Journal of pharmaceutical sciences最新文献_第3页

Hot melt extrusion-driven cocrystallization of aceclofenac with nicotinamide: A strategy to enhance solubility, bioavailability, and therapeutic effect. 热熔挤压驱动的醋氯芬酸与烟酰胺共结晶：一种提高溶解度、生物利用度和治疗效果的策略。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-04-24 DOI: 10.1016/j.xphs.2026.104294

Sneha Balu Govind, Elvis A F Martis, Vaishali Ashish Shirsat

{"title":"Hot melt extrusion-driven cocrystallization of aceclofenac with nicotinamide: A strategy to enhance solubility, bioavailability, and therapeutic effect.","authors":"Sneha Balu Govind, Elvis A F Martis, Vaishali Ashish Shirsat","doi":"10.1016/j.xphs.2026.104294","DOIUrl":"https://doi.org/10.1016/j.xphs.2026.104294","url":null,"abstract":"<p><p>Aceclofenac (ACF) is a commonly used non-steroidal anti-inflammatory drugs (NSAID) for numerous inflammatory conditions; however, its therapeutic potential is limited due to suboptimal solubility. Pharmaceutical cocrystals have demonstrated favorable and sustainable results in improving the physicochemical and biopharmaceutical characteristics of poorly soluble drugs. To enhance the solubility, dissolution rate, and bioavailability of ACF, we aimed to prepare cocrystals of this biopharmaceutics classification system (BCS) class II drug with a coformer including nicotinamide (NCT), using hot melt extrusion (HME) and liquid-assisted grinding (LAG) methods. ACF-NCT cocrystals synthesized using these methods were characterized using various methods and were further assessed for in vitro anti-osteoporotic and in vivo anti-arthritic activities. The results indicate that both LAG and HME cocrystals demonstrated significant improvement in solubility and dissolution profile compared to pure ACF. However, among these two methods, HME offered more advantages, including better solubility and dissolution profile, than the LAG method. The cocrystals achieved a remarkable 6.15-fold increase in solubility and ⁓3-fold enhancement in dissolution over pure ACF. The relative bioavailability of ACF-NCT HME cocrystal was 249.98% of pure ACF, indicating an improvement in oral bioavailability. The in vivo anti-arthritic activity also demonstrated significant improvement when compared to pure ACF. ACF-nicotinamide cocrystals prepared by hot melt extrusion achieved remarkable gains in solubility, bioavailability, and therapeutic efficacy, providing a promising strategy to overcome ACF's clinical limitations.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":" ","pages":"104294"},"PeriodicalIF":3.8,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reimagining Carrier-Based Formulations for Inhalation: Respirable Agglomerates. 重新构想以载体为基础的吸入制剂：可吸入凝聚体。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-04-18 DOI: 10.1016/j.xphs.2026.104289

Jeffry G Weers, Thomas E Tarara, Danforth P Miller

引用次数: 0

SMARCA2 PROTAC-dendrimer conjugates for the treatment of non-small cell lung cancer. 用于治疗非小细胞肺癌的SMARCA2 protac -树突状分子偶联物。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-04-15 DOI: 10.1016/j.xphs.2026.104286

Matthew O'Brien Laramy, Rosliana Halim, Summer Baker Dockrey, Shang-Fan Yu, Geoff Del Rosario, Robert L Yauch, Xiaofen Ye, Donglu Zhang, Ely Cosino, Graham Heery, Gareth Chadwick, David Owen, Richard Hufton

{"title":"SMARCA2 PROTAC-dendrimer conjugates for the treatment of non-small cell lung cancer.","authors":"Matthew O'Brien Laramy, Rosliana Halim, Summer Baker Dockrey, Shang-Fan Yu, Geoff Del Rosario, Robert L Yauch, Xiaofen Ye, Donglu Zhang, Ely Cosino, Graham Heery, Gareth Chadwick, David Owen, Richard Hufton","doi":"10.1016/j.xphs.2026.104286","DOIUrl":"https://doi.org/10.1016/j.xphs.2026.104286","url":null,"abstract":"<p><p>Targeted protein degradation of SMARCA2 (SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily A, member 2) with proteolysis targeting chimeras (PROTACs) represents a promising approach for the treatment of non-small cell lung cancer (NSCLC). SMARCA2 PROTACs have been reported with sufficient potency and selectivity to drive in vitro activity, however their rapid clearance from systemic circulation, limited tumor distribution, and dose-limiting toxicity prevented sustained tumor growth inhibition in mouse NSCLC xenograft models. To overcome these issues, we conjugated known SMARCA2 PROTACs to poly-L-lysine dendrimers via hydrolytically cleavable linkers with tunable release rates. We found that the PROTAC release rate from the dendrimer conjugate correlated with the systemic and tumor exposure of the free PROTAC, SMARCA2 degradation in tumor and downstream target modulation, and efficacy in a mouse NSCLC xenograft model. A single dose of an optimized dendrimer-PROTAC conjugate achieved tumor stasis up to 21 days at a significantly lower dose than the PROTAC alone, with no adverse effects. This work highlights the potential of dendrimer-based technologies to deliver PROTACs to solid tumors, to mitigate common PROTAC liabilities, and to enable the use of PROTACs from a broader medicinal chemistry design space.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":" ","pages":"104286"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fe²⁺-activated reactive oxygen species amplification via metal-organic frameworks loaded with paclitaxel for enhanced radiosensitivity in breast cancer radiotherapy. Fe 2 +经负载紫杉醇的金属有机框架活化活性氧扩增增强乳腺癌放疗中的放射敏感性。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-04-15 DOI: 10.1016/j.xphs.2026.104285

Zohreh Daliri Sosefi, Marjan Ghorbani, Motahareh Khoshkar Foshtomi, Ali Reza Naseri, Javad Jalili J, Ali Reza Farajollahi

{"title":"Fe²⁺-activated reactive oxygen species amplification via metal-organic frameworks loaded with paclitaxel for enhanced radiosensitivity in breast cancer radiotherapy.","authors":"Zohreh Daliri Sosefi, Marjan Ghorbani, Motahareh Khoshkar Foshtomi, Ali Reza Naseri, Javad Jalili J, Ali Reza Farajollahi","doi":"10.1016/j.xphs.2026.104285","DOIUrl":"https://doi.org/10.1016/j.xphs.2026.104285","url":null,"abstract":"<p><p>Cancer stands as a significant contributor to global mortality. Innovative and targeted strategies, particularly the design of purposeful nanostructures with multifunctional applications, have gained interest in chemo-radiotherapy. This approach aims to enhance the radio-sensitization of tumor tissues while concurrently reducing unnecessary damage to surrounding healthy organs. This study aimed to synthesize ferrous-based metal-organic frameworks (Fe-MOF), a class of hybrid nanomaterials consisting of Fe²⁺ ions and organic ligands, loaded with paclitaxel (PTX) and coated with Bovine Serum Albumin (BSA), to investigate their effects at different doses of X-ray radiation on Human breast epithelial adenocarcinoma (MCF-7) cells. Fe-MOFs were evaluated as a potential drug-releasing nanoparticle, aiming to enhance PTX solubility and promote radiation sensitivity in the MCF-7 breast cancer cell line during radiotherapy. The successful synthesis of Fe-MOF@PTX-BSA and drug loading were confirmed by DLS, TEM, FT-IR, XRD, and BET analyses. Anticancer effects and enhanced radio-sensitivity were validated using MTT, apoptosis, and DAPI assays under irradiated (6MV) and non-irradiated conditions. Fe-MOF@BSA nanoparticles exhibited suitable hemolytic properties at various concentrations. After successfully demonstrating the efficient cellular uptake of nMOFs, in vitro experiments showed that Fe-MOF@PTX-BSA, along with X-ray radiation, activated substantial in situ generation of ROS, leading to increased radio-sensitivity and apoptosis in MCF-7 cells. Therefore, Fe-MOF@PTX-BSA shows potential as both a drug carrier and radiosensitizer for future in vivo studies.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":" ","pages":"104285"},"PeriodicalIF":3.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dose accuracy, parenteral material administration compatibility, surfactant choices, and formulation development in large molecules using quartz crystal microbalance. 剂量准确性，肠外给药的相容性，表面活性剂的选择，并在大分子使用石英晶体微天平配方的发展。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-04-03 DOI: 10.1016/j.xphs.2026.104278

Joe Weidman, Ligi Mathews, Kedar Gokhale

{"title":"Dose accuracy, parenteral material administration compatibility, surfactant choices, and formulation development in large molecules using quartz crystal microbalance.","authors":"Joe Weidman, Ligi Mathews, Kedar Gokhale","doi":"10.1016/j.xphs.2026.104278","DOIUrl":"https://doi.org/10.1016/j.xphs.2026.104278","url":null,"abstract":"<p><p>Making positive-impact formulation decisions for antibodies and integrated design of clinical durability creates a better drug product (DP). The goal of this study was to prevent dose loss to surfaces during clinical administration, especially when surfactant and/or antibody levels were low or when stressors were present. Studied here were 6 common polymers coated on QCM sensors in the presence of varying DP solutions to study surface interactions. Three immuno-oncology antibody DPs in in-use sterile conditions were characterized: one intravenously (IV) at low polysorbate 20 (PS, PS20) concentration and varying antibody concentration, one IV at low, constant antibody concentration and varying concentrations of PS20, and another with constant PS20 to antibody ratio diluted subcutaneously (SC). Experiments mimicked clinical conditions, and characterized the impact of inline filtration, dilution, stressor forces, interaction behavior at interfaces, and adsorption during both administration types. Formulations and dilutions with and without antibody or PS20 were studied to estimate individual substance mass contribution at the surface. By laddering protein and/or PS20 concentrations, a method to find the minimum antibody or surfactant concentration was found. An adsorption model for DPs in clinic was formed to characterize protein loss and adsorption.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":" ","pages":"104278"},"PeriodicalIF":3.8,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147623246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sericin and alginate loaded nanocomposite hydrogels for encapsulation and oral administration of insulin 丝胶和海藻酸盐负载纳米复合水凝胶用于胰岛素包封和口服给药。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-04-01 Epub Date: 2026-01-27 DOI: 10.1016/j.xphs.2026.104175

Sania Faiz, Hafiz Muhammad Tahir, Rida Mahnoor, Aamir Ali, Ayesha Muzamil, Fariha Munir, Sidra Arshad, Fatima Ijaz, Ayesha Afzal, Farwa Shafique

{"title":"Sericin and alginate loaded nanocomposite hydrogels for encapsulation and oral administration of insulin","authors":"Sania Faiz, Hafiz Muhammad Tahir, Rida Mahnoor, Aamir Ali, Ayesha Muzamil, Fariha Munir, Sidra Arshad, Fatima Ijaz, Ayesha Afzal, Farwa Shafique","doi":"10.1016/j.xphs.2026.104175","DOIUrl":"10.1016/j.xphs.2026.104175","url":null,"abstract":"<div><div>Diabetes mellitus is a major global health concern, with limited progress in the development of efficient oral insulin formulations. The current study was designed to assess the physicochemical, biochemical, and therapeutic efficiency of alginate and sericin loaded nanocomposites, which were developed as a protective oral delivery route for insulin. Ionic gelation was used to create the nanocomposites, which demonstrated excellent stability, controlled release, and high encapsulation efficiency in gastrointestinal simulations. Mice with alloxan induced diabetes were used for in-vivo evaluations. Insulin-loaded sericin-alginate nanocomposites administered orally for 21 days preserved body weight and significantly decreased fasting blood glucose levels as compared to the negative control. Blood glucose levels in the NC group increased gradually, from about 210 mg/dL to about 348 mg/dL, while 60 UI INS/60 kg reduced fasting blood glucose level from 220 mg/dL to 115 mg/dL. Significant improvements in liver and kidney function were evident by biochemical study, coupled with restored lipid profiles that showed higher HDL and lower levels of LDL, triglycerides, and cholesterol. Histological analysis revealed normal architecture of pancreatic and liver tissue in treatment groups similar to positive control. It can be concluded from the study that the sericin–alginate nanocomposites are safe, natural, and efficient oral insulin delivery method that can replace traditional subcutaneous injections.</div></div>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":"115 4","pages":"Article 104175"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dual-layer tissue scaffolds with antibacterial and regenerative properties: Integration of melt electrowriting and electrospray technologies. 具有抗菌和再生特性的双层组织支架：熔体电解和电喷涂技术的集成。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-03-19 DOI: 10.1016/j.xphs.2026.104249

Irem Aydos, Sabereh Nouri, Sibel Daglilar, Sena Su Torun, Sevval Gunes, Elif Ilhan, Eray Altan, Oguzhan Gunduz

{"title":"Dual-layer tissue scaffolds with antibacterial and regenerative properties: Integration of melt electrowriting and electrospray technologies.","authors":"Irem Aydos, Sabereh Nouri, Sibel Daglilar, Sena Su Torun, Sevval Gunes, Elif Ilhan, Eray Altan, Oguzhan Gunduz","doi":"10.1016/j.xphs.2026.104249","DOIUrl":"10.1016/j.xphs.2026.104249","url":null,"abstract":"<p><p>Efficient wound healing requires the design of advanced biomaterials that combine structural integrity, antimicrobial functionality, and the ability to promote tissue regeneration. The paper discusses the development of dual-layer tissue scaffolds (DLS) using poly (lactic acid) (PLA) and amoxicillin (AMOX) nanoparticles at different concentrations (0.5% w/v and 1% w/v). The scaffolds were characterized using Scanning Electron Microscopy (SEM) for morphological analysis, Fourier-transform infrared spectroscopy (FTIR) for chemical interactions, Differential Scanning Calorimetry (DSC) for thermal stability, and tensile testing for mechanical properties. Swelling, degradation, drug release and drug release kinetic analyses were performed. Antibacterial efficacy against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) was performed along with cytocompatibility via MTT assays using fibroblast cells. SEM revealed microporous scaffolds with approximate pore diameters of ∼370 µm for 0.05 AMOX and ∼302 µm for 0.1 AMOX. Mechanical testing demonstrated that tensile strength and strain decrease with increasing drug loading. Antibacterial testing showed activity against S. aureus but limited efficacy against E. coli. MTT assays confirmed cytocompatibility of the scaffold, showing enhanced cell viability for the DLS-0.05 AMOX scaffold. Considering the obtained results, dual-layer tissue scaffolds with antibacterial properties present significant potential for a wide range of wound care applications.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":" ","pages":"104249"},"PeriodicalIF":3.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a melt-cast microneedle patch for sustained drug release of islatravir. 用于islatravir缓释的熔铸微针贴片的研制。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-03-19 DOI: 10.1016/j.xphs.2026.104256

Mikayla L Rahman, Sijia Tao, Camryn P Mekal, Gulcin Arslan Azizoglu, Raymond F Schinazi, Mark R Prausnitz

{"title":"Development of a melt-cast microneedle patch for sustained drug release of islatravir.","authors":"Mikayla L Rahman, Sijia Tao, Camryn P Mekal, Gulcin Arslan Azizoglu, Raymond F Schinazi, Mark R Prausnitz","doi":"10.1016/j.xphs.2026.104256","DOIUrl":"10.1016/j.xphs.2026.104256","url":null,"abstract":"<p><p>Low adherence to daily oral drug regimens is a significant obstacle in effectively managing chronic therapies like HIV treatment, pre-exposure prophylaxis (PrEP), and contraception. While long-acting injectables eliminate the need for daily compliance, they often require administration by healthcare professionals. To facilitate self-administration of long-acting treatments, we developed a microneedle patch (MNP) for the sustained release of islatravir or levonorgestrel, used for HIV treatment/PrEP or contraception, respectively. The MNPs were produced using a melt-casting technique to quickly create biodegradable polycaprolactone microneedles for continuous drug delivery. The low melting point of polycaprolactone and the high thermal stability of islatravir and levonorgestrel allowed melt casting at 65 °C. Incorporating centrifugation during fabrication improved the attachment of microneedles to the patch backing, making it easier to remove MNPs from the mold and ensuring effective microneedle insertion into skin. The MNPs demonstrated a sustained release of islatravir with roughly first-order release kinetics for ∼40 days in vitro. We conclude that MNPs made with a simple melt-casting process can enable prolonged drug release for HIV treatment/PrEP, contraception, and other therapeutic applications.</p>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":" ","pages":"104256"},"PeriodicalIF":3.8,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147493582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2026 scientific advisors to the editors (SAEs) appointments and updates 2026编辑科学顾问（sae）的任命和更新。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-03-01 Epub Date: 2025-12-17 DOI: 10.1016/j.xphs.2025.104131

Kenneth L. Audus

引用次数: 0

Quantitative prediction of human metabolites formed from the oxidation of the alcohol group of the glucokinase activator, TMG-123, using chimeric mice with humanized livers 使用人源化肝脏的嵌合小鼠，定量预测葡萄糖激酶激活剂TMG-123的醇组氧化形成的人类代谢物。

IF 3.8 3区医学

Journal of pharmaceutical sciences Pub Date : 2026-03-01 Epub Date: 2026-01-27 DOI: 10.1016/j.xphs.2026.104177

Akiko Watanabe , Seishiro Sakamoto , Shigeru Ohta , Seigo Sanoh

{"title":"Quantitative prediction of human metabolites formed from the oxidation of the alcohol group of the glucokinase activator, TMG-123, using chimeric mice with humanized livers","authors":"Akiko Watanabe , Seishiro Sakamoto , Shigeru Ohta , Seigo Sanoh","doi":"10.1016/j.xphs.2026.104177","DOIUrl":"10.1016/j.xphs.2026.104177","url":null,"abstract":"<div><div>Pharmacokinetic (PK) predictions in humans are important for both the parent compounds and their metabolites, as these predictions help decide whether to progress to human clinical trials. More human PK prediction studies have been conducted on unchanged compounds than on their metabolites. Human PK predictions are more complex for metabolites than for unchanged compounds due to the large number of metabolic enzymes involved and the need to consider species-related differences in these enzymes. Mice with humanized livers are expected to serve as simple and useful tools for assessing a wide range of metabolic enzymes. We confirmed the production of the metabolite formed from the oxidation of the alcohol group of the glucokinase activator, TMG-123, in humans; in addition, we conducted a predictive study on TMG-123 using chimeric mice. Furthermore, we identified the drug-metabolizing enzymes involved in this metabolic reaction. The in vivo production rate of GDI-1202 was 19.1% in humans, 17.0% in chimeric mice, and 5.0% in ICR mice. The main enzyme that metabolizes TMG-123 to GDI-1202 was found to be alcohol dehydrogenase (ADH)/aldehyde dehydrogenase (ALDH). Therefore, chimeric mice are effective animal models for predicting the PK of metabolites formed via the action of non-cytochrome P450 enzymes in humans.</div></div>","PeriodicalId":16741,"journal":{"name":"Journal of pharmaceutical sciences","volume":"115 3","pages":"Article 104177"},"PeriodicalIF":3.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146086159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0