Middle Black Sea Journal of Health Science最新文献

{"title":"Endometrioma cerrahisinde kistektomi over rezervini olumsuz etkiler: Kistektomi öncesi ve sonrası serum FSH, AMH ve AFC'nin karşılaştırılması","authors":"Fatma TANILIR ÇAĞIRAN, Zercan Kali","doi":"10.19127/mbsjohs.1266532","DOIUrl":"https://doi.org/10.19127/mbsjohs.1266532","url":null,"abstract":"Objective: Surgical removal of endometriomas, even if performed in experienced hands, leads to a decrease in ovarian reserve in varying degrees depending on age. This study was designed to determine the pre- and post-surgical changes of ovarian reserve markers in patients who underwent endometrioma cystectomy. \u0000Materials and Methods: Fourteen normo-ovulatory women aged between 21-36 were included in the study. In addition to serum anti-Mullerian hormone (AMH), FSH and estradiol levels, antral follicle count (AFC) was evaluated before and 3 months after cystectomy. Ovarian damage was avoided as much as possible during endometrioma surgery. \u0000Results: After endometrioma cystectomy, serum AMH levels were significantly decreased (3.21 ± 1.1 ng/ml vs 1.9 ± 0.6 ng/ml; p< 0.02). There was no significant change in serum FSH (5.97 ± 1.6 mIU/mL vs 7.34±0.55 mIU/L, p","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"100 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132866898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the Effectiveness of Cl-Amidine on Wound Healing: An In Vitro Study","authors":"Pınar Naile Öğüten, Selin ENGÜR ÖZTÜRK, M. Dikmen","doi":"10.19127/mbsjohs.1315678","DOIUrl":"https://doi.org/10.19127/mbsjohs.1315678","url":null,"abstract":"Abstract \u0000Objective: Peptidylarginine deiminases (PADs) are enzymes converting the arginine to citrulline. They play a role in embryogenesis and cell signaling activities. But excessive or dysregulated PAD levels were determined to be associated with disorders and to increase in many diseases. It has been shown that Chloramidine (Cl-amidine) used as a PAD inhibitor suppresses increased PAD activity and shows anti-cancer, anti-inflammatory and antioxidant activities. Anti-inflammatory and antioxidant properties play an important role in wound healing. In this study, the possible efficacy of Cl-amidine on wound healing in the keratinocyte cell line was investigated by considering these parameters. \u0000Method: Cell proliferation evaluations of Cl-amidine concentrations (500, 125, 31.25 and 7.81 µM) determined according to the results of MTT method on HaCaT keratinocyte cells were performed using Real-Time Cell Analysis System (RTCA DP). COL1A1 mRNA expression levels were analyzed by RT (Real Time)-PCR (Polymerase Chain Reaction) method at the concentrations where proliferation was achieved (125, 31.25 µM). Migration effects of Cl-amidine on cells were evaluated by performing scratch analysis. MTT results were statistically analyzed with one-way ANOVA and Tukey test, and p","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127974414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of 55 Adult Cases Surgically Treated for Pontocerebellar Angle Tumors","authors":"İbtahim Başar, S. Bahadır, M. Yücel, T. Yilmaz","doi":"10.19127/mbsjohs.1307344","DOIUrl":"https://doi.org/10.19127/mbsjohs.1307344","url":null,"abstract":"Abstract \u0000 \u0000Objective: Pontocerebellar angle (PCA) tumors, although typically of benign nature, are of significant clinical and pathological importance. The aim of this study is to investigate the clinical and pathological characteristics of PCA tumors, as well as surgical outcomes, which hold a significant place in clinical practice. \u0000 \u0000Methods: 55 adult patients who underwent surgery for PCA tumors at the Department of Neurosurgery, Dicle University Faculty of Medicine, between 2013 and 2023 were included in the study. The clinical and pathological records of these patients were retrospectively reviewed. \u0000 \u0000Results: The age of the patients (17 male, 38 female) ranged from 18 to 75 years. According to pathological diagnosis, 23 cases were diagnosed as meningioma, 19 as schwannoma, 6 as epidermoid tumors, 2 as metastases, 1 as hemangioblastoma, 1 as hemangioma, 1 as medulloblastoma, 1 as neuroblastoma, and 1 as small round cell tumor. Gross total resection was achieved in all cases. Overall, 47.3% of the patients had one or more postoperative complications. Postoperative permanent facial palsy developed in 6 patients. The overall mortality rate was 9%. \u0000 \u0000Conclusion: Pontocerebellar angle tumors constitute a significant group among intracranial tumors. Surgical treatment is an important option for the management of these tumors. Primary goal of the surgery is gross total resection which is feasible in today. Though postoperative complications are common, majority of them is temporary.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130360997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Risk Factors and Risky Pregnancies Among Pregnant Women Who Admitted to Hospital for Prenatal Care","authors":"H. Ulubaşoğlu, S. Şahinöz, T. Şahi̇nöz, Pınar Ulubaşoğlu","doi":"10.19127/mbsjohs.1242118","DOIUrl":"https://doi.org/10.19127/mbsjohs.1242118","url":null,"abstract":"Objective: The aim of this study is to determine the frequency of risk factors leading to risky pregnancies which are important for public health, to reveal the reasons and to offer solutions. \u0000Methods: This is a cross – sectional study of 409 married women who applied to the hospital for prenatal care. A questionnaire prepared by the researchers was used for data collection by face-to-face interview technique. Percentage, mean, and chi-square test were used to evaluate the data. \u0000Results: Although pregnancy is a physiological process, 67.7% of the pregnant women had at least one risk factor and 27.6% had more than one risk factor. Risk factors such as having caesarean section, having four or more pregnancies, being 35 and over age, unwanted pregnancy status and having less than two years between the last two pregnancies were found to be the most common risk factors seen in pregnant women. \u0000Conclusion: Because risky pregnancies are an important public health problem and most of them are preventable; preconceptional care should be expanded to control the mother and baby before threatening their health.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133119679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Factors Affecting Severity of Helicobacter Pylori for Gastric Biopsy Samples by CART Decision Tree Algorithm","authors":"T. Yar, Ülkü Karaman, Yeliz Kaşko Arıcı","doi":"10.19127/mbsjohs.1316728","DOIUrl":"https://doi.org/10.19127/mbsjohs.1316728","url":null,"abstract":"Aim:The aim of this study was to determine the factors affecting disease severity in patients with a positive pathologic diagnosis of Helicobacter pylori after gastric biopsy by data mining. It was aimed to utilize the more descriptive structure of data mining algorithms compared to traditional classification and regression approaches. \u0000Methods:The study data were obtained from gastric biopsy samples of 1247 patients, 40.5% male and 59.5% female, who were sent to the pathology laboratory between 2014 and 2018. A total of 6 factors including age, gender, inflammation, metaplasia, atrophy and activation, which are thought to have an effect on gastric H. pylori severity, were examined. Querying the effects of factors was done with the CART (Classification and Regression Trees) decision tree algorithm, one of the data mining algorithms. \u0000Results:The factors ranking as their effect on the severity of gastric h. pylori, as follows; activation > inflammation > metaplasia > atrophy > age > gender in a percentage of normalized importance at 100.00%, 88.6%, 51.4%, 38.1%, 12.8%, 3.3% respectively. \u0000Conclusion:As a result, levels of activation, inflammation, and metaplasia emerged as the most important factors affecting gastric H. pylori severity.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116319675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Approach for Thyroid Cancer Diagnosis Using Clinical Data","authors":"İpek BALIKÇI ÇİÇEK, Zeynep Küçükakçali","doi":"10.19127/mbsjohs.1282265","DOIUrl":"https://doi.org/10.19127/mbsjohs.1282265","url":null,"abstract":"Aim: With an early diagnosis of thyroid cancer, one of the world's most significant health issues, it is feasible to treat the nodules before the spread of malignant thyroid gland cells. It has become crucial to develop models for predicting thyroid cancer. In light of this, the purpose of this study is to develop a clinical decision support model using the Bagged CART model, a machine learning (ML) model for the prediction of thyroid cancer. \u0000Material and Method: Between 2010 and 2012, 724 patients who applied to China Median University Shengjing Hospital comprised the study's data set. The dataset comprise information on nodule malignancies, demographic characteristics, ultrasound characteristics, and blood test results for all patients who underwent thyroidectomy. Using this open-access data set, the Bagged CART modeling technique was applied. Negative predictive value (NPV), specificity (Spe), balanced accuracy (BACC), positive predictive value (PPV), accuracy (ACC), sensitivity (Sen), and F1-score performance metrics were used to evaluate the model's predictive performance. In addition, a 10-fold cross-validation method was used to determine the validity of the model. In addition, variable importance was established, which reveals how much the input variables impact the output variable. \u0000Results: ACC, BACC, Sen, Spe, PPV, NPV, and F1-score obtained from the model performance metrics were calculated to 99.1%, 98.7%, 99.7%, 97.7%, 99.1%, 99.2%, and 99.4%, respectively, as a result of modeling. According to the variable importance values that were acquired for the input variables in the dataset that was investigated in this study, the seven variable that hold the greatest significance are as follows: size, TSH, blood flow: size, TSH, blood flow: enriched, multilateral: yes, FT4, site: isthmus, and age, in that order. \u0000Conclusion: As a result, the Bagged CART model was found to be effective at predicting thyroid cancer based on the findings of this study. In addition, in this study, risk factors for thyroid cancer were evaluated and their importance values were given. With these results, the decision-making process about the disease will be able to accelerate and thus, it will be able to effective in preventive medicine practices.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"658 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116486990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessments of Students' Numeracy Knowledge Levels in Health Literacy and Their Knowledge, Attitude, and Behavior Regarding Antibiotic Use","authors":"A. Aykaç, Banu Tuncay, A. Sehirli","doi":"10.19127/mbsjohs.1276058","DOIUrl":"https://doi.org/10.19127/mbsjohs.1276058","url":null,"abstract":"Objectives: Rational antibiotic use, which is examined under the heading of rational drug use, draws an important road map in the prevention of antibiotic resistance development, which is a global problem that threatens future generations. It was aimed to evaluate the factors that determine the antibiotic use behaviors of students and the level of numeracy knowledge in health literacy, which is effective in reducing unnecessary or incorrect antibiotic use. \u0000Methods: In the study, in which 212 students voluntarily participated, a questionnaire consisting of questions was used, in which socio-demographic characteristics, knowledge, attitudes, and behaviors related to antibiotic use were examined, as well as the level of numerical knowledge in health literacy. \u0000Results: It was found that the average age of participants was 20.33±2.50, and 53.8% were females. It was determined that 77.4% of the participants preferred to go to the doctor when they had any health problems, and the most common reason for using antibiotics was fever (51.4%). The answer given for the \"disease that requires antibiotic use\" question was bacterial infections with 64.6%. Participants' numeracy level in health literacy was questioned with six different questions, and their average score was determined to 8.1±2.0. It was determined that the highest numeracy knowledge level score among the departments belonged to the students of the anesthesia and first and emergency departments. Moreover, it was found that the numeracy knowledge level score in health literacy for females was higher than that of males. \u0000Conclusion: It has been determined that students studying in health sciences have sufficient knowledge about rational antibiotic use and numeracy, but they do not have an excellent level of knowledge yet despite being health students. It is believed that the regulation of the \" rational antibiotic use\" course, which is included in the education curriculum, will be effective in solving this problem.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128973894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Patients with Asthma Attack Followed in the Intensive Care Unit","authors":"S. Karaoğlanoğlu, Ö. Bostan, Serpil Öcal, Ebru ERSOY ORTAÇ, A. Demir, G. Karakaya, A. Kalyoncu","doi":"10.19127/mbsjohs.1289201","DOIUrl":"https://doi.org/10.19127/mbsjohs.1289201","url":null,"abstract":"Abstract \u0000Background/aim: Asthma attack is a critical reason for morbidity and mortality if not treated effectively at the right time. Data about the efficiency of noninvasive and invasive mechanical ventilation (NIV, IMV) in respiratory failure due to asthma attacks are scant. The aim of this study was to investigate the relationship between asthma-related factors, medical and NIV/IMV treatments received in the Intensive Care Unit (ICU), and the mortality rates and length of hospital stay, in asthma attacks. \u0000Methods: The characteristics of patients with severe asthma treated in Hacettepe University Medical ICU for a ten-year period were analyzed from patient records retrospectively. The association between age, sex, comorbidities, asthma duration, treatment, adherence to the treatment, the effectiveness of NIV/IMV treatment if performed, and asthma attack severity, length of hospital stay, and mortality were investigated. \u0000Results: A total of 22 patients were included in this study. In addition to medical treatment, eight (36.6%) patients received NIV, five (22.7%) received invasive mechanical ventilation (IMV), and five (22.7%) patients had both. Four (18.1%) patients died in the ICU. There was no significant relationship between these parameters and length of hospital stay and mortality. The relationship between baseline PaCO2, pH, and HCO3 and the difference of PaCO2, pH, and HCO3¯ changes were significant, indicating the correct and effective use of NIV/IMV. \u0000Conclusion: NIV applications, which have been proven to be effective in hypercapnic respiratory failure, were also found to be effective in hypoxemic respiratory failure due to asthma attacks. The absence of a relationship between the investigated parameters and mortality revealed that the reasons for the mortality might be infections or comorbidities, not the respiratory tract.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115030853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence Of Questionnare Based Food Allergy In Adult Population Of Eastern Blacksea Region of Turkey","authors":"H. Duman, A. B. Dursun","doi":"10.19127/mbsjohs.1177217","DOIUrl":"https://doi.org/10.19127/mbsjohs.1177217","url":null,"abstract":"Objective: Food allergy (FA) is an important public health problem which affects children and adults, its prevelance is increasing with the change of dietary habits in recent years. FA is a life-threatening allergic reaction which can lead to anaphylaxis and is very difficult to treat. In our study, we wanted to contribute to the literature by investigating the prevalence of FA in the Eastern Black Sea Region based on a questionnaire. \u0000Method: This study was planned as a cross-sectional web-based survey study. The questionnaire was prepared including 12 questions related with health problems that develop following food intake. Eastern Black Sea Region of Turkey was chosen as the target group of the study population. The questionnaire was published in local online and printed media during three months and the participants were allowed to fill it out. \u0000Results: The study included 920 people (604 female, 316 male) who completed the questionnaire and 157 (17%) of the participants noted that they had food allergies. The most common allergen foods were spices (15%), tomatoes (10.9%), and cow's milk (7.5%). The most common symptoms were urticaria (63.5%), gastrointestinal symptoms (30.2%), rhinitis (15.1%), oral allergy syndrome (OAS) symptoms (11.3%). Young age (p= 0.004), presence of atopic disease or family history of atopy (p=0.001) were found to be risk factors for the development of food allergy. \u0000Conclusion: The prevalence of self-reported FA based on web based survey in Eastern Black Sea residents is relatively high and specific to the region.","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"137 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122977701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of carbon monoxide intoxication on thiol/disulfide hemostasis","authors":"Özge Ebru DAĞCI VARHAN, Gülşah Çıkrıkçı Işık, M. Eki̇ci̇, Tuba Şafak, Ş. K. Çorbacıoğlu, Y. Çevik","doi":"10.19127/mbsjohs.1280857","DOIUrl":"https://doi.org/10.19127/mbsjohs.1280857","url":null,"abstract":"Objective: Carbon monoxide (CO) poisoning is an oxidative stress factor. The aim of the study is to evaluate impact of CO intoxication on thiol/disulfide homeostasis (TDH), an important antioxidative system of the body. \u0000Methods: This is a prospective study included 84 participants in each group. Blood samples were taken two time in study group (CO intoxication group), before and at the end of the 3rd hour of normobaric oxygen therapy and once in the control group. TDH parameters were studied with an automated assay developed by Erel et al. Statistical analysis done with SPSS program. \u0000Results: Among thiol/disulfide homeostasis parameters, in study group native (sh) and total thiol (tt) levels in samples taken at the beginning of the oxygen treatment were significantly higher than sh and tt levels of the control group [Study group sh: 399.70 μmoll−1 (354.50-423.65), tt: 439.1 μmoll−1 (390.9-467.3) and control group sh: 362.95 μmoll−1 (321.95-401.25), tt: 396.1 μmoll−1 (358.5-435), p=0.01 and p","PeriodicalId":166758,"journal":{"name":"Middle Black Sea Journal of Health Science","volume":"109 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114240985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}