Journal of pharmaceutical sciences最新文献

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Oral viscous budesonide solution for enhanced localized treatment of eosinophilic esophagitis through improved mucoadhesion and permeation. 粘稠布地奈德口服溶液通过改善粘附性和渗透性加强对嗜酸性粒细胞食管炎的局部治疗
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-24 DOI: 10.1016/j.xphs.2024.09.016
Dongyu Wu, Tiantian Zhang, Yuzhen Kang, Yan Zhong, Shiqi Chen, Yue Zhang, Xuyu Chai
{"title":"Oral viscous budesonide solution for enhanced localized treatment of eosinophilic esophagitis through improved mucoadhesion and permeation.","authors":"Dongyu Wu, Tiantian Zhang, Yuzhen Kang, Yan Zhong, Shiqi Chen, Yue Zhang, Xuyu Chai","doi":"10.1016/j.xphs.2024.09.016","DOIUrl":"10.1016/j.xphs.2024.09.016","url":null,"abstract":"<p><p>Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus that is immune/antigen-mediated and often requires targeted treatment. In clinical practice, an oral viscous budesonide suspension prepared by adding sucralose to a budesonide suspension for inhalation (Pulmicort®) is used to treat adult EoE and enhance retention in the esophageal mucosa. Inspired by this off-label drug use, oral viscous budesonide solutions (OVBSs) were developed in this study, and their capacities for adhesion, permeation, and stability were explored. Given the insolubility of budesonide as a BCS II drug, we first evaluated its equilibrium solubility and found that Transcutol® HP was an excellent choice for creating an OVBS at a concentration of 0.2 mg/g. The rheological properties of the OVBSs were evaluated with a rheometer, and shear-thinning, which aids in swallowing, was observed. The addition of hydroxyethyl cellulose (HEC) increased the adhesion strength of the preparation, which was associated with the hydration and thickening mechanism. This result was confirmed in a dynamic gelation study and in vitro elution experiment conducted with porcine esophagus tissue. Furthermore, the permeabilities of the OVBSs in the porcine esophagus were evaluated with a Franz diffusion cell device. >80 % of the budesonide was released after 24 h, and the release profile was similar to that of the solution. To explore the storage conditions of OVBSs, critical factors such as pH, content, and impurities were determined. It was found that OVBSs exhibited different behaviors at different pH values and temperatures. Notably, the OVBSs containing 1.7 % HEC could be stored for >6 months at a temperature of 5 °C ± 3 °C and a pH of 4.5 without significant degradation. Overall, this study demonstrated that OVBSs have the potential to adhere to the esophageal mucosa, permeate the tissue, and remain stable during storage. Moreover, OVBSs exhibit a distinct advantage over traditional converted inhalation-to-oral budesonide therapies by enabling flexible dose adjustment in clinical applications, thereby potentially minimizing systemic side effects commonly associated with oral glucocorticoid administration.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of Solid-State Acidity of Lyophilized Trehalose Containing Citrate, Phosphate, and Histidine Buffers Using UV/VIS Diffuse Reflectance and Solid-State NMR Spectroscopy. 利用 UV/VIS 漫反射和固态 NMR 光谱测定含柠檬酸盐、磷酸盐和组氨酸缓冲液的冻干海藻糖的固态酸度。
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-21 DOI: 10.1016/j.xphs.2024.09.019
Ashley Lay-Fortenbery, Xiaoda Yuan, Lukáš Veselý, Dominik Heger, Evgenyi Shalaev, Yongchao Su, Eric Munson
{"title":"Determination of Solid-State Acidity of Lyophilized Trehalose Containing Citrate, Phosphate, and Histidine Buffers Using UV/VIS Diffuse Reflectance and Solid-State NMR Spectroscopy.","authors":"Ashley Lay-Fortenbery, Xiaoda Yuan, Lukáš Veselý, Dominik Heger, Evgenyi Shalaev, Yongchao Su, Eric Munson","doi":"10.1016/j.xphs.2024.09.019","DOIUrl":"https://doi.org/10.1016/j.xphs.2024.09.019","url":null,"abstract":"<p><p>Changes in the protonation state of lyophilized proteins can impact structural integrity, chemical stability, and propensity to aggregate upon reconstitution. When a buffer is chosen, the freezing/drying process may result in dramatic changes in the protonation state of the protein due to ionization shift of the buffer. In order to determine whether protonation shifts are occurring, ionizable probes can be added to the formulation. Optical probes (dyes) have shown dramatic ionization changes in lyophilized products, but it is unclear whether the pH indicator is uniform throughout the matrix and whether the change in the pH indicator actually mirrors drug ionization changes. In solid-state NMR (SSNMR) spectroscopy, the chemical shift of the carbonyl carbon in carboxylic acids is very sensitive to the ionization state of the acid. Therefore, SSNMR can be used to measure ionization changes in a lyophilized matrix by employing a small quantity of an isotopically-labeled carboxylic acid species in the formulation. This paper compares the apparent pH of six trehalose-containing lyophilized buffer systems using SSNMR and UV-Vis diffuse reflectance spectroscopy (UVDRS). Both SSNMR and UVDRS results using two different ionization probes (butyric acid and bromocresol purple, respectively) showed little change in apparent acidity compared to the pre-lyophilized solution in a sodium citrate buffer, but a greater change was observed in potassium phosphate, sodium phosphate, and histidine buffers. While the trends between the two methods were similar, there were differences in the numerical values of equivalent pH (pHeq) observed between the two methods. The potential causes contributing to the differences are discussed.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Population pharmacokinetics and dosing simulations of meropenem in septic critically ill patients with complicated intra-abdominal infection or pneumonia. 美罗培南在患有复杂腹腔内感染或肺炎的化脓性重症患者中的群体药代动力学和剂量模拟。
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-21 DOI: 10.1016/j.xphs.2024.09.011
Jingjing Huang, Tong Wu, Ruoming Tan, Yunqi Dai, Yuzhen Qiu, Haiwen Lu, Xiaoli Cao, Jialin Liu, Hongping Qu, Xiaoli Wang
{"title":"Population pharmacokinetics and dosing simulations of meropenem in septic critically ill patients with complicated intra-abdominal infection or pneumonia.","authors":"Jingjing Huang, Tong Wu, Ruoming Tan, Yunqi Dai, Yuzhen Qiu, Haiwen Lu, Xiaoli Cao, Jialin Liu, Hongping Qu, Xiaoli Wang","doi":"10.1016/j.xphs.2024.09.011","DOIUrl":"https://doi.org/10.1016/j.xphs.2024.09.011","url":null,"abstract":"<p><strong>Objectives: </strong>Meropenem pharmacokinetics (PK) may be altered in septic critically ill patients with complicated intra-abdominal infections (cIAI) and pneumonia. We aimed to evaluate the covariates affecting meropenem PK and the performance of different dosing regimens to optimize the PK/pharmacodynamic target.</p><p><strong>Methods: </strong>Population PK analysis was performed using non-linear mixed-effects modeling. The final model was validated and used to simulate meropenem exposure to assess the probability of attaining the 100%ƒT<sub>>MIC</sub> target.</p><p><strong>Results: </strong>Forty-six and 14 patients were respectively enrolled for PK analysis and external validation. A one-compartment linear model adequately described the data of 226 concentrations. The typical clearance (CL) and volume of distribution (Vd) were 9.69 L/h and 27.4 L, respectively. Septic shock from cIAI (cIASS) and actual body weight were significant covariates for meropenem Vd in addition to the influential covariates of creatinine clearance (CL<sub>CR</sub>-CG) and augmented renal clearance for CL. External validation showed the robustness and accuracy of this model. Simulation results proposed continuous infusion (CI) dosing regimens of meropenem against pathogens with MICs ≥ 2 mg/L in patients with cIASS and CL<sub>CR</sub>-CG ≥ 60 mL/min.</p><p><strong>Conclusions: </strong>For the patients with cIASS and CL<sub>CR</sub>-CG ≥ 60 mL/min, CI meropenem is proposed for treatment of less sensitive pathogens with MICs ≥ 2 mg/L.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering of Layer-by-layer Acetate-coated Paclitaxel Loaded Poly(lactide-co-glycolide) Acid Nanoparticles for Prostate Cancer Therapy- in vitro. 用于前列腺癌治疗的逐层醋酸纤维包覆紫杉醇聚乳酸-共聚甘醇酸纳米粒子的体外工程学研究
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-21 DOI: 10.1016/j.xphs.2024.09.014
Albert Nguessan Ngo, Kierston K Chatman, Dezirae Douglas, Keb M Mosley-Kellum, Ke Wu, Jaydutt Vadgama
{"title":"Engineering of Layer-by-layer Acetate-coated Paclitaxel Loaded Poly(lactide-co-glycolide) Acid Nanoparticles for Prostate Cancer Therapy- in vitro.","authors":"Albert Nguessan Ngo, Kierston K Chatman, Dezirae Douglas, Keb M Mosley-Kellum, Ke Wu, Jaydutt Vadgama","doi":"10.1016/j.xphs.2024.09.014","DOIUrl":"10.1016/j.xphs.2024.09.014","url":null,"abstract":"<p><p>It is hypothesized that layer-by-layer acetate-coated Paclitaxel-loaded PLGA nanoparticles (F2) can be engineered to potentiate the effectiveness of Paclitaxel (PTX) on LNCaP, a human prostate cancer cell line. The core of the layer-by-layer NPs is formed by nanoprecipitation, and the shell of the NPs is engineered using the sodium acetate's unique coating mechanism and surface-active properties. The resulting nanoformulation physicochemical properties are characterized by Fourier Transform Infra-Red (FTIR), Differential Scanning Calorimetry (DSC) Transmission Electron Microscopy (TEM), NanoSight NS300, spectrophotometry, Korsmeyer-Peppas model, respectively. The NP's cytotoxicity on LNCaP is assessed by MTS assay. The DSC and the FTIR confirm SA's coating of the NPs. The particle's mean diameters (PMD) are 89.4±2.3- to 114.4±7.6 nm. The TEM shows a unique multilayer and spherical nanoparticle. The encapsulation efficiency of commonly PTX-loaded PLGA NPs (F1) and F2 are 84.37±2.71% and 86.74±2.22, respectively. The drug transport mechanism of F1 and F2 is anomalous transport and case II, respectively. F2 follows a zero-order release mechanism. The cell viability is 45.08±2.18% and 60.17±4.72% when LNCaP is treated with 10 µg/mL of F2 and F1, respectively, after 48 hours of exposure. F2 and F1 cell growth inhibition are dose-dependent. This unique process of engineering the layer-by-layer NPs will provide new horizons for developing future innovative nanoparticles for targeted prostate cancer therapy.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality risk management and data integrity in R&D laboratories supporting CMC lifecycle of biological products. 支持生物产品 CMC 生命周期的研发实验室的质量风险管理和数据完整性。
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-21 DOI: 10.1016/j.xphs.2024.09.013
Brent S Kendrick, John P Gabrielson, Deanna Hunt, Merry Christie, Steven Bowen, Christina Vessely, Richard S Rogers, Chad Cleveland, Karl Maluf, Shawn Roach, Nadine Ritter
{"title":"Quality risk management and data integrity in R&D laboratories supporting CMC lifecycle of biological products.","authors":"Brent S Kendrick, John P Gabrielson, Deanna Hunt, Merry Christie, Steven Bowen, Christina Vessely, Richard S Rogers, Chad Cleveland, Karl Maluf, Shawn Roach, Nadine Ritter","doi":"10.1016/j.xphs.2024.09.013","DOIUrl":"10.1016/j.xphs.2024.09.013","url":null,"abstract":"<p><p>The development of pharmaceutical products is the critical bridge that moves a potential new medicine from academic discovery to applied treatment of patients. It translates an idea for a new drug to bench-level research on how it can be manufactured, formulated, characterized and controlled for use in non-clinical and early clinical trials. From pre-clinical R&D discovery work through the commercial launch, substantial R&D CMC data is generated to develop and optimize cGMP manufacturing and testing operations, while also supporting product comparability, elucidating product / impurity structures, assessing critical quality attributes, developing the drug delivery mode, and developing the product formulation for long-term stability. Significant R&D CMC work continues post-approval to support continuous improvement and market expansion of the commercial product. These activities are crucial elements of Product Lifecycle Management, and taken together, they comprise Pharmaceutical Quality or Chemistry, Manufacturing and Controls (CMC). The objective of this paper is to mitigate the regulatory ambiguity of R&D quality systems with practical, risk-based examples and recommendations when conducting supportive CMC studies for biological products. Making sound strategic CMC decisions under any circumstances assumes data from R&D studies are reliable, traceable, and complete. While there are specific regulatory guidelines on phase-appropriate cGMP activities, none exist for quality practices in R&D CMC laboratories conducting non-cGMP studies. Hindsight is not the time to discover that R&D studies lack key elements that would otherwise have allowed the data to be directly presented to regulators, if needed. There is a strong prospective business interest in protecting considerable investments made for CMC R&D studies. Therefore, establishment of a robust and stage-appropriate R&D laboratory quality system is essential for companies seeking to capitalize on prior knowledge, protect investments, and be prepared for accelerated approval pathways.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Visualisation and quantification of subcutaneous injections of different volumes, viscosities and injection rates: An ex-vivo micro-CT study. 不同体积、粘度和注射速度的皮下注射的可视化和量化:体外显微 CT 研究。
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-19 DOI: 10.1016/j.xphs.2024.08.019
Joel Gresham, Gerard Bruin, Marie Picci, Karoline Bechtold-Peters, Thomas Dimke, Evan Davies, Kasia Błażejczyk, Wouter Willekens, Heleen Fehervary, Greetje Vande Velde
{"title":"Visualisation and quantification of subcutaneous injections of different volumes, viscosities and injection rates: An ex-vivo micro-CT study.","authors":"Joel Gresham, Gerard Bruin, Marie Picci, Karoline Bechtold-Peters, Thomas Dimke, Evan Davies, Kasia Błażejczyk, Wouter Willekens, Heleen Fehervary, Greetje Vande Velde","doi":"10.1016/j.xphs.2024.08.019","DOIUrl":"10.1016/j.xphs.2024.08.019","url":null,"abstract":"<p><p>The effects of subcutaneous (SC) injection parameters such as drug formulation volume, viscosity and injection rate on therapeutic performance and tolerability have not been established for any drug product. In this study four groups of SC injections were performed on fresh ex vivo minipig abdominal tissue samples, varying volume (0.5-1 mL), viscosity (1-11 cP) and rate (0.02-0.1 mL/s). Micro-CT provided high resolution (50 micron) imaging of the SC tissues before and after injection, enabling a detailed 3D visualisation and analysis of how both injection parameters and tissue microstructure influence spatial distribution of injectables. We found that volume was the only significant factor for spatial distribution of injectate within our design space, and there were no significant factors for tissue backpressure. Variability within test groups was typically greater than differences between group means. Accordingly, whilst the higher viscosity formulations consistently exhibited reduced spatial distribution, the sample size was not large enough to establish confidence in this result. Comparing our findings to clinical evidence, we conclude that injection site and depth are more likely to influence PK and bioavailability than volume, viscosity and rate within our experimental space.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding Excipient-Induced Crystallization of Spray-Dried Amorphous Solid Dispersion. 了解喷雾干燥无定形固体分散体的赋形剂诱导结晶。
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-19 DOI: 10.1016/j.xphs.2024.08.024
Dongyue Yu, Meng Li, Stephen W Hoag, Haichen Nie
{"title":"Understanding Excipient-Induced Crystallization of Spray-Dried Amorphous Solid Dispersion.","authors":"Dongyue Yu, Meng Li, Stephen W Hoag, Haichen Nie","doi":"10.1016/j.xphs.2024.08.024","DOIUrl":"10.1016/j.xphs.2024.08.024","url":null,"abstract":"<p><p>This study investigates the compatibility of excipients with the model system SDI-X and their role in the induced crystallization of the amorphous compound-X in tablet formulations. We aimed to establish a straightforward and practical screening approach for evaluating excipient-induced crystallization of SDI in tablet matrices. Three methodologies-binary powder mixture, binary compact, and bilayer tablets-were employed to qualitatively and quantitatively evaluate the recrystallization of SDI-X with various excipients under accelerated storage conditions. The results demonstrated that binary compacts, providing direct physical contact between SDI-X and excipients, are superior in reflecting realistic drug-excipient contact within pharmaceutical tablets, enabling a more accurate assessment of excipient-induced crystallization for SDI-X. In contrast, the broadly used conventional binary blends can significantly underestimate this risk due to insufficient proximity. In addition, the bilayer tablets further confirmed that crystallization initiates at the contact surface between SDI-X and the excipients. The study highlighted that not only hygroscopicity but also the type of excipient and its physical contact with SDI-X significantly influence the recrystallization extent and rate of SDI-X. Interestingly, less hygroscopic diluents such as mannitol and lactose induced much higher levels of crystallization of SDIs, contrary to expectations based on moisture content alone. This suggests that the excipient type and contact surface are more critical in inducing recrystallization than just the level of moisture. The findings emphasize the need for careful excipient selection, study design, and sample preparation to enable appropriate assessments of SDI-excipient compatibility.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of differential scanning calorimetry as a rapid, effective in-process check method for impurity quantitation of an early clinical batch of Giredestrant (GDC-9545). 使用差示示踪表量热法作为早期临床批次吉瑞司群 (GDC-9545) 杂质定量的一种快速、有效的过程中检查方法。
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-19 DOI: 10.1016/j.xphs.2024.09.003
Paroma Chakravarty, Karthik Nagapudi
{"title":"Use of differential scanning calorimetry as a rapid, effective in-process check method for impurity quantitation of an early clinical batch of Giredestrant (GDC-9545).","authors":"Paroma Chakravarty, Karthik Nagapudi","doi":"10.1016/j.xphs.2024.09.003","DOIUrl":"10.1016/j.xphs.2024.09.003","url":null,"abstract":"<p><p>Giredestrant (GDC-9545) is a selective estrogen receptor degrader (SERD) that was developed for treatment of ER+/HER2- metastatic breast cancer. An anhydrous crystalline tartrate salt was identified as the solid form suitable for clinical development. An early clinical batch of the active pharmaceutical ingredient (API)/drug substance failed to pass the GMP purity specifications owing to the presence of a substantial amount of high molecular weight impurities (oligomers), as determined by size exclusion chromatography. Several trial rework batches were manufactured using various re-slurry and recrystallization conditions to purge impurities in the drug substance to adhere to purity specifications. Based on the melting point depression of the API in presence of oligomers in these rework batches, a differential scanning calorimetry method was developed to quantify impurity content as a function of melting point onset of the API. This thermal analysis method was used as a surrogate for chromatography as a rapid, effective in-process check method for impurity quantitation to enable the timely release of the final reworked clinical batch. Post release, the % w/w oligomer value determined by calorimetry was in excellent agreement to that obtained by size exclusion chromatography.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leadership and mentorship of Professor Lynne S. Taylor: A personal account from former mentees. Lynne S. Taylor 教授的领导力和导师精神:前学员的亲身经历。
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-17 DOI: 10.1016/j.xphs.2024.09.009
Amjad Alhalaweh, Anura S Indulkar, Laura I Mosquera-Giraldo, Hitesh S Purohit, Shweta A Raina, Niraj S Trasi, Håkan Wikström
{"title":"Leadership and mentorship of Professor Lynne S. Taylor: A personal account from former mentees.","authors":"Amjad Alhalaweh, Anura S Indulkar, Laura I Mosquera-Giraldo, Hitesh S Purohit, Shweta A Raina, Niraj S Trasi, Håkan Wikström","doi":"10.1016/j.xphs.2024.09.009","DOIUrl":"10.1016/j.xphs.2024.09.009","url":null,"abstract":"<p><p>This article highlights the profound impact of Professor Lynne S. Taylor, Retter Distinguished Professor of Pharmacy at Purdue University, on her mentees in terms of scientific and professional experience. The former students summarize some of her important contributions, including her emphasis on critical thinking, collaboration, and work-life balance, which have shaped her students into dedicated scientists advancing the pharmaceutical sciences. This acknowledgment recognizes her valuable impact on both her students and the broader scientific community.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of a UV-vis spectrometer to investigate the effect of dissolution media on the diffusivity of small molecules and proteins. 应用紫外可见光谱仪研究溶解介质对小分子和蛋白质扩散性的影响。
IF 3.7 3区 医学
Journal of pharmaceutical sciences Pub Date : 2024-09-14 DOI: 10.1016/j.xphs.2024.09.008
Hao Lou, Gang Hu, Xi Luan, Jill M Steinbach-Rankins, Michael J Hageman
{"title":"Application of a UV-vis spectrometer to investigate the effect of dissolution media on the diffusivity of small molecules and proteins.","authors":"Hao Lou, Gang Hu, Xi Luan, Jill M Steinbach-Rankins, Michael J Hageman","doi":"10.1016/j.xphs.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.xphs.2024.09.008","url":null,"abstract":"<p><p>To date, the commonly used methods for diffusion coefficient measurements have some hurdles that prevent them from being widely applied in pharmaceutical laboratories. This study aimed to modify a method developed by di Cagno et al. based on the use of a UV-Vis spectrometer and apply the method to investigate the effect of dissolution media on the diffusivity of small molecules and proteins. A total of five small molecules and two proteins in different aqueous media and polymer solutions were investigated in this study. By attaching a 3D-printed cover with an open slit to a standard UV-Vis cuvette, the incident UV light could only pass through the open slit to measure the local drug concentration. During the diffusion experiment, drug molecules diffused from the cuvette bottom to the slit. According to the concentration measured as a function of time, diffusion coefficient was calculated based on Fick's law of diffusion using the analytical and numerical approaches. As a result, diffusion coefficients could be accurately measured with high reproducibility. The results also suggested that different media could affect the diffusion coefficients of small molecules by < 10% and proteins by < 15%. Since the UV-Vis spectrometer is a routine instrument, this method can potentially be employed by many pharmaceutical laboratories for diffusion coefficient measurements.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142289712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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