Middle Black Sea Journal of Health Science最新文献

{"title":"Relationship of thyroid function with metabolic parameters in euthyroid adults","authors":"Gülsen Sener","doi":"10.19127/mbsjohs.1215262","DOIUrl":"https://doi.org/10.19127/mbsjohs.1215262","url":null,"abstract":"Background: Thyroid hormones have a significant effect on carbohydrate, lipid metabolism disorders, and insulin resistance (HOMA-IR) development. Vitamin D (25(OH)D) has been shown also can affect almost all tissues in the body, including the thyroid, except the musculoskeletal system in recent years. In the study, we aim of this study is to investigate the relationship between the levels of thyroid-stimulating hormone (TSH) within the reference range and metabolic parameters in adults. \u0000Materials and Methods: 561 adult outpatients were divided into 2 groups low normal range (0.27-2.5 mIU/mL) and high normal range (2.5-4.2 mIU/mL) according to TSH, and HOMA-IR, 25(OH)D, and lipid levels were compared. \u0000Results: A statistically significant positive correlation was found between TSH and HOMA-IR in both the low normal range group (r = 0.123, p = 0.041) and the high normal range group (r = 0.196, p = 0.001). In the high normal range group, the relationship between TSH with vitamin D (r =-0.200, p =0.003), cholesterol (r =0.143, p =0.024), LDL cholesterol (r =0.154, p =0.018), non-HDL cholesterol (r = 0.134, p = 0.035) levels was statistically significant. \u0000Conclusion: Our study shows that high normal TSH levels in euthyroid adults are related to higher insulin resistance and lower 25(OH)D levels, and this interaction is a major contributor to dyslipidemia. Thyroid hormones explain the metabolic disorder in the early stages of T2DM. Therefore, we believe that screening TSH levels and determining the optimal TSH target will be beneficial.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130347307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypernatremia in Critically Ill COVID-19 Patients: Is it a manifestation of COVID-19 or acquired in the ICU?","authors":"Özgür Kılıç, M. Polat, Kamil Sannah, M. Dilek","doi":"10.19127/mbsjohs.1225466","DOIUrl":"https://doi.org/10.19127/mbsjohs.1225466","url":null,"abstract":"Objective: It has been noted that COVID-19 patients experienced electrolyte problems more frequently, and these disturbances were linked to unfavorable results. The purpose of this study was to investigate the incidence and consequences of hypernatremia in severely ill COVID-19 patients receiving intensive care (ICU). \u0000Methods: Retrospective data analysis was done on COVID-19 patients who were admitted to ICUs over a six-month period at two centers. \u0000Results: Data from 270 patients were collected in total. 138 (51%) patients developed hypernatremia (Na >145 mmol/l) during ICU stay. Hypernatremia was observed to be more in older or ventilated patients, whereas less in patients with chronic kidney disease. However, in patients with and without hypernatremia, unfavorable outcomes like length of stay (LOS) or mortality were comparable. Frequency of hypertension, septic shock as well as SOFA score, and serum BUN levels were significantly higher in moderate to severe hypernatremic (Na ≥150 mmol/l) vs mild hypernatremic (Na=146-149 mmol/l) group. Moderate to severe hypernatremia had worse prognosis than the mild group: ICU LOS (12 vs 9 day, p=0.033), ICU mortality (86% vs 61 %, p=0.001 and 28-day mortality (89% vs 68%, p=0.004). Eelevated serum BUN levels and moderate to severe hypernatremia were independent predictors of both ICU and 28-day mortality. \u0000Conclusions: Critically ill COVID-19 patients experienced hypernatremia more frequently than expected, suggesting that hypernatremia may be a manifestation of systemic involvement of COVID-19 rather than iatrogenic. Patients with and without hypernatremia were found to have similar outcomes.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122280732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE RELATIONSHIP BETWEEN CORONARY SLOW FLOW AND MYOCARDIAL ISCHAEMIA EVALUATED WITH TIMI FRAME COUNT AND MYOCARDIAL PERFUSION SCINTIGRAPHY","authors":"Mehmet Zeki Yilmazteki̇n, O. Kayapınar, Gulşah Aktüre, Muhammet Aşik, Hamdi Afsin","doi":"10.19127/mbsjohs.1155632","DOIUrl":"https://doi.org/10.19127/mbsjohs.1155632","url":null,"abstract":"THE RELATIONSHIP BETWEEN CORONARY SLOW FLOW AND MYOCARDIAL ISCHAEMIA EVALUATED WITH TIMI FRAME COUNT AND MYOCARDIAL PERFUSION SCINTIGRAPHY \u0000 \u0000ABSTRACT \u0000Aim: Coronary slow flow (CSF) is known as a form or early stage of common atherosclerotic disease. Myocardial perfusion scintigraphy (MPS) is a valuable technique in the diagnosis of coronary artery disease and prediction of prognosis. The aim of this study was to investigate the relationship between the myocardial defect score and ischaemia in patients with CSF. \u0000 \u0000Method: A total of 169 patients who applied with the complaint of angina pectoris and underwent SPECT as a non-invasive test followed by coronary angiography were included in this retrospective study. 10 patient was excluded from the study for various reasons. The study population comprised 91 (58%) determined with CSF and no obstructive stricture in the coronary arteries and 68 (42%) with normal flow. The mean age of the patients was 56±12 years. The scores obtained from Quantitative Perfusion SPECT (QPS) and Quantitative Gated SPECT (QGS) software were used in the myocardial perfusion evaluation. The TIMI frame counts were compared with the myocardial defect and ischaemia scores. The TIMI frame count method was used in the determination of CSF. In patients with slow flow in the circumflex (Cx) coronary artery, the stress total perfusion defect Cx (sTPD-Cx) was found to be 0.1 (range, 0.0-1.3), and in those with normal flow, it was 0.0 (range, 0.0-0.28) (p=0.002). The stress score Cx (sscore-Cx) was found to be 1.0 (range, 0.0-3.0) in patients with slow flow and 0.0 (range, 0.0-2.0) in those with normal flow (p=0.031). A linear correlation was determined between the Cx TIMI frame count and the sTPD-Cx and sscore-Cx values (r=0.207, p=0.009; r=0.159, p=0.045). No relationship was found between slow flow and the defect and ischemia scores in other myocardial regions. \u0000Conclusion: In patients with slow flow in the Cx coronary artery, the sTPD-Cx and the sscore-Cx values were found to be significantly high. Although at a weak level, a linear correlation was found between the Cx TIMI frame count and the sTPD-Cx and the sscore-Cx values. \u0000Key Words: Coronary slow flow, TIMI frame count, myocardial perfusion scintigraphy","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133268713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weight Drop Models in Traumatic Brain Injury","authors":"Yusuf Müslüm Ergül, Görkem Can Öksüz, G. Akcay","doi":"10.19127/mbsjohs.1187145","DOIUrl":"https://doi.org/10.19127/mbsjohs.1187145","url":null,"abstract":"Traumatic Brain Injury (TBI) is the firstly reason of mortality and morbidity for around the world. After TBI motor, cognitive and sensorial disfunction are typically seen. TBI causes serious health problem like death, disability and mental disorder. TBI is going to be an increasing public health problem for all around the world. According to estimates for every year approximately 1.7 million people undergo head trauma and from these people approximately 50.000 people losing their lives. TBI can seen at every age and population although this case seen mostly children and old persons. Falling, sporting activities and motor vehicle accident these are the top risk factors for traumatic brain damage. Before development diagnosis and therapeutic approaches for traumatic brain damage need to known neuropathologic underlying results and cellular mechanisms. Therefore, different models of mild, moderate and severe experimental traumatic brain damage models are used. Animal models of TBI are broadly classified as focal, diffuse, and mixed injury. Fluid percussion, controlled cortical effect, falling weight and blast wave are most preferred models in TBI experimental research. In this chapter strong and weak sides of existing rodent models for TBI are going to explain.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123792222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy Rats of Transcranial Direct Current Stimulation Enhance Learning and Memory","authors":"G. Akcay","doi":"10.19127/mbsjohs.1207315","DOIUrl":"https://doi.org/10.19127/mbsjohs.1207315","url":null,"abstract":"ABSTRACT \u0000Objective: The brain plays a vital role in physiological functions such as sleep, wakefulness, cognitive and physical activities such as learning and memory. Glutamate is the main excitatory neurotransmitter responsible for learning and memory, and is mostly released in the hippocampus, the learning and memory area of the brain. tDCS has a neuromodulatory effect on membrane potential in the glutamatergic pathway. The hippocampus plays a fundamental role in neuronal plasticity, learning, and spatial memory. Our aim in this study is to investigate the effects of tDCS stimulation, which is known to be effective on AMPA and NMDA, with different anodal and cathodal stimulation types and 0.25 mA and 0.5 mA current intensities on learning and memory by behavioral and molecular mechanisms. \u0000Methods: 50 male Wistar rats weighing 290-310 g were divided into 5 groups as control, C1-tDCS, C2-tDCS, A1-tDCS and A2-tDCS. In the C1-tDCS group, 0.25 mA cathodal tDCS stimulation for 30 min per day for 5 days, in the C2-tDCS group for 30 min per day for 0.5 mA cathodal tDCS stimulation for 5 days, in the A1-tDCS group for 5 days with 0.25 mA anodal tDCS stimulation for 30 min per day and A2-tDCS group The tDCS group received 0.5 mA anodal tDCS stimulation for 30 minutes per day for 5 days. On the 6th and 7th days of the experiment, the locomotor activity, learning and memory behaviors of the rats were evaluated by open field test, y maze test and object localization test. In addition, glutamate levels were measured in hippocampus tissues by ELISA method. \u0000Results: It was observed that there were non-significant decreases in the results of the C1-tDCS and C2-tDCS groups in which cathodal stimulation was applied compared to the control group in locomotor activity, learning and memory data. On the other hand, an increase was observed in the data of the A1-tDCS and A2-tDCS groups in which anodal stimulation was applied, and the increase in the data of the A2-tDCS group from these groups was found to be statistically significant compared to the control (p","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116671128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Burrhole Craniostomy in Chronic Subdural Hematoma. A Retrospective 9-Year Study","authors":"Hıdır Özer, Ö. Şahin","doi":"10.19127/mbsjohs.1179140","DOIUrl":"https://doi.org/10.19127/mbsjohs.1179140","url":null,"abstract":"Aim: To demonstrate the effectiveness, possible complications, and difference of Burr-hole craniostomy surgical technique applied to patients diagnosed with chronic subdural hematoma from other surgical techniques. \u0000Material and Methods: The surgical techniques and postoperative clinical and radiological details of 36 patients who were operated on with the diagnosis of chronic subdural hematoma in the Neurosurgery Clinic of Ordu University Training and Research Hospital between 01.01.2013 and 15.08.2022 were retrospectively analyzed. \u0000Twenty-eight (77.7%) of the cases were male and 8 (22.3%) were female. The mean age was 70, with an age range of 54-87. Ten of the cases had a GCS of 15 (28%), 20 had a GCS of 13-14 (56%), and 6 had a GCS of 8-12. The most prominent complaints of the patients were headache and confusion. While 22 patients (61.1%) had a history of head trauma, 14 patients (38.9%) had no history of trauma. There was a history of anticoagulant or antiaggregant drug use in 9 patients (25%). \u0000In all patients in the post-op period, control brain CT was taken within the first 24 hours and compared with the pre-op CT. Again, at the end of post-op 1st, 2nd week and 1st month, control brain CT was taken for all patients and GCS was compared with pre-op scores. After determining the post-op complications, the treatment and results of these complications were examined. \u0000Results: In all patients in the post-op period, control brain CT was taken within the first 24 hours and compared with the pre-op CT. Again, at the end of post-op 1st, 2nd week and 1st month, control brain CT was taken for all patients and GCS was compared with pre-op scores. Craniotomy + membranectomy was performed in 6 patients because of residual bleeding in the post-op period and no improvement in their neurological status. One of the patients who were operated on by craniotomy died due to sepsis in the later period. One patient who was operated on with Burr-Hole developed motor dysphasia in the post-op period, and intraparenchymal hemorrhage was detected in the post-op tomography of this patient. This patient's dysphasia resolved at the end of the post-op 1 month. Although pneumocephaly developed in the post-op period in 9 patients who underwent burr-hole craniostomy, they did not require surgical treatment and were observed to be spontaneously resorbed. In addition, wound site infection developed in the post-op period in 4 patients who underwent Burr-hole craniostmia. Appropriate antibiotic therapy was given to these patients. At the end of the first week, radiological examination of 18 patients with CT showed no residual hematoma or recurrent hematoma. The radiological improvement of 10 patients was completed at the end of the 1st month and the radiological recovery of 7 patients was completed at the end of the 3rd month. Post-op clinical and radiological results of patients who underwent burr-hole craniostomy were significantly better than pre-op clinical and radiologica","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133243366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the effect of bleaching on discolored teeth after regenerative treatment on fracture resistance of teeth","authors":"Funda Fundaoğlu Küçükekenci","doi":"10.19127/mbsjohs.1196394","DOIUrl":"https://doi.org/10.19127/mbsjohs.1196394","url":null,"abstract":"Objective: This study aimed to evaluate the effect of bleaching discolored teeth after regenerative endodontic treatment on fracture resistance. \u0000Methods: Forty human maxillary incisors were selected for the study and were divided into four study groups (n=10). Group 1 was called the positive control group and no treatment was applied. In Group 2; root canals were enlarged to size 6 peezo reamer bur to mimic an immature tooth. The disinfection protocol was performed according to the regenerative endodontic treatment protocol of the American Association of Endodontists. 3 mm thick MTA was placed at the cementoenamel margin and restored with a temporary restorative material. The samples in group 3 were restored with glass ionomer and composite resin. In Group 4 bleaching was applied with 35% hydrogen peroxide bleaching agent to the samples before restoration with glass ionomer and composite resin. Then each group were applied to the fracture resistance test with a universal testing machine. The fracture resistance values were recorded in Newtons (N), and the obtained data were analyzed statistically. \u0000Results: While the highest fracture strength was obtained in group 1 (1092 ±9.27N), the lowest fracture resistance was observed in group 2 (493.8 ±7.60N). The difference between all groups was statistically significant (p","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125130060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are Prostate Cancer Screenings Performed in Compliance with Cancer Guidelines?","authors":"I. Nalbant, Erdal Benli, Abullah Çirakoğlu, M. Keles, Ibrahim Yazici, A. Acet","doi":"10.19127/mbsjohs.1184893","DOIUrl":"https://doi.org/10.19127/mbsjohs.1184893","url":null,"abstract":"Are Prostate Cancer Screenings Performed in Compliance with Cancer Guidelines? \u0000Aim: This study aims to examine whether our region's Prostate Cancer (PCa) screening programs comply with the European Association of Urology (EAU) Guidelines. \u0000Method: This study was conducted as a retrospective, cross-sectional study between April 2014 and July 2022. Two hundred seventy patients who applied to our clinic for various reasons and were diagnosed with PCa were included in the study. Characteristics of the patients, such as age at diagnosis, comorbidities, age at first PSA examination, and PSA values, were recorded. \u0000Results: At the time of diagnosis of cancer, the mean age of the patients was 67.42±8.64 (43-91) years, and the PSA value (median±IQR) was 9.58±19.43 (1.83-3437) ng/ml. The age of the first urological examination was 63.14±8.31 (40-91) years. Only 31.3% of the patients were regularly followed up by a specific urology doctor. When the distribution of cancer was investigated, there were in the 40-50 age range 5(%1,8), 50-60 age range 44(%16,1), 60-70 age range 111(%40,7), 70-80 age range 86(%31,5) and over the 80 age 24(%8,8) patients. While 138(51.1%) patients had local and good tumor characteristics, 59(21.9%) patients were diagnosed with metastatic findings.The mean age of the patients at the time of cancer diagnosis was 67.42±8.64 (43-91) years. PSA value (median±IQR) at the diagnosis was 9.58±19.43 (1.83-3437) ng/ml. When the distribution of cancer according to different decades of life was examined, there were 5 (%1.8) patients in the 40-50 age range, 44 (16.1%) in the 50-60 age range, 111 (40.7%) in the 60-70 age range, 86 (31.5%) in the 70-80 age range, and 24 (8.8%) after the age of 80. While 138 patients (51.1%) had local and benign tumor features, 59 (21.9%) patients were diagnosed with metastatic findings. Only 31.3% (61/195) of the patients were under regular follow-up by a specific urology doctor. \u0000Conclusion: It was found that the screening of prostate cancer, the most common type of cancer in men, was not performed by the guidelines, and as a result, diagnosis and treatment were delayed. It was determined that many patients lost the chance of curative treatment. In this disease, where early diagnosis is vital for effective treatment and preservation of quality of life, it is essential to follow up with aging men in accordance with the guidelines. It may be beneficial to periodically train and follow up with all health professionals interested in this issue. \u0000Key Words: EAU Guidelines, Prostate cancer, Age","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116749747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiological Evaluation of the Relationship between Plantar Fasciitis and Foot Arch Angles in Adults: A Descriptive Cross-sectional Study","authors":"M. Boz, A. Şahin, M. Akçiçek","doi":"10.19127/mbsjohs.1183351","DOIUrl":"https://doi.org/10.19127/mbsjohs.1183351","url":null,"abstract":"Abstract \u0000Objective: The foot arch deformation increases plantar fasciitis (PF) and plantar calcaneal spur (PCS) formation. As a result, the heel fat pad becomes thinner. This study investigated the relationship between plantar fasciitis and foot arch angles. \u0000Methods: We performed a retrospective review of patients who had PF patients (n = 53) and healthy individuals (n = 71) without PF. We have evaluated the presence of PCS and heel fat pad thickness measurements on magnetic resonance imaging (MRI), and the lateral talus-first metatarsal angle (Meary’s angle), lateral talocalcaneal angle, and calcaneal inclination angle measurements were performed on X-ray images. \u0000Results: The mean age of the PF group was significantly higher than the control group (p = 0.001). The degrees of Meary’s angle and calcaneus inclination angle were significantly higher in the PF group (p < 0.001 and p = 0.026, respectively) than in the control group. The incidence of PCS was significantly higher in the PF group (p = 0.028). In the binary logistic regression analysis model, high Meary’s angle and calcaneal pitch angle were found to be associated with the risk of PF. There was also a significant association between age and the presence of PCS and PF. \u0000Conclusion: Changes in Meary’s angle and calcaneal pitch angle were significant risk factors for PF.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134334899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the efficiency of neuronavigation in patients with glioblastoma","authors":"Bülent Gülensoy","doi":"10.19127/mbsjohs.1158897","DOIUrl":"https://doi.org/10.19127/mbsjohs.1158897","url":null,"abstract":"Objective: To investigate the effect of neuronavigation use on mortality in patients with glioblastoma. \u0000Methods: Neurosurgical Clinic of Lokman Hekim Hospital; For each of the 26 patients who underwent navigation-assisted supratotal resection for glioblastoma between 2018 and 2020, one patient who underwent supratotal resection without navigation was selected. \u0000Results: Radiographic radicality was seen in 35% of cases with navigation and in 29% of cases with conventional surgery. Absolute and relative residual tumor volumes were significantly lower with neuronavigation. Radical tumor resection was associated with a very significant increase in survival. There was no significant difference in survival rates between patients operated on with neuronavigation and patients operated on without neuronavigation. This is because the small number of subjects participating in the study was statistically determined and supratotal resection was performed in all patients. In addition, it should not be ignored that the low median surveillance duration of glioblastoma may also contribute. \u0000Conclusions: Surgery plays an important role in the treatment of glioblastoma. A combination of techniques such as intraoperative MRI, neuronavigation, ultrasound, and fluorescence-guided surgery allows safe and maximal surgical resection, leading to a better outcome in terms of survival and postoperative functional recovery. Despite maximal surgical resection and adjuvant chemoradiography, tumor recurrence occurs within 10 months in many cases thought to be due to established cancer stem cells. The development of more effective treatment strategies for glioblastoma is urgently needed.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123963835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}