Journal of Science: Advanced Materials and Devices最新文献

{"title":"Ultrasmall Ag6Cu2 clusters for accelerating wound healing through the activation of antibacterial activity and endogenous anti-inflammatory property","authors":"Yan Chen ,&nbsp;Baixing Li ,&nbsp;Bin Pan ,&nbsp;Han Du ,&nbsp;Xuzhuo Chen ,&nbsp;Yazi Huang ,&nbsp;Changqing Zhao","doi":"10.1016/j.jsamd.2024.100768","DOIUrl":"10.1016/j.jsamd.2024.100768","url":null,"abstract":"<div><p>Significal challenges exist to bacterial infection wound healing. The bacterial infection and inflammation generated by oxidative stress inevitably hinder the process of wound healing. Ag₆Cu₂ nanoclusters in this study were successfully prepared and displayed excellent physiological stability. Noticeably, Ag₆Cu₂ nanoclusters exhibited efficient therapeutic potentials for accelerating the process of wound healing, which had good biosafety under the appropriate concentration. The treatment of Ag₆Cu₂ was able to suppress the bacterial proliferation by destructing the bacterial, resulting in the secondary release of bacterial contents and to exert anti-inflammatory properties via scavenging the overproduction of reactive oxygen species and upregulating the expression of Nrf2 as well as its downstream genes including HO-1 and NQO1. <em>In</em><em>-</em><em>vivo</em> studies further validated the efficient therapeutic effects of Ag₆Cu₂ nanoclusters by inhibiting the activation of the cascade of inflammatory factors and the proliferation of bacteria as a novel agent in a nano scale for accelerating the process of wound healing.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100768"},"PeriodicalIF":6.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000996/pdfft?md5=dbe3015bf03bc0bdbb1f32c89eaf250c&pid=1-s2.0-S2468217924000996-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative simulation study of light–matter coupling in 1D photonic crystals with 2D perovskite active layer","authors":"Thuat Nguyen-Tran ,&nbsp;Hieu Chi Hoang ,&nbsp;Tu Thanh Truong ,&nbsp;Khai Dinh Do ,&nbsp;Duc Ngoc Le ,&nbsp;Chi Kim Thi Tran ,&nbsp;Linh Khanh Le ,&nbsp;Le Si Dang","doi":"10.1016/j.jsamd.2024.100766","DOIUrl":"10.1016/j.jsamd.2024.100766","url":null,"abstract":"<div><p>Light–matter interaction operating in the strong coupling regime offers wide prospects of applications going from nano-photonics to quantum communications. The most practical implementations are to embed the active matter into Fabry–Perot microcavities or photonic crystals. In this work we focus on the strong coupling of two-dimensional (2D) perovskite in 1D grating waveguide. We use rigorous coupled wave analysis to simulate electromagnetic wave confinement in the 1D waveguide. Various sets of waveguide geometrical parameters are examined to achieve the strong coupling regime for three different configurations of the active layer in the waveguide. To extract quantitatively the relevant physical parameters, such as strength of light–matter interaction, we develop a Hamiltonian formalism to reproduce results obtained by simulation. It is shown that the strongest interaction is to have the active layer inserted in the main slab of the waveguide. It is, however, still weaker by about 20% as compared to the use of Fabry–Perot microcavities.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100766"},"PeriodicalIF":6.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000972/pdfft?md5=a9286a531a18bc60de93592b694f7ab4&pid=1-s2.0-S2468217924000972-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of GN/ MnO2 nanocomposite materials for photo-assisted supercapacitor with enhanced capacities","authors":"Yanyun Liu,&nbsp;Na Wang,&nbsp;Wanxi Li,&nbsp;Yangjie Wang,&nbsp;Linkun Liang","doi":"10.1016/j.jsamd.2024.100771","DOIUrl":"10.1016/j.jsamd.2024.100771","url":null,"abstract":"<div><p>Supercapacitors with the advantages of high power density and rapid discharging rate have widespread applications in energy storage. Nevertheless, their development is hindered by the limitation of low specific capacity. Traditional approaches to enhance specific capacity primarily involve incorporating foreign atoms and blending with additional reactive substances. Herein, a photo-assisted supercapacitor electrode material (GN/MnO₂ nanocomposite) with excellent capacity is developed. As a photoactive material, graphene generates electrons and holes with photoirradiation. As the photogenerated carriers increase, electrons are separated from the holes and stored as charges. Photoirradiation is the driving force that promotes the energy storage and conversion of supercapacitors. Although there are many reports on GN/MnO₂ composites, there are still few reports on the photo-assisted energy storage of this composite material. The specific capacity of this photo-assisted GN/MnO₂ electrode materials could reach 210 F/g with photoirradiation. It was higher than that without photoirradiation (170 F/g). The development of this study provides important theoretical guidance and practical significance for the research of photo-assisted energy storage materials, and plays a significant role in advancing the progress of energy storage devices with high specific capacity.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100771"},"PeriodicalIF":6.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924001023/pdfft?md5=5d5db468f53815f3cd5df8a5d222bedc&pid=1-s2.0-S2468217924001023-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and characterization of novel PBI/SGO composites as possible proton exchange membranes filling the “conductivity gap”","authors":"Matteo Di Virgilio,&nbsp;Andrea Basso Peressut,&nbsp;Sophie Provato,&nbsp;Saverio Latorrata","doi":"10.1016/j.jsamd.2024.100767","DOIUrl":"10.1016/j.jsamd.2024.100767","url":null,"abstract":"<div><p>The research for non-fluorinated polymeric electrolytes able to operate at temperatures of 80–120 °C, the so-called “conductivity gap”, is becoming central. Within this frame, the present work discusses the investigation of innovative self-assembling polybenzimidazole/sulfonated graphene oxide (PBI/SGO) composite membranes. A set of five samples, characterized by never-explored PBI-to-SGO mass ratios between 3:1 and 1:3, is studied through surface and cross-sectional SEM, XRD, ATR-FTIR spectroscopy, and TGA. The experimental outcomes reveal the reciprocal compatibility between PBI and SGO, whose main features appear to be evenly distributed within the composites. Water immersion tests demonstrate the excellent interplay between the membranes and the aqueous environment. EIS experiments, performed with the in-plane and through-plane configurations, disclose the improvement of the proton transfer ability (σ) in both directions. At 120 °C, PBI/SGO 1:2 achieves the highest in-plane σ of 0.113 S cm⁻¹, while PBI/SGO 1:3 shows the best through-plane σ of 0.025 S cm⁻¹. The preference toward planar proton migration is confirmed by the computation of the anisotropy factor, which is attenuated to ≈0.5 with the aid of temperature. Based on these findings, the composites with large SGO content seem to possess great potential as alternative non-fluorinated proton exchange membranes.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100767"},"PeriodicalIF":6.7,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000984/pdfft?md5=34081a70b93d241e06bfd79988af6aa0&pid=1-s2.0-S2468217924000984-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141841720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Displacement damage effect of proton irradiation on vertical β-Ga2O3 and SiC Schottky barrier diodes (SBDs)","authors":"Young Jo Kim ,&nbsp;Youngboo Moon ,&nbsp;Jeong Hyun Moon ,&nbsp;Hyoung Woo Kim ,&nbsp;Wook Bahng ,&nbsp;Hongsik Park ,&nbsp;Young Jun Yoon ,&nbsp;Jae Hwa Seo","doi":"10.1016/j.jsamd.2024.100765","DOIUrl":"10.1016/j.jsamd.2024.100765","url":null,"abstract":"<div><p>In this study, we fabricated vertical Schottky barrier diodes (SBDs) based on wide bandgap semiconductor beta-phase gallium oxide (β<strong>-</strong>Ga₂O₃) and silicon carbide (SiC), respectively, and conducted proton irradiation experiments to analyze the radiation hardness of the SBDs comparatively. The effects of proton radiation on the performance of SBDs were assessed through measurements of forward current, capacitance, and breakdown characteristics. Both devices exhibited degradation in current and capacitance characteristics following proton irradiation, attributed to displacement damage (DD). Notably, the β<strong>-</strong>Ga₂O₃-based SBD demonstrated more pronounced deterioration compared to the SiC-based device despite similar vacancy distributions as confirmed by SRIM simulation. Moreover, a decrease in contact radius correlated with exacerbated degradation in the current characteristics of the β<strong>-</strong>Ga₂O₃-based SBD. Following proton irradiation, breakdown voltages of both devices increased due to elevated resistance induced by displacement damage. While both β<strong>-</strong>Ga₂O₃ and SiC-based SBDs experienced displacement damage under high fluence proton irradiation, the extent of performance degradation varied depending on the dimensions and quality of epitaxial and substrate layers.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100765"},"PeriodicalIF":6.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000960/pdfft?md5=f08c241591c3a07e5bd46d287a99b43f&pid=1-s2.0-S2468217924000960-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141699554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gas phase alloyed crystalline S–Se dielectrics with high ionic mobility","authors":"Pradyumna Kumar Chand ,&nbsp;Radha Raman ,&nbsp;Zhi-Long Yen ,&nbsp;Ian Daniell Santos ,&nbsp;Wei-Ssu Liao ,&nbsp;Ya-Ping Hsieh ,&nbsp;Mario Hofmann","doi":"10.1016/j.jsamd.2024.100763","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100763","url":null,"abstract":"<div><p>The advancement of future electronic devices necessitates dielectric materials with enhanced compositional complexity and improved capabilities. We here demonstrate a gas-phase alloying approach that yields ultrathin and crystalline dielectrics with attractive properties for the integration into electronics. A surface-selective deposition process was shown to produce sulfur (S) and selenium (Se) alloys with large-scale uniformity. Through combination of experimental diffraction analysis and materials modeling, we establish the crystallinity of the alloy with a modified lattice structure compared to the host materials. The resulting lattice arrangement endows the alloy dielectric with high ionic mobility as validated by electrochemical impedance spectroscopy. Leveraging this innovative feature, we fabricate memristive devices exhibiting promising performance characteristics. Our findings demonstrate the feasibility of utilizing gas-phase alloying to engineer dielectrics with superior properties and functionality for future device integration.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100763"},"PeriodicalIF":6.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000947/pdfft?md5=2e2390255e9e259672a7b80db97bfb4f&pid=1-s2.0-S2468217924000947-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of broad-spectrum photocatalyst films through interface engineering: Orchestrating Bi nanoparticles in TiO2/BiVO4 Z-scheme heterojunctions","authors":"Yuan-Chang Liang,&nbsp;Chih-Chen Kuo","doi":"10.1016/j.jsamd.2024.100764","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100764","url":null,"abstract":"<div><p>We successfully synthesized three-layered photocatalysts by modifying Bi nanoparticles on TiO₂/BiVO₄ bilayer composite films through a sol-gel process and sputtering. When exposed to ambient air, the surface of the prepared Bi nanoparticles oxidizes to form an amorphous ultra-thin Bi₂O₃ out layer. Under light exposure, this layer is reduced to metallic Bi, thanks to the band alignment between the Bi nanoparticles and TiO₂/BiVO₄ Z-scheme composite. The addition of Bi nanoparticles in the composite films improves visible-light absorption by the surface plasmon resonance (SPR), which contributes to the hot electron and enhances the photocatalytic characteristics. By constructing effective TiO₂/BiVO₄ Z-scheme heterostructures to facilitate photoinduced electron-hole pair separation and prevent recombination, Bi nanoparticles can efficiently capture photons and enhance the photocatalytic efficiency of semiconductors through the SPR effect. Optimizing the content of Bi nanoparticles decorated on the TiO₂/BiVO₄ Z-scheme composite film is a promising approach for designing a highly efficient photocatalyst, as evidenced by the performance of photoelectrochemical properties and RhB photodegradation ability.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100764"},"PeriodicalIF":6.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000959/pdfft?md5=5d214488e862e1028e43ad2d8c623a45&pid=1-s2.0-S2468217924000959-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141606008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Partially oxidized polyvinyl alcohol + functionalized water soluble multiwalled carbon nanotubes: A new conductive nanocomposite material with promising implications for neuroregeneration","authors":"Elena Stocco ,&nbsp;Silvia Barbon ,&nbsp;Ludovica Ceroni ,&nbsp;Marta Confalonieri ,&nbsp;Giada Pulzato ,&nbsp;Samuel Pressi ,&nbsp;Alice D'Osualdo ,&nbsp;Marta Contran ,&nbsp;Rafael Boscolo-Berto ,&nbsp;Cesare Tiengo ,&nbsp;Silvia Todros ,&nbsp;Piero G. Pavan ,&nbsp;Veronica Macchi ,&nbsp;Raffaele De Caro ,&nbsp;Laura Calvillo ,&nbsp;Enzo Menna ,&nbsp;Andrea Porzionato","doi":"10.1016/j.jsamd.2024.100762","DOIUrl":"10.1016/j.jsamd.2024.100762","url":null,"abstract":"<div><p>Carbon nanotubes (CNT) are promising electroconductive nano-scale materials for neuroregeneration. Herein, we report on a new electroconductive composite scaffold made of the polymer 1% oxidized polyvinyl alcohol (OxPVA) combined with functionalized water soluble multiwalled CNT (OxPVA + MWCNT-S) (diazotization reaction). Preliminarily, MWCNT-S were characterized to evaluate the reaction outcome, the degree of functionalization and the dispersibility in water. Thereafter, OxPVA + MWCNT-S nanocomposite membranes were fabricated and analyzed for physicochemical properties (Raman spectroscopy, thermal decomposition, calorimetric properties, electroconductivity), macroscopic appearance and ultrastructure, mechanical behavior, <em>in vitro</em> cytotoxicity and <em>in vivo</em> biocompatibility. In parallel, OxPVA + MWCNT-S membranes with a linear pattern were also developed and analyzed for interaction with SH-SY5Y cells. Compared to OxPVA, the presence of MWCNT-S (only 0.016 wt%) significantly increased polymer conductivity and imparted a certain porosity without altering mechanical behaviour, as corroborated by uniaxial tensile tests. Neither cytotoxicity nor local signs of inflammation were detected <em>in vitro</em> and after subcutaneous implantation (14 and 42 days), proving composite material biocompatibility. OxPVA + MWCNT-S nanocomposite revealed as promising for future electroconductive conduits free from toxic effects amenable to CNT agglomeration within the polymer. Ideally, nerve lesions with wide gaps, may be effectively supported by those “active” devices, overcoming limitations of the available ones. Despite preliminary data, the presence of a linear pattern confirmed to have a beneficial effect over the scaffold/cells interaction.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100762"},"PeriodicalIF":6.7,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000935/pdfft?md5=2199d2409ff7b8da052c7fe640acc250&pid=1-s2.0-S2468217924000935-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micrometric thermal electronic nose able to detect and quantify individual gases in a mixture","authors":"Matteo Tonezzer ,&nbsp;Michele Ricci ,&nbsp;Nguyen X. Thai ,&nbsp;Hugo Nguyen ,&nbsp;Nguyen V. Duy ,&nbsp;Nguyen D. Hoa","doi":"10.1016/j.jsamd.2024.100760","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100760","url":null,"abstract":"<div><p>Recent urbanization and environmental problems urge for networks of sensors that can monitor air quality. Small, inexpensive, and smart sensors are one of the key components enabling the realization of such networks. Chemoresistive sensors are the ideal candidate, but they greatly lack selectivity, and for this reason, they are usually combined in arrays to create electronic noses, whose dimensions, however, make them not miniaturizable and cannot be integrated into portable devices. To overcome this inconvenience, we present a thermal electronic nose consisting of identical resistive sensors working at different temperatures so that the whole device is simple to make and tiny. The device contains two sensor arrays based on tin oxide nanowires decorated with Ag and Pt nanoparticles, respectively. The five sensors in each array are identical, but their response is differentiated by different temperatures locally generated by an on-chip integrated heater. This innovative approach allows the tiny array of five sensors together with the integrated heater to occupy only approximately 50 × 200 μm² and consume only 120 μW. The tiny and portable device can estimate the concentration of H₂ and NH₃ in a mixture with a root mean square error of 6.1 ppm and 13.3 ppm, respectively, and it still works well after two months. The performance analysis of the double partial least squares regression used for concentration estimation also allows for feedback on which sensors are the most sensitive to which gas so that the electronic nose can be engineered for specific applications using the most suitable sensors. The size of the thermal electronic nose allows it to be integrated into portable and wearable devices, and its performance makes it suitable for any gas detection application. For example, a smartphone with an integrated sensor could carry out breath analysis and act as medical pre-screening or be used to evaluate the freshness of agri-food products in a rapid and non-invasive way.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100760"},"PeriodicalIF":6.7,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000911/pdfft?md5=1dc070a65bdc12edc6a81917ef96cf82&pid=1-s2.0-S2468217924000911-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141594080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CPP10-targeted photoactivatable MOF nanosystem for combined photodynamic Therapy−Chemotherapy of cancer","authors":"Jiahui Kong,&nbsp;Mengru Cai,&nbsp;Rongyue Zhu,&nbsp;Yongqiang Zhang,&nbsp;Yuji Du,&nbsp;Xiaohong Jing,&nbsp;Yufei Sun,&nbsp;Rongrong Chang,&nbsp;Changhai Qu,&nbsp;Xiaoxv Dong,&nbsp;Jian Ni,&nbsp;Xingbin Yin","doi":"10.1016/j.jsamd.2024.100761","DOIUrl":"https://doi.org/10.1016/j.jsamd.2024.100761","url":null,"abstract":"<div><p>The annual prevalence of gastric cancer has increased in recent years. Curcumin (CUR) has shown great potential in the treatment of gastric cancer; however, its low bioavailability and poor efficacy hinder its widespread clinical application. Additionally, CUR has been found to be excellent photosensitizer in photodynamic therapy. In this study, the Fe-based metal-organic framework (MOF) Fe Tetrakis (4-carboxyphenyl) porphyrin (Fe-TCPP，FT) was used as a photosensitizer and mononuclear agent. The natural anti-tumor active ingredient CUR was loaded as both a chemotherapeutic agent and photosensitizer to form the nanoparticles CUR@FT (CF). Finally, a cell-penetrating peptide (CPP10) was modified on the surface of the nanoparticles to construct a drug delivery system (named CPP10-PEG@CUR@FT, CCF) that could actively target tumor cells while exerting a synergistic therapeutic effect of chemotherapy and photodynamic therapy. This can improve the efficacy of CUR as a chemotherapeutic drug or photosensitizer, and the high drug load and pH sensitivity of FT nanoparticles provide an excellent carrier for the efficient delivery of CUR. The polyethene glycol (PEG)-conjugated CPP10 (PEG-CPP10) coating allows nanoparticles to specifically target gastric cancer cells, significantly improving the absorption of nanoparticles in vivo and in vitro and improving biosafety. We evaluated the thermal stability, drug loading capacity, and safety of FT as a drug delivery vehicle. We also assessed the in vitro photodynamic performance and toxicity of various nanoparticles and the targeting and biocompatibility of CPP10-PEG@CUR@FT. CPP10-PEG@CUR@FT could specifically target tumor cells, and its effect on killing gastric cancer cells (MKN45) under light was much stronger than that of free CUR. Its toxicity and side effects to other organs and tissues are low, offering good biosafety. The experimental results showed that FT and CUR exerted synergistic effects on photodynamic therapy and chemotherapy. In summary, our novel CUR-loaded targeted nano drug delivery system offers significant advantages by combining photodynamic therapy and chemotherapy for tumor treatment. This approach introduces a new concept for integrating chemotherapy, photodynamic therapy and targeted drug delivery, potentially providing a new strategy for the clinical treatment of gastric cancer.</p></div>","PeriodicalId":17219,"journal":{"name":"Journal of Science: Advanced Materials and Devices","volume":"9 3","pages":"Article 100761"},"PeriodicalIF":6.7,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468217924000923/pdfft?md5=5270e2b1be4d104451eb0ca533fc1b29&pid=1-s2.0-S2468217924000923-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}