ALKHAS The Journal of Environment Agriculture and Biological Sciences最新文献

Effect of Fine Grinding Process on Temperature Characteristics and Water-Binding Capacity of Chicken Bone Paste 细磨工艺对鸡骨膏温度特性及水结合力的影响

ALKHAS The Journal of Environment Agriculture and Biological Sciences Pub Date : 2022-05-30 DOI: 10.47176/alkhass.4.1.1

B. Kabdylzhar, A. Kakimov, A. Suychinov, Madina Rakimova, Syrym Yessengeldin, G. Bekeshova

引用次数: 0

Effect of Alkaline Solutions on Bentonite-Based Eco-Friendly Geopolymer Composite 碱性溶液对膨润土基环保型地聚合物复合材料的影响

ALKHAS The Journal of Environment Agriculture and Biological Sciences Pub Date : 2022-05-30 DOI: 10.47176/alkhass.4.1.5

Alireza Esparham, Mohadeseh Mohammadi

引用次数: 1

Marine Algae as a New Source of Bioactive Compositionsin 海藻作为生物活性成分的新来源

ALKHAS The Journal of Environment Agriculture and Biological Sciences Pub Date : 2021-10-20 DOI: 10.47176/alkhass.3.4.1

A. Ghafarizadeh, A. Niroomand

引用次数: 0

Study of the status of black fungus disease in case reports of coronavirus in susceptible animals 冠状病毒易感动物病例报告中黑木耳病状况的研究

ALKHAS The Journal of Environment Agriculture and Biological Sciences Pub Date : 2021-10-20 DOI: 10.47176/alkhass.3.4.6

Donya Nikaien, Neshat Resalepour, Seyyed Alireza Rezaie

引用次数: 0

In Silico Screening of Hispolon and its Analogs: Pharmacokinetics and Molecular Docking Studies with Cyclooxygenase-2 Enzyme Hispolon及其类似物的硅筛选:药代动力学及与环氧合酶-2的分子对接研究

ALKHAS The Journal of Environment Agriculture and Biological Sciences Pub Date : 2021-10-20 DOI: 10.47176/alkhass.3.3.1

Mohadeseh Mohammadi, Mohammad Firoz Khan, Ridwan Bin Rashid, Sina Mirzaie Nokhostin, Mohammad A. Rashid

{"title":"In Silico Screening of Hispolon and its Analogs: Pharmacokinetics and Molecular Docking Studies with Cyclooxygenase-2 Enzyme","authors":"Mohadeseh Mohammadi, Mohammad Firoz Khan, Ridwan Bin Rashid, Sina Mirzaie Nokhostin, Mohammad A. Rashid","doi":"10.47176/alkhass.3.3.1","DOIUrl":"https://doi.org/10.47176/alkhass.3.3.1","url":null,"abstract":"Hispolon is a phenolic compound with diverse biological activities. The analgesic action of hispolon is due to the inhibition of prostaglandins biosynthesis. However, the molecular basis of this inhibition has not been explored yet. Therefore, we have carried out theoretical investigations to evaluate the molecular basis of analgesic action. Furthermore, we have conducted high throughput in silico screening of a library of compounds to get novel cyclooxygenase 2 (COX-2) inhibitors with better pharmacokinetic and analgesic properties. The docking study was conducted using PyRx and the drug-like properties were calculated by MarvinSketch. Furthermore, the pharmacokinetic properties were computed on the online server PreADMET. In this study, our virtual screening based on structure similarity search using hispolon as reference structure afforded 1,699 compounds. These compounds were subjected to molecular docking with COX-2. These were then filtered based on binding affinity, binding poses, and drug-like properties which yielded seven compounds. The in silico pharmacokinetic study revealed that these compounds possess good human intestinal absorption and moderate permeability. Moreover, molecular docking of these compounds revealed that all the ligands possess moderate to good binding affinity (−7.6 to −8.9 Kcal/mol). Our computed properties may assist in developing hispolon derivatives with better pharmacokinetic and COX-2 inhibitory activity.","PeriodicalId":169640,"journal":{"name":"ALKHAS The Journal of Environment Agriculture and Biological Sciences","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133149609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction of Long non-coding RNA and Their Potential Role as a Biomarker in Breast Cancer 长链非编码RNA的介绍及其作为乳腺癌生物标志物的潜在作用

ALKHAS The Journal of Environment Agriculture and Biological Sciences Pub Date : 2021-09-01 DOI: 10.22034/MBT.2021.135215

Mighmig Simonian Gharghani, K. Ghaedi

{"title":"Introduction of Long non-coding RNA and Their Potential Role as a Biomarker in Breast Cancer","authors":"Mighmig Simonian Gharghani, K. Ghaedi","doi":"10.22034/MBT.2021.135215","DOIUrl":"https://doi.org/10.22034/MBT.2021.135215","url":null,"abstract":"Breast cancer (BC), also known as breast tumor, is major life- threatening diseases for women worldwide representing about 30% of all cancers affecting women. In order to cure and prevent the progression of such malignancy, the use of sensitive and specific biomarker1 is essential to aid the detection of breast cancer at an early stage. Furthermore, it has to be precise enough to monitor progression of the disease, and could predict the individual patient’s response to treatment. Unfortunately, markers with such characteristics have not been introduced and implemented in clinical level. Recent Bioinformatics studies have revealed a broad spectrum of noncoding RNAs called lncRNAs that are involved in breast cancer. They have a role in cell growth, apoptosis2, cell migration and invasiveness as well as cancer cell stemness. Although, their exact mechanisms and potential to serve as a biomarkers are yet to be clarified, they could be utilized for diagnostic purposes and therapeutic targets. This review is to summarize the to date information about lncRNAs that are particularly involved in breast cancer and could possibly named as a biomarker in foreseeable future.","PeriodicalId":169640,"journal":{"name":"ALKHAS The Journal of Environment Agriculture and Biological Sciences","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127797715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0