Journal of Pharmacology and Toxicology最新文献_第7页

Antidiabetic Activity and Safety Used of Nutrasucre, a Food Complement, in Alloxan Induced Diabetic Rats 四氧嘧啶诱导的糖尿病大鼠的抗糖尿病活性及其安全性

Journal of Pharmacology and Toxicology Pub Date : 2017-04-01 DOI: 10.3923/JPT.2017.161.169

P. Manda, N. Go, G. ArthurStephane, Alain Didier Abo, Aholia Jean Bapti, Djedje Sebastien

引用次数: 0

Epidemiological and Clinical Aspects of Carbon Monoxide Poisoning in Fez City (Case of Ibn Alkhatib Hospital) 非斯市一氧化碳中毒流行病学及临床分析(以Ibn Alkhatib医院为例)

Journal of Pharmacology and Toxicology Pub Date : 2017-04-01 DOI: 10.3923/JPT.2017.191.200

A. Tahouri, Jad Tahouri, Faical Boutlib, S. Achour, B. Lyoussi

引用次数: 1

Assessment of Sub-chronic Effect of Two Artificial Food Additives on Selected Biochemical Parameters in Wistar Rats 两种人工食品添加剂对Wistar大鼠部分生化指标亚慢性影响的评价

Journal of Pharmacology and Toxicology Pub Date : 2017-04-01 DOI: 10.3923/JPT.2017.180.190

G. Ikechukwu, S. Egba, R. Ibeh, E. Helal, E. Ejiofor, P. Okafor

引用次数: 3

Assessment of Toxicity of Myristicin and 1’-Hydroxymyristicin in HepG2 Cell Line 肉豆蔻素和1′-羟基肉豆蔻素对HepG2细胞株的毒性评价

Journal of Pharmacology and Toxicology Pub Date : 2017-04-01 DOI: 10.3923/JPT.2017.170.179

L. Marabini, Laura Neglia, E. Monguzzi, C. Galli, M. Marinovich

{"title":"Assessment of Toxicity of Myristicin and 1’-Hydroxymyristicin in HepG2 Cell Line","authors":"L. Marabini, Laura Neglia, E. Monguzzi, C. Galli, M. Marinovich","doi":"10.3923/JPT.2017.170.179","DOIUrl":"https://doi.org/10.3923/JPT.2017.170.179","url":null,"abstract":"Background and Objective: Myristicin belongs to a class of potentially toxic chemicals (alkoxy substituted allylbenzenes) and despite the structural analogy with safrole, data on this compound are very controversial and unclear. In this study assessed the cytotoxic and genotoxic potential of myristicin and 1’-hydroxy-myristicin after 24 h of exposure in HepG2 cells. Methodology: The compounds were tested up to 600 μM concentration, for 24 h. The genotoxicity was assessed with alkaline and neutral comet assay and micronucleus assay. The data were analysed by one-way ANOVA. Results: It is to be emphasized that only the synthetic Phase 1 metabolite (1’-hydroxymyristicin) showed a genotoxic effect starting from the concentration of 150 μM both in comet and micronucleus tests. However, it is important to point out that the same concentration cause a statistically significant (p<0.001) apoptotic process. Conclusion: The consumption of a traditional diet determines very low levels of exposure to the parent myristicin. This fact implies as the primary metabolic pathway the O-demethylation (5-allyl-2,3-dihidroxyanisole) and not to Phase I metabolism, which leads to the conclusion that this substance could not present a significant risk to humans.","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"14 1","pages":"170-179"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82186132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Determination and Assessment of Glyphosate Exposure Among Farmers from Northern Part of Thailand 泰国北部农民草甘膦暴露的测定与评估

Journal of Pharmacology and Toxicology Pub Date : 2017-03-15 DOI: 10.3923/JPT.2017.97.102

Watcharapol Polyiem, Surat Hongsibson, S. Chantara, T. Kerdnoi, Vanvimol Patarasiri, Tippawan Prapamonto, R. Sapbamrer

引用次数: 5

Metaformin-Based Regimen Inhibits Glucose Uptake and G6PD Activity: A de novo Anti-cervical Cancer Strategy Tackles HeLa and its Derivative Hep2 Cells 基于二甲双胍的方案抑制葡萄糖摄取和G6PD活性:一种全新的抗宫颈癌策略处理HeLa及其衍生物Hep2细胞

Journal of Pharmacology and Toxicology Pub Date : 2017-03-15 DOI: 10.3923/JPT.2017.76.86

Ahmed A. Abd-Rabou, Safaa H. Mohamed, M. Mwaheb, O. Sayed, Mohamed S. Kishta

引用次数: 1

Toxicity Evaluation of Vernonia mespilifolia Less (A South Africa Medicinal Plant) Using Brine Shrimp 南非药用植物Vernonia mespilifolia Less用盐水对虾进行毒性评价

Journal of Pharmacology and Toxicology Pub Date : 2017-03-15 DOI: 10.3923/JPT.2017.103.110

J. O. Unuofin, G. Otunola, A. Afolayan

引用次数: 5

Plants for Female Fertility Regulation: A Review 植物对女性生育能力的调控研究进展

Journal of Pharmacology and Toxicology Pub Date : 2017-03-15 DOI: 10.3923/JPT.2017.57.75

A. S. Ansari, K. Sevliya, I. Mohammad, A. Badar, N. K. Lohiya

引用次数: 6

Assessment of DNA Damage and Biochemical Responses in Rhyzopertha dominica Exposed to Some Plant Volatile Oils 几种植物挥发油对蛇尾草DNA损伤及生化反应的影响

Journal of Pharmacology and Toxicology Pub Date : 2017-03-15 DOI: 10.3923/JPT.2017.87.96

Sameer H Qari, Nilly A.H. Abdel-Fatt, A. Shehawy

引用次数: 21

Long Term Immunity to Hepatitis B Vaccine Among a Sample of Secondary School Students in Damietta 达米埃塔市中学生乙肝疫苗长期免疫调查

Journal of Pharmacology and Toxicology Pub Date : 2016-01-01 DOI: 10.3923/JPT.2016.27.32

Mohamad M. El Mazahi, H. Maksoud, M. A. Hady, Mekky A. Ali, Ali N. El Nawawy, Shaimaa Ahmad

{"title":"Long Term Immunity to Hepatitis B Vaccine Among a Sample of Secondary School Students in Damietta","authors":"Mohamad M. El Mazahi, H. Maksoud, M. A. Hady, Mekky A. Ali, Ali N. El Nawawy, Shaimaa Ahmad","doi":"10.3923/JPT.2016.27.32","DOIUrl":"https://doi.org/10.3923/JPT.2016.27.32","url":null,"abstract":"The aim of the present study was to assess the long term immunity to hepatitis B vaccine among secondary school students aging from 1517 years; and to evaluate the efficacy of vaccination schedule of HBV vaccine in Egypt. Subjects and methods: A total number of children from 15 to 17 years (teenagers' students) in EL-Zarka district was 1106 from which 200 vaccinated children was the sample size of the study 103(51.5%) males and 97(48.5%) females .The studied students were chosen randomly from 3 secondary schools in EL-Zarka district. 118 students (59.0%) were from rural areas and 82(41.0%) from urban areas. All included children were subjected to complete history taking by the self-administered questionnaire, clinical examinations, and laboratory investigations (CBC, Anti HBs antibodies by ELISA and Anti HBc antibodies by ELISA). Results: The titer of HBsAb in 40% is less than (10IU/L) meaning loss of immunity to hepatitis B, and 59.5% of waning immunity (10100), only 0.5% had good immunity. There was significant difference between different HBsAb levels as regard to gender distribution (i.e., gender had an effect on seroconversion of HBV vaccine). There was no effect of residence, socioeconomic status, BMI, ICU admission, feeding pattern, Hgb level and WBCs count on the seroconversion of HBV vaccine level. Conclusion: Hepatitis B vaccine has long lasting immunity extended to at least 15 years. No effect of urbanization, socioeconomic standards, BMI or Hgb% on level of HBsAb seroprotection. [Mohamad M. El Mazahi; Hussein M. Abdel Maksoud; Mohamed A. Salam; Mekky A. Ali; Ali N. El-Nawawy; Shaimaa M. A. Ahmad. Long Term Immunity to Hepatitis B Vaccine Among a Sample of Secondary School Students in Damietta] J Am Sci 2014;10(3):140-145]. (ISSN: 1545-1003). http://www.jofamericanscience.org. 18","PeriodicalId":16816,"journal":{"name":"Journal of Pharmacology and Toxicology","volume":"1 1","pages":"27-32"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73068739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6