Journal of The American Society of Hypertension最新文献

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Corrigendum to “Role of angiotensin II type 2 receptor during electrophysiological remodeling of left ventricular hypertrophic myocardium in spontaneously hypertensive rats” Journal of the American Society of Hypertension, January 2018, Volume 12, Issue 1, Pages 58–65 “血管紧张素II型受体在自发性高血压大鼠左室肥厚心肌电生理重构中的作用”,《美国高血压学会杂志》,2018年1月,第12卷,第1期,页58-65
Journal of The American Society of Hypertension Pub Date : 2018-08-01 DOI: 10.1016/j.jash.2018.05.004
Ying Xiao PhD , Wei-Qing Long MD , Kai-Pan Guan MD , Ming Long PhD , Gui-Hua Lu PhD , Zhi-Bin Huang MD
{"title":"Corrigendum to “Role of angiotensin II type 2 receptor during electrophysiological remodeling of left ventricular hypertrophic myocardium in spontaneously hypertensive rats” Journal of the American Society of Hypertension, January 2018, Volume 12, Issue 1, Pages 58–65","authors":"Ying Xiao PhD , Wei-Qing Long MD , Kai-Pan Guan MD , Ming Long PhD , Gui-Hua Lu PhD , Zhi-Bin Huang MD","doi":"10.1016/j.jash.2018.05.004","DOIUrl":"10.1016/j.jash.2018.05.004","url":null,"abstract":"","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.05.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36246006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editor's Page 编辑的页面
Journal of The American Society of Hypertension Pub Date : 2018-08-01 DOI: 10.1016/j.jash.2018.06.019
Daniel Levy MD (Editor-in-Chief)
{"title":"Editor's Page","authors":"Daniel Levy MD (Editor-in-Chief)","doi":"10.1016/j.jash.2018.06.019","DOIUrl":"10.1016/j.jash.2018.06.019","url":null,"abstract":"","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.06.019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36492806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA成人高血压预防、检测、评估和管理指南:执行摘要
Journal of The American Society of Hypertension Pub Date : 2018-08-01 DOI: 10.1016/j.jash.2018.06.010
Paul K. Whelton MB, MD, MSc, FAHA (Chair, Writing Committee), Robert M. Carey MD, FAHA (Vice Chair, Writing Committee), Wilbert S. Aronow MD, FACC, FAHA (Writing Committee Member) , Donald E. Casey Jr. MD, MPH, MBA, FAHA (Writing Committee Member) , Karen J. Collins MBA (Writing Committee Member) , Cheryl Dennison Himmelfarb RN, ANP, PhD, FAHA (Writing Committee Member) , Sondra M. DePalma MHS, PA-C, CLS, AACC (Writing Committee Member) , Samuel Gidding MD, FAHA (Writing Committee Member) , Kenneth A. Jamerson MD (Writing Committee Member) , Daniel W. Jones MD, FAHA (Writing Committee Member) , Eric J. MacLaughlin PharmD (Writing Committee Member) , Paul Muntner PhD, FAHA (Writing Committee Member) , Bruce Ovbiagele MD, MSc, MAS, MBA, FAHA (Writing Committee Member) , Sidney C. Smith Jr. MD, MACC, FAHA (Writing Committee Member) , Crystal C. Spencer JD (Writing Committee Member) , Randall S. Stafford MD, PhD (Writing Committee Member) , Sandra J. Taler MD, FAHA (Writing Committee Member) , Randal J. Thomas MD, MS, FACC, FAHA (Writing Committee Member) , Kim A. Williams Sr. MD, MACC, FAHA (Writing Committee Member) , Jeff D. Williamson MD, MHS (Writing Committee Member) , Jackson T. Wright Jr. MD, PhD, FAHA (Writing Committee Member)
{"title":"2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary","authors":"Paul K. Whelton MB, MD, MSc, FAHA (Chair, Writing Committee), Robert M. Carey MD, FAHA (Vice Chair, Writing Committee), Wilbert S. Aronow MD, FACC, FAHA (Writing Committee Member) , Donald E. Casey Jr. MD, MPH, MBA, FAHA (Writing Committee Member) , Karen J. Collins MBA (Writing Committee Member) , Cheryl Dennison Himmelfarb RN, ANP, PhD, FAHA (Writing Committee Member) , Sondra M. DePalma MHS, PA-C, CLS, AACC (Writing Committee Member) , Samuel Gidding MD, FAHA (Writing Committee Member) , Kenneth A. Jamerson MD (Writing Committee Member) , Daniel W. Jones MD, FAHA (Writing Committee Member) , Eric J. MacLaughlin PharmD (Writing Committee Member) , Paul Muntner PhD, FAHA (Writing Committee Member) , Bruce Ovbiagele MD, MSc, MAS, MBA, FAHA (Writing Committee Member) , Sidney C. Smith Jr. MD, MACC, FAHA (Writing Committee Member) , Crystal C. Spencer JD (Writing Committee Member) , Randall S. Stafford MD, PhD (Writing Committee Member) , Sandra J. Taler MD, FAHA (Writing Committee Member) , Randal J. Thomas MD, MS, FACC, FAHA (Writing Committee Member) , Kim A. Williams Sr. MD, MACC, FAHA (Writing Committee Member) , Jeff D. Williamson MD, MHS (Writing Committee Member) , Jackson T. Wright Jr. MD, PhD, FAHA (Writing Committee Member)","doi":"10.1016/j.jash.2018.06.010","DOIUrl":"10.1016/j.jash.2018.06.010","url":null,"abstract":"","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.06.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36492807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 47
Social capital and depression among migrant hypertensive patients in primary care 基层医疗流动高血压患者社会资本与抑郁的关系
Journal of The American Society of Hypertension Pub Date : 2018-08-01 DOI: 10.1016/j.jash.2018.06.006
Wu Zhu MSc , Haitao Li PhD , Xuejun Wang PhD , Chen Mao PhD
{"title":"Social capital and depression among migrant hypertensive patients in primary care","authors":"Wu Zhu MSc ,&nbsp;Haitao Li PhD ,&nbsp;Xuejun Wang PhD ,&nbsp;Chen Mao PhD","doi":"10.1016/j.jash.2018.06.006","DOIUrl":"10.1016/j.jash.2018.06.006","url":null,"abstract":"<div><p>This study was to investigate prevalence of depression among migrant hypertensive patients in primary care and to examine hypertensive patients' social capital and its relationship with the prevalence of depression. An on-site–based cross-sectional study was performed in Shenzhen, China. A total of 830 migrant hypertensive patients completed the survey by using systematic sampling design. A questionnaire including information of depressive symptoms and social capital was administered by face-to-face interview surveys. We found that the prevalence of depression was 11.0% among migrant hypertensive patients in primary care. Social ties (odds ratio = 1.197, 95% confidence interval: 1.034, 1.387) and trust (odds ratio = 2.061, 95% confidence interval: 1.342, 3.165) were statistically significant associated with the prevalence of depression. Our study shows that the prevalence of depression is high among migrant hypertensive patients in primary care. It also suggests an inverse association between social capital and depression among migrant hypertensive patients. Although causal pathways between social capital and depression cannot be established by the present study, it is plausible to design and implement social interventions to improve mental health of migrant hypertensive patients in primary care.</p></div>","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.06.006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36256998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Aerobic training reduces blood pressure and waist circumference and increases HDL-c in metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials 有氧训练可以降低代谢综合征患者的血压和腰围,增加HDL-c:一项随机对照试验的系统回顾和荟萃分析
Journal of The American Society of Hypertension Pub Date : 2018-08-01 DOI: 10.1016/j.jash.2018.06.007
Ítalo Ribeiro Lemes MSc , Bruna Camilo Turi-Lynch PhD , Iván Cavero-Redondo PhD , Stephanie Nogueira Linares MSc , Henrique Luiz Monteiro PhD
{"title":"Aerobic training reduces blood pressure and waist circumference and increases HDL-c in metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials","authors":"Ítalo Ribeiro Lemes MSc ,&nbsp;Bruna Camilo Turi-Lynch PhD ,&nbsp;Iván Cavero-Redondo PhD ,&nbsp;Stephanie Nogueira Linares MSc ,&nbsp;Henrique Luiz Monteiro PhD","doi":"10.1016/j.jash.2018.06.007","DOIUrl":"10.1016/j.jash.2018.06.007","url":null,"abstract":"<div><p><span><span>The objective of this study is to estimate the effect of aerobic training (AT) on metabolic syndrome (MetS) outcomes. The Medline, EMBASE, SPORTDiscus, The Cochrane Library, and PEDro databases were searched from inception to May 2017. Two independent reviewers selected the studies and assessed their quality and data. The pooled mean differences between intervention groups and the control group were calculated using a random-effect model. Only </span>randomized controlled trials<span> that compared the effect of AT on MetS with a control group were included. Seventeen published studies were included in the meta-analysis. Systolic and diastolic blood pressure were significantly reduced (−5.11 mmHg [95% confidence interval [CI] −7.36, −2.85] and −2.97 mmHg [−4.99, −0.94], respectively), following AT. There was also a significant reduction in waist circumference (−2.18 cm [95% CI −3.75, −0.62]) and a significant increase in high-density lipoprotein cholesterol (95% CI −3.15 mg/dL [−5.30, −1.01]). The pooled effect showed a reduction of −7.64 mg/dL [95% CI −17.65, 2.37] in triglycerides and −1.36 mg/dL [95% CI −4.11, 1.40] in fasting glucose. This </span></span>systematic review and meta-analysis provides an overview of the evidence supporting AT as an effective approach to reduce blood pressure levels and waist circumference and increase high-density lipoprotein cholesterol levels. These changes may help to reduce the risk of stroke mortality and mortality from heart disease in people with MetS.</p></div>","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.06.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36259973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Measurement of pulse wave velocity, augmentation index, and central pulse pressure in atrial fibrillation: a proof of concept study 心房颤动的脉搏波速度、增强指数和中心脉压测量:概念验证研究
Journal of The American Society of Hypertension Pub Date : 2018-08-01 DOI: 10.1016/j.jash.2018.06.016
Rogier Caluwé MD , An S. De Vriese MD, PhD , Bruno Van Vlem MD, PhD , Francis Verbeke MD, PhD
{"title":"Measurement of pulse wave velocity, augmentation index, and central pulse pressure in atrial fibrillation: a proof of concept study","authors":"Rogier Caluwé MD ,&nbsp;An S. De Vriese MD, PhD ,&nbsp;Bruno Van Vlem MD, PhD ,&nbsp;Francis Verbeke MD, PhD","doi":"10.1016/j.jash.2018.06.016","DOIUrl":"10.1016/j.jash.2018.06.016","url":null,"abstract":"<div><p><span><span><span>Individualized weighing of the risk benefit of anticoagulation is recommended </span>in patients with </span>atrial fibrillation<span><span> (AF) who have low established risk scores or, conversely, are at increased risk for bleeding. Parameters of arterial stiffness and wave reflection could improve </span>risk stratification<span>, but their use has not been evaluated in arrhythmia. We measured carotid-femoral pulse wave velocity<span> (PWV), central augmentation index (AI), and central pulse pressure (CPP) using the SphygmoCor system in 34 patients (53 to 85 years; 25 males) with AF before and after elective electrical cardioversion<span>. Agreement was assessed using the intraclass correlation coefficient (ICC) and the coefficient of variation, completed with Bland–Altman plots. After cardioversion, mean arterial blood pressure (MAP) and heart rate (HR) decreased significantly by 8 mmHg and 18 bpm, respectively. PWV decreased from 11.8 m/s to 10.7 m/s, AI increased from 24% to 29%, and CPP rose from 38 mmHg to 43 mmHg. The decrease in PWV was related to the decrease in MAP (beta = 0.57; R</span></span></span></span></span><sup>2</sup> = 0.33; <em>P</em> &lt; .001), whereas changes in AI and CPP were related to the decrease in HR (AI: beta = −0.59; R<sup>2</sup> = 0.35; <em>P</em> &lt; .001, CPP: beta = −0.55; R<sup>2</sup> = 0.28; <em>P</em> = .001). After adjustment for changes in MAP and HR, reliability analysis showed an excellent agreement for PWV (ICC = 0.89; 95% confidence interval (CI): 0.79–0.95) but moderate agreement for AI (ICC = 0.59; 95% CI: 0.17–0.80). Excellent agreement was also found for CPP (ICC = 0.89; 95% CI: 0.72–0.95). Measurement of PWV and CPP is reliable in patients with AF, as they appear unaffected by the presence of arrhythmia.</p></div>","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.06.016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36348147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Postmicturition syndrome: a neglected syndrome dangerous for the bladder and the heart 排尿后综合征:一种被忽视的对膀胱和心脏都有危险的综合征
Journal of The American Society of Hypertension Pub Date : 2018-08-01 DOI: 10.1016/j.jash.2018.06.008
Ilaria Jane Romano MD, Francesco Gentile MD, Antonio Lippolis MD
{"title":"Postmicturition syndrome: a neglected syndrome dangerous for the bladder and the heart","authors":"Ilaria Jane Romano MD,&nbsp;Francesco Gentile MD,&nbsp;Antonio Lippolis MD","doi":"10.1016/j.jash.2018.06.008","DOIUrl":"10.1016/j.jash.2018.06.008","url":null,"abstract":"<div><p><span>Postmicturition syndrome refers to symptoms caused by overdistension of the bladder<span><span> or micturition. Bladder paraganglioma is a rare neuroendocrine neoplasm, which arises from the chromaffin tissue of the </span>sympathetic nervous system<span> embedded in the muscle layer of the bladder wall<span>. Clinical presentation of catecholamine-secreting paragangliomas may mimic that of hyperfunctioning adrenal pheochromocytoma<span>. Typical symptoms such as sweating, palpitations, headache, nausea, hypertension, or flushing are due to </span></span></span></span></span>catecholamine<span> release and are related to micturition or bladder overdistension. We herein report the case of a 22-year-old woman admitted to the Emergency Department<span><span><span><span> because of cranial trauma secondary to a car accident. She referred history of micturition-related headache, nausea, sweating, and increase in blood pressure since she was 13 years old. The neurological investigation was normal. No urogenital tract investigation was performed and, on admission, blood pressure was 190/125 mmHg. During hospitalization, </span>abdominal ultrasonography, performed to rule out secondary hypertension, unexpectedly showed a large vascular soft tissue mass in the bladder wall, compatible with a paraganglioma. Twenty-four hours of </span>urinalysis<span> of catecholamines revealed high values of urine metanephrines. Abdominal magnetic resonance imaging and histopathological evaluation of the surgical specimen, following resection of the </span></span>bladder lesion, confirmed the diagnosis. Our case underlines the importance not to underestimate symptoms compatible with postmicturition syndrome, especially in young patients, to make early diagnosis of bladder paraganglioma.</span></span></p></div>","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.06.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36270202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Stroke and (or) myocardial infarction attributable to modifiable risk factors in Henan, China 中国河南可改变的危险因素导致的中风和(或)心肌梗死
Journal of The American Society of Hypertension Pub Date : 2018-07-01 DOI: 10.1016/j.jash.2018.03.013
Kaiyan Dong MS , Qian Yang MS , Fujiao Duan PhD , Shuying Liang PhD , Nan Ma MS , Wei Nie PhD , Yali Yan MS , Ye Zhang MS , Rui Peng MS , Shuaibing Wang MS , Chunhua Song PhD , Kaijuan Wang PhD
{"title":"Stroke and (or) myocardial infarction attributable to modifiable risk factors in Henan, China","authors":"Kaiyan Dong MS ,&nbsp;Qian Yang MS ,&nbsp;Fujiao Duan PhD ,&nbsp;Shuying Liang PhD ,&nbsp;Nan Ma MS ,&nbsp;Wei Nie PhD ,&nbsp;Yali Yan MS ,&nbsp;Ye Zhang MS ,&nbsp;Rui Peng MS ,&nbsp;Shuaibing Wang MS ,&nbsp;Chunhua Song PhD ,&nbsp;Kaijuan Wang PhD","doi":"10.1016/j.jash.2018.03.013","DOIUrl":"10.1016/j.jash.2018.03.013","url":null,"abstract":"<div><p><span>Estimating population attributable risks of potential modifiable risk factors for stroke and (or) myocardial infarction may be useful for planning cardiovascular disease (CVD) preventive strategies. A population of 17,292 adults aged 18 years and older from a cross-sectional survey was included in the study. The binary </span>logistic regression<span><span> was used to evaluate the association between risk factors with disease events, then population attributable fraction according to prevalence and odds ratios were calculated to identify and compare the effects at different subpopulations. We found that the main risk factor for CVD events was hypertension with about 50% of population attributable fraction; prehypertension (22.24%) only acts at rural older females; the efficiency of low- and moderate-level physical activities were higher in males (over 20%) than females (under 20%); ever smoked contributed to CVDs in rural older populations (males, 19.25%; females, 5.57%) and urban younger males (54.52%); while as for high </span>body mass index, overweight (12.59%) only made contribution to rural males over 60 years. In conclusion, hypertension control in the whole population, physical activity increasing in males and older females, smoking prevention in rural elders and urban younger males, and slimming in rural elder males might be effective to reduce the burden of CVDs in Henan.</span></p></div>","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.03.013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36047600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Renovascular hypertension in small children—is it Takayasu arteritis or fibromuscular dysplasia? 儿童肾血管性高血压——是高须动脉炎还是纤维肌肉发育不良?
Journal of The American Society of Hypertension Pub Date : 2018-07-01 DOI: 10.1016/j.jash.2018.04.011
Kjell Tullus MD, PhD , Derek J. Roebuck MB BS, FRANZCR
{"title":"Renovascular hypertension in small children—is it Takayasu arteritis or fibromuscular dysplasia?","authors":"Kjell Tullus MD, PhD ,&nbsp;Derek J. Roebuck MB BS, FRANZCR","doi":"10.1016/j.jash.2018.04.011","DOIUrl":"10.1016/j.jash.2018.04.011","url":null,"abstract":"","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.04.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36188965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Chronic kidney disease as a cardiovascular risk factor: lessons from kidney donors 慢性肾脏疾病作为心血管危险因素:来自肾脏捐赠者的经验教训
Journal of The American Society of Hypertension Pub Date : 2018-07-01 DOI: 10.1016/j.jash.2018.04.010
Anna M. Price MB, ChB, Nicola C. Edwards PhD, Manvir K. Hayer MB, ChB, William E. Moody PhD, Richard P. Steeds MD, Charles J. Ferro MD, Jonathan N. Townend MD
{"title":"Chronic kidney disease as a cardiovascular risk factor: lessons from kidney donors","authors":"Anna M. Price MB, ChB,&nbsp;Nicola C. Edwards PhD,&nbsp;Manvir K. Hayer MB, ChB,&nbsp;William E. Moody PhD,&nbsp;Richard P. Steeds MD,&nbsp;Charles J. Ferro MD,&nbsp;Jonathan N. Townend MD","doi":"10.1016/j.jash.2018.04.010","DOIUrl":"10.1016/j.jash.2018.04.010","url":null,"abstract":"<div><p>Chronic kidney disease (CKD) is a major risk factor for cardiovascular disease but is often associated with other risks such as diabetes and hypertension and can be both a cause and an effect of cardiovascular disease. Although epidemiologic data of an independent association of reduced glomerular filtration rate with cardiovascular risk are strong, causative mechanisms are unclear.</p><p>Living kidney donors provide a useful model for assessing the “pure” effects of reduced kidney function on the cardiovascular system. After nephrectomy, the glomerular filtration rate ultimately falls by about one-third so many can be classified as having chronic kidney disease stages 2 or 3. This prompts concern based on the data showing an elevated cardiovascular risk with these stages of chronic kidney disease. However, initial data suggested no increase in adverse cardiovascular effects compared with control populations. Recent reports have shown a possible late increase in cardiovascular event rates and an early increase in left ventricular mass and markers of risk such as urate and albuminuria. The long-term significance of these small changes is unknown. More detailed and long-term research is needed to determine the natural history of these changes and their clinical significance.</p></div>","PeriodicalId":17220,"journal":{"name":"Journal of The American Society of Hypertension","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.jash.2018.04.010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36124582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
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