Journal of parenteral science and technology : a publication of the Parenteral Drug Association最新文献_第3页

Chemical stability of the cardioprotective agent ICRF-187 in infusion fluids. 心脏保护剂ICRF-187在输液中的化学稳定性

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-07-01

J H Beijnen, R van Gijn

{"title":"Chemical stability of the cardioprotective agent ICRF-187 in infusion fluids.","authors":"J H Beijnen, R van Gijn","doi":"","DOIUrl":"","url":null,"abstract":"The chemical stability of the cardioprotective agent ICRF-187 in 0.9% sodium chloride and 5% dextrose infusion fluids has been investigated. The admixtures (concentration: 10 mg/mL and 1 mg/mL) were stored in glass bottles or polyvinyl chloride containers at 4 degrees C in the dark and at room temperature (20-22 degrees C) both protected from light and under normal room fluorescent light conditions in a day-night rhythm. Samples withdrawn immediately after preparation and after 6 hours, 1, 2, 3 and 6 days were analyzed using high performance liquid chromatography with ultraviolet detection. Samples were also inspected for visual changes and tested for changes in pH. Chemical stability of ICRF-187 was also investigated as a function of pH (range 1-12) at room temperature. It is concluded that ICRF-187 is slightly more stable in 5% dextrose than in 0.9% sodium chloride infusion fluids. The stability of the drug is not influenced by normal room fluorescent light nor by the type of container material used. Precipitation occurred in both 5% dextrose and 0.9% sodium chloride with a drug concentration of 10 mg/mL and storage in the refrigerator at 4 degrees C. The chemical stability of ICRF-187 in aqueous solution is mainly a function of pH. At pH 1, no decomposition is detected within 24 hours, at pH 7, 35% decomposition occurs in 21 hours, while at pH 12 it degrades completely within 20.5 hours.","PeriodicalId":16667,"journal":{"name":"Journal of parenteral science and technology : a publication of the Parenteral Drug Association","volume":"47 4","pages":"166-71"},"PeriodicalIF":0.0,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19396021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The generalized form of electrical resistance for a frozen matrix of an aqueous solution. 水溶液中冻结基质的电阻的广义形式。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-07-01

S P Sheu, J Willson

引用次数: 0

Enhanced stability of two model proteins in an agitated solution environment using poloxamer 407. 使用poloxam407增强两种模型蛋白在搅拌溶液环境中的稳定性。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-07-01

P L Wang, T P Johnston

{"title":"Enhanced stability of two model proteins in an agitated solution environment using poloxamer 407.","authors":"P L Wang, T P Johnston","doi":"","DOIUrl":"","url":null,"abstract":"To enhance the physical stability of two model proteins during solution agitation, we investigated the interaction of the nonionic surfactant poloxamer 407 (Pluronic F-127) with each protein. Vigorous agitation of aqueous solutions of interleukin-2 and urease which contained no poloxamer 407 and were maintained at 4 degrees C resulted in a greater than 50% loss in the biological activity at 12 and 24 hours, respectively. Similar aqueous solutions which were maintained at 4 degrees C and contained either urease or interleukin-2 and poloxamer 407 at a concentration of 10% w/w and 0.5% w/w, respectively lost negligible biological activity when left undisturbed for 96 hours. Moreover, when aqueous solutions of urease and interleukin-2 which contained poloxamer 407 at a concentration of 10% w/w and 0.5% w/w, respectively were maintained at 4 degrees C and subjected to agitation for 96 hours, no significant loss in the biological activity was observed for either protein. In addition, urease was observed to have increased enzymatic activity at early time points regardless of the hydrodynamic solution conditions and poloxamer 407 concentrations evaluated. In contrast, a negligible enhancement in the biological activity of interleukin-2 was observed when aqueous solutions of the protein were exposed to similar hydrodynamic conditions employed for urease solutions, but different poloxamer concentrations (0% w/w vs. 0.5% w/w). Results of molar ellipticity, [theta], versus wavelength, lambda, profiles using CD spectropolarimetry on individual aqueous solutions of both proteins containing 2% w/w poloxamer 407 were in close agreement to spectrum obtained with each protein in pH = 7 phosphate buffer (PB).(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":16667,"journal":{"name":"Journal of parenteral science and technology : a publication of the Parenteral Drug Association","volume":"47 4","pages":"183-9"},"PeriodicalIF":0.0,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19394593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-process protein degradation by exposure to trace amounts of sanitizing agents. 接触微量杀菌剂导致加工过程中蛋白质降解。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-07-01

L E Kirsch, R M Riggin, D A Gearhart, D S Lefeber, D L Lytle

引用次数: 0

Accumulation model for solutes leaching from polymeric containers. 聚合物容器中溶质浸出的积累模型。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-07-01

D R Jenke, A V Martinez, L A Cruz, S R Zimmerman

引用次数: 0

Studies in phlebitis. VI: Dilution-induced precipitation of amiodarone HCL. 静脉炎的研究。六:稀释诱导胺碘酮盐酸沉淀。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-07-01

G H Ward, S H Yalkowsky

引用次数: 0

Meeting of the Parenteral Society. 肠外注射协会会议。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-05-01

B Reeks

引用次数: 0

Comparative terminal sterilization. 比较终末绝育。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-05-01

W G Lindboe, K Hayakawa

引用次数: 0

IV fluidmakers: preparation of sterile water for injection in a field setting. 静脉注射制液器:在现场环境中制备无菌注射用水。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-05-01

W D Burrows, J H Nelson

引用次数: 0

The validation life cycle. 验证生命周期。

Journal of parenteral science and technology : a publication of the Parenteral Drug Association Pub Date : 1993-05-01

J Agalloco

引用次数: 0