{"title":"Preparing the way for novel blood-based biomarkers and disease-modifying treatments for Alzheimer's disease in the NHS in the UK.","authors":"Roxanna Korologou-Linden, Lefkos Middleton, Azeem Majeed, Dasha Nicholls, Oliver Robinson, Benedict Hayhoe","doi":"10.1177/01410768241311139","DOIUrl":"https://doi.org/10.1177/01410768241311139","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":" ","pages":"1410768241311139"},"PeriodicalIF":8.8,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regulating reliably: building high-reliability regulators in healthcare.","authors":"Carl Macrae","doi":"10.1177/01410768241309191","DOIUrl":"10.1177/01410768241309191","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":" ","pages":"1410768241309191"},"PeriodicalIF":8.8,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"'Adult ADHD' and 'neurodevelopmental disorder' - a critique of the latest socio-psychiatric 'epidemic'.","authors":"Derek Summerfield","doi":"10.1177/01410768241311321","DOIUrl":"10.1177/01410768241311321","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":" ","pages":"1410768241311321"},"PeriodicalIF":8.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143007459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CORRIGENDUM to 'British maternal mortality in the 19th and early 20th centuries'.","authors":"","doi":"10.1177/01410768241310682","DOIUrl":"10.1177/01410768241310682","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":" ","pages":"1410768241310682"},"PeriodicalIF":8.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755419/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"John Keats: the mystery years.","authors":"Nick Black","doi":"10.1177/01410768241279029","DOIUrl":"10.1177/01410768241279029","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":" ","pages":"392-397"},"PeriodicalIF":8.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Whether you are highly numerate, literate, or both, stay humble and read more poetry.","authors":"Kamran Abbasi","doi":"10.1177/01410768241308879","DOIUrl":"10.1177/01410768241308879","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":"117 12","pages":"391"},"PeriodicalIF":8.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Death Notices.","authors":"","doi":"10.1177/01410768241306260","DOIUrl":"10.1177/01410768241306260","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":"117 12","pages":"417"},"PeriodicalIF":8.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11662318/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Whether you are highly numerate, literate, or both, stay humble and read more poetry.","authors":"Kamran Abbasi","doi":"10.1177/01410768241308879","DOIUrl":"https://doi.org/10.1177/01410768241308879","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":"117 12","pages":"391"},"PeriodicalIF":8.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Food in Daniel 1:1-16: the first report of a controlled experiment?","authors":"Susan Weingarten","doi":"10.1177/01410768241294253","DOIUrl":"10.1177/01410768241294253","url":null,"abstract":"","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":" ","pages":"415-416"},"PeriodicalIF":8.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142639168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karen Jeffrey, Vicky Hammersley, Rishma Maini, Anna Crawford, Lana Woolford, Ashleigh Batchelor, David Weatherill, Chris White, Tristan Millington, Robin Kerr, Siddharth Basetti, Calum Macdonald, Jennifer K Quint, Steven Kerr, Syed Ahmar Shah, Amanj Kurdi, Colin R Simpson, Srinivasa Vittal Katikireddi, Igor Rudan, Chris Robertson, Lewis Ritchie, Aziz Sheikh, Luke Daines
{"title":"Deriving and validating a risk prediction model for long COVID: a population-based, retrospective cohort study in Scotland.","authors":"Karen Jeffrey, Vicky Hammersley, Rishma Maini, Anna Crawford, Lana Woolford, Ashleigh Batchelor, David Weatherill, Chris White, Tristan Millington, Robin Kerr, Siddharth Basetti, Calum Macdonald, Jennifer K Quint, Steven Kerr, Syed Ahmar Shah, Amanj Kurdi, Colin R Simpson, Srinivasa Vittal Katikireddi, Igor Rudan, Chris Robertson, Lewis Ritchie, Aziz Sheikh, Luke Daines","doi":"10.1177/01410768241297833","DOIUrl":"10.1177/01410768241297833","url":null,"abstract":"<p><strong>Objectives: </strong>Using electronic health records, we derived and internally validated a prediction model to estimate risk factors for long COVID and predict individual risk of developing long COVID.</p><p><strong>Design: </strong>Population-based, retrospective cohort study.</p><p><strong>Setting: </strong>Scotland.</p><p><strong>Participants: </strong>Adults (≥18 years) with a positive COVID-19 test, registered with a general medical practice between 1 March 2020 and 20 October 2022.</p><p><strong>Main outcome measures: </strong>Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) for predictors of long COVID, and patients' predicted probabilities of developing long COVID.</p><p><strong>Results: </strong>A total of 68,486 (5.6%) patients were identified as having long COVID. Predictors of long COVID were increasing age (aOR: 3.84; 95% CI: 3.66-4.03 and aOR: 3.66; 95% CI: 3.27-4.09 in first and second splines), increasing body mass index (BMI) (aOR: 3.17; 95% CI: 2.78-3.61 and aOR: 3.09; 95% CI: 2.13-4.49 in first and second splines), severe COVID-19 (aOR: 1.78; 95% CI: 1.72-1.84); female sex (aOR: 1.56; 95% CI: 1.53-1.60), deprivation (most versus least deprived quintile, aOR: 1.40; 95% CI: 1.36-1.44), several existing health conditions. Predictors associated with reduced long COVID risk were testing positive while Delta or Omicron variants were dominant, relative to when the Wild-type variant was dominant (aOR: 0.85; 95% CI: 0.81-0.88 and aOR: 0.64; 95% CI: 0.61-0.67, respectively) having received one or two doses of COVID-19 vaccination, relative to unvaccinated (aOR: 0.90; 95% CI: 0.86-0.95 and aOR: 0.96; 95% CI: 0.93-1.00).</p><p><strong>Conclusions: </strong>Older age, higher BMI, severe COVID-19 infection, female sex, deprivation and comorbidities were predictors of long COVID. Vaccination against COVID-19 and testing positive while Delta or Omicron variants were dominant predicted reduced risk.</p>","PeriodicalId":17271,"journal":{"name":"Journal of the Royal Society of Medicine","volume":" ","pages":"402-414"},"PeriodicalIF":8.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11574934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}