Journal of oral tissue engineering最新文献_第9页

Evaluation of the Taste of Value Added Generic Drugs by a Taste Sensor 用味觉传感器评价高附加值仿制药的味道

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.9.152

Toshimi Iizuka, Takahiko Kagaya, K. Atsuda, Y. Yoshiyama

{"title":"Evaluation of the Taste of Value Added Generic Drugs by a Taste Sensor","authors":"Toshimi Iizuka, Takahiko Kagaya, K. Atsuda, Y. Yoshiyama","doi":"10.11223/JARDE.9.152","DOIUrl":"https://doi.org/10.11223/JARDE.9.152","url":null,"abstract":"152 INTRODUCTION The isosorbide dinitrate or mononitrate are used chiefly to treat angina pectoris, and used as the osmotic diuretics in Japan. Additionally, it is used as a treatment of the intracranial hypertension, the ocular hypertension, and Meniere's disease. ISOBIDE was approved and put on the market in Japan in 1968. ISOBIDE is raising plasma osmolality and shows a brain pressure descent action, an intraocular pressure descent action, an inner lymph pressure descent action of an ear, and a diuretic effect. Moreover, a brain tumor patient may be administered for the purpose of brain pressure descent. However, the taste of ISOBIDE is unpalatable in the one that sweetness, acidity, and bitterness existed together. Generally, a bad taste drug may resist taking medicine, the possibility that the effect of the drug therapy is not achieved is thought, and there is a possibility that a satisfactory therapeutic effect is not obtained. In a package insert, it is important to consider the taste to complete the drug therapy though the method to take by the dilution with water is adopted to secure the adherence of ISOBIDE. In Evaluation of the Taste of Value Added Generic Drugs by a Taste Sensor","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"15 1","pages":"152-158"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73657764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biological Effects of Emdogain ® -derived Oligopeptides on Rat Bone Marrow Cells in Vitro Emdogain®衍生寡肽对体外大鼠骨髓细胞的生物学效应

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.9.126

Natsuki Yasui, Y. Taguchi, A. Tanaka, M. Ueda, M. Umeda

{"title":"Biological Effects of Emdogain ® -derived Oligopeptides on Rat Bone Marrow Cells in Vitro","authors":"Natsuki Yasui, Y. Taguchi, A. Tanaka, M. Ueda, M. Umeda","doi":"10.11223/JARDE.9.126","DOIUrl":"https://doi.org/10.11223/JARDE.9.126","url":null,"abstract":"126 INTRODUCTION Emdogain (EMD) extracted from the tooth germ of juvenile swine is a material that can generate acellular cementum and facilitate periodontal regeneration in patients with periodontitis featuring marked alveolar bone resorption. EMD has been clinically used as Emdogain gel for more than a decade to produce marked regenerative effects . In addition, the molecular mechanisms behind the action of EMD on the structural cells of periodontal tissue have been comprehensively investigated for about a decade to substantiate its regenerative effects. Periodontal regenerative therapy with EMD is being established. The therapy is recognized as an advanced medical technology in Japan. However, EMD is a biological material extracted from the tooth germ of juvenile swine. Thus, patients reject EMD treatment because of concerns about unknown pathogens. Currently, many patients still choose guided tissue regeneration (GTR) with a blocking membrane, recommended for periodontal regenerative therapy in Japan . Thus, synthetic peptides should be developed. To make the best use of clinical data obtained over approximately a decade concerning the regenerative effects and postoperative stability of EMD, EMD-derived synthetic peptides should be developed. Traditional Biological Effects of Emdogain-derived Oligopeptides on Rat Bone Marrow Cells in Vitro","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"C-18 1","pages":"126-135"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85047648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Fibronectin Adsorption by using 27M Hz Quartz-crystal Microbalance Technique 27M Hz石英晶体微天平法吸附纤维连接蛋白

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.10

T. Hayakawa, T. Fukushima

引用次数: 0

An Attempt to Study of Mouse ES Cell Differentiation using Collagen Derived from Tilapia Scale 罗非鱼鳞片胶原诱导小鼠胚胎干细胞分化的研究

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.10.89

K. Imai, T. Uemura, A. Tanoue, Kazuaki Nakamura, K. Suese, H. Takashima

引用次数: 5

Study of Pluripotency and Activation of Totipotency in Human Bone Marrow Mesenchymal Stem Cells 人骨髓间充质干细胞多能性及全能性活化的研究

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.10.95

S. Izawa, K. Yamaji, Tomohiro Hoshika, Y. Nishitani, M. Yoshiyama

引用次数: 2

Effects of Acetylcholine on H 2 O 2 -induced Oxidative Stress in H9c2 Cells 乙酰胆碱对h2o2诱导的H9c2细胞氧化应激的影响

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.10.77

H. Ariumi, T. Sonobe, Y. Yoshiyama

引用次数: 0

Osteogenesis by Bone Marrow Cells in a Novel Hybrid Alginate/calcium Phosphate Sponge Scaffold 新型海藻酸盐/磷酸钙复合海绵支架中骨髓细胞的成骨作用

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.9.113

Hideyuki Kakigi, M. Yoshikawa, H. Hayashi

{"title":"Osteogenesis by Bone Marrow Cells in a Novel Hybrid Alginate/calcium Phosphate Sponge Scaffold","authors":"Hideyuki Kakigi, M. Yoshikawa, H. Hayashi","doi":"10.11223/JARDE.9.113","DOIUrl":"https://doi.org/10.11223/JARDE.9.113","url":null,"abstract":"113 INTRODUCTION Porous hydroxyapatite has been used as a scaffold for the regeneration of alveolar bone, tooth root and dentin-pulp complex. The hydroxyapatite is appropriate as a scaffold for the regeneration of hard tissue because its hardness is thought to be similar to that of dentine. However, the hardness of hydroxyapatite is disadvantageous as a scaffold. Hydroxyapatite is too hard to modify its shape. It may be desirable in dental clinics that the scaffold would be easily adjusted to a tooth defect. Sodium alginate (AL) gel has been used as a scaffold for osteogenesis by the three-dimensional culture of stem cells. A sponge-like porous scaffold prepared from AL gel was also used for regeneration of bone or hard tissue. The AL gel has excellent biocompatibility and biodegradability. The sponge-like porous material prepared from the gel is inferior in physical strength to hydroxyapatite. Therefore, a sponge-like scaffold prepared from AL gel would be shaped easily. AL gel might be suitable for the preparation of sponge-like porous materials as a scaffold for the regeneration of defective dentine. Osteogenesis by Bone Marrow Cells in a Novel Hybrid Alginate/calcium Phosphate Sponge Scaffold","PeriodicalId":16589,"journal":{"name":"Journal of oral tissue engineering","volume":"124 1","pages":"113-125"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76741585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison between the Two Endpoints of the Embryotoxicity Test using the Contracting Myocardial Cells and the Alkaline Phosphatase (ALP) Activity 收缩心肌细胞和碱性磷酸酶(ALP)活性胚胎毒性试验两个终点的比较

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.10.82

K. Imai, Kazuaki Nakamura, A. Tanoue, K. Suese, Fumiya Ogawa, H. Takashima

引用次数: 3

Connective Tissue Reaction and Bone-cement Contact after Implantation of PMMA Resin Cements PMMA树脂骨水泥植入后结缔组织反应与骨水泥接触

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.10.1

T. Morishita, T. Sugaya, Megumi Nakatsuka, Maki Sunosaki, M. Kawanami

引用次数: 2

Cell Viability of Mouse Cells by Exposure to the Dental Adhesives using Cell Recovery Test with 3D Culture 用三维培养细胞恢复试验观察牙胶粘剂对小鼠细胞的影响

Journal of oral tissue engineering Pub Date : 2012-01-01 DOI: 10.11223/JARDE.10.42

K. Imai, Kazuaki Nakamura, A. Tanoue, K. Suese, T. Nishikawa, A. Tanaka, Chiaki Watanabe, H. Ohmukai, H. Takashima

引用次数: 3