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New, convenient route for trifluoromethylation of steroidal molecules 甾体分子三氟甲基化的新便捷途径
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-20 DOI: 10.1039/A706552C
X. Fei, W. Tian, Qing‐Yun Chen
{"title":"New, convenient route for trifluoromethylation of steroidal molecules","authors":"X. Fei, W. Tian, Qing‐Yun Chen","doi":"10.1039/A706552C","DOIUrl":"https://doi.org/10.1039/A706552C","url":null,"abstract":"A new convenient route for direct trifluoromethylation of steroidal compounds is described. Steroidal alkenyl bromides, derived from steroidal unsaturated ketones, react with FO2SCF2CO2Me in the presence of CuI in DMF to give the corresponding trifluoromethylated steroids in good yields (70–91%).","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"16 1","pages":"1139-1142"},"PeriodicalIF":0.0,"publicationDate":"2010-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76482319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 22
Facile preparation of N-methyl secondary amines by titanium(IV) isopropoxide-mediated reductive amination of carbonyl compounds 异丙醇钛介导羰基化合物还原胺化制备n -甲基仲胺
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-18 DOI: 10.1039/A803703E
K. A. Neidigh, M. Avery, J. Williamson, S. Bhattacharyya
{"title":"Facile preparation of N-methyl secondary amines by titanium(IV) isopropoxide-mediated reductive amination of carbonyl compounds","authors":"K. A. Neidigh, M. Avery, J. Williamson, S. Bhattacharyya","doi":"10.1039/A803703E","DOIUrl":"https://doi.org/10.1039/A803703E","url":null,"abstract":"A simple, mild and efficient procedure for obtaining N-methyl secondary amines from aldehydes and ketones is reported. Treatment of carbonyl compounds with methylamine hydrochloride, triethylamine and titanium(IV) isopropoxide, followed by in situ sodium borohydride reduction and straightforward aqueous work-up, affords clean products in good to excellent yields.","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"24 1","pages":"2527-2532"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75115420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
The stereochemistry of the vinylogous Peterson elimination 葡萄皮特森消去的立体化学
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-18 DOI: 10.1039/A804090G
I. Fleming, I. Morgan, A. K. Sarkar
{"title":"The stereochemistry of the vinylogous Peterson elimination","authors":"I. Fleming, I. Morgan, A. K. Sarkar","doi":"10.1039/A804090G","DOIUrl":"https://doi.org/10.1039/A804090G","url":null,"abstract":"Base-induced eliminations of the vinylogous β-hydroxysilanes 7, 9, 11 and 12 are stereospecifically syn, giving largely the trans,trans-diene 8 from 7 and 11, the cis,trans-diene 10 from 9, and the trans,cis-diene 13 from 12. When a cis double bond is produced, it is selectively placed adjacent to the carbon atom that originally carried the hydroxy group. E2′ Reactions with silyl as the electrofugal group and acetate as the nucleofugal group, initiated by fluoride ion, are not stereospecific, but can be highly stereoselective in favour of the trans,trans-diene 8 when the carbon substituent at the silicon-bearing end is a cyclohexyl group and the double bond is cis, and in favour of the trans,cis-diene 13 when the carbon substituent at the silicon-bearing end is a methyl group and the double bond is trans. Attempts to use the Peterson reactions to make o-quinodimethanes stereospecifically failed, with no evidence of 1,4-elimination from the alcohols 40 and 41. The corresponding E2′ reaction from the esters using fluoride ion on the acetates or formates 46 and 47 gave stereoselectively the E,E-quinodimethane 48.","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"138 1","pages":"2749-2764"},"PeriodicalIF":0.0,"publicationDate":"2010-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89357670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Cycloadditions in synthesis 合成中的环加成
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-16 DOI: 10.1039/A803583K
C. Dell
{"title":"Cycloadditions in synthesis","authors":"C. Dell","doi":"10.1039/A803583K","DOIUrl":"https://doi.org/10.1039/A803583K","url":null,"abstract":"","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"1 1","pages":"3873-3905"},"PeriodicalIF":0.0,"publicationDate":"2010-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74500437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 92
The synthesis of novel 3′,5′-homocyclic nucleotides as potential anti-HIV agents 作为潜在抗hiv药物的新型3 '，5 ' -同环核苷酸的合成
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-14 DOI: 10.1039/A900800D
M. Drew, S. Gorsuch, Jayne H. M. Gould, J. Mann
{"title":"The synthesis of novel 3′,5′-homocyclic nucleotides as potential anti-HIV agents","authors":"M. Drew, S. Gorsuch, Jayne H. M. Gould, J. Mann","doi":"10.1039/A900800D","DOIUrl":"https://doi.org/10.1039/A900800D","url":null,"abstract":"(5S)-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H)-one has been converted into cytosine 2′,3′-dideoxy-3′,5′-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"26 1","pages":"969-978"},"PeriodicalIF":0.0,"publicationDate":"2010-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87230105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Saturated and unsaturated lactones 饱和和不饱和内酯
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-13 DOI: 10.1039/A808137I
I. Collins
{"title":"Saturated and unsaturated lactones","authors":"I. Collins","doi":"10.1039/A808137I","DOIUrl":"https://doi.org/10.1039/A808137I","url":null,"abstract":"Covering: 1 November 1996 to 31 October 1997Previous review: Contemp. Org. Synth., 1997, 4, 281","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"38 1","pages":"1377-1396"},"PeriodicalIF":0.0,"publicationDate":"2010-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88651783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 118
Synthesis of aromatic heterocycles 芳香族杂环的合成
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-12 DOI: 10.1039/A904578C
T. L. Gilchrist
{"title":"Synthesis of aromatic heterocycles","authors":"T. L. Gilchrist","doi":"10.1039/A904578C","DOIUrl":"https://doi.org/10.1039/A904578C","url":null,"abstract":"Covering March 1999 to February 2001. Previous review: J. Chem. Soc., Perkin Trans. 1, 1999, 2849","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"7 1","pages":"615-628"},"PeriodicalIF":0.0,"publicationDate":"2010-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89142461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 216
Imines, enamines and oximes 亚胺，胺和肟
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-09 DOI: 10.1039/A808142E
Joseph P. Adams
{"title":"Imines, enamines and oximes","authors":"Joseph P. Adams","doi":"10.1039/A808142E","DOIUrl":"https://doi.org/10.1039/A808142E","url":null,"abstract":"Covering: January 1997 to December 1998Continuing the coverage in Contemp. Org. Synth., 1997, 4, 517 \u0000p","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"1 1","pages":"125-139"},"PeriodicalIF":0.0,"publicationDate":"2010-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82930624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 189
An efficient semisynthesis of 7-deoxypaclitaxel from taxine 7-去氧紫杉醇半合成的研究
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-09 DOI: 10.1039/A907288H
R. Saicic, R. Matovic
{"title":"An efficient semisynthesis of 7-deoxypaclitaxel from taxine","authors":"R. Saicic, R. Matovic","doi":"10.1039/A907288H","DOIUrl":"https://doi.org/10.1039/A907288H","url":null,"abstract":"A semisynthesis of 7-deoxypaclitaxel 4 is described, starting from taxine 6 \u0000– the most abundant naturally occurring taxane diterpene fraction. A key step in this transformation is a tandem reaction: stereoselective osmylation of cinnamic ester 14/intramolecularly assisted methanolysis of 16, which gives the key intermediate 5, along with the optically pure ester 17 \u0000– a precursor for the synthesis of the paclitaxel side-chain. In this way, the cinnamoyltaxicine 9 is converted into 7-deoxybaccatin III 25 in 11 steps, and in 15% overall yield.","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"32 4 1","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"2010-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90057865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Carboxylic acids and esters 羧酸和酯
Journal of The Chemical Society-perkin Transactions 1 Pub Date : 2010-06-08 DOI: 10.1039/A808136K
A. Franklin
{"title":"Carboxylic acids and esters","authors":"A. Franklin","doi":"10.1039/A808136K","DOIUrl":"https://doi.org/10.1039/A808136K","url":null,"abstract":"Covering: 1 August 1997 to 31 July 1998Previous review: J. Chem. Soc., Perkin Trans. 1, 1998, 2451","PeriodicalId":17267,"journal":{"name":"Journal of The Chemical Society-perkin Transactions 1","volume":"10 1","pages":"2451-2466"},"PeriodicalIF":0.0,"publicationDate":"2010-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86182781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
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