Neuroprotection - New Approaches and Prospects最新文献

Alzheimer’s Disease Neuroprotection: Associated Receptors 阿尔茨海默病神经保护:相关受体

Neuroprotection - New Approaches and Prospects Pub Date : 2020-03-28 DOI: 10.5772/intechopen.91918

Alice Barros Câmara

引用次数: 0

Neuroprotective and Neurorestorative Properties of Copolymer-1: Its Immunomodulating Effects on Ischemic Stroke 共聚物-1的神经保护和神经恢复特性:其对缺血性脑卒中的免疫调节作用

Neuroprotection - New Approaches and Prospects Pub Date : 2020-03-02 DOI: 10.5772/intechopen.91343

María Yolanda Cruz Martínez, Melanie Tessa Saavedra Navarrete, José Juan Antonio Ibarra Arias

引用次数: 0

Extracts and Essential Oils from Medicinal Plants and Their Neuroprotective Effect 药用植物提取物、精油及其神经保护作用

Neuroprotection - New Approaches and Prospects Pub Date : 2020-02-28 DOI: 10.5772/intechopen.90903

I. M. Costa, Elaine Cristina Gurgel Andrade Pedrosa, Ana Paula de Carvalho Bezerra, L. Fernandes, J. Cavalcanti, M. Freire, Dayane Pessoa de Araújo, Amália Cinthia Menezes Rêgo, I. Filho, Francisco Irochima Pinheiro, F. Guzen

引用次数: 1

An Alternate View of Neuroprotection with Peptides in Alzheimer’s Disease 阿尔茨海默病中多肽神经保护的另一种观点

Neuroprotection - New Approaches and Prospects Pub Date : 2020-02-19 DOI: 10.5772/intechopen.91065

S. King, C. Suphioglu

引用次数: 1

Glyproline Pro-Ampakine with Neuroprotective Activity 具有神经保护作用的甘脯氨酸亲安帕平

Neuroprotection - New Approaches and Prospects Pub Date : 2020-02-18 DOI: 10.5772/intechopen.91192

K. N. Koliasnikova, P. Povarnina, A. V. Tallerova, Yu. N. Firsova, Sergei V. Nikolaev, T. Antipova, A. Nadorova, L. Kolik, T. Gudasheva, S. Seredenin

{"title":"Glyproline Pro-Ampakine with Neuroprotective Activity","authors":"K. N. Koliasnikova, P. Povarnina, A. V. Tallerova, Yu. N. Firsova, Sergei V. Nikolaev, T. Antipova, A. Nadorova, L. Kolik, T. Gudasheva, S. Seredenin","doi":"10.5772/intechopen.91192","DOIUrl":"https://doi.org/10.5772/intechopen.91192","url":null,"abstract":"Previously it was shown that neuropeptide cyclo-L-prolylglycine (CPG) is a positive modulator of AMPA receptors, which increases BDNF level in neuronal cell cultures. The spectrum of CPG’s pharmacological effects corresponds to that of BDNF. Dipeptide N-phenylacetyl-glycyl-L-proline ethyl ester (GZK-111) was designed and synthesized as a linear analog of CPG. The aim of the present work was to reveal the pharmacological profile of GZK-111. Dipeptide GZK-111 was shown to metabolize into CPG in vitro and increased cell survival by 28% at concentrations of 10-7–10-6 M in a Parkinson’s disease cell model. In a model of cerebral ischemia, GZK-111, at a dose of 0.5 mg/kg, i.p., was found to have neuroprotective effects, reducing the cerebral infarct volume by 1.6 times. Similar to CPG, GZK-111, at the range 0.1–1.0 mg/kg, i.p., possessed a stereospecific antiamnesic activity. A significant anxiolytic effect was observed at a dose of 1.5 mg/kg. GZK-111, at the range 0.5–4.0 mg/kg, i.p., demonstrated analgesic activity. GZK-111, at a dose of 10 mg/kg/7 days, i.p., possessed antidepressant-like activity. So, the neuroprotective, nootropic, antihypoxic, anxiolytic, antidepressant-like, and analgesic effects of GZK-111 were revealed. Thus, GZK-111 can be considered as a pharmacologically active pro-ampakine with a BDNF-ergic mechanism of action.","PeriodicalId":165931,"journal":{"name":"Neuroprotection - New Approaches and Prospects","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131732626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Neuroprotective Potentials of Natural Vitamin E for Cerebral Small Vessel Disease 天然维生素E对脑血管疾病的神经保护作用

Neuroprotection - New Approaches and Prospects Pub Date : 2020-02-17 DOI: 10.5772/intechopen.91028

M. Mustapha, Che Mohd Nasril Che Mohd Nassir, Y. K. Hay, Fung Wai Yee, H. Hamid

引用次数: 3

Neuroprotection: The Way of Anti-Inflammatory Agents 神经保护:抗炎药的途径

Neuroprotection - New Approaches and Prospects Pub Date : 2020-01-03 DOI: 10.5772/intechopen.90509

Patrice Mendel Nzogang, M. Donkeng

{"title":"Neuroprotection: The Way of Anti-Inflammatory Agents","authors":"Patrice Mendel Nzogang, M. Donkeng","doi":"10.5772/intechopen.90509","DOIUrl":"https://doi.org/10.5772/intechopen.90509","url":null,"abstract":"Neurons are basic structural and functional units of the nervous system with major function being that of integration and interpretation of neuronal input or information. The lifespan of a nerve cell generally last throughout the individual lifetime. However, some physiologic or pathologic processes may affect the neuron causing premature death of this cell or tissue. This premature neurological death caused by pathologic circumstances is what we call neurotoxicity. The biochemical mechanisms put forward to explain neurotoxicity are not fully known. Nonetheless, whatever the mechanism involved, the outcome usually results in apoptosis, pyropoptosis, or necrosis. Examples of these mechanisms include excitotoxicity, oxidative stress, glial cell destruction, vascular interruptions, and inflammation. The idea about possibly protecting neurons against insults using pharmacologic means leads to the birth of the neuroprotection concept. This new concept has emerged based on ongoing research, suggesting it is possible through physical and pharmacological means to prevent or avoid neurotoxicity by the abovementioned mechanisms but with the exception of vascular interruption mechanisms. We will present in this chapter a synoptic view of the inflammatory mechanisms implicated in neurotoxicity and bring out the possible implications in neuroprotection.","PeriodicalId":165931,"journal":{"name":"Neuroprotection - New Approaches and Prospects","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114726232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hydrogen Sulfide as a Factor of Neuroprotection during the Constitutive and Reparative Neurogenesis in Fish Brain 硫化氢在鱼脑构成性和修复性神经发生中的神经保护作用

Neuroprotection - New Approaches and Prospects Pub Date : 2019-12-24 DOI: 10.5772/intechopen.90547

E. V. Pushchina, A. A. Varaksin, D. Obukhov

{"title":"Hydrogen Sulfide as a Factor of Neuroprotection during the Constitutive and Reparative Neurogenesis in Fish Brain","authors":"E. V. Pushchina, A. A. Varaksin, D. Obukhov","doi":"10.5772/intechopen.90547","DOIUrl":"https://doi.org/10.5772/intechopen.90547","url":null,"abstract":"The H2S-producing systems were studied in trout telencephalon, tectum, and cerebellum at 1 week after eye injury. The results of ELISA analysis have shown a 1.7-fold increase in the CBS expression at 1 week post-injury, as compared to the intact trout. In the ventricular and subventricular regions of trout telencephalon, CBS+ cells, as well as neuroepithelial and glial types, were detected. As a result of injury, the number of CBS+ neuroepithelial cells in the pallial and subpallial periventricular regions of the telencephalon increases. In the tectum, a traumatic damage leads to an increase in the CBS expression in radial glia with a simultaneous decrease in the number of CBS immunopositive neuroepithelial cells detected in intact animals. In the cerebellum, we revealed neuroglial interrelations, in which H2S is probably released from the astrocyte-like cells with subsequent activation of the neuronal NMDA receptors. The organization of the H2S-producing cell complexes suggests that the amount of glutamate produced in the trout cerebellum and its reuptake is controlled with the involvement of astrocyte-like cells, reducing its excitotoxicity. We believe that the increase in the number of H2S-producing cells constitutes a response to oxidative stress, and the overproduction of H2S neutralizes the reactive oxygen species.","PeriodicalId":165931,"journal":{"name":"Neuroprotection - New Approaches and Prospects","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114750137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Aptamers and Possible Effects on Neurodegeneration 适体及其对神经退行性变的可能影响

Neuroprotection - New Approaches and Prospects Pub Date : 2019-11-26 DOI: 10.5772/INTECHOPEN.89621

F. Söylemez, Çağatay Han Türkseven

{"title":"Aptamers and Possible Effects on Neurodegeneration","authors":"F. Söylemez, Çağatay Han Türkseven","doi":"10.5772/INTECHOPEN.89621","DOIUrl":"https://doi.org/10.5772/INTECHOPEN.89621","url":null,"abstract":"Aptamers are a new class of recognizing agents which are defined as short biomolecules like oligonucleotides and peptides that are used in diagnostics and therapeutics. They can bind to specific targets with extremely high affinity based on their structural conformations. It is believed that in the near future, aptamers could replace monoclonal antibody. The biggest advantage of using aptamers is that the process is in vitro in nature and does not require the use of animals and they also have unique properties, such as thermal stability, low cost, and unlimited applications. Aptamers have been studied as a biomaterial in numerous investigations concerning their use as a diagnostic and therapeutic tool and biosensing probe. DNA aptamers were also used for the diagnosis and treatment of neurodegeneration and neurodegenerative diseases. For example, functional nucleic acid aptamers have been developed to detect Aβ fragments in Alzheimer’s brain hippocampus tissue samples. Aptamers are promising materials for diverse areas, not just as alternatives to antibodies but as the core components of medical equipment. Although they are in the preliminary stages of development, results are quite encouraging, and it seems that aptamer research has a very bright future in neuroscience.","PeriodicalId":165931,"journal":{"name":"Neuroprotection - New Approaches and Prospects","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130287714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Polyphenols as Potential Therapeutic Drugs in Neurodegeneration 多酚作为神经退行性疾病的潜在治疗药物

Neuroprotection - New Approaches and Prospects Pub Date : 2019-10-23 DOI: 10.5772/intechopen.89575

P. P. Laureto, L. Palazzi, L. Acquasaliente

引用次数: 3