Russian Military Medical Academy Reports最新文献

{"title":"Acute appendicitis in adults: only clinical and laboratory diagnostics, only imaging, or both?","authors":"Vladimir V. Ryazanov, G. K. Sadykova, G. Trufanov, I. Zheleznyak, S. Bagnenko, V. V. Ipatov, Leonid V. Voronkov, G. G. Romanov, G. O. Bagaturia","doi":"10.17816/rmmar623170","DOIUrl":"https://doi.org/10.17816/rmmar623170","url":null,"abstract":"The presented article is devoted to the discussion of the necessity and expediency of using medical visualization diagnostics — radiological imaging — of acute appendicitis as an independent or complex approach in combination with clinical and laboratory data. Until now, the clinical diagnosis of each individual case of acute appendicitis is complicated, and its formulation requires combining clinical, laboratory and imaging data, since it includes a wide range of differential diagnoses depending on age and gender. The literature provides data that the frequency of negative appendectomies based on the results of a clinical examination can be up to 28.2%. Radiological imaging is used as an adjunct to clinical diagnostics using ultrasound examination, computed tomography and magnetic resonance imaging, but the role of the latter is limited by the duration of the study, increased cost, unavailability around the clock, as well as the presence of absolute contraindications. Sonography and computed tomography in diagnostics have a number of advantages and disadvantages, and the question of choosing a specific method still causes scientific controversy. We also provide illustrative clinical examples demonstrating echographic and computed tomographic imaging manifestations of acute appendicitis, as well as discuss visualization signs. For a patient with suspected acute appendicitis, in order to increase the accuracy of diagnosis, reduce complications or the need of undergoing unnecessary diagnostic and therapeutic procedures, a multidisciplinary and multimodal approach is necessary, taking into account age, gender and constitution, however, the question of choosing the optimal method of medical imaging in the diagnosis of acute appendicitis between ultrasound and computed tomography remains debatable.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"37 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state functional magnetic resonance imaging: features of statistical processing of ROI-analysis data","authors":"Sh K Abdulaev, D. Tarumov, K. Markin, Aleksandra А. Ustyuzhina","doi":"10.17816/rmmar623485","DOIUrl":"https://doi.org/10.17816/rmmar623485","url":null,"abstract":"BACKGROUND: In many works, to study intra- and inter-network connections, a method for constructing networks is used — ROI-analysis (region of interest analysis). The conflicting results obtained when assessing brain connectivity using ROI-analysis can be explained by methodological differences associated with the statistical processing of fMRI data. In this regard, it is relevant to conduct a study with a comparative assessment of various statistical methods of ROI-analysis in processing resting state fMRI data. \u0000AIM: to assess the functional connectivity of the main resting state networks of the brain using ROI-analysis using various statistical approaches. \u0000MATERIALS AND METHODS: We analyzed data from 15 resting-state fMRI studies of the brain of patients without neurological and mental pathology. fMRI scanning was performed on a Phillips Ingenia 1.5 T scanner using a gradient echo-planar imaging (EPI-BOLD) sequence. ROI-analysis was used to build networks. Statistical data processing was performed using methods: functional network connectivity, randomization/permutation spatial pairwise clustering statistics, and threshold-free cluster enhancement. \u0000RESULTS: The number of connections between the structures of brain networks recorded using the method of functional network connectivity is 280, spatial pairwise clustering — 186, threshold-free cluster enhancement — 182. An interesting fact is that negative connections were identified only when using parametric statistics. \u0000CONCLUSION: A comparative assessment of methods for statistical processing of fMRI data during ROI-analysis was carried out. The functional network connectivity method based on multivariate parametric statistics turned out to be more informative than randomization/permutation spatial pairwise clustering statistics and the method based on threshold-free cluster enhancement. Despite the growing popularity in recent years of resting-state fMRI in the study of functional activity and connectivity of the brain, there are no standardized algorithms for constructing networks of the brain.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140674517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oleg Konstantinovich Bumay (in memory of a teacher, colleague, comrade)","authors":"O. G. Chernikov, Uriy V. Grabskiy","doi":"10.17816/rmmar626432","DOIUrl":"https://doi.org/10.17816/rmmar626432","url":null,"abstract":"January 1, 2024 marked the 70th anniversary of the birth of the former head of the organization and tactics of the medical service of the fleet (with a course of tactics and combat weapons of the fleet) department of the S.M. Kirov Military Medical Academy, effective director for modern topics of the Federal State Budgetary Institution Research Institute of Industrial and Marine Medicine FMBA of Russia, candidate of medical sciences, associate professor Oleg Konstantinovich Bumay (1954–2022). O.K. Bumay was born in the village of Bogudenka, Belarus. He was alumnus the faculty of training doctors for the Navy of the S.M. Kirov Military Medical Academy. After graduating from the academy in 1977, for a decade he provided and organized medical support for nuclear submarines as the head of the ship’s medical service, the cheef of medical a submarine forces in the Northern Fleet, and subsequently served as a senior medical officer in the Baltic Fleet. Over the course of two decades, O.K. Bumay was associated with the organization and tactics of the naval medical service (with a course of tactics and combat weapons of the fleet) department of S.M. Kirov Military Medical Academy. In 1991, he entered the adjunct program at the department; upon completion of his studies, he was appointed as a teacher, subsequently as a senior teacher, and since 2009 — deputy head of the department. He received the rank of Philosophy doctor of Medical Sciences (1994), associate professor (1998). After leaving the Armed Forces of the Russian Federation in 2007, he continued his career as deputy director for special topics at the Federal State Budgetary Institution Research Institute of Industrial and Marine Medicine of the Federal Medical and Biological Agency of Russia. O.K. Bumay developed origins medical support system for the domestic nuclear submarine fleet. Was appointed on the post the head of the ship’s medical service and after that officer of the command-and-control body of an operational-tactical formation. Throughout their career he left a multifaceted scientific and practical legacy, which is used by new generations of naval doctors.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"52 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140672558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nodopathy: clinic, diagnosis, treatment. Clinical description","authors":"Al'bert R. Bulatov, I. Litvinenko, Nikolay V. Tsygan, Sergei N Bardakov, Aleksandra A. Boykova, Tatyana A. Kolesnik, Lyudmila S. Onishchenko","doi":"10.17816/rmmar611154","DOIUrl":"https://doi.org/10.17816/rmmar611154","url":null,"abstract":"AIM: Evaluation of the significance and possibilities of laboratory-instrumental diagnostic methods in establishing the diagnosis and selection of targeted therapy in patients with nodopathies. \u0000MATERIALS AND METHODS: System analysis of data from foreign and domestic literature with the presentation of a clinical case. \u0000RESULTS: Polyneuropathies are classified as demyelinating or axonal based on electrophysiological studies. However, in 2015, in addition to axonal and demyelinating neuropathies, it was proposed to distinguish a separate pathophysiological group — nodopathies. The pathogenesis of nodopathies may differ depending on the type of ion channels involved in the process, but always leads to a loss of excitability of the axon membrane; in the nodal region the membrane becomes inexcitable. Such neuropathies are characterized by transient conduction blocks followed by the development of axonal degeneration. Typical examples of nodopathies are acute motor axonal neuropathy, as well as multifocal motor neuropathy. Current pathophysiological understanding of specialized nodal regions (nodes of Ranvier) and associated axoglial proteins is growing. Hypotheses have been put forward about their role in the pathogenesis of immune-mediated attack on the peripheral myelinated axon. Recently, high titers of antibodies directed against a number of key adhesion molecules have been identified in both acute and chronic inflammatory neuropathies. These facts add to the differences in differential diagnosis between axonal and demyelinating peripheral neuropathies. New disease classification schemes based on seropositivity, improved electrophysiological and ultrasound classification, and identification of putative underlying pathological targets and mechanisms are being rapidly developed. \u0000CONCLUSION: Using our clinical example, we demonstrated the capabilities of laboratory and instrumental diagnostic methods in establishing a diagnosis in a patient with one of the forms of nodopathies — multifocal motor neuropathy.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"5 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138586221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography with angiography in the diagnosis of Alzheimer’s disease","authors":"E. S. Strumentova, V. Lobzin, Dmitriy S. Mal'tsev, M. A. Burnasheva, Maria M. Mosina, Almira A. Khasanova, Anna N. Doronina","doi":"10.17816/rmmar492301","DOIUrl":"https://doi.org/10.17816/rmmar492301","url":null,"abstract":"BACKGROUND: Alzheimer’s disease is becoming increasingly common and the number of patients with dementia is steadily increasing. Existing diagnostic methods (neuropsychological testing, cerebrospinal fluid examination, magnetic resonance imaging, and positron emission tomography) are either subjective, inaccessible or invasive and expensive, therefore the search for new methods of Alzheimer’s disease diagnosis is necessary. The retina and the human brain share a common embryonic origin. The use of optical coherence tomography with angiography can help in the diagnosis of the disease, especially at an early stage. \u0000AIM: To perform a comparative analysis of the vascular density of the peripapillary region of the human retina with the severity of cognitive impairment and atrophic changes according to MRI in patients with Alzheimer’s disease. \u0000MATERIALS AND METHODS: Thirty patients participated in the study: 20 with Alzheimer’s disease and 10 in the control group. All patients underwent collection of complaints and history, general neurological and ophthalmological examination to evaluate inclusion and noninclusion criteria. Subsequently, neuropsychological testing, magnetic resonance imaging of the brain with assessment according to standardized neuroimaging scales, and optical coherence tomography with angiography according to a standard protocol were performed. The results were processed using the Statistica 10 software package (StatSoft, USA). \u0000RESULTS: Assessment of retinal microvascular bed condition in Alzheimer’s disease patients revealed a significant level of relative vascular density reduction in the upper half of radial peripapillary plexus of the retina due to reduction of small vessel density (p = 0.02). There was a direct correlation between the severity of the decrease in the FCSRT total score and changes in vascular density in the nasal sector of the retina (r = 0.52). There was a significant inverse relationship between vascular density in the temporal sector and the final GCA score for patients with Alzheimer’s disease (r = 0.57). The Fazekas scale score revealed an inverse correlation between its score and the vascular density in the upper retinal half and its upper sector (r = 0.53). \u0000CONCLUSION: Оptical coherence tomography with angiography is a highly informative and promising method for early, including pre-diagnosis of Alzheimer’s disease, which is considerably more accessible and accurate than other techniques.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of blast-induced traumatic brain injury","authors":"Vasiliy O. Nikishin, I. Litvinenko, K. M. Naumov","doi":"10.17816/rmmar611153","DOIUrl":"https://doi.org/10.17816/rmmar611153","url":null,"abstract":"Traumatic brain injury, despite its prevalence and study, is the most urgent issue of medicine in clinical, social and military-medical significance. In Russia, about 500 thousand people receive a traumatic brain injury every year, and the damage to the country’s economy exceeds 500 billion rubles a year. Traumatic brain injury is damage by mechanical energy to the skull and intracranial contents (brain, meninges, vessels, cranial nerves), accompanied by clinical symptoms and, in most cases, morphological changes. Recently, blast-induced traumatic brain injury has acquired particular importance, which is due to the change in modern tactics of warfare and the predominance of explosive trauma in the structure of all injuries. The features of blast-induced traumatic brain injury are associated with a variety of factors affecting a person (shock wave, light, heat radiation, fragments, etc.). Such a multifactorial effect on a person makes it difficult to identify a blast-induced traumatic brain injury, especially a brain concussion. This is due to a possible combination of damage to different organs and systems of a person during an explosion, which can simulate or mask a brain concussion. When diagnosing a traumatic brain injury, it is especially important to assess the circumstances and information from witnesses of the event, which often presents a certain complexity in the conditions of hostilities. Currently, methods for detecting symptoms of instability, visual and disorders of other sensory systems involved in maintaining balance are considered as a promising direction for the diagnosis of mild traumatic brain injury. It is also important to note that patients who have suffered a traumatic brain injury have a risk of developing neurodegenerative diseases. All this further emphasizes the relevance of traumatic brain injury and the existing need to develop an optimal algorithm for the examination of such patients.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"5 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epilepsy, epileptoma, surgery (based on clinical case data)","authors":"Ekaterina S. Mongaleva, Polina A. Lyubimova, Ekaterina V. Gyulova, Nina O. Den'gina, G. V. Odintsova","doi":"10.17816/rmmar607448","DOIUrl":"https://doi.org/10.17816/rmmar607448","url":null,"abstract":"Tumor-associated epilepsy is a comorbid disease with focal symptoms or focal, bilateral tonic-clonic seizures. This paper presents the case of a 36-year-old woman hospitalized due to frequent generalized seizures with focal onset and marked pharmacoresistance. The first epileptic seizure occurred at the age of 23 at night during sleep, manifested by tonic seizures with turning of the head to the right, impaired consciousness. The patient took lamotrigine and lacosamide, which resulted in remissions, but freedom from seizures was not achieved. MRI revealed structural changes in the medio-basal regions of the right temporal lobe. PET-CT revealed signs of metabolically active tumor tissue in the right temporal region.Based on the findings, it was concluded that the patient had a ganglioglioma. The patient underwent selective resection of the area of structural changes in the basal parts of the right temporal lobe. By the time of her discharge from the hospital on the 10th day after the surgical intervention, her general condition had fully recovered, no generalised seizures were noted in the postoperative period. During the evaluation of the catamnesis, an isolated aura occurred once. The presence of the disease significantly impaired the patient’s work activity, quality of life and socialisation and led to a depressive episode. This surgical intervention significantly reduced the patient’s quality of life. Thus, tumor-associated epilepsies caused by epileptomas are characterized by pharmacoresistance. Drug treatment did not have a stable effect and the course of the disease was accompanied by a recurrence of seizures. Surgical treatment is the method of choice. With the development of modern neurosurgery, cognitive functions could be preserved despite the long history of the disease.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of diagnosis, treatment and curation of patients with neuropathic pain syndrome of traumatic genesis","authors":"S. Kolomentsev, I. Litvinenko, Nikolay V. Tsygan, Al'bert R. Bulatov, Alexey I. Gayvoronsky, Anna V. Kolomentseva, Natalia Y. Polushina, A. V. Ryabtsev, Vladimir A. Panov, E. I. Shermatyuk, Peter A. Polezhaev, Anna A. Kirpichenko, Marina S. Yaroslavtseva","doi":"10.17816/rmmar611148","DOIUrl":"https://doi.org/10.17816/rmmar611148","url":null,"abstract":"BACKGROUND: The existing international and national clinical recommendations for the treatment of neuropathic pain syndrome are based mainly on the experience of providing care to patients with non-traumatic genesis of neuropathic pain. Approaches to the diagnosis, treatment and curation patients with neuropathic pain syndrome due damage of the nervous system as a result of wounds received during hostilities may differ from those in patients with somatic diseases. \u0000AIM: To systematize the features of medical care and improve the methodological approach of curation patients with traumatic neuropathic pain syndrome. \u0000MATERIALS AND METHODS: The practical experience of providing assistance to the wounded with traumatic lesions of the peripheral nervous system (including patients with phantom pain syndrome) accumulated by the staff of the Department and the Clinic of Nervous Diseases Military Medical Academy for 2022–2023 is summarized. \u0000RESULTS: The features of inpatient routing, diagnosis, treatment and organization of medical care for patients with traumatic neuropathic pain syndrome at the stage of a specialized medical institution are systematized. The practical aspects of the curation patients with neuropathic pain due to wounds received during hostilities, related to the appointment of medications (including narcotic analgesics), regional anesthesia and the provision of neurosurgical care are highlighted. A separate emphasis is placed on the importance of assessing the mental state and quality of sleep of the wounded with neuropathic pain syndrome, the features of drug correction identified disorders. Practical recommendations for the treatment of patients based on the results of assessing the severity neuropathic pain syndrome using a daily graphic pain diary are presented. \u0000CONCLUSION: The revealed differences in therapeutic and diagnostic approaches in providing medical care to the wounded with traumatic neuropathic pain syndrome, the importance of interdisciplinary interaction different specialties doctors (neurologists, surgeons, traumatologists, neurosurgeons, psychiatrists) at the early stages of treatment indicate the need to develop separate recommendations for the treatment of neuropathic pain in victims of armed conflicts.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The method for assessing the severity and monitoring the effectiveness of treatment neuropathic pain syndrome","authors":"S. Kolomentsev, Anna V. Kolomentseva, Peter A. Polezhaev, Marina S. Yaroslavtseva, Anna A. Kirpichenko, A. V. Ryabtsev, Natalia Y. Polushina, Nikolay V. Tsygan, I. Litvinenko","doi":"10.17816/rmmar611147","DOIUrl":"https://doi.org/10.17816/rmmar611147","url":null,"abstract":"The existing difficulties in objectifying the patient’s complaints about the severity of the pain syndrome create the need to create new practical tools for assessing its intensity, as well as monitoring the effectiveness of treatment. Based on the accumulated experience of providing care to patients with neuropathic pain syndrome of traumatic genesis, the staff of the M.I. Astvatsaturov Clinic of Nervous Diseases of the Kirov Military Medical Academy has developed a method for assessing the severity and monitoring the effectiveness of treatment of neuropathic pain syndrome. The method is based on the patient’s auto-monitoring of his pain sensations during one day with the sequential fixation of the average hourly indicator of the severity of the pain experienced on an 11-point digital rating scale, as well as indicating the duration and quality of sleep in a daily graphic pain diary. The doctor evaluates the average daily and total daily pain indicators, as well as sleep parameters. The developed method has high visibility and reproducibility, has been tested, implemented and is used at the Kirov Military Medical Academy in the treatment of patients with neuropathic pain syndrome.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Speech disorders in genetically determined forms of epilepsy in children. Clinical observations","authors":"Valentina I. Guzeva, Yulia A. Eremkina, O. Guzeva, V. V. Guzeva, D. A. Malekov, Viktoriya A. Vedernikova","doi":"10.17816/rmmar585236","DOIUrl":"https://doi.org/10.17816/rmmar585236","url":null,"abstract":"BACKGROUND: Speech disorders in children are one of the pressing problems of child neurology. In recent years, much attention has been paid to studying the genetic aspects of the development of speech disorders in children with epilepsy. Speech function in childhood is vulnerable, and its violation has a number of significant consequences. Specialists from different disciplines focus on specific aspects of speech disorders. Speech therapists consider speech disorders based on linguistic criteria, psychologists evaluate the psychological characteristics of children with speech disorders. The rapid development of genetic research, the availability of many molecular genetic tests, especially such a method as next generation sequencing, allowed us to pay more attention to the study of genetic aspects of the development of speech disorders in children with epilepsy. \u0000AIM: to present options for speech disorders in genetically determined forms of epilepsy in children based on clinical examples. \u0000RESULTS: The article analyzes 3 clinical cases of epilepsy in children, combined with speech pathology (2 boys and 1 girl aged 2 to 5 years). The data of anamnesis of life and disease, neurological examination with assessment of speech function, results of genetic research, electroencephalographic examination and magnetic resonance imaging are presented. \u0000CONCLUSION: All patients are united by a combination of speech disorders, epileptic seizures, and the presence of genetic pathologies that are responsible for speech function. These clinical observations demonstrate the need for a comprehensive, multidisciplinary approach both at the stage of early diagnosis of speech impairment in children with epileptic seizures and at the stage of further treatment of such patients.","PeriodicalId":167099,"journal":{"name":"Russian Military Medical Academy Reports","volume":"17 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138585458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}