Journal of Phytology最新文献_第6页

Molecular docking analysis on 16 therapeutic ligands of Ocimum tenuiflorum L. (Tulasi) and their prospects in drug design for COVID-19 细辛16个治疗配体的分子对接分析及其在新冠肺炎药物设计中的应用前景

Journal of Phytology Pub Date : 2022-07-27 DOI: 10.25081/jp.2022.v14.7842

Guruprasad Anantharam, S. Geetha, P. Santhana Pandi, N. Krithika, C. Chittibabu

{"title":"Molecular docking analysis on 16 therapeutic ligands of Ocimum tenuiflorum L. (Tulasi) and their prospects in drug design for COVID-19","authors":"Guruprasad Anantharam, S. Geetha, P. Santhana Pandi, N. Krithika, C. Chittibabu","doi":"10.25081/jp.2022.v14.7842","DOIUrl":"https://doi.org/10.25081/jp.2022.v14.7842","url":null,"abstract":"The PyRx software and Discovery studio were used in the present molecular docking studies of the 16 ligands of Ocimum tenuiflorum L., selected based on their high therapeutic potentials, viz., (E)-6-hydroxy-4,6-dimethylhept-3-en-2-one, Apigenin, Bieugenol, Cirsilineol, Cirsimaritin, β-Caryophyllene epoxide, Dehydrodieugenol B, Eugenol, Ferulaldehyde, Isothymonin, Isothymusin, Linalool, Luteolin, Ocimarin, Rosmarinic acid, and Thymol. Saquinavir was used as a positive control. The binding affinities of the 16 ligands to the main proteases of COVID-19 6LU7 and 6Y2E (critical for viral replication) and their ability to arrest the virus replication were recorded. The binding affinities of the ligands to 6LU7 and 6Y2E ranged from -4.3 and -4.7 kcal/mol (for (E)-6-hydroxy-4,6-dimethylhept-3-en-2-one) to -7.6 (for Rosmarinic acid to both target proteins). While the corresponding values for the control drug Saquinavir were -7.8 and -7.6 respectively. The Rosmarinic acid, in binding with both the proteases (-7.6 and -7.6 kcal/mol) showed six conventional hydrogen bonds, one carbon hydrogen bond (ASP 153 had one conventional hydrogen bond and one carbon hydrogen bond), one Pi-alkyl bond, one Pi-Pi stacked bond, eight van der waals bonds for 6LU7 protease; it formed three conventional hydrogen bonds, two Pi-alkyl bonds, one unfavourable donor – donor bond and 14 van der waals bonds with 6Y2E protease. The control drug – Saquinavir in binding with 6LU7 protease showed 12 van der waals, one alkyl, one Pi-alkyl, one Pi-cation, one Pi-stacked and four conventional hydrogen bonds, which indicates that it has less affinity when compared with Rosmarinic acid. Similarly, the control drug on binding with 6Y2E protease exhibited ten van der waals, four Pi-alkyl, one cation and three hydrogen bonds. The results are in conformity to similar other studies, and herald a promising scope for Rosmarinic acid as lead molecule in the drug discovery for COVID-19.","PeriodicalId":16777,"journal":{"name":"Journal of Phytology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48844617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular phylogeny of Annonaceae species from Binh Chau-Phuoc Buu Nature Reserve based on two chloroplast gene regions 基于两个叶绿体基因区域的平州-福布自然保护区番荔枝科物种的分子系统发育

Journal of Phytology Pub Date : 2022-07-22 DOI: 10.25081/jp.2022.v14.7414

Ngoc Duyen Nguyen, T. N. Luu, N. Trinh, Van-Son Le, H. Van

引用次数: 0

Facile synthesis and optimization of nickel oxide nanoparticles using Polianthes tuberosa extract and its anticancer activity 利用马铃薯提取物及其抗癌活性促进氧化镍纳米颗粒的合成和优化

Journal of Phytology Pub Date : 2022-07-22 DOI: 10.25081/jp.2022.v14.7853

Kaveri Sundaram, Santhosh Kumar Mohanrao

引用次数: 0

Expression analysis of diosgenin pathway genes and diosgenin accumulation in fenugreek sprouts after exposure to copper sulfate 胡芦巴芽经硫酸铜处理后薯蓣皂苷元途径基因的表达及积累

Journal of Phytology Pub Date : 2022-07-08 DOI: 10.25081/jp.2022.v14.7769

Do Yeon Kwon, R. Sathasivam, Yeon-Bok Kim, H. Kim, S. Park, B. B. Park

{"title":"Expression analysis of diosgenin pathway genes and diosgenin accumulation in fenugreek sprouts after exposure to copper sulfate","authors":"Do Yeon Kwon, R. Sathasivam, Yeon-Bok Kim, H. Kim, S. Park, B. B. Park","doi":"10.25081/jp.2022.v14.7769","DOIUrl":"https://doi.org/10.25081/jp.2022.v14.7769","url":null,"abstract":"Trigonella foenum-graecum L. is an annual herb belonging to the family Fabaceae commonly called Fenugreek. It is rich in various secondary metabolites such as alkaloids, flavonoids, phenolic compounds, and steroidal saponins. In recent years, diosgenin has much attention in the cosmetic, functional food, and pharmaceutical industries. In this study we aimed to examine the effect of different concentrations of copper sulfate (CuSO4) on growth, diosgenin biosynthetic (DB) gene expression, and diosgenin accumulation in T. foenum-graecum sprouts. Results showed that the seed germination, fresh weight, shoot length, and root length were gradually decreased with increasing the CuSO4 concentrations. In contrast, the expression level of DBGs i.e., TfSQS, TfSQLE, TfCAS, and TfSTRL were gradually upregulated with increasing the CuSO4 concentrations. Among all those tested concentrations, the expression levels of all those genes were significantly higher in 0.5 mM CuSO4 treated sprouts. The highest expression level was obtained in the TfCAS gene, which was 3.25-fold higher than the unexposed sprouts. The diosgenin content was significantly influenced in the CuSO4 exposed sprouts. The highest diosgenin content was achieved in the 5.0 mM followed by 1.0, 10.0, and 0.5 mM CuSO4 exposed concentrations, with a reduction of 41%, 39%, 36%, and 35%, respectively. From these results, it is shown that exposure of fenugreek sprout to CuSO4 is one of the suitable strategies to enhance the accumulation of diosgenin content.","PeriodicalId":16777,"journal":{"name":"Journal of Phytology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49480014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Purification and partial characterization of a novel lectin from Ruta montana roots 一种新型凝集素的纯化及部分特性研究

Journal of Phytology Pub Date : 2022-06-23 DOI: 10.25081/jp.2022.v14.7473

A. Messai, Youcef Necib

引用次数: 0

Inflorescence appearance timing and production rate traits in wild Zoysiagrass (Zoysia spp) 野生结缕草花序、外观、时代性及产量性状

Journal of Phytology Pub Date : 2022-05-14 DOI: 10.25081/jp.2022.v14.7276

G. Han, Jiyeong Jung, Y. Chung

引用次数: 0

Chemical profiles and biological activities of essential oils of Arisaema and Homalomena species (Araceae) – A review 天南星科Arisaema和Homalomena属植物精油的化学成分和生物活性综述

Journal of Phytology Pub Date : 2022-04-08 DOI: 10.25081/jp.2022.v14.7444

S. Dam, H. Van

引用次数: 1

Effect of silver nitrate and putrescine on in vitro shoot organogenesis of Polygonum multiflorum 硝酸银和腐胺对何首乌离体茎器官发生的影响

Journal of Phytology Pub Date : 2022-03-31 DOI: 10.25081/jp.2022.v14.7593

W. Park, Yeon-Bok Kim, R. Sathasivam, H. Kim, S. Park

{"title":"Effect of silver nitrate and putrescine on in vitro shoot organogenesis of Polygonum multiflorum","authors":"W. Park, Yeon-Bok Kim, R. Sathasivam, H. Kim, S. Park","doi":"10.25081/jp.2022.v14.7593","DOIUrl":"https://doi.org/10.25081/jp.2022.v14.7593","url":null,"abstract":"Polygonum multiflorum is a flowering plant that belongs to the family Polygonaceae and it is commonly used for medicinal and ornamental purposes. Few studies have been studied about the regeneration of this species. Therefore, we aimed to develop a suitable protocol for regeneration and subsequent growth of shoots by comparing the silver nitrate (AgNO3) (ethylene inhibitor) and the putrescine (polyamine). Internode explants were cultured on shoot regeneration media (Murashige and Skoog (MS) media containing 2 mg L-1 of 6-benzylaminopurine). To analysis, the effect of AgNO3 and putrescine on shoot regeneration and length, different concentrations (mg L-1) of AgNO3 (0, 1, 5, 7, 10, and 20) and putrescine (0, 10, 30, 50, 100, and 200) were added to the MS media. The result showed that at highest concentration (20 mg L-1) of AgNO3 treatment decrease number of shoots (NOS) (1.4 ± 0.2 mm) and shoot length (9.7 ± 1.6 mm) was observed. Putrescine considerably increased the regeneration efficiency, NOS per explant, and shoot length in all the concentrations when compared to AgNO3 treatment. Among the different concentrations, the highest NOS (2.52 ± 0.2 mm) was obtained in cultures supplemented with 30 mg L-1 putrescine, whereas the further increase in putrescine concentration reduced shoot regeneration. The longest shoots (20.5 ± 1.7 mm) were achieved in cultures supplemented with 200 mg L-1 putrescine. The findings of this study indicate that the addition of putrescine to the media could be suitable for P. multiflorum micropropagation and plant transformation.","PeriodicalId":16777,"journal":{"name":"Journal of Phytology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43601756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of traditional medicinal plants on Peatland conditions in Central Kalimantan 加里曼丹中部泥炭地条件下传统药用植物的开发

Journal of Phytology Pub Date : 2022-03-30 DOI: 10.25081/jp.2022.v14.7184

Herry Palangka Jaya, Y. Ludang, Sarwoko Mangkoedihardjo

引用次数: 2

Antioxidant and Phytochemical analysis of selected lichen species from Mizoram, India 印度米佐拉姆邦部分地衣的抗氧化和植物化学分析

Journal of Phytology Pub Date : 2022-03-30 DOI: 10.25081/jp.2022.v14.7211

P. Lalremruata, R. Lalmuanpuii, V. Ralte, Zothanmawia, P. Lalthanpuii, K. Lalchhandama, R. Lalfakzuala

{"title":"Antioxidant and Phytochemical analysis of selected lichen species from Mizoram, India","authors":"P. Lalremruata, R. Lalmuanpuii, V. Ralte, Zothanmawia, P. Lalthanpuii, K. Lalchhandama, R. Lalfakzuala","doi":"10.25081/jp.2022.v14.7211","DOIUrl":"https://doi.org/10.25081/jp.2022.v14.7211","url":null,"abstract":"Lichens are an important source of biologically active substances, primarily phenols, which are well known for their antioxidant properties. The aim of the present study was to evaluated phytochemical constituents (flavonoids and phenols), and the antioxidant activity of the methanol extract of the selected lichens species viz. Usnea baileyi, Hypotrachyna cirrhata and Lobaria pulmonaria collected from Tawi Wildlife Sanctuary, Mizoram, India. The total phenolic content and total flavonoid of the various extracts varied from 31.11 to 67.84 mg of Gallic acid equivalent per gram dry weight (GAE/g DW) and from 27.43 to 37.06 mg of Quercetin equivalent per gram dry weight (QE/g DW) respectively. DPPH free radical scavenging activity of the methanol extract of tested samples showed a concentration-dependent manner with an IC50 value ranges from 133.6 µg/ml in L. pulmonaria to 243.9 µg/ml in U. baileyi. A comparison between lichens extract and positive control (BHT) showed a strong antioxidant capacity (IC50=10.81 μg/ml) of positive control than the lichens methanolic extract. A high negative and significant negative correlation (P<0.05) was observed between total phenol content and antioxidant activity IC50 of DPPH assay. Moreover, a positively high significant correlation was also obtained between total flavonoid and phenol content (P<0.01). The present study showed that bioactive compounds present in the lichen thallus may be used as good sources of natural antioxidants and a potential candidate for curing several ailments. ","PeriodicalId":16777,"journal":{"name":"Journal of Phytology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45430050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1