Journal of Radiation and Cancer Research最新文献_第8页

Palliative hypofractionated radiation therapy in incurable head-and-neck cancer patients – 2-year follow-up experience from a tertiary center from South India 姑息性低分割放射治疗在无法治愈的头颈癌患者中的应用——来自印度南部三级中心的2年随访经验

Journal of Radiation and Cancer Research Pub Date : 2022-04-01 DOI: 10.4103/jrcr.jrcr_53_21

S. Velarasan, Deivanayagam Ramasundaram

{"title":"Palliative hypofractionated radiation therapy in incurable head-and-neck cancer patients – 2-year follow-up experience from a tertiary center from South India","authors":"S. Velarasan, Deivanayagam Ramasundaram","doi":"10.4103/jrcr.jrcr_53_21","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_53_21","url":null,"abstract":"Purpose: The main aim of the study was to assess tumor response to hypofractionated (HYPO Trial schedule) course of radiotherapy in patients with incurable squamous cell carcinoma of the head and neck in our patients. Materials and Methods: We retrospectively reviewed records of 23 patients treated between January 2019 and December 2019 with hypofractionated radiation therapy. These patients were given palliative radiation if they were deemed to be unsuitable for curative treatment due to poor general condition, comorbidities, advanced stage of disease, and/or advanced age. Radiation therapy schedule was 30 Gy in 5 fractions twice weekly and all the patients were treated with telecobalt machine. The assessment was done clinically. Records of tumor response, mucosal, and skin toxicity noted during radiation therapy and during follow-up were taken from patient records. Results: The most common primary site was oral cavity (48%) followed by oropharynx (31%). Most of the patients presented in Stage IVA (52%) followed by Stage III (31%) at diagnosis. Grades 2 and 3 mucositides were reported in 14 (64%) and 8 (36%), respectively. Eighty percent of the patients had partial response in primary and 65% of the patients had partial response in node. Twenty-seven percent of our patients had stable diseases. Partial response was seen in highest in patients with primary in oral cavity (80%) patients followed by hypopharynx (75%). Conclusion: This regimen offers better symptom palliation, acceptable treatment toxicity and appears practical in centers having a significant proportion of incurable head-and-neck cancer patients.","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":"31 1","pages":"60 - 64"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85647051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Study of serum cytokines (interleukin-6 and tumor necrosis factor-alpha) in acute leukemias 急性白血病患者血清细胞因子(白细胞介素-6和肿瘤坏死因子- α)的研究

Journal of Radiation and Cancer Research Pub Date : 2022-04-01 DOI: 10.4103/jrcr.jrcr_48_21

Divita Saxena, Leelavathi Dawson, R. Gera

{"title":"Study of serum cytokines (interleukin-6 and tumor necrosis factor-alpha) in acute leukemias","authors":"Divita Saxena, Leelavathi Dawson, R. Gera","doi":"10.4103/jrcr.jrcr_48_21","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_48_21","url":null,"abstract":"Objectives: The objectives of this study were to assess the cutoff levels of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-alpha) for predicting acute leukemia with special attention to their correlation with blast counts in leukemia subtypes of acute lymphoblastic leukemia (ALL), acute myeloid leukemia, and mixed phenotypic acute leukemia. Methods: This observational cross-sectional case–control study was done from September 2018 to March 2020. A total of 35 newly diagnosed patients of acute leukemia were taken as cases and compared with 140 healthy controls. Complete phenotyping and blood film analysis was done for the cases. The serum levels of IL-6 and TNF-alpha levels were assessed and compared among cases and controls. The levels of IL-6 and TNF-alpha were correlated with blast counts of subtypes of acute leukemia. P < 0.05 was considered statistically significant. Results: Compared to controls, acute leukemia cases had significantly higher levels of IL-6 median interquartile range value (12.39 [8.056–136.894] vs. 8.27 [6.477–10.849]) and TNF-alpha (192.48 ± 633.01 vs. [20.63 ± 8.17]) with P < 0.05. TNF-alpha was found to be the better predictor of acute leukemias at cutoff of >24.906 with sensitivity of 71.43% as compared to IL-6 (Sn of 48.57%). Only TNF-alpha had a significant correlation with absolute blast count in ALL cases (r = 0.579, P = 0.0118). Conclusion: It can be concluded that an aberrant increased production of the pro-inflammatory cytokines IL-6 and TNF-alpha is shown in the acute leukemia patients as compared to the healthy controls. TNF-alpha is a better marker among both the cytokines for predicting acute leukemia with significant correlation with blast counts in ALL.","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":"78 1","pages":"74 - 80"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80267926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Esophageal carcinoma: An epidemiological analysis and study of the time trends over the last 20 years from a single center in India 食管癌:印度单一中心近20年时间趋势的流行病学分析和研究

Journal of Radiation and Cancer Research Pub Date : 2022-01-01 DOI: 10.4103/jrcr.jrcr_38_21

Shahida Nasreen, Shaiba Hussain, Asifa Andleeb, A. Manzoor, K. Fatima, M. Sofi

{"title":"Esophageal carcinoma: An epidemiological analysis and study of the time trends over the last 20 years from a single center in India","authors":"Shahida Nasreen, Shaiba Hussain, Asifa Andleeb, A. Manzoor, K. Fatima, M. Sofi","doi":"10.4103/jrcr.jrcr_38_21","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_38_21","url":null,"abstract":"Aims: Esophageal carcinoma is a common gastrointestinal malignancy. The aim of the study was to evaluate the time trends over 20 years and observe how they differ from the West. Materials and Methods: The study was conducted at SKIMS Regional Cancer Centre in Radiation Oncology Department. This was a retrospective study. Retrospective analysis was carried out from records available at the Regional Cancer Center from 1993 to 2013. The case records of 2090 patients with histological proven squamous and adenocarcinoma (AC) of the esophagus were studied in terms of age, sex, risk factors, and mode of presentation. Results: Data of 2190 patients with esophageal cancer were retrieved. Out of 2190 patients, group A included 1060 and group B had 1130 patients. The mean age at presentation was 59 years in both groups. Five hundred and thirty-eight (56.4%) were male and 477 (43.6%) were females in group A, whereas in group B, 615 were male and 515 were female. Most of the patients presented with dysphagia 2139 (97.67%). In group A, 1030 (97.16%) presented with dysphagia, whereas 1090 (96.46%) presented with dysphagia in group B. Most of the patients had lesion in middle 3rd of esophagus, 849 (80%) in group A whereas 903 (79.9%) in group B. Squamous cell carcinoma (SCC) was the most common histology in both groups, 1010 (95.2%) in group A whereas 1060 (93.8%) in group B. Most common appearance was proliferative (37.7% in group A and 37.6% in group B). Most of the patients were salt tea takers in both groups (98.11% in group A and 97.34% in group B). Conclusion: Our study suggests that esophageal cancer occurs a decade earlier in India. It affects males more than females. SCC is still the most common histological subtype and is way ahead of AC. The mid esophagus is still the most common site. There is no evidence of an increase in the rate of lower esophageal malignancy in our study as opposed to western literature.","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":"13 1","pages":"8 - 11"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75482737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Cancer profile in South Kashmir, India: A hospital-based study from a newly commissioned level II cancer center 印度南克什米尔的癌症概况:一项来自新委托的二级癌症中心的基于医院的研究

Journal of Radiation and Cancer Research Pub Date : 2022-01-01 DOI: 10.4103/jrcr.jrcr_63_22

S. Wani, Z. Paul, BilalAhmad Nayak, AshfaqAhmad Naqash, M. Teli

引用次数: 0

Clinicoepidemiological profile of adenoid cystic carcinoma: Experience from a tertiary care oncology center in Kashmir, India 腺样囊性癌的临床流行病学概况:来自印度克什米尔三级保健肿瘤中心的经验

Journal of Radiation and Cancer Research Pub Date : 2022-01-01 DOI: 10.4103/jrcr.jrcr_36_21

M. Sofi, M. Mir, K. Fatima, Asifa Andleeb, F. Siraj, N. Dar

{"title":"Clinicoepidemiological profile of adenoid cystic carcinoma: Experience from a tertiary care oncology center in Kashmir, India","authors":"M. Sofi, M. Mir, K. Fatima, Asifa Andleeb, F. Siraj, N. Dar","doi":"10.4103/jrcr.jrcr_36_21","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_36_21","url":null,"abstract":"Background: Adenoid cystic carcinoma (ACC) is a relatively rare tumor mostly involving head and neck region of the body. Due to lack of high-quality evidence, optimal treatment is still controversial and continues to evolve over time. Aim and Objectives: To analyze the clinicoepidemiological profile of ACC in Kashmir. Materials and Methods: Data of 30 patients, who were treated in the Regional Cancer Center at She-i-Kashmir Institute of Medical Sciences (Deemed University, Srinagar) between January 2015 and December 2019, were reviewed with respect to their demographic and clinical profile. Results: The study included 30 patients with ACC. The mean age at presentation was 55 ± 12.15 years. There were 10 (33.3%) males and 20 (66.6%) females. Among salivary gland ACC s, sublingual gland (06/30, 20%) was the most common site followed by parotid gland (05/30, 16.7%). Nonhead and neck primary ACC cases were reported from lung (6.7%) and breast (6.7%). Majority of the patients presented in stage-III (43.3). Only 5 patients presented with distant metastasis. All patients were subjected to surgery. Adjuvant radiotherapy was given in 18 patients (60%). Three patients received all three modalities (surgery, radiotherapy, and chemotherapy). The overall one year survival was 96%. However, the mean & median survivals reported were 24 & 18 months respectively. Surgery with negative surgical margin is the first choice of treatment for the patients with ACC. Our findings show that the prognosis of patients with ACC in our center is comparable to other parts of country. Conclusion: ACC has locally aggressive behavior. Adjuvant radiotherapy improves local control in locally advanced disease. Longer follow-up is mandatory in view of incidence of late metastasis.","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":"120 1","pages":"19 - 22"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87732168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chordoma: Retrospective analysis of patients treated with radiotherapy at a single institution 脊索瘤:在单一机构接受放射治疗的患者回顾性分析

Journal of Radiation and Cancer Research Pub Date : 2022-01-01 DOI: 10.4103/jrcr.jrcr_18_22

M. Mehta, M. Patel, Ankita Parikh, U. Suryanarayan, Jayesh Singh, A. Thimmarayappa, Aakash Pandya

引用次数: 0

Unusual solitary rectal relapse of mantle cell lymphoma after second remission 罕见的直肠单发套细胞淋巴瘤第二次缓解后复发

Journal of Radiation and Cancer Research Pub Date : 2022-01-01 DOI: 10.4103/jrcr.jrcr_12_22

V. Jagtap, Anthialisha Nongkynrih, Sumit Kumar, Navin Nayan, B. Dey, V. Raphael

引用次数: 0

The effect of prophylactic cranial irradiation on brain 18F-fluorodeoxyglucose uptake in small cell lung cancer in the metabolic imaging era 代谢成像时代预防性颅脑照射对小细胞肺癌患者脑18f -氟脱氧葡萄糖摄取的影响

Journal of Radiation and Cancer Research Pub Date : 2022-01-01 DOI: 10.4103/jrcr.jrcr_60_21

Sibel Goksel, Sema Yilmaz Rakici

{"title":"The effect of prophylactic cranial irradiation on brain 18F-fluorodeoxyglucose uptake in small cell lung cancer in the metabolic imaging era","authors":"Sibel Goksel, Sema Yilmaz Rakici","doi":"10.4103/jrcr.jrcr_60_21","DOIUrl":"https://doi.org/10.4103/jrcr.jrcr_60_21","url":null,"abstract":"Introduction: Prophylactic cranial irradiation (PCI) increases survival in patients with small-cell lung cancer. Although the underlying pathophysiology is not fully understood, it has been associated with posttreatment neurocognitive impairment. Our study aims to show the brain's glucose metabolism change after PCI with 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). Materials and Methods: A total of 17 patients who underwent PET/CT before and after PCI were evaluated retrospectively. 18F-FDG PET images of the brain before and after PCI were compared visually and semi-quantitatively using MI-Neurology Software. The brain was automatically segmented into eleven regions by this software. The mean standard uptake values (SUVmean) of all brain regions were measured within the automatically drawn region of interest area, and standard uptake value ratio (SUVR) values were found for each region by taking the brainstem SUVmean value as a reference. SUVR values were calculated from PET/CT scannings taken before and after PCI for each patient. The P < 0.05 value was considered statistically significant in comparisons. Results: We found a significant decrease in 18F-FDG uptake and glucose metabolism of the brain after PCI when compared with PET/CT before PCI in all brain regions identified according to the Combined-AAL atlas (all P < 0.001). Similarly, a significant decrease was found in brain 18F-FDG uptake on PET/CT taken after PCI in the brainstem used to calculate SUVR (P = 0.039). Conclusion: 18F-FDG PET/CT neuroimaging may be a new metabolic imaging technique for diagnosing radiation-induced cognitive impairment in the metabolic imaging era.","PeriodicalId":16923,"journal":{"name":"Journal of Radiation and Cancer Research","volume":"16 1","pages":"1 - 7"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88007163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Squamous cell carcinoma of gallbladder: A systematic review 胆囊鳞状细胞癌:系统综述

Journal of Radiation and Cancer Research Pub Date : 2022-01-01 DOI: 10.4103/jrcr.jrcr_70_22

Anirban Halder, Rituparna Biswas, ManasPratim Roy

引用次数: 0

Stereotactic ablative radiotherapy for the primary site in a patient with nonmetastatic castration-resistant prostate cancer 非转移性去势抵抗性前列腺癌原发部位的立体定向消融放疗

Journal of Radiation and Cancer Research Pub Date : 2022-01-01 DOI: 10.4103/jrcr.jrcr_13_22

Atsuto Katano

引用次数: 0