{"title":"New Chemical Scaffolds to Selectively Target the Trypanothione Metabolism","authors":"A. Ilari, G. Colotti","doi":"10.1201/9781351011655-11","DOIUrl":"https://doi.org/10.1201/9781351011655-11","url":null,"abstract":"","PeriodicalId":166352,"journal":{"name":"Medicinal Chemistry of Neglected and Tropical Diseases","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127741011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recent Advances in Repositioning Non-Antibiotics against Tuberculosis and other Neglected Tropical Diseases","authors":"M. Semenya","doi":"10.1201/9781351011655-7","DOIUrl":"https://doi.org/10.1201/9781351011655-7","url":null,"abstract":"","PeriodicalId":166352,"journal":{"name":"Medicinal Chemistry of Neglected and Tropical Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130000968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Renewal of Interest in Nitroaromatic Drugs","authors":"N. Primas, C. Ducros, P. Vanelle, P. Verhaeghe","doi":"10.1201/9781351011655-12","DOIUrl":"https://doi.org/10.1201/9781351011655-12","url":null,"abstract":"","PeriodicalId":166352,"journal":{"name":"Medicinal Chemistry of Neglected and Tropical Diseases","volume":"106 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128127495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Curcumin and Neglected Infectious Diseases","authors":"F. Mazzacuva, A. Cilibrizzi","doi":"10.1201/9781351011655-14","DOIUrl":"https://doi.org/10.1201/9781351011655-14","url":null,"abstract":"","PeriodicalId":166352,"journal":{"name":"Medicinal Chemistry of Neglected and Tropical Diseases","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131942070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Calogeropoulou, George E. Magoulas, Ina Pöhner, R. Wade, Joanna Panecka-Hofman, Pasquale, Linciano, S. Ferrari, Maria Paola Costi, N. Santarém, Ma., Dolores M. Jiménez‐Antón, A. I. Olías-Molero, Anabela, C. Silva, J. M. Alunda
{"title":"Hits and Lead Discovery in the Identification of New Drugs against the Trypanosomatidic Infections","authors":"T. Calogeropoulou, George E. Magoulas, Ina Pöhner, R. Wade, Joanna Panecka-Hofman, Pasquale, Linciano, S. Ferrari, Maria Paola Costi, N. Santarém, Ma., Dolores M. Jiménez‐Antón, A. I. Olías-Molero, Anabela, C. Silva, J. M. Alunda","doi":"10.1201/9781351011655-10","DOIUrl":"https://doi.org/10.1201/9781351011655-10","url":null,"abstract":"The Neglected Tropical Diseases (NTDs) are a group of 17 pathologies, recognized by the World Health Organization (WHO), which are endemic in 149 countries of tropical and sub-tropical areas of the globe, and affect more than one billion people overall (Feasey et al. 2010). The pathologies are all caused by microparasites or macroparasites. Among the diseases provoked by microparasites, three are caused by kinetoplastidae, a group of flagellated protozoa transmitted by insect vectors: Chagas disease, Human African Trypanosomiasis and leishmaniasis. The focus of the present chapter is on the identification of new drugs for the treatment of trypanosomatidic infections such as Chagas disease, caused by Trypanosoma cruzi, and Human African Trypanosomiasis, caused by Trypanosoma brucei (Filardy et al. 2018).","PeriodicalId":166352,"journal":{"name":"Medicinal Chemistry of Neglected and Tropical Diseases","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128805463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}