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Abstract PO-074: Identification of C-MET receptor as a therapeutic target in patient-specific tumoroid models of metastatic pancreatic adenocarcinoma allows identification of a new mode of action for its inhibitors 摘要PO-074:在转移性胰腺腺癌患者特异性类肿瘤模型中，C-MET受体作为治疗靶点的鉴定允许鉴定其抑制剂的新作用模式
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-074
Liam Deems, M. Ivanova, C. Murphy, Amit Shahar, D. Deems, D. Shvartsman
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引用次数: 0
Abstract PO-070: Longitudinal precision oncology platform to identify chemotherapy-induced vulnerabilities in pancreatic cancer PO-070:纵向精确肿瘤学平台，用于识别胰腺癌化疗诱导的脆弱性
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-070
K. Peschke, Hannah Jakubowski, A. Schäfer, Carlo Maurer, S. Lange, F. Orben, Raquel Bernad, Felix N. Harder, M. Eiber, R. Öllinger, M. Schlitter, W. Weichert, V. Phillip, C. Schlag, R. Schmid, R. Braren, B. Kong, E. Demir, H. Friess, R. Rad, D. Saur, G. Schneider, M. Reichert
{"title":"Abstract PO-070: Longitudinal precision oncology platform to identify chemotherapy-induced vulnerabilities in pancreatic cancer","authors":"K. Peschke, Hannah Jakubowski, A. Schäfer, Carlo Maurer, S. Lange, F. Orben, Raquel Bernad, Felix N. Harder, M. Eiber, R. Öllinger, M. Schlitter, W. Weichert, V. Phillip, C. Schlag, R. Schmid, R. Braren, B. Kong, E. Demir, H. Friess, R. Rad, D. Saur, G. Schneider, M. Reichert","doi":"10.1158/1538-7445.panca21-po-070","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-070","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"66 1-2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114008942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-062: EUS-guided biopsy of pancreatic mass lesions for the development of patient-derived organoids in Puerto Rico PO-062:在波多黎各，eus引导下胰腺肿块病变活检用于患者源性类器官的发展
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-062
Andrea S. Flores Pérez, J. Vega, Ana M. Reyes Ramos, C. Micames, M. Torres-Lugo, Maribella Domenech
{"title":"Abstract PO-062: EUS-guided biopsy of pancreatic mass lesions for the development of patient-derived organoids in Puerto Rico","authors":"Andrea S. Flores Pérez, J. Vega, Ana M. Reyes Ramos, C. Micames, M. Torres-Lugo, Maribella Domenech","doi":"10.1158/1538-7445.panca21-po-062","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-062","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134449154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-068: Cholesterol auxotrophy promotes the expansion of centroacinar cells giving rise to the basal subtype of pancreatic adenocarcinoma PO-068:胆固醇营养不良促进中央腺泡细胞的扩张，导致胰腺腺癌的基底亚型
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-068
M. Kotliar, A. Surumbayeva, L. Gabitova, S. Peri, D. Restifo, K. Cai, A. Barski, I. Astsaturov
{"title":"Abstract PO-068: Cholesterol auxotrophy promotes the expansion of centroacinar cells giving rise to the basal subtype of pancreatic adenocarcinoma","authors":"M. Kotliar, A. Surumbayeva, L. Gabitova, S. Peri, D. Restifo, K. Cai, A. Barski, I. Astsaturov","doi":"10.1158/1538-7445.panca21-po-068","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-068","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131075396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Abstract PO-072: Inhibiting vasoactive intestinal peptide receptor signaling elicits T cell dependent anti-tumor response of pancreatic ductal adenocarcinoma to immune checkpoint therapy PO-072:抑制血管活性肠肽受体信号通路可诱导T细胞依赖性胰腺导管腺癌对免疫检查点治疗的抗肿瘤反应
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-072
S. Ravindranathan, Passang Tenzin, J. M. Li, Rohan Dhamsania, M. Ware, Mohammad Y Zaidi, Shuhua Wang, Jingru Zhu, Maria A Cardenas, Yuan Liu, G. Joshi, S. Gumber, B. Robinson, A. Sen-Majumdar, S. Chandrakasan, H. Kissick, A. Frey, S. Thomas, B. El-Rayes, G. Lesinski, E. Waller
{"title":"Abstract PO-072: Inhibiting vasoactive intestinal peptide receptor signaling elicits T cell dependent anti-tumor response of pancreatic ductal adenocarcinoma to immune checkpoint therapy","authors":"S. Ravindranathan, Passang Tenzin, J. M. Li, Rohan Dhamsania, M. Ware, Mohammad Y Zaidi, Shuhua Wang, Jingru Zhu, Maria A Cardenas, Yuan Liu, G. Joshi, S. Gumber, B. Robinson, A. Sen-Majumdar, S. Chandrakasan, H. Kissick, A. Frey, S. Thomas, B. El-Rayes, G. Lesinski, E. Waller","doi":"10.1158/1538-7445.panca21-po-072","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-072","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131138888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-063: Functional interrogation of immune escape in neoantigen-expressing pancreatic cancer identifies a critical role for the CD155/TIGIT axis PO-063:表达新抗原的胰腺癌中免疫逃逸的功能研究发现CD155/TIGIT轴的关键作用
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-063
William A. Freed-Pastor, Laurens J. Lambert, Zackery A. Ely, Nimisha B. Pattada, A. Bhutkar, Alex M. Jaeger, George Eng, Kim L. Mercer, W. Hwang, T. Jacks
{"title":"Abstract PO-063: Functional interrogation of immune escape in neoantigen-expressing pancreatic cancer identifies a critical role for the CD155/TIGIT axis","authors":"William A. Freed-Pastor, Laurens J. Lambert, Zackery A. Ely, Nimisha B. Pattada, A. Bhutkar, Alex M. Jaeger, George Eng, Kim L. Mercer, W. Hwang, T. Jacks","doi":"10.1158/1538-7445.panca21-po-063","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-063","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127798124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-066: High uptake, retention, and in vivo activity of L-Annamycin in pancreatic cancer models PO-066在胰腺癌模型中具有较高的L-Annamycin吸收、保留和体内活性
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-066
Ya'an Kang, Rafal Zieliński, Roberto Cardenas Zuniga, R. Venugopal, M. Poimenidou, Magdalena Remiszewski, S. Peng, Edd Felix, Krzysztof Grela, S. Skóra, V. N. Nguyen, I. Fokt, W. Priebe
{"title":"Abstract PO-066: High uptake, retention, and in vivo activity of L-Annamycin in pancreatic cancer models","authors":"Ya'an Kang, Rafal Zieliński, Roberto Cardenas Zuniga, R. Venugopal, M. Poimenidou, Magdalena Remiszewski, S. Peng, Edd Felix, Krzysztof Grela, S. Skóra, V. N. Nguyen, I. Fokt, W. Priebe","doi":"10.1158/1538-7445.panca21-po-066","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-066","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"390 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124561646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-065: SIWA318H, an advanced glycation end product (AGE) targeting antibody, is efficacious in a humanized mouse xenograft model for pancreatic cancer PO-065: SIWA318H是一种晚期糖基化终产物(AGE)靶向抗体，在人源化小鼠胰腺癌异种移植模型中有效
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-065
A. Jensen, G. Rossi, R. Muñoz, Kimberly M. Brothers, L. Gruber, Misty S. Gruber, Haiyong Han
{"title":"Abstract PO-065: SIWA318H, an advanced glycation end product (AGE) targeting antibody, is efficacious in a humanized mouse xenograft model for pancreatic cancer","authors":"A. Jensen, G. Rossi, R. Muñoz, Kimberly M. Brothers, L. Gruber, Misty S. Gruber, Haiyong Han","doi":"10.1158/1538-7445.panca21-po-065","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-065","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128068516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-077: Establishment of a novel living biobank of patient-derived pancreatic cancer organoids with genomic and drug response characterization 摘要PO-077:建立具有基因组和药物反应表征的患者来源的胰腺癌类器官的新型活生物库
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-077
Irene Y. Xie, L. Tamblyn, Karen Ng, E. Flores-Figueroa, Julie M. Wilson, G. Jang, A. Zhang, S. Ramotar, A. Dodd, N. Radulovich, Julia Knox, G. O’Kane, S. Gallinger, F. Notta
{"title":"Abstract PO-077: Establishment of a novel living biobank of patient-derived pancreatic cancer organoids with genomic and drug response characterization","authors":"Irene Y. Xie, L. Tamblyn, Karen Ng, E. Flores-Figueroa, Julie M. Wilson, G. Jang, A. Zhang, S. Ramotar, A. Dodd, N. Radulovich, Julia Knox, G. O’Kane, S. Gallinger, F. Notta","doi":"10.1158/1538-7445.panca21-po-077","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-077","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133692639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract PO-076: Murine adapted FOLFIRINOX for standard-of-care in KPC mice PO-076:适用于KPC小鼠标准护理的小鼠FOLFIRINOX
Preclinical Models Pub Date : 2021-11-15 DOI: 10.1158/1538-7445.panca21-po-076
Martin C. Whittle, A. Palkar, R. Fasnacht, James Yan, Borith Kheng, Kianna Sinfuego, Shelley M. Thorsen, S. Hingorani
{"title":"Abstract PO-076: Murine adapted FOLFIRINOX for standard-of-care in KPC mice","authors":"Martin C. Whittle, A. Palkar, R. Fasnacht, James Yan, Borith Kheng, Kianna Sinfuego, Shelley M. Thorsen, S. Hingorani","doi":"10.1158/1538-7445.panca21-po-076","DOIUrl":"https://doi.org/10.1158/1538-7445.panca21-po-076","url":null,"abstract":"","PeriodicalId":169481,"journal":{"name":"Preclinical Models","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124691846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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