Journal of The Chinese Institute of Chemical Engineers最新文献_第6页

Neuroimaging study of partial differential equation reading in brain 脑偏微分方程阅读的神经影像学研究

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-07-01 DOI: 10.1016/j.jcice.2008.03.003

Xiao-Dong Wang , Ming-Tung Wang , Duu-Jong Lee

引用次数: 9

A novel perspective on designing the inhibitor of HER2 receptor HER2受体抑制剂设计的新视角

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-07-01 DOI: 10.1016/j.jcice.2008.02.003

Calvin Yu-Chian Chen

{"title":"A novel perspective on designing the inhibitor of HER2 receptor","authors":"Calvin Yu-Chian Chen","doi":"10.1016/j.jcice.2008.02.003","DOIUrl":"10.1016/j.jcice.2008.02.003","url":null,"abstract":"<div><p>The hot topic in cancer therapy, human epidermal growth factor receptor 2 protein (HER2), have been indicated that the overexpression of HER2 associated with ovarian, esophageal, gastric and breast cancers recently. To investigate the novel tyrosine kinase inhibitor of HER2 receptor, we employed the molecular simulation and structure-based drug design. Compounds from our laboratory database and two control kinase inhibitors, Tarceva and Iressa, were employed to dock into the HER2 ATP binding site. Three candidates with the highest dockscore were used for De Novo Evolution and 24 virtual compounds were generated. We found that the key residue, Phe731, would construct the pi-stacking interaction with both Tarceva and Iressa was conclusively regarded as the key residue for the inhibitory efficiency. The addition of 1,5-dimethyl-1H-imidazole group on compound A<sub>1</sub> produced the extra hydrophobic interaction, and the pi-stacking interaction with Phe731 was generated by the same aromatic group on both compound A and A<sub>1</sub>. Although compound B<sub>1</sub> and C<sub>1</sub> could not produce the pi-stacking interaction with Phe731, both compounds which possessed the lower binding energy and higher dockscore than the two control compounds were believed to compete with the ATP molecule. Compound A<sub>1</sub>, B<sub>1</sub> and C<sub>1</sub> were suggested the potent ATP-competitive inhibitors through the significant scores, binding affinity, hydrogen bond linkages and pi-stacking interaction, and these scaffolds were proposed for further drug design.</p></div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2008.02.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90804943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Recovering phenanthrene from spiked sand by a combined remediation process of micellar solubilization and cloud-point extraction 胶束增溶和云点萃取联合修复法回收尖刺砂中的菲

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-07-01 DOI: 10.1016/j.jcice.2008.01.005

Jing-Liang Li , Bing-Hung Chen

{"title":"Recovering phenanthrene from spiked sand by a combined remediation process of micellar solubilization and cloud-point extraction","authors":"Jing-Liang Li , Bing-Hung Chen","doi":"10.1016/j.jcice.2008.01.005","DOIUrl":"10.1016/j.jcice.2008.01.005","url":null,"abstract":"<div><p>A remediation process, which combines the micellar solubilization and the cloud-point extraction technique by a nonionic surfactant Tergitol 15-S-7, was used to decontaminate phenanthrene, as a model hydrophobic pollutant, from spiked sand samples. A first-order kinetics model was employed to describe the solubilization behavior of phenanthrene well. It was observed that presence of surfactant decreased the mass-transfer coefficient of phenanthrene from sand surface to surfactant solutions, however, higher solubilization rate was obtained due to enhanced aqueous solubility and, thus, the larger driving force resulted from solublization. Cloud-point extraction was used to concentrate the phenanthrene solubilized in the washing solutions in an attempt to minimize the amount of wastewater. The extraction was carried out, subsequently, at room temperature by adding sodium sulfate to suppress the cloud-point low enough to induce phase-separation of the surfactant-rich phase with a minimal phase volume from the coexisting water phase. Recoveries higher than 93% were achieved in the combined process of micellar solubilization and cloud-point extraction on ultimate removal of immobilized phenanthrene sorbed on sands. The results showed that this combined process is efficient in recovering phenanthrene sorbed and immobilized on sands from contaminated sites, and produces only minimal amount of wastewater, i.e. less than 3% of its original volume.</p></div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2008.01.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80656340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Effect of plate aspect ratio on the recovery of deuterium from water–isotope mixture in flat-plate thermal diffusion columns with transverse sampling streams 平板宽高比对横向采样流平板热扩散塔水同位素混合物中氘回收的影响

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-07-01 DOI: 10.1016/j.jcice.2008.01.007

Ho-Ming Yeh

引用次数: 1

Isobaric vapor–liquid equilibria for mixtures of tetrahydrofuran, 2-propanol, and 2,2,4-trimethylpentane at 101.3 kPa 四氢呋喃、2-丙醇和2,2,4-三甲基戊烷混合物在101.3 kPa下的等压汽液平衡

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-05-01 DOI: 10.1016/j.jcice.2007.12.015

Chia-Chiang Hsu, Chein-Hsiun Tu

{"title":"Isobaric vapor–liquid equilibria for mixtures of tetrahydrofuran, 2-propanol, and 2,2,4-trimethylpentane at 101.3 kPa","authors":"Chia-Chiang Hsu, Chein-Hsiun Tu","doi":"10.1016/j.jcice.2007.12.015","DOIUrl":"10.1016/j.jcice.2007.12.015","url":null,"abstract":"<div><p>Vapor–liquid equilibrium (VLE) at 101.3kPa have been determined for a ternary system (tetrahydofuran+2-propanol+2,2,4-trimethylpentane) and its constituent binary systems (tetrahydrofuran+2-propanol, tetrahydrofuran+2,2,4-trimethylpentane, and 2-propanol+2,2,4-trimethylpentane). The activity coefficients of liquid mixtures were calculated from the modified Raoult's law. Thermodynamic consistency tests were performed for all VLE data. The VLE data of the binary mixtures and ternary mixtures were correlated using the Margules, Wilson, NRTL, and UNIQUAC activity-coefficient models. The models with their best-fitted interaction parameters of the binary systems were used to predict the ternary vapor–liquid equilibrium. All VLE data are also used to calculate the reduced excess molar Gibbs free energy <em>g</em><sup>E</sup>/<em>RT</em> and the deviations in the boiling point Δ<em>T</em>. The calculated quantities of <em>g</em><sup>E</sup>/<em>RT</em> and Δ<em>T</em> were fitted to variable-degree polynomials in terms of liquid composition.</p></div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2007.12.015","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86749952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Modeling convective drying of wet cake 湿饼对流干燥模拟

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-05-01 DOI: 10.1016/j.jcice.2007.12.010

Tao Tao , Xiao-Feng Peng , Ay Su , Duu-Jong Lee , Arun Sadashiv Mujumdar

引用次数: 19

Penicillin G acylase purification with the aid of high-throughput screening approach 借助高通量筛选方法纯化青霉素G酰化酶

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-05-01 DOI: 10.1016/j.jcice.2007.12.013

Jin Zhou, Yong-Hong Wang, Ju Chu, Bing-Quan Gou, Ying-Ping Zhuang, Si-Liang Zhang, Zhong-Yi Yuan

{"title":"Penicillin G acylase purification with the aid of high-throughput screening approach","authors":"Jin Zhou, Yong-Hong Wang, Ju Chu, Bing-Quan Gou, Ying-Ping Zhuang, Si-Liang Zhang, Zhong-Yi Yuan","doi":"10.1016/j.jcice.2007.12.013","DOIUrl":"10.1016/j.jcice.2007.12.013","url":null,"abstract":"<div><p>Penicillin G acylase (PGA) is one of the most important enzymes for the production of semi-synthetic β-lactam antibiotics and their key intermediates. Purification of penicillin G acylase from fermentation broth with the aid of high-throughput screening (HTS) process has been examined in this study. We used a microtiter-plate based on screening method to find appropriate purification conditions for the target protein. The screening method is based on a 96-well plate format, and different matrices and conditions (pH, salt concentration and type) were tested. Through analyses of all pooled fractions (flow-through and elution) we gained appropriate information to choose the best performing matrix and buffer conditions for upscaling. After an upscaled purification step the second unit operation is screened in the similar way and parameters for this operation can be chosen. The purification parameter of purified PGA at the small-screen and upscaling levels were measured, respectively. The results indicate that high-throughput progress based on a 96-well plate is a flexible and efficient paradigm for recombinant protein purification.</p></div>","PeriodicalId":17285,"journal":{"name":"Journal of The Chinese Institute of Chemical Engineers","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2008-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jcice.2007.12.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81899024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Plasma-assisted supercritical carbon dioxide removal process for photoresist stripping applications 等离子体辅助超临界二氧化碳去除光刻胶剥离应用

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-05-01 DOI: 10.1016/j.jcice.2007.12.008

Yen-Ping Wang, Tsao-Jen Lin, Tai-Chou Lee

引用次数: 3

Two-phase flow simulation of reactor clarifiers 反应器澄清池的两相流模拟

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-05-01 DOI: 10.1016/j.jcice.2008.01.002

Wen-Jie Yang, Chu-Chuao Wang, Ren-Yi Hsu, Rome-Ming Wu

引用次数: 9

An enzymatic/acid-catalyzed hybrid process for biodiesel production from soybean oil 酶法/酸催化大豆油制备生物柴油的混合工艺研究

Journal of The Chinese Institute of Chemical Engineers Pub Date : 2008-05-01 DOI: 10.1016/j.jcice.2008.01.004

Wei-Jia Ting , Chun-Ming Huang , Nair Giridhar , Wen-Teng Wu

引用次数: 60