{"title":"New hopes on \"SLU-PP-332\" as an effective agent for weight loss with indirect kidney protection efficacy; a nephrology point of view","authors":"Hamid Nasri","doi":"10.34172/jre.2024.25143","DOIUrl":"https://doi.org/10.34172/jre.2024.25143","url":null,"abstract":"SLU-PP-332 activates estrogen receptor-related orphan receptors, increasing energy expenditure, fatty acid oxidation, and decreasing fat mass accumulation. The drug enhances mitochondrial function and cellular respiration in skeletal muscle cell lines, increases the expression of an estrogen receptor-related orphan receptor target gene, and enhances mitochondrial respiration in C2C12 myocytes. The drug also increases oxidative fibers in skeletal muscle and improves exercise endurance in C57BL/6J mice.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"26 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139633363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Vitamin D and its role in health; A review of mechanisms, risk factors, sources, and health benefits","authors":"Moloud Alsadat Mousavi, M. Hosseinifard, Maryam Aligholizadeh, Siavash Sangi, Zahra Kordeyazdi, Faraz Zandiyeh","doi":"10.34172/jre.2024.25133","DOIUrl":"https://doi.org/10.34172/jre.2024.25133","url":null,"abstract":"Vitamin D is crucial for maintaining optimal health. This review study evaluates health problems related to deficiency and ways to maintain sufficient levels. We conducted a review of the association between vitamin D inadequacy and various diseases, explored the various sources of vitamin D and the risk factors associated with vitamin D insufficiency, examined the consequences of insufficient vitamin D levels, and assessed the potential benefits of taking vitamin D supplements for promoting good health. A literature review demonstrated that maintaining sufficient levels of vitamin D is essential for improving health and preventing various diseases. Vitamin D deficiency is a common condition, and it can be addressed by consuming a balanced diet, getting regular exposure to sunlight, or taking supplements as necessary.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"53 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139633228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contrast-induced acute kidney injury; possible ameliorative effect of sodium-glucose co-transporter 2 inhibitors","authors":"Hamid Nasri","doi":"10.34172/jre.2024.25142","DOIUrl":"https://doi.org/10.34172/jre.2024.25142","url":null,"abstract":"Contrast-associated acute renal injury is a common complication that occurs after the administration of contrast media for diagnostic or therapeutic purposes. It is characterized by a sudden decline in kidney function within 48-72 hours after the administration of contrast media. The incidence of contrast-associated acute renal injury varies depending on the patient’s risk factors and the type and amount of contrast media used. Sodium-glucose co-transporter 2 (SGLT2) inhibitors are a group of antidiabetic drugs that inhibit the reabsorption of glucose in the nephrons, running to raise urinary glucose excretion and improve glycemic control. Recent studies have shown that SGLT2 inhibitors may have a protective effect against contrast-associated acute renal injury. Preventive measures for contrast-associated acute renal injury include hydration, minimizing contrast volume and rate of administration, and avoiding contrast in high-risk patients. The administration of SGLT2 inhibitors may also be a useful preventive measure in patients at risk for contrast-associated acute renal injury.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139632062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Contrast-induced nephropathy; an update on pathophysiology","authors":"Yasaman Yadollahi Fars, Razieh Moghadasi, Shokouh Shayanpour","doi":"10.34172/jre.2023.25099","DOIUrl":"https://doi.org/10.34172/jre.2023.25099","url":null,"abstract":"Contrast-induced nephropathy (CIN) is a well-known complication of contrast media administration for diagnostic and therapeutic purposes. The incidence of CIN has increased with the widespread use of diagnostic imaging and contrast media. CIN is a pathological condition that typically occurs within 48 hours of exposure to contrast material and results in an increase in serum creatinine levels of more than 44 µmol/L (0.5 mg/dL) or 25% above baseline or an increase in serum creatinine of more than 1.5 times the baseline level within 7 days of exposure to contrast material or a reduction in urine output to less than 0.5 mL/h for at least 6 hours after exposure to contrast material. The mechanism of CIN is not fully understood, but it is thought to involve direct nephrotoxic effects of contrast particles, hemodynamic changes, hypoxia and oxidative stress, apoptosis, inflammation, and immune responses. Prevention of CIN involves identifying the risk factors and taking appropriate measures to mitigate them. Currently, there is no definitive treatment for CIN, and treatment is mainly symptomatic, with supportive care being the mainstay. Experimental treatments such as renal replacement therapy, extracorporeal blood purification, and stem cell therapy are being investigated, but their clinical efficacy is yet to be established.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78917137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Farinaz Fattahi, M. Farnia, Bareza Rezaei, Hooman Rafiei, Aisan Ghasemi Oskui, A. Amiri, Mohammad Reza Rezaei
{"title":"COVID-19 patients’ lung involvement severity as a predictor of kidney dysfunction and coagulopathy disorders","authors":"Farinaz Fattahi, M. Farnia, Bareza Rezaei, Hooman Rafiei, Aisan Ghasemi Oskui, A. Amiri, Mohammad Reza Rezaei","doi":"10.34172/jre.2023.25096","DOIUrl":"https://doi.org/10.34172/jre.2023.25096","url":null,"abstract":"Introduction: Kidney dysfunction, coagulopathy disorders, and lung involvement are the most common disorders caused by the COVID-19 virus. Objectives: This study aimed to investigate the correlation of lung involvement severity with kidney dysfunction and coagulopathy disorders in COVID-19 patients. Patients and Methods: This descriptive-analytical study was conducted on 97 patients with COVID-19 referred to Imam Reza hospital in Kermanshah from December 2020 to June 2021. Lung involvement severity, kidney function tests, and coagulation laboratory data were collected. Logistic regression test was conducted to explore the correlation between lung involvement with kidney dysfunction and coagulopathy disorders. Results: Out of 97 patients, 53 (54.6%) were male, with a mean age of 59.31 ± 16.44 years. The correlation between lung involvement severity with kidney function tests, including, blood urea nitrogen, serum creatinine, and coagulation factors, including prothrombin time (PT), partial thromboplastin time (PTT), and D-dimer, were significant (P > 0.05). Lung involvement severity significantly predicted kidney dysfunction and coagulopathy disorders. Conclusion: Lung involvement severity would be able to predict kidney dysfunction and coagulopathy disorders in patients with COVID-19.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82567434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of vitamin D in COVID-19 management","authors":"S. Zandifar","doi":"10.34172/jre.2023.25091","DOIUrl":"https://doi.org/10.34172/jre.2023.25091","url":null,"abstract":"Implication for health policy/practice/research/medical education: Vitamin D plays an essential role in the management of COVID-19.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76181712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nephroceuticals as a new hope for the treatment of kidney diseases","authors":"M. Zahmatkesh","doi":"10.34172/jre.2023.25112","DOIUrl":"https://doi.org/10.34172/jre.2023.25112","url":null,"abstract":"Nephroceuticals are natural or pharmacologically active compounds used to manage and even reverse certain kidney diseases. The term \"nephroceuticals\" is relatively new, although the study of utilizing natural or active compounds to manage kidney disease has been emerging for many years. Nephroceuticals have shown promise in supporting conventional therapies such as dialysis and kidney transplantation, and are purported to have fewer adverse effects compared to conventional chemical compounds.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84453539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Onco-hypertension; a collaboration among oncologists, nephrologists and cardiologists","authors":"Sara Dehghan","doi":"10.34172/jre.2023.25098","DOIUrl":"https://doi.org/10.34172/jre.2023.25098","url":null,"abstract":"It is essential to manage hypertension in cancer patients because uncontrolled high blood pressure can increase the risk of cardiovascular complications and negatively impact overall health. We searched PubMed, Web of Science, EBSCO, Scopus, Google Scholar, Directory of Open Access Journals (DOAJ), and Embase, using keywords including; hypertension, onco-hypertension, and Neoplasms; and found that several factors can contribute to the development of onco-hypertension, including certain types of cancer, chemotherapy drugs, targeted therapies, and hormonal treatments. Favorable cooperation of multi-specialists in this disease treatment can lead to better and more optimal treatment management for these patients.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89455713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rokhsare Zareie, Mahsa Asadollahi Hamedani, Reyhaneh Sadeghian, Y. Khanchemehr, M. Belali Kharaji, E. Zaremoghadam, Negar Shahkarami, Atena Samareh Fekri
{"title":"Biomarkers in IgA nephropathy; an update to recent data","authors":"Rokhsare Zareie, Mahsa Asadollahi Hamedani, Reyhaneh Sadeghian, Y. Khanchemehr, M. Belali Kharaji, E. Zaremoghadam, Negar Shahkarami, Atena Samareh Fekri","doi":"10.34172/jre.2023.25120","DOIUrl":"https://doi.org/10.34172/jre.2023.25120","url":null,"abstract":"Biomarkers are molecules that can be measured in the body and can reflect disease activity or progression. They can be used to diagnose and monitor disease, predict treatment response, and identify potential therapeutic targets. Several types of biomarkers have been studied in the context of IgA nephropathy, including protein, gene expression, epigenetic, and microRNA biomarkers. Biomarkers have the potential to improve the accuracy and specificity of the diagnosis of IgA nephropathy and predict the disease progression and response to treatment. However, further studies are needed to validate their diagnostic value in larger cohorts of patients and to integrate them into clinical practice. The development of multi-omics approaches that combine different types of biomarkers may provide a more comprehensive understanding of the disease pathogenesis and potential treatments.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75827641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kolsoum Teimouri, K. Khoshgard, M. Rouzbahani, Samaneh Pakravan
{"title":"Cardiac alterations following radiation therapy in individuals with breast cancer","authors":"Kolsoum Teimouri, K. Khoshgard, M. Rouzbahani, Samaneh Pakravan","doi":"10.34172/jre.2023.25066","DOIUrl":"https://doi.org/10.34172/jre.2023.25066","url":null,"abstract":"One of the most prevalent cancers in women is breast cancer, which is typically treated with radiation therapy (RT) which can lead to cardiovascular (CV) disease. The severity of these complications depends on the amount of radiation to the heart. In addition to hurting the cardiac tissue, RT also damages the blood vessels. Individuals with left breast cancer have a higher risk of developing CV disease as a result of RT than those with right breast cancer. Furthermore, women with risk factors for heart disease, such as diabetes, high cholesterol, smoking, and family history, are more likely to develop CV disease side effects from RT.","PeriodicalId":16964,"journal":{"name":"Journal of Renal Endocrinology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72696414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}