant database.","authors":"Shujuan Zhang, Shixia Dong, Zepeng Hou, Shaobo Liu, Cheng Lyu, Hong Zhou, Li-Jiezhuo Ai, Yiming Guo, Yanyan Dong, Meng Zhao, Tianhao Li, Bo Jiang, Tianyu Zhai, Jiahui Pan, Wei Wang, Dapeng Hao, Guomin Shen","doi":"10.1016/j.jtha.2025.07.030","DOIUrl":"10.1016/j.jtha.2025.07.030","url":null,"abstract":"<p><strong>Background: </strong>Hundreds of PROC variants have been identified that cause inherited PROC deficiency (PCD), which increases the risk of thrombosis and other complications, however, it is not well studied for inherited PCD globally.</p><p><strong>Objectives: </strong>To build an interactive PROC variant database for conveniently communicating, and to systematically study the epidemiology, genotype-phenotype relationships, and pathogenesis of inherited PCD.</p><p><strong>Methods: </strong>An interactive PROC variant database was built by collecting the inherited PCD data from literature. Statistical analysis was performed for the epidemiology, clinical characteristics, genotype-phenotype's relationship, risk assessment and pathogenesis of inherited PCD.</p><p><strong>Results: </strong>In the database, 3995 entries, including 242 individuals with biallelic variations (BVs) and 3753 individuals with monoallelic variations (MVs), were collected and 506 unique variations were identified. Some hotspot variations exhibited ethnic specificity and different prevalence. The spectrums of clinical presentations and the first onset age were different between individuals with BVs and MVs. Besides thrombotic related symptoms, a few nonthrombotic symptoms, including miscarriage in individuals with MVs, bleeding disorder, ocular disorder and hypertension in BV individuals, should not be overlooked. The PROC activity was linearly related to the first onset age in BV individuals, but not MV individuals. There might be other thrombophilia factors to trigger thrombosis for MV individuals. Additionally, missense variations in different PROC's subdomains should have different pathogenesis.</p><p><strong>Conclusion: </strong>The database was convenient to retrieve pathogenic variants and clinical presentations, and useful to understand clinical heterogeneity of inherited PCD and pathogenic risk of the variations, which should benefit the diagnosis and management of inherited PCD patients.</p>","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protease domain exosites regulate extravascular binding of factor IX(a).","authors":"Pamela R Westmark, Douglas S Annis, Brianna Torres, Tina M Misenheimer, Bradford S Schwartz, Paul R Hutson, John P Sheehan","doi":"10.1016/j.jtha.2025.07.036","DOIUrl":"10.1016/j.jtha.2025.07.036","url":null,"abstract":"<p><strong>Background: </strong>Factor (F)IX is unique among the vitamin K-dependent coagulation factors in that a substantial portion is bound to extravascular sites.</p><p><strong>Objectives: </strong>Determine the impact of exosites in the human FIX protease domain on clearance, tissue distribution, and activity in hemophilic mice.</p><p><strong>Methods: </strong>Human FIX(a) variants with protease domain substitutions in the antithrombin (R150A), heparin (K126A/K132A), and FIX-Padua (R170A) exosites were evaluated in hemophilia B (zymogen) and A (protease) mice. Pharmacokinetic modeling of FIX(a) clearance, select tissue content, and in vivo activity were determined.</p><p><strong>Results: </strong>FIX wild-type (WT) demonstrated poor plasma recovery, biphasic clearance, and heterogeneous tissue binding. FIX WT was predominantly found in liver, followed by plasma, kidney, heart, and brain. Equimolar FIX variants were similar except for FIX K126A/K132A, which demonstrated 2.3-fold higher plasma recovery and reduced liver content. FIXa WT was cleared more rapidly than zymogen, but also had poor recovery, biphasic clearance, and heterogeneous tissue binding. FIXa-Glu-Gly-Arg-chloromethyl ketone accelerated clearance from all compartments in the distribution phase but prolonged the terminal phase relative to FIXa. FIXa K126A/K132A, R150A, and R170A demonstrated 2- to 3-fold higher plasma recovery than WT, with reduced liver content for FIXa K126A/K132A. Despite reduced coagulant activity, FIX K126A/K132A and R150A demonstrated intact or enhanced potency relative to FIX WT in the saphenous vein bleeding and FeCl₃-induced carotid artery occlusion models, while FIX R170A had enhanced potency in both models.</p><p><strong>Conclusion: </strong>Protease exosites regulate in vivo clearance, distribution, and FIX(a) activity. Human FIX(a) demonstrates extensive tissue-specific binding to extravascular sites.</p>","PeriodicalId":17326,"journal":{"name":"Journal of Thrombosis and Haemostasis","volume":" ","pages":""},"PeriodicalIF":5.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}