Journal of the American Medical Association最新文献

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Remains.
Journal of the American Medical Association Pub Date : 2025-01-30 DOI: 10.1001/jama.2024.22200
Janice Lynch Schuster
{"title":"Remains.","authors":"Janice Lynch Schuster","doi":"10.1001/jama.2024.22200","DOIUrl":"https://doi.org/10.1001/jama.2024.22200","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143066610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overcoming Hepatitis B Vaccine Nonresponsiveness. 克服乙型肝炎疫苗无反应性。
Journal of the American Medical Association Pub Date : 2025-01-28 DOI: 10.1001/jama.2024.24028
Ivan Hung, Anna S Lok
{"title":"Overcoming Hepatitis B Vaccine Nonresponsiveness.","authors":"Ivan Hung, Anna S Lok","doi":"10.1001/jama.2024.24028","DOIUrl":"10.1001/jama.2024.24028","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":" ","pages":"291-292"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Collaborator Corrected.
Journal of the American Medical Association Pub Date : 2025-01-28 DOI: 10.1001/jama.2024.27745
{"title":"Collaborator Corrected.","authors":"","doi":"10.1001/jama.2024.27745","DOIUrl":"10.1001/jama.2024.27745","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":"333 4","pages":"351"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
JAMA. 美国医学会杂志
Journal of the American Medical Association Pub Date : 2025-01-28 DOI: 10.1001/jama.2024.18716
{"title":"JAMA.","authors":"","doi":"10.1001/jama.2024.18716","DOIUrl":"https://doi.org/10.1001/jama.2024.18716","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":"333 4","pages":"271-272"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HepB-CpG vs HepB-Alum Vaccine in People With HIV and Prior Vaccine Nonresponse: The BEe-HIVe Randomized Clinical Trial. 乙肝- cpg与乙肝-明矾疫苗在HIV感染者和既往疫苗无应答中的应用:BEe-HIVe随机临床试验
Journal of the American Medical Association Pub Date : 2025-01-28 DOI: 10.1001/jama.2024.24490
Kristen M Marks, Minhee Kang, Triin Umbleja, Andrea Cox, Karen J Vigil, Ngan T Ta, Ayotunde Omoz-Oarhe, Hugo Perazzo, Josphat Kosgei, Timothy Hatlen, Jennifer Price, Leolin Katsidzira, Khuanchai Supparatpinyo, Kevin Knowles, Beverly L Alston-Smith, Parita Rathod, Kenneth E Sherman
{"title":"HepB-CpG vs HepB-Alum Vaccine in People With HIV and Prior Vaccine Nonresponse: The BEe-HIVe Randomized Clinical Trial.","authors":"Kristen M Marks, Minhee Kang, Triin Umbleja, Andrea Cox, Karen J Vigil, Ngan T Ta, Ayotunde Omoz-Oarhe, Hugo Perazzo, Josphat Kosgei, Timothy Hatlen, Jennifer Price, Leolin Katsidzira, Khuanchai Supparatpinyo, Kevin Knowles, Beverly L Alston-Smith, Parita Rathod, Kenneth E Sherman","doi":"10.1001/jama.2024.24490","DOIUrl":"10.1001/jama.2024.24490","url":null,"abstract":"<p><strong>Importance: </strong>Nonresponse to hepatitis B vaccine is common among people with HIV, resulting in vulnerability to infection with hepatitis B virus (HBV).</p><p><strong>Objective: </strong>To compare the seroprotection response achieved with a 2-dose (noninferiority, 10% margin) and a 3-dose hepatitis B vaccine with a cytosine phosphoguanine adjuvant (HepB-CpG vaccine) vs a conventional 3-dose hepatitis B vaccine with an aluminum hydroxide adjuvant (HepB-alum vaccine) in people with HIV and prior nonresponse to HepB-alum vaccine.</p><p><strong>Design, setting, and participants: </strong>This phase 3, open-label, randomized clinical trial included people with HIV receiving antiretroviral therapy (CD4 cell count ≥100 cells/μL and HIV RNA <1000 copies/mL) without past or present serological evidence of having HBV or a response to hepatitis B vaccine. From December 2020 to February 2023, 561 adults were enrolled in the study at 41 sites in 10 countries in Africa, Asia, North America, and South America with follow-up for the primary outcome analysis through September 4, 2023.</p><p><strong>Interventions: </strong>Participants were randomly assigned to receive 2 doses of HepB-CpG vaccine administered intramuscularly at weeks 0 and 4; 3 doses of HepB-CpG vaccine administered intramuscularly at weeks 0, 4, and 24; or 3 doses of HepB-alum vaccine administered intramuscularly at weeks 0, 4, and 24.</p><p><strong>Main outcomes and measures: </strong>The primary outcome was a seroprotection response to hepatitis B vaccine (defined as level of antibody titer against hepatitis B surface antigen [HBsAg] ≥10 mIU/mL) at week 12 for the 2-dose regimen (8 weeks after dose 2) and at week 28 for 3-dose regimens (4 weeks after dose 3). Key secondary outcomes included seroprotection response at additional time points, antibody titer against HBsAg, and adverse events within 4 weeks of hepatitis B vaccination.</p><p><strong>Results: </strong>Of 561 participants included in the analysis (median age, 46 years [IQR, 31-56 years]); 64% were male; 17% of participants were Asian, 42% were Black, and 35% were White), a seroprotection response was achieved in 93.1% who received 2 doses of HepB-CpG vaccine (n = 174), in 99.4% who received 3 doses of HepB-CpG vaccine (n = 169), and in 80.6% who received 3 doses of HepB-alum vaccine (n = 165). The stratified difference in seroprotection response between the 2-dose HepB-CpG vaccine group and the 3-dose HepB-alum vaccine group was 12.5% (97.5% CI, 4.1%-20.9%), achieving noninferiority and indicating superiority. The 3-dose HepB-CpG vaccine regimen was superior to the 3-dose HepB-alum vaccine regimen (stratified difference in seroprotection response, 18.4% [repeated 97.5% CI, 10.4%-26.2%]). By week 12, more than 90% of participants who received HepB-CpG vaccine achieved a seroprotection response. The 3-dose regimen of HepB-CpG vaccine achieved a higher proportion of participants with antibody titer against HBsAg greater","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":" ","pages":"295-306"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142770093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Audio Highlights: Best of JAMA 2024.
Journal of the American Medical Association Pub Date : 2025-01-28 DOI: 10.1001/jama.2024.18717
{"title":"Audio Highlights: Best of JAMA 2024.","authors":"","doi":"10.1001/jama.2024.18717","DOIUrl":"https://doi.org/10.1001/jama.2024.18717","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":"333 4","pages":"e2418717"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143052768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unionization Efforts by Physicians Between 2000 and 2024. 2000 年至 2024 年医生的工会努力。
Journal of the American Medical Association Pub Date : 2025-01-28 DOI: 10.1001/jama.2024.23721
Hayden Rooke-Ley, Barak Richman, Daniel S Bowling, Margaret Nikolov, Kevin Schulman
{"title":"Unionization Efforts by Physicians Between 2000 and 2024.","authors":"Hayden Rooke-Ley, Barak Richman, Daniel S Bowling, Margaret Nikolov, Kevin Schulman","doi":"10.1001/jama.2024.23721","DOIUrl":"10.1001/jama.2024.23721","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":" ","pages":"347-348"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11775727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
US Elections Will Determine the Fate of Extended ACA Subsidies. 美国大选将决定 ACA 津贴延期的命运。
Journal of the American Medical Association Pub Date : 2025-01-28 DOI: 10.1001/jama.2024.22992
Patrick N O'Mahen, Laura A Petersen
{"title":"US Elections Will Determine the Fate of Extended ACA Subsidies.","authors":"Patrick N O'Mahen, Laura A Petersen","doi":"10.1001/jama.2024.22992","DOIUrl":"10.1001/jama.2024.22992","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":" ","pages":"287-288"},"PeriodicalIF":0.0,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142569028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
USPSTF Recommendation Statement About Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy. USPSTF 关于妊娠期缺铁和缺铁性贫血筛查与补充的建议声明。
Journal of the American Medical Association Pub Date : 2025-01-27 DOI: 10.1001/jama.2024.26286
Peter Kranke, Daniel Surbek, Maureen O Achebe
{"title":"USPSTF Recommendation Statement About Screening and Supplementation for Iron Deficiency and Iron Deficiency Anemia During Pregnancy.","authors":"Peter Kranke, Daniel Surbek, Maureen O Achebe","doi":"10.1001/jama.2024.26286","DOIUrl":"https://doi.org/10.1001/jama.2024.26286","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-Term Prognosis of Patients With Myocarditis-Reply.
Journal of the American Medical Association Pub Date : 2025-01-27 DOI: 10.1001/jama.2024.25766
Laura Semenzato, Stéphane Le Vu, Mahmoud Zureik
{"title":"Long-Term Prognosis of Patients With Myocarditis-Reply.","authors":"Laura Semenzato, Stéphane Le Vu, Mahmoud Zureik","doi":"10.1001/jama.2024.25766","DOIUrl":"https://doi.org/10.1001/jama.2024.25766","url":null,"abstract":"","PeriodicalId":17196,"journal":{"name":"Journal of the American Medical Association","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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