OBM Hepatology and Gastroenterology最新文献

Piperine: A Savor Inducer and a Cancer Reducer 胡椒碱:一种味觉诱导剂和抗癌剂

OBM Hepatology and Gastroenterology Pub Date : 2021-07-26 DOI: 10.21926/obm.hg.2103061

M. Djaldetti

引用次数: 0

Non-Celiac Gluten Sensitivity in Children: Controversial Role of Gluten and Diagnostic Enigma 儿童非乳糜泻谷蛋白敏感性:谷蛋白的争议作用和诊断难题

OBM Hepatology and Gastroenterology Pub Date : 2021-07-07 DOI: 10.21926/OBM.HG.2103059

C. Devulapalli

{"title":"Non-Celiac Gluten Sensitivity in Children: Controversial Role of Gluten and Diagnostic Enigma","authors":"C. Devulapalli","doi":"10.21926/OBM.HG.2103059","DOIUrl":"https://doi.org/10.21926/OBM.HG.2103059","url":null,"abstract":"Non-celiac gluten sensitivity (NCGS) is a debatable condition that affects less than 6% of children. The absence of specific diagnostic markers and standardized diagnostic procedures make the diagnosis of NCGS challenging, covering patients with different and varied symptoms. Generally, the parents of small and younger children introduce a gluten-free diet (GFD) based on their personal experiences and expectations. Additionally, a “fad component” exists, contributing to the recent rise in the popularity of GFD. Thus, celiac disease (CD) and wheat allergy (WA) must be excluded as these also appear in individuals experiencing symptoms similar to those of NCGS, improving and worsening with gluten withdrawal and consumption, respectively. The role of gluten inducing gastrointestinal symptoms in individuals with self-reported NCGS has been skeptically assessed based on evidence in recent years. However, currently, it is unknown whether a strict GFD is necessary for patients with NCGS. Thus, the placebo-controlled gluten challenge remains the gold standard for a challenging diagnosis like NCGS. The present review evaluates the published studies based largely on the adult population and describes the key elements in diagnosing NCGS and differential diagnosis with CD and WA.","PeriodicalId":165895,"journal":{"name":"OBM Hepatology and Gastroenterology","volume":"184 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114431973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastro-Esophageal Reflux in the Newborn: Pathologic Event or Does Spit Happen? 新生儿胃食管反流:病理事件还是唾液的发生?

OBM Hepatology and Gastroenterology Pub Date : 2021-04-19 DOI: 10.21926/obm.hg.2103060

G. Stepanovich, S. Donn

引用次数: 0

Varicella-Zoster Gastritis in a Liver Transplant Patient: A Call to Attention 肝移植患者的水痘-带状疱疹胃炎:引起注意

OBM Hepatology and Gastroenterology Pub Date : 2021-03-01 DOI: 10.21926/obm.hg.2102057

Víctor Escrich, Á. Herreros, Berta Lapeña, M. Mayorga, A. Cuadrado, J. Crespo, E. Fábrega

{"title":"Varicella-Zoster Gastritis in a Liver Transplant Patient: A Call to Attention","authors":"Víctor Escrich, Á. Herreros, Berta Lapeña, M. Mayorga, A. Cuadrado, J. Crespo, E. Fábrega","doi":"10.21926/obm.hg.2102057","DOIUrl":"https://doi.org/10.21926/obm.hg.2102057","url":null,"abstract":"The reactivation of the Varicella-zoster virus (VZV) is a rare cause of acute gastritis in adults. About 30 cases have been reported in the literature, mostly with immunocompromised patients and mainly after bone marrow transplantation or during the development of malignant hematological diseases. Clinically, it is usually accompanied by cutaneous manifestations. Here, we studied a case of VZV gastritis in a liver transplant (LT) patient. We described the main symptoms, endoscopic findings, histologic changes, and treatment of VZV gastritis. Till now, no case of acute gastritis due to the reactivation of VZV after solid organ transplantation had been reported [2–5]. This was the first reported case of acute gastritis by the reactivation of VZV after LT without cutaneous vesicular eruption. Gastrointestinal symptoms usually develop a week before the onset of fever and cutaneous manifestations. However, in some cases, like this one, vesicular rashes may be absent, making the diagnosis quite challenging. In conclusion, through this case, we suggest including VZV gastritis in the differential diagnosis of gastrointestinal symptoms after transplantation and informing about the response of VZV gastritis to treatment with oral acyclovir.","PeriodicalId":165895,"journal":{"name":"OBM Hepatology and Gastroenterology","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133994703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effects of Mediterranean Diet on the Human Gut Microbiota; a Brief Discussion of Evidence in Humans 地中海饮食对人体肠道菌群的影响关于人类证据的简要讨论

OBM Hepatology and Gastroenterology Pub Date : 2021-02-05 DOI: 10.21926/OBM.HG.2101056

Anita H. Kelleher, A. Sikalidis

引用次数: 2

The Physiology of Esophageal Reflexes 食道反射的生理学

OBM Hepatology and Gastroenterology Pub Date : 2020-11-02 DOI: 10.21926/obm.hg.2004052

I. Lang

引用次数: 1

The Timing of Endoscopic Evaluation of Anti-TNFα Therapy Patients with Ulcerative Colitis 溃疡性结肠炎患者抗tnf α治疗的内镜评估时机

OBM Hepatology and Gastroenterology Pub Date : 2020-08-10 DOI: 10.21926/obm.hg.2103058

Hiroyuki Kashiwagi, A. Ito, H. Kambayashi, S. Murasugi, T. Omori, M. Yonezawa, Shinichi Nakamura, K. Tokushige

{"title":"The Timing of Endoscopic Evaluation of Anti-TNFα Therapy Patients with Ulcerative Colitis","authors":"Hiroyuki Kashiwagi, A. Ito, H. Kambayashi, S. Murasugi, T. Omori, M. Yonezawa, Shinichi Nakamura, K. Tokushige","doi":"10.21926/obm.hg.2103058","DOIUrl":"https://doi.org/10.21926/obm.hg.2103058","url":null,"abstract":"Anti-TNFα Therapy are used to induce remission and as maintenance therapy in refractory ulcerative colitis (UC) to achieve mucosal healing (MH). However, the time at which mucosal healing should be assessed is unclear. We retrospectively examined the optimal timing for colonoscopy and the criteria to determine the need for the continuation of treatment. We evaluated 44 UC patients that were treated with anti-TNFα Therapy and categorized them into the following groups according to the degree of MH within 12 months: MH and non-MH/NMH, early-MH (EMH, healing within three months), and slow MH/SMH (healing between 4-12 months). We compared the Mayo Endoscopic Subscore (MES) between the MH vs. NMH and SMH vs. NMH groups. The Lichtiger index and blood test results were investigated as predictive factors of MH. MH was defined as an MES of ≤ 1. The MES was significantly lower in the MH group at 3, 6, and 12 months, compared to the NMH group. Significant changes were observed in the platelet counts, the Lichtiger index, the levels of C-reactive protein (lower), and hemoglobin (higher) in the MH group at 3- and 6-months following treatment. However, the only significant difference between the SMH and NMH groups was in the endoscopic findings at 6- or 12-months post-treatment. Colonoscopy should be performed three months after treatment with anti-TNFα Therapy. The treatment should be continued in patients who do not achieve mucosal healing at 3-months, and colonoscopy should be repeated at 6- or 12-months to assess the outcomes.","PeriodicalId":165895,"journal":{"name":"OBM Hepatology and Gastroenterology","volume":"116 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123364610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Sleep Deprivation and Metformin Treatment on Pancreatic and Liver Function in Mice 睡眠剥夺与二甲双胍治疗小鼠胰、肝功能的关系

OBM Hepatology and Gastroenterology Pub Date : 2020-05-18 DOI: 10.21926/obm.hg.2002047

S. Periasamy, S. Chien, Chen Hsu, D. Hsu, Ming‐Yie Liu

{"title":"Association between Sleep Deprivation and Metformin Treatment on Pancreatic and Liver Function in Mice","authors":"S. Periasamy, S. Chien, Chen Hsu, D. Hsu, Ming‐Yie Liu","doi":"10.21926/obm.hg.2002047","DOIUrl":"https://doi.org/10.21926/obm.hg.2002047","url":null,"abstract":"Metformin has been widely used as a therapeutic drug for hyperglycemia and diabetes. Sleep is a vital and restorative process that is necessary for the proper functioning of organs. Sleep deprivation can induce multi-organ injury, including damage to the pancreas and liver that may result in hyperglycemia and diabetes. We studied the role of metformin in reversing sleep deprivation-induced hyperglycemia and pancreatic and liver dysfunction in mice. Mice were kept in However, compared with control, sleep deprivation decreased the levels of proteins involved in the GLUT2- PPARγ -pAMPK glycolytic pathway. Sleep deprivation plus metformin decreased blood glucose and GPT levels and pancreatic inflammation. However, the combination increased the levels of proteins involved in the GLUT2- PPARγ -pAMPK glycolytic pathway. In addition, metformin alone increased the levels of AMYL, as well as resulted in islet atrophy, edge irregularities, and disordered pancreatic acinar cells. Metformin attenuates hyperglycemia and reduces pancreatic and liver inflammation in sleep-deprived mice; however, it may cause pancreatic dysfunction.","PeriodicalId":165895,"journal":{"name":"OBM Hepatology and Gastroenterology","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129173863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin D in Patients with Chronic Hepatitis C Virus Infection Receiving the Direct Antiviral Agents 服用直接抗病毒药物的慢性丙型肝炎病毒感染患者的维生素D

OBM Hepatology and Gastroenterology Pub Date : 2020-03-30 DOI: 10.21926/obm.hg.2001044

Hsuan-Wei Chen, Hsuan-Hwai Lin, Y. Shih, T. Hsieh, Jung-Chun Lin

引用次数: 2

Endoscopic Therapy for Recurrent Acute Pancreatitis 复发性急性胰腺炎的内镜治疗

OBM Hepatology and Gastroenterology Pub Date : 2019-10-17 DOI: 10.21926/obm.hg.1904042

P. Testoni, S. Testoni

引用次数: 0