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Correction to “Sex Differences in Patterns of Potentially Inappropriate Prescribing and Adverse Drug Reactions in Hospitalized Older People: Findings From the SENATOR Trial” 住院老年人潜在不当处方和药物不良反应模式的性别差异:SENATOR 试验结果"。
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-11 DOI: 10.1111/jgs.19410
{"title":"Correction to “Sex Differences in Patterns of Potentially Inappropriate Prescribing and Adverse Drug Reactions in Hospitalized Older People: Findings From the SENATOR Trial”","authors":"","doi":"10.1111/jgs.19410","DOIUrl":"10.1111/jgs.19410","url":null,"abstract":"<p>\u0000 \u0000 <span>O'Mahony, D</span>, <span>Cruz-Jentoft, AJ</span>, <span>Gudmundsson, A</span>, <span>Soiza, RL</span>, <span>Petrovic, M</span>, <span>Cherubini, A</span>, <span>Byrne, S</span>, and <span>Rochon, P.</span> <span>Sex Differences in Patterns of Potentially Inappropriate Prescribing and Adverse Drug Reactions in Hospitalized Older People: Findings From the SENATOR Trial</span>. <i>Journal of the American Geriatrics Society</i> <span>72</span>, no. <span>11</span> (<span>2024</span>): <span>3476</span>–<span>3483</span>. doi: 10.1111/jgs.19071\u0000 \u0000 </p><p>In the author affiliation section, under the title and list of authors, Professor Antonio Cherubini's second affiliation was omitted.</p><p>We apologize for this error.</p>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 5","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.19410","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association of Long COVID-19 Symptoms, Physical Function, and Activities of Daily Living Among Older Women 老年妇女长期COVID-19症状、身体功能和日常生活活动的关系
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-10 DOI: 10.1111/jgs.19434
Xiaochen Zhang, Chloe Hery, Eric M. McLaughlin, Nancy F. Woods, Marian L. Neuhouser, Holly Harris, Emily W. Gower, Jean Wactawski-Wende, Aladdin H. Shadyab, Robert B. Wallace, Electra D. Paskett
{"title":"The Association of Long COVID-19 Symptoms, Physical Function, and Activities of Daily Living Among Older Women","authors":"Xiaochen Zhang,&nbsp;Chloe Hery,&nbsp;Eric M. McLaughlin,&nbsp;Nancy F. Woods,&nbsp;Marian L. Neuhouser,&nbsp;Holly Harris,&nbsp;Emily W. Gower,&nbsp;Jean Wactawski-Wende,&nbsp;Aladdin H. Shadyab,&nbsp;Robert B. Wallace,&nbsp;Electra D. Paskett","doi":"10.1111/jgs.19434","DOIUrl":"10.1111/jgs.19434","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The impact of COVID-19 on physical function (PF) outcomes among older adults remains unclear. We examined the long-term association between COVID, PF, and Activities of Daily Living (ADLs) among women from the Women's Health Initiative (WHI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Participants from the WHI who completed the COVID-19 survey (2021–2022) and annual survey (2022) were included. Self-reported data on COVID-19 testing and symptoms (2021–2022) were used. PF score and ADLs were evaluated pre- and post-COVID-19 survey by the 36-Item Short Form Survey PF subscale, the Lawton Instrumental Activities of Daily Living, and the Katz Index of Independence in ADL. Multivariable linear regression and logistic regression were used and adjusted for pre-COVID functioning to examine the association between COVID status, PF, and ADLs. The interaction between pre-COVID functioning and COVID status was tested.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 13,933 WHI participants, 71.4% were aged ≥ 80 years, and 88.6% were Non-Hispanic White. Only 8.7% tested positive for COVID-19 (<i>n</i> = 1210), with 35.1% having long COVID (<i>n</i> = 425). The most common long COVID symptoms were fatigue (18.2%), malaise (12.2%), memory problems (12.1%), and brain fog (11.2%). Women who tested COVID+ had lower PF scores (60 vs. 65, <i>p</i> = 0.045) and were less likely to be able to do all ADLs without help (74% vs. 79.2%, <i>p</i> = 0.015) compared to those who never tested COVID+. After controlling for covariates, post-COVID PF scores did not differ by COVID status (<i>p</i> = 0.30), although pre-COVID PF scores were significantly linked to post-COVID scores (<i>p</i> &lt; 0.001). Similarly, the odds of being able to do all ADLs without any help did not differ by COVID status (<i>p</i> = 0.31), with pre-COVID ADLs significantly associated with post-COVID ADLs (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In older women, after accounting for pre-COVID functional status, the association between long COVID and lower functioning became nonsignificant. Our findings highlight the importance of preserving physical functioning among older women.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 6","pages":"1711-1721"},"PeriodicalIF":4.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.19434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143588888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reply to: Comment on: Neuropsychiatric Presentations of Common Dementia Syndromes: A Concise Review for Primary Care Team Members 回复:评论:常见痴呆综合征的神经精神表现:初级保健团队成员的简明回顾。
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-07 DOI: 10.1111/jgs.19413
Zoe Bell, Maureen K. O'Connor, Lauren R. Moo
{"title":"Reply to: Comment on: Neuropsychiatric Presentations of Common Dementia Syndromes: A Concise Review for Primary Care Team Members","authors":"Zoe Bell,&nbsp;Maureen K. O'Connor,&nbsp;Lauren R. Moo","doi":"10.1111/jgs.19413","DOIUrl":"10.1111/jgs.19413","url":null,"abstract":"&lt;p&gt;In Strijkert et al. [&lt;span&gt;1&lt;/span&gt;]'s response to our article “Neuropsychiatric presentations of common dementia syndromes: A concise review for primary care team members” [&lt;span&gt;2&lt;/span&gt;] describing the neuropsychiatric symptoms (NPS) of common dementia syndromes, they point out that impairment in social cognition may explain many of the symptoms associated with mild behavioral impairment (MBI). Therefore, they advocate for assessing for changes in social cognition during dementia screenings in primary care. We agree that social cognition is an important facet of NPS in emerging dementia syndromes and therefore should be evaluated. However, as the authors point out, social cognition cannot be fully assessed during a routine primary care visit.&lt;/p&gt;&lt;p&gt;In our article, we suggest the use of questionnaires such as the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Symptom Inventory (NSI) to assess for behavioral impairment. In Strijkert et al. [&lt;span&gt;1&lt;/span&gt;]'s reply, they point out that these measures rely on subjective sources of information and omit certain aspects of social cognition. Other questionnaires have similar shortcomings [&lt;span&gt;3, 4&lt;/span&gt;]. We acknowledge the limitations of these questionnaires and time burden of administering such questionnaires in a primary care setting. In their reply, the authors suggest that well-validated objective neuropsychological measures be used to assess different aspects of social cognition, and we agree. However, as we have noted previously, referral to specialty care, including neuropsychology, though ideal, is not always possible [&lt;span&gt;2, 5&lt;/span&gt;]. We are not aware of a standardized way to assess for changes in social cognition in a generalist setting. In the service of providing guidance to individuals in a primary care setting, as was the focus of our original article, we suggest that when there is concern for changes in cognitive, behavioral, or psychiatric functioning in adults age 50+, primary care team members ask broad, open-ended questions that may be sensitive to changes in social cognition. A simple inquiry into the patient's social relationships (e.g., “Have you noticed any changes in your relationships?”) may help to elucidate emerging impairments in social cognition by revealing recent relational tension or discord, as impaired social cognition is expected to negatively affect interpersonal dynamics [&lt;span&gt;6&lt;/span&gt;]. A query regarding changes in sexual behavior/sexual health may also be telling, as changes in sexual behavior are often associated with changes in social cognition [&lt;span&gt;7, 8&lt;/span&gt;]. If the response to these screening questions conveys a possible decline in social cognition, this becomes another data point that the primary care team member can use to determine whether further evaluation by specialty care is warranted.&lt;/p&gt;&lt;p&gt;In short, we agree that changes in social cognition should be added to the list of NPS that can accompany or predate dementi","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 6","pages":"1966-1967"},"PeriodicalIF":4.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.19413","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comment on: “Neuropsychiatric Presentations of Common Dementia Syndromes: A Concise Review for Primary Care Team Members” 评论:“常见痴呆综合征的神经精神表现:初级保健团队成员的简明回顾”。
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-07 DOI: 10.1111/jgs.19412
Fijanne Strijkert, Myrthe E. Scheenen, Rients B. Huitema, Esther van den Berg, Barbara C. van Munster, Jacoba M. Spikman
{"title":"Comment on: “Neuropsychiatric Presentations of Common Dementia Syndromes: A Concise Review for Primary Care Team Members”","authors":"Fijanne Strijkert,&nbsp;Myrthe E. Scheenen,&nbsp;Rients B. Huitema,&nbsp;Esther van den Berg,&nbsp;Barbara C. van Munster,&nbsp;Jacoba M. Spikman","doi":"10.1111/jgs.19412","DOIUrl":"10.1111/jgs.19412","url":null,"abstract":"&lt;p&gt;Bell et al. [&lt;span&gt;1&lt;/span&gt;] provide a highly insightful and clinically useful overview of the behavioral presentation of four types of dementia (i.e., Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD), dementia with Lewy bodies (DLB) and vascular dementia (VaD), that are often encountered in both memory clinics and by primary care providers. In their article, they stress the importance of timely recognition of neuropsychiatric symptoms (NPS) as potential early markers of neurodegeneration and explain symptoms such as social inappropriateness, lack of motivation, and impulsivity to be part of the construct of mild behavioral impairment (MBI), analogous to mild cognitive impairment (MCI), which can precede cognitive symptoms [&lt;span&gt;2&lt;/span&gt;]. However, in our opinion, an important concept related to NPS and MBI is missing, namely social cognition. Social cognition, first added as a core neurocognitive domain in the fifth edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-5) [&lt;span&gt;3&lt;/span&gt;], refers to the processing and understanding of socially relevant information, necessary for adequately regulating behavior in a social interpersonal context [&lt;span&gt;4&lt;/span&gt;]. Socio-cognitive processes include empathy, emotion recognition, and mentalizing about others' thoughts, beliefs, and feelings, which is also being referred to as Theory of Mind (ToM)) [&lt;span&gt;4&lt;/span&gt;]. Consequently, impairments in social cognition are often at the root of behaviors such as social inappropriateness, aggression, lack of motivation, and impulsivity, that are referred to as NPS and are described as being part of MBI.&lt;/p&gt;&lt;p&gt;Ample evidence already exists of impaired social cognition in patients with neurodegenerative diseases [&lt;span&gt;5&lt;/span&gt;], and particularly in patients with bvFTD, impaired social cognition is a core feature [&lt;span&gt;6&lt;/span&gt;]. In addition to the clear descriptions by Bell et al. [&lt;span&gt;1&lt;/span&gt;] of typical behavioral symptoms in four often encountered types of dementia (i.e., bvFTD, AD, VaD and LBD), we would like to describe the most common changes in social cognition in these dementia types, to enhance their early recognition in primary care settings. Furthermore, we give suggestions for follow up analysis in a memory clinic.&lt;/p&gt;&lt;p&gt;As previously mentioned, in patients with bvFTD, impaired social cognition is a core feature [&lt;span&gt;6&lt;/span&gt;], with early symptoms of loss of empathy and impairments in both emotion recognition and in mentalizing/ToM. In patients with AD, social cognitive functions are also known to be impaired, including emotion recognition and ToM, albeit to a lesser extent than in patients with bvFTD [&lt;span&gt;7&lt;/span&gt;]. Particularly in young onset AD, social behavioral symptoms can be prevalent from an early phase on, which led to the definition of a behavioral subtype of AD [&lt;span&gt;8&lt;/span&gt;]. Up until now, in patients with VaD and LBD, less is known about social cognitive functioning in an early","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 6","pages":"1964-1965"},"PeriodicalIF":4.3,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.19412","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Goals of Frail Older People Living With Chronic Kidney Disease: A Mixed Methods Study 老年慢性肾病患者的目标:一项混合方法研究
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-05 DOI: 10.1111/jgs.19421
Benignus Logan, Kristiana Ludlow, Elaine M. Pascoe, Andrea K. Viecelli, David W. Johnson, Carmel M. Hawley, Laura E. Hickey, Charani Kiriwandeniya, Misa Matsuyama, Allison Jaure, Ruth E. Hubbard
{"title":"Goals of Frail Older People Living With Chronic Kidney Disease: A Mixed Methods Study","authors":"Benignus Logan,&nbsp;Kristiana Ludlow,&nbsp;Elaine M. Pascoe,&nbsp;Andrea K. Viecelli,&nbsp;David W. Johnson,&nbsp;Carmel M. Hawley,&nbsp;Laura E. Hickey,&nbsp;Charani Kiriwandeniya,&nbsp;Misa Matsuyama,&nbsp;Allison Jaure,&nbsp;Ruth E. Hubbard","doi":"10.1111/jgs.19421","DOIUrl":"10.1111/jgs.19421","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Frail older adults with chronic kidney disease (CKD) have complex care needs, and their priorities may differ from those assumed by healthcare providers. Understanding their goals is crucial to delivering person-centred care. This study aimed to identify and categorize the goals of this population and determine any association with participants' frailty status, quality of life, and CKD stage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We report the goals of frail older people living with moderate to severe CKD enrolled as participants in the GOAL trial, a cluster-randomized controlled trial assessing the effectiveness of comprehensive geriatric assessment. This study employs a mixed-methods approach, utilizing a triangulation design and a data transformation model. Participants set goals by Goal Attainment Scaling. Deductive content analysis was undertaken, aided by a pre-specified matrix (physical health; psychological health; function; planning; social engagement). Descriptive statistics assessed the relationships between goals and participant characteristics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 224 participants (mean age 77 [±6.7]; 56% male; 84% white/European; median FI 0.39 [IQR: 0.33–0.47]) set 408 goals in the categories of function, physical health, social engagement and leisure, psychological health, and future readiness. Most participants set one or two goals (<i>n</i> = 183, 82%). They were most frequently set in the function (<i>n</i> = 172, 42%), physical health (<i>n</i> = 86, 21%), and social engagement and leisure (<i>n</i> = 79, 19%) domains. The number and nature of the set goals were similar across participant frailty status, quality of life (EQ-5D-5L) scores, and CKD stage.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Frail older adults with CKD most frequently focus their goals on function, physical health, social engagement, and leisure. These goals did not vary by participants' frailty status or CKD stage. This study's findings can guide healthcare professionals in ensuring management plans consider these identified priorities. Geriatricians may have a role in managing this population, given the commonality of these goals with those of older people more generally.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 6","pages":"1742-1752"},"PeriodicalIF":4.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.19421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disparities in Timely Receipt of Home Healthcare: Neighborhood Disadvantage and Delayed Start-of-Care Visits in New York City 及时接收家庭医疗保健的差异:纽约市的社区劣势和延迟开始护理访问。
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-04 DOI: 10.1111/jgs.19406
Sasha M. Vergez, Yolanda Barrón, Margaret V. McDonald
{"title":"Disparities in Timely Receipt of Home Healthcare: Neighborhood Disadvantage and Delayed Start-of-Care Visits in New York City","authors":"Sasha M. Vergez,&nbsp;Yolanda Barrón,&nbsp;Margaret V. McDonald","doi":"10.1111/jgs.19406","DOIUrl":"10.1111/jgs.19406","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Research has shown that delayed receipt of home healthcare (HHC) is linked to negative patients' outcomes such as hospitalizations, emergency department visits, and death. Studies have looked at factors contributing to delays including high-unemployment areas and racial/ethnic backgrounds of patients. However, no previous study had examined how the deliverance of timely care differs among levels of neighborhood disadvantage within an urban city. The objective of this study was to assess if there were associations between neighborhood disadvantage and delayed start-of-care (SOC) HHC visits.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective observational study on newly admitted HHC patients after a hospital discharge during the years 2021 and 2022. The total sample included 73,536 HHC episodes of care. We used log-binomial regressions to examine the association between a delayed SOC HHC visit, defined as a first HHC visit occurring after 48 h of hospital discharge, and neighborhood disadvantage, adjusting for patients' age, race, sex, and clinical status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Close to one-third (23,712; 32.3%) of HHC episodes experienced a delayed SOC HHC visit. As the level of neighborhood disadvantage increased, so did the risk of experiencing delayed care. After adjusting for covariates, patients living in the most disadvantaged neighborhoods (level 5) had a 13% (RR 1.13; 95% CI 1.10–1.17) higher risk of experiencing delayed care when compared to those in the least disadvantaged neighborhoods (level 1). As the level of neighborhood disadvantage increased, so did the proportion of minority patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings underscore the disparities in receipt of timely HHC among differing levels of neighborhood disadvantage. As HHC is presented as a safer and more comfortable alternative to institutional post-acute care, ensuring the availability and equitable care is essential for maintaining high-quality care especially for already marginalized populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 5","pages":"1462-1471"},"PeriodicalIF":4.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk 长期服用非甾体抗炎药物与痴呆风险的关系
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-04 DOI: 10.1111/jgs.19411
Ilse vom Hofe, Bruno H. Stricker, M. Kamran Ikram, Frank J. Wolters, M. Arfan Ikram
{"title":"Long-Term Exposure to Non-Steroidal Anti-Inflammatory Medication in Relation to Dementia Risk","authors":"Ilse vom Hofe,&nbsp;Bruno H. Stricker,&nbsp;M. Kamran Ikram,&nbsp;Frank J. Wolters,&nbsp;M. Arfan Ikram","doi":"10.1111/jgs.19411","DOIUrl":"10.1111/jgs.19411","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Non-steroidal anti-inflammatory (NSAID) medication could reduce dementia risk due to anti-inflammatory and possibly amyloid-lowering properties. However, the results of observational studies and short-term randomized-controlled trials have been inconsistent, and duration and dose–response relationships are still unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We included 11,745 dementia-free participants from the prospective population-based Rotterdam Study (59.5% female, mean age 66.2 years). NSAID use from 1991 was derived from pharmacy dispensing records, from which we determined cumulative duration and dose. We defined four mutually exclusive categories of cumulative use: non-use, short-term use (&lt; 1 month), intermediate-term use (between 1 and 24 months), and long-term use (&gt; 24 months). We determined the association with dementia risk until 2020 using Cox regression models, including NSAID use as a time-varying exposure. Models were adjusted for lifestyle factors, comorbidity, and comedication use. We repeated the analyses stratified by previously established amyloid-β lowering properties of different NSAIDs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During an average follow-up period of 14.5 years, a total of 9520 (81.1%) participants had used NSAIDs at any given time, and 2091 participants developed dementia. Use of NSAIDs was associated with lower dementia risk for long-term users (HR [95% CI]: 0.88 [0.84–0.91]), and a small increased risk with short-term use (HR [95% CI]: 1.04 [1.02–1.07]) or intermediate-term use (HR: 1.04 [1.02–1.06]). The cumulative dose of NSAIDs was not associated with decreased dementia risk (HR for ≤ 25th percentile: 1.06 [1.03–1.09], 26–50th percentile: 1.02 [0.99–1.05], 51–75th percentile: 1.03 [0.99–1.06], &gt; 75th percentile: 0.99 [0.96–1.02]). Associations were somewhat stronger for long-term use of NSAIDs without known effects on amyloid-β than for amyloid-lowering NSAIDs (HR [95% CI]: 0.79 [0.74–0.85] versus 0.89 [0.85;0.93]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Long-term NSAID use, but not cumulative dose, was associated with decreased dementia risk. This suggests that prolonged rather than intensive exposure to anti-inflammatory medication may hold potential for dementia prevention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 5","pages":"1484-1490"},"PeriodicalIF":4.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgs.19411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of Nursing Homes Among Medicaid Beneficiaries Newly Diagnosed With Cancer 新诊断为癌症的医疗补助受益人中疗养院的使用。
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-04 DOI: 10.1111/jgs.19391
Amanda C. Chen, David C. Grabowski
{"title":"Use of Nursing Homes Among Medicaid Beneficiaries Newly Diagnosed With Cancer","authors":"Amanda C. Chen,&nbsp;David C. Grabowski","doi":"10.1111/jgs.19391","DOIUrl":"10.1111/jgs.19391","url":null,"abstract":"","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 6","pages":"1957-1959"},"PeriodicalIF":4.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Depression and Antidepressant Prescription in Hospitalized Centenarians 住院百岁老人的抑郁和抗抑郁药物处方
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-04 DOI: 10.1111/jgs.19415
Taylor Fistel, Kathryn Lotharius, Gabriella Engstrom, Joseph G. Ouslander
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引用次数: 0
“Nobody Can Be Equipped for This”: Advice From New Residents of Long-Term Care Facilities “没人能做到这一点”:来自长期护理机构新居民的建议。
IF 4.3 2区 医学
Journal of the American Geriatrics Society Pub Date : 2025-03-04 DOI: 10.1111/jgs.19405
Kenneth Lam, James D. Harrison, Landon Haller, William J. Deardorff, Rebecca L. Sudore, Kenneth E. Covinsky, Dan D. Matlock, Daniel Dohan
{"title":"“Nobody Can Be Equipped for This”: Advice From New Residents of Long-Term Care Facilities","authors":"Kenneth Lam,&nbsp;James D. Harrison,&nbsp;Landon Haller,&nbsp;William J. Deardorff,&nbsp;Rebecca L. Sudore,&nbsp;Kenneth E. Covinsky,&nbsp;Dan D. Matlock,&nbsp;Daniel Dohan","doi":"10.1111/jgs.19405","DOIUrl":"10.1111/jgs.19405","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The transition into a long-term care facility (LTCF) is difficult for older adults, prompting calls for clinicians to help guide and plan. Yet we know little about how those with lived experience of moving into an LTCF would advise others.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted in-person semi-structured interviews with nursing home (NH) and assisted living (AL) residents within 6 months of moving into an urban non-profit continuing care retirement community in California between 2023 and 2024. Interviews were guided by theories of long-term care utilization and asked, “what advice would you give others considering an LTCF?” We thematically analyzed interviews using the constant comparative method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We interviewed 8 NH and 6 AL residents. Mean participant age was 82 (range 73–90); 8 were female, 1 participant was Asian, 13 participants were White, and mean Montreal Cognitive Assessment was 19 (range 12–25). Residents talked about LTCF entry within a broader phase of life defined by dependence following sudden unexpected health crises. Advice reflected strategies for this phase of life and highlighted challenges outside of their control. Some residents advised <i>preparation</i> by visiting facilities and budgeting time and resources to plan but discovered care arrangements did not work out as promised; care was fragmented, and dependence caused them to re-evaluate what they wanted. Some advised <i>avoidance</i> as they disliked living in an LTCF but had little control over entry, leading to distrust of those making decisions for them. Others advised <i>acceptance</i> and believed luck or fate dictated how everything worked out in the end.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Unanticipated health crises catalyze entry into LTCFs. New residents advised others to prepare for, avoid, or accept LTCF entry, reflecting different strategies for approaching a unique phase of life and highlighting systemic problems that could be improved. Anticipatory guidance for LTCF transitions should acknowledge their sudden nature, these strategies, and the need for system reform.</p>\u0000 </section>\u0000 </div>","PeriodicalId":17240,"journal":{"name":"Journal of the American Geriatrics Society","volume":"73 5","pages":"1506-1516"},"PeriodicalIF":4.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143545131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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