Journal of pediatric surgery最新文献

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Beyond Physical Injury: Routine Screening for Acute Stress Disorder and Posttraumatic Stress Disorder in Pediatric Trauma Patients - A Longitudinal Cohort Pilot Study. 超越身体伤害:儿科创伤患者急性应激障碍和创伤后应激障碍的常规筛查--一项纵向队列试点研究。
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-10-03 DOI: 10.1016/j.jpedsurg.2024.161982
Norah E Liang, Katherine Alvarez, Kyla Dalusag, Katy Chan, Brittney Bunnell, Melanie Stroud, Kathleen Steele, Stephanie D Chao
{"title":"Beyond Physical Injury: Routine Screening for Acute Stress Disorder and Posttraumatic Stress Disorder in Pediatric Trauma Patients - A Longitudinal Cohort Pilot Study.","authors":"Norah E Liang, Katherine Alvarez, Kyla Dalusag, Katy Chan, Brittney Bunnell, Melanie Stroud, Kathleen Steele, Stephanie D Chao","doi":"10.1016/j.jpedsurg.2024.161982","DOIUrl":"https://doi.org/10.1016/j.jpedsurg.2024.161982","url":null,"abstract":"<p><strong>Introduction: </strong>Early identification of children at risk for PTSD is critical for improving mental health outcomes after traumatic injury. Currently, there is no standard PTSD screen for pediatric trauma patients and limited data on long-term quality of life for those who screen positive.</p><p><strong>Methods: </strong>In 2022, we piloted a comprehensive routine screening program for ASD and PTSD at our Level I PTC. All admitted trauma patients ≥8 years old were eligible for screening. Inpatients were administered the ASC3. Those who screened positive were referred for follow-up and repeat mental health evaluation. PTSD screening (CTSQ, CPSS) and quality-of-life screening (PedsQL™) surveys were administered to eligible discharged trauma patients at 1-month post-injury. Children who screened positive on the CTSQ or CPSS were referred for behavioral health services.</p><p><strong>Results: </strong>205 children were screened for ASD using the ASC3. 49/205 children (23.9 %) had a positive screen (score ≥3). 56 children completed PTSD screening at 1-month post-discharge. 14/54 children (25.9 %) screened positive on CTSQ, and 8/50 children (16 %) screened positive on CPSS. There was a significant positive correlation between CTSQ and CPSS scores (r 0.76, ∗P<0.0001). When stratified by screening results, patients who screened positive on CTSQ and CPSS were found to have the most significant correlations with poor School and Emotional Functioning on their quality-of-life inventory.</p><p><strong>Conclusion: </strong>Early screening for ASD may be predictive of later development of PTSD in children. Screening using previously validated tools (ASC3, CTSQ, CPSS) were effective in identifying children with negative emotional functioning lasting beyond the acute phase of physical recovery following injury. CTSQ and CPSS both performed well for screening at one-month post-discharge. Early identification can facilitate timely referral to mental health services to potentially minimize long-term socioemotional impact of PTSD.</p>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":" ","pages":"161982"},"PeriodicalIF":2.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142391342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative Identification of Adamkiewicz Artery in Pediatric Posterior Thoracic Tumors: Fact or Fiction? A Systematic Review from the International Society of Pediatric Surgical Oncology (IPSO) 术前识别小儿胸骨后肿瘤的 Adamkiewicz 动脉:事实还是虚构?来自国际儿科肿瘤外科学会 (IPSO) 的系统回顾。
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-10-03 DOI: 10.1016/j.jpedsurg.2024.161985
Angelo Zarfati , Florent Guérin , Marco Dioguardi Burgio , Jorg Fuchs , Sabine Sarnacki , Paul D. Losty , Luca Pio
{"title":"Preoperative Identification of Adamkiewicz Artery in Pediatric Posterior Thoracic Tumors: Fact or Fiction? A Systematic Review from the International Society of Pediatric Surgical Oncology (IPSO)","authors":"Angelo Zarfati ,&nbsp;Florent Guérin ,&nbsp;Marco Dioguardi Burgio ,&nbsp;Jorg Fuchs ,&nbsp;Sabine Sarnacki ,&nbsp;Paul D. Losty ,&nbsp;Luca Pio","doi":"10.1016/j.jpedsurg.2024.161985","DOIUrl":"10.1016/j.jpedsurg.2024.161985","url":null,"abstract":"<div><h3>Background and aims</h3><div>We aimed to review current literature on the impact of Preoperative Identification (POI) of the Adamkiewicz Artery (AKA) in solid pediatric Posterior Thoracic Tumors (PTT), comprising a spectrum of neuroblastic tumors and neuroblastoma, with particular focus on Complete Macroscopic Excision (CME) and Neurologic Complications/Sequelae (NCS).</div></div><div><h3>Methods</h3><div>A systematic review in accordance with PRISMA guidelines was undertaken. The study included reports on pediatric patients providing available data on POI of the AKA in PTT.</div></div><div><h3>Results</h3><div>Among 838 records screened, 33 full-texts underwent evaluation, and 8 papers were included. Among 49 tumors (N = 49 patients), 30 were neuroectodermic tumors. Spinal angiography (SA) was undertaken in four studies for 32 (65%) patients. No SA-related morbidity was recorded. Otherwise, a combination of CT and/or MRI imaging was described. The lack of detailed reporting on CT/MRI imaging, hindered a feasible detailed comparative analysis among non-SA imaging modality techniques.</div><div>The overall success rate of AKA POI was 65%, 71% with SA and 33% with non-SA studies. CME was achieved in 73% of SA and 80% non-SA groups. Overall, 5 children experienced NCS, 60% of those who had dumbbell tumors. All NCS occurred in patients without successful POI of the AKA. Furthermore, no SA patient had NCS, while 33% of the non-SA sustained NCS.</div></div><div><h3>Conclusions</h3><div>Successful POI of the AKA may play a key role in prevention of NCS. SA showed the utility of deploying POI, without added morbidity. Furthermore, SA appeared to have a preventive impact on NCS. SA may have a key role on CME which may also be operator dependent.</div></div>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":"59 12","pages":"Article 161985"},"PeriodicalIF":2.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitigating Ergonomic Injury. 减轻人体工学伤害。
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-10-01 DOI: 10.1016/j.jpedsurg.2024.161979
Kristy Rialon, Jeffery W Gander, Mary Brandt, Terry L Buchmiller
{"title":"Mitigating Ergonomic Injury.","authors":"Kristy Rialon, Jeffery W Gander, Mary Brandt, Terry L Buchmiller","doi":"10.1016/j.jpedsurg.2024.161979","DOIUrl":"https://doi.org/10.1016/j.jpedsurg.2024.161979","url":null,"abstract":"","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":" ","pages":"161979"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142580993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Leader's Role in Hospital Surgeon Wellbeing: Organizational Wellness and Peer Support for APSA. 领导者在医院外科医生福祉中的作用:为 APSA 提供组织健康和同伴支持。
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-10-01 DOI: 10.1016/j.jpedsurg.2024.161977
Terry Buchmiller, Kurt Heiss, Loren Berman
{"title":"The Leader's Role in Hospital Surgeon Wellbeing: Organizational Wellness and Peer Support for APSA.","authors":"Terry Buchmiller, Kurt Heiss, Loren Berman","doi":"10.1016/j.jpedsurg.2024.161977","DOIUrl":"https://doi.org/10.1016/j.jpedsurg.2024.161977","url":null,"abstract":"","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":" ","pages":"161977"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composite Functional and Quality of Life Outcomes in Adults Operated for Cloacal Malformation 成人泄殖腔畸形手术的综合功能和生活质量结果
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-10-01 DOI: 10.1016/j.jpedsurg.2024.161981
L. Örtqvist , G. Holmdahl , H. Borg , K. Bjornland , H. Lilja , P. Stenström , N. Qvist , T. Sæther Hagen , M. Pakarinen , T. Wester , R. Rintala
{"title":"Composite Functional and Quality of Life Outcomes in Adults Operated for Cloacal Malformation","authors":"L. Örtqvist ,&nbsp;G. Holmdahl ,&nbsp;H. Borg ,&nbsp;K. Bjornland ,&nbsp;H. Lilja ,&nbsp;P. Stenström ,&nbsp;N. Qvist ,&nbsp;T. Sæther Hagen ,&nbsp;M. Pakarinen ,&nbsp;T. Wester ,&nbsp;R. Rintala","doi":"10.1016/j.jpedsurg.2024.161981","DOIUrl":"10.1016/j.jpedsurg.2024.161981","url":null,"abstract":"<div><h3>Introduction</h3><div>Composite long-term outcomes of cloacal malformations remain unclear. We aimed to evaluate bowel and bladder control, sexual function, reproductive health, and quality of life in adulthood.</div></div><div><h3>Methods</h3><div>A Nordic multi-center cross-sectional observational study evaluating the outcome of adult patients with cloacal malformations was performed. Patient characteristics were retrieved from case records. Established questionnaires were sent to the patients to evaluate bowel- bladder- and sexual function and quality of life.</div></div><div><h3>Results</h3><div>Thirty-four of 48 (70%) eligible patients with median age 28 years (18–45) responded. Eight (24%) patients had a common channel &gt;3 cm. Imaging-confirmed spinal and sacral abnormalities were present in 4 and 17 patients respectively. 85% (n = 29/34, four patients with permanent urinary diversions after bladder neck closure excluded) reported no urinary leakage without physical activity or urge to urinate. Three patients had a permanent enterostomy. 42 % (n = 11/26) reported acceptable bowel function according to Bowel Function Score (with eventual ongoing bowel management). The median Profile of Female Sexual Function Score was below normative values. Quality of life was comparable to the reference population, but thirty percent scored within the distress domains. Eight patients (24%) had been pregnant (15 pregnancies), resulting in seven live births, but the need of assisted reproduction techniques (40%, n = 6/15) and miscarriage (40%, n = 6/15) was common.</div></div><div><h3>Conclusions</h3><div>Adequate spontaneous bowel control was rare, while most patients were dry for urine without additional procedures. Cloacal malformation also have a negative impact on sexual function health related quality of life and reproductive health. Long-term follow-up is crucial, not only regarding bowel and bladder function, but also for sexual and reproductive function, which may be important negative factors for health-related quality of life.</div></div><div><h3>Level of Evidence</h3><div>Level IV.</div></div>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":"60 1","pages":"Article 161981"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142468261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxic Environments: Recovery or Renewal. 有毒环境:恢复还是重建?
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-10-01 DOI: 10.1016/j.jpedsurg.2024.161980
Thomas F Tracy, Terry Buchmiller
{"title":"Toxic Environments: Recovery or Renewal.","authors":"Thomas F Tracy, Terry Buchmiller","doi":"10.1016/j.jpedsurg.2024.161980","DOIUrl":"https://doi.org/10.1016/j.jpedsurg.2024.161980","url":null,"abstract":"","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":" ","pages":"161980"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Connect & Share": Collaboratively Addressing Moral Distress Among Pediatric Surgeons. "连接与分享":合作解决儿科外科医生的道德压力。
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-10-01 DOI: 10.1016/j.jpedsurg.2024.161978
Jason P Sulkowski, Mindy B Statter, Terry L Buchmiller
{"title":"\"Connect & Share\": Collaboratively Addressing Moral Distress Among Pediatric Surgeons.","authors":"Jason P Sulkowski, Mindy B Statter, Terry L Buchmiller","doi":"10.1016/j.jpedsurg.2024.161978","DOIUrl":"https://doi.org/10.1016/j.jpedsurg.2024.161978","url":null,"abstract":"","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":" ","pages":"161978"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142502510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Quality of Life With Dynamic Compression Bracing in Patients With Pectus Carinatum 用动态加压支撑提高胸肌患者的生活质量
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-09-30 DOI: 10.1016/j.jpedsurg.2024.161975
Hendrik van Braak , Sjoerd A. de Beer , Jos W.R. Twisk , Sander Zwaveling , Matthijs W.N. Oomen , Justin R. de Jong , L.W. Ernest van Heurn
{"title":"Improving Quality of Life With Dynamic Compression Bracing in Patients With Pectus Carinatum","authors":"Hendrik van Braak ,&nbsp;Sjoerd A. de Beer ,&nbsp;Jos W.R. Twisk ,&nbsp;Sander Zwaveling ,&nbsp;Matthijs W.N. Oomen ,&nbsp;Justin R. de Jong ,&nbsp;L.W. Ernest van Heurn","doi":"10.1016/j.jpedsurg.2024.161975","DOIUrl":"10.1016/j.jpedsurg.2024.161975","url":null,"abstract":"<div><h3>Background</h3><div>Patients with pectus carinatum have lower quality of life and self-esteem than their peers. We assessed the impact of dynamic compression system bracing on quality of life in patients with pectus carinatum.</div></div><div><h3>Methods</h3><div>We conducted a prospective cohort study on patients aged 10–21 years. We assessed quality of life using the Child Health Questionnaire-87, the State-Trait Anxiety Inventory-6, the World Health Organization Quality of Life-BREF, the 36-Item Short Form Survey, and the Single-Step Questionnaire adapted for pectus carinatum.</div></div><div><h3>Results</h3><div>Between March 2013 and March 2016, 225 patients treated with dynamic compression system bracing were included. Patients showed improvements across the overall scores of the 36-Item Short Form Survey (Δ7.7 (2.9–12.4)), Single-Step Questionnaire (Δ4.1 (2.0–6.3)) and three out of four World Health Organization Quality of Life-BREF domains (physical health (Δ8.7 (3.7–13.7)), psychological health (Δ11.8 (6.1–17.5)), environment (Δ5.7 (0.2–11.3))). No changes across the Child Health Questionnaire-87 overall score were observed (Δ5.5 (−0.5–11.5)). Most improvement occurred within six to twelve months after treatment initiation, stabilizing thereafter. Anxiety scores on the State-Trait Anxiety Inventory-6 did not improve (Δ0.5 (−0.1–1.2)). Scores on physical complaints, pain, psychological health and self-esteem/self-image improved across all questionnaires. In contrast to the successfully treated group, the unsuccessfully treated group showed no improvement on any of the questionnaires. Most patients (87.2 %) would choose bracing again, 94.9 % of patients were satisfied with the treatment.</div></div><div><h3>Conclusions</h3><div>Dynamic compression system bracing improves quality of life, reduces physical complaints and pain and boosts psychological health and self-esteem in patients with pectus carinatum.</div></div>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":"60 1","pages":"Article 161975"},"PeriodicalIF":2.4,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142381140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Repair of Type C Tracheo-esophageal Fistula/Esophageal Atresia With or Without Trans Anastomotic Tube: A Pilot Randomized Controlled Trial 使用或不使用经吻合器管道修复 C 型气管食管瘘/食管闭锁:一项试点随机对照试验。
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-09-28 DOI: 10.1016/j.jpedsurg.2024.161970
Ramyasree Bade , Nitin James Peters , Shivani Dogra , Muneer Abas Malik , Jai Kumar Mahajan , Sandhya Yaddanapudi , Shailesh Solanki , Monika Bawa , Ram Samujh
{"title":"Repair of Type C Tracheo-esophageal Fistula/Esophageal Atresia With or Without Trans Anastomotic Tube: A Pilot Randomized Controlled Trial","authors":"Ramyasree Bade ,&nbsp;Nitin James Peters ,&nbsp;Shivani Dogra ,&nbsp;Muneer Abas Malik ,&nbsp;Jai Kumar Mahajan ,&nbsp;Sandhya Yaddanapudi ,&nbsp;Shailesh Solanki ,&nbsp;Monika Bawa ,&nbsp;Ram Samujh","doi":"10.1016/j.jpedsurg.2024.161970","DOIUrl":"10.1016/j.jpedsurg.2024.161970","url":null,"abstract":"<div><h3>Background</h3><div>The use of trans anastomotic feeding tube (TAFT) during the repair of Esophageal atresia/Tracheo-esophageal fistula (EA/TEF) aims to enhance outcomes by enabling early feeding, reducing the requirement for parenteral nutrition, and reducing complications such as anastomotic leak by stenting the anastomosis. However, TAFT's benefits and drawbacks are debated due to conflicting reports. Thus, we conducted a prospective pilot randomized control trial to elucidate the impact of TAFT on postoperative outcomes and the potential benefits of avoidance of TAFT.</div></div><div><h3>Methods</h3><div>We performed a single-center randomized controlled trial in 53 neonates diagnosed with Type C EA/TEF who were operated on from January 2022 to June 2023. The patients were randomized into TAFT (n = 30) and non-TAFT (n = 23) groups. The patients were followed up for a minimum of 6 months following discharge. The primary objective of the study was to compare the rate of anastomotic leaks following primary repair of EA/TEF in both groups. Secondary objectives included early postoperative outcomes such as the occurrence of anastomotic stricture, time taken to initiate feeding, the time required to reach full feeding, the incidence of brief resolved unexplained events (BRUE) or acute life-threatening events (ALTE), the incidence of gastroesophageal reflux (GER), somatic growth, and all-cause mortality within 30 days post-surgery.</div></div><div><h3>Result</h3><div>The study demonstrated that TAFT placement was associated with a higher incidence of anastomotic leaks (20 % vs 0, p = 0.03). However, there was no difference in the 30-day mortality between both groups. Although the rate of anastomotic strictures and GER was higher in the TAFT group (54.5 % vs 27.8 %, p = 0.08 and 25 % vs 57.1 %, p = 0.076), it did not reach statistical significance. Avoiding TAFT resulted in earlier initiation of enteral feeding (18 vs 22 days, p = 0.002), shorter time to achieve full feeds (15 vs 21 days, p = 0.03), reduced duration of TPN (3 vs 10 days; p = 0.001), improved weight gain at the 2-week follow-up (27.5 vs. 24.4 g/kg/day, p-value = 0.037) and lesser incidence of ALTE/BRUE (11.1 % vs 48 %, p = 0.01) at 6 months.</div></div><div><h3>Conclusion</h3><div>While previous research has covered TAFT's impact on complications such as anastomotic leak, stricture, use of TPN and enteral feed, prospective randomized studies remain limited, and the impact on GER, somatic growth, and occurrence of ALTE/BRUE is still unexplored. This study evaluated the short-term outcomes of EA/TEF in a resource-challenged setting, shedding light on the potential benefits of repair without TAFT such as reduction in the rate of anastomotic leak, earlier feeding, reduced GER, better somatic growth and reduced incidence of ALTE/BRUE.</div></div><div><h3>Level of Evidence</h3><div>Level II (Treatment study/Randomized controlled trial).</div></div>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":"60 1","pages":"Article 161970"},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Risk Factors for Kasabach Merritt Phenomenom in Children With Kaposiform Hemangioendothelioma. 卡巴赫-梅里特现象在罹患卡波斯状血管内皮瘤的儿童中的风险因素分析
IF 2.4 2区 医学
Journal of pediatric surgery Pub Date : 2024-09-28 DOI: 10.1016/j.jpedsurg.2024.161932
Chen Chen, Hanlei Yan, Wei Yao, Zuopeng Wang, Kai Li
{"title":"Analysis of Risk Factors for Kasabach Merritt Phenomenom in Children With Kaposiform Hemangioendothelioma.","authors":"Chen Chen, Hanlei Yan, Wei Yao, Zuopeng Wang, Kai Li","doi":"10.1016/j.jpedsurg.2024.161932","DOIUrl":"https://doi.org/10.1016/j.jpedsurg.2024.161932","url":null,"abstract":"<p><strong>Background: </strong>This study generalized and analyzed the clinical attributes observed in patients afflicted with Kaposiform hemangioendothelioma (KHE) with the aim of elucidating the risk factors contributing to the manifestation of Kasabach-Merritt phenomenon (KMP).</p><p><strong>Methods: </strong>We retrospectively analyzed 96 pediatric cases diagnosed with KHE at the Children's Hospital of Fudan University from January 2013 to December 2021. Among them, 62 patients (65%) showed KMP (KHE + KMP group), while 34 patients (35%) did not (KHE-KMP group). The risk factors for KMP associated with KHE were analyzed using univariate analysis and binary logistic regression analysis, comparing the differences between KHE + KMP group and KHE-KMP group.</p><p><strong>Results: </strong>Univariate analysis indicated no statistically significant differences between the two groups in gender, prematurity, family history, or color of involved skin. However, statistically significant differences were observed in age of onset, lesion site, and lesion depth. Multivariate analysis revealed significant associations: children with onset age ≤1 month had a 51-fold increased risk of KMP compared to those with onset age >1 month (95% CI 5.238-501.663); non-extremity lesion sites exhibited a 21-fold higher risk of KMP compared to extremity sites (95% CI 3.970-105.958); deeper lesions conferred a 5-fold higher risk of KMP compared to superficial lesions (95% CI 1.073-21.005); lesions >60 mm carried a 17-fold higher risk of KMP compared to lesions ≤60 mm (95% CI 2.999-96.157). A comprehensive predictive model was developed using the fitting formula: Logit (P) = 3.937∗(age at onset) + 1.558∗(lesion depth) + 3.021∗(lesion site) + 2.832∗(lesion size), demonstrating an accuracy of 82.9%. Furthermore, a scoring system was established to assess the likelihood of KMP occurrence. Children diagnosed with KHE were likely to have KMP if their score exceeded 72.5, as determined by Receiver Operating Characteristic (ROC) curve analysis.</p><p><strong>Conclusion: </strong>Age of onset ≤1 month, deeper lesions, non-extremity sites, and lesions >60 mm are independent risk factors for KMP in children with KHE. The cumulative presence of these factors escalates the likelihood of KMP development. Additionally, the identification of these factors allows for the early recognition of potential KMP cases among children with KHE, facilitating prompt therapeutic intervention.</p><p><strong>Category of the manuscript: </strong>Clinical Research article.</p><p><strong>Level of evidence: </strong>LEVEL Ⅲ.</p>","PeriodicalId":16733,"journal":{"name":"Journal of pediatric surgery","volume":" ","pages":"161932"},"PeriodicalIF":2.4,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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