Journal of Medicinal Plants最新文献

{"title":"Effects of Imfluna, an Iranian traditional polyherbal medicine, on COVID-19 symptoms: A randomized, double-blind and placebo-controlled clinical trial","authors":"Hasan Fallah Huseini, Mohammadreza Gholibeikian, M. Shohrati, Afsaneh Kaffash, Ali Taheri, Hojatolah Khajepour, M. Raei, S. Kianbakht, Amena Fallah Hosseini, Majid Ghorbani Nohooji, R. Mohtashami","doi":"10.52547/jmp.21.81.51","DOIUrl":"https://doi.org/10.52547/jmp.21.81.51","url":null,"abstract":"Background: The current pandemic of Coronavirus disease 2019 (COVID-19) and severity of the infection and high mortality have almost unprecedented challenges in the health systems of most countries around the world. Objective: The present study aimed to evaluate the effect of Iranian traditional polyherbal medicine (Imfluna) containing a mixture of echinacea, stachys, artemisia, hyssopus, polybody, alpinia, ginger, and ginseng extract on symptoms of COVID-19 infected patients. Methods: In this placebo-controlled and double-blind clinical trial, a total of 60 voluntarily approved patients with COVID-19 were randomly assigned to the placebo and Imfluna groups. Patients in each group, in addition to receiving standard medications, took two 500 mg capsules of Imfluna or placebo every 8 hours for 2 weeks. The patient's vital signs, including the severity of shortness of breath, cough, and body temperature, were recorded during the study. Also blood ESR, liver and kidney function tests were performed at baseline and endpoint. Results: The results showed that patients in the Imfluna-treated group had significantly greater improvement in daily cough, shortness of breath and ESR compared with the placebo group. In addition, lung lesions improved in the Imfluna-treated group, although not significantly. Conclusion: Patients with COVID-19 who were treated with Imfluna for 2 weeks had better comfort and fewer symptoms associated with the disease with no any drug side effects.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48170186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Process optimization for green synthesis of iron nanoparticles by extract of fenugreek (Trigonella foenum-graecum L.) seeds","authors":"R. Ghafarzadegan, M. Yaghoobi, S. Momtaz, Nasim Ashoory, Mona Ghiaci Yekta, R. Hajiaghaee","doi":"10.52547/jmp.21.81.22","DOIUrl":"https://doi.org/10.52547/jmp.21.81.22","url":null,"abstract":"Background: The green synthesis of nanoparticles using plants presents important advantages over other biological systems. Natural compounds present in plant extracts can reduce metal ions to nanoparticles in a single-step green synthesis process. Seeds of fenugreek with various compounds and antioxidant activity are suitable for green synthesis. Objective: In this study, the performance of fenugreek seeds extract was evaluated for iron nanoparticles production. Methods: The fenugreek ( Trigonella foenum-graecum L.) seeds were extracted with a distilled water solution at environmental temperature and this aqueous extract was used for the iron nanoparticles synthesis. Response surface methodology was applied to optimize nanoparticle production by considering three independent variables: the extract to metal ion ratio (1.5-6.5), incubation time (30-90 min), and temperature (35-65 °C). Results: Mixing the fenugreek seeds extract and iron salt solution with a volume ratio of 1.5 at 36.5 °C for 90 min led to the optimization of iron nanoparticle production with the narrowest size distribution. At the optimized condition, the nanoparticle size was in the range of 20-40 nm. Conclusion: Iron nanoparticles were successfully synthesized with fenugreek seed extract. Physical parameters such as time, temperature, and mixing volume ratio of the extract to metal ions can control the average size of the synthesized green iron nanoparticles.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48324088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of Citrullus colocynthis (L.) Schard. fruit extract on high glucose-induced neurotoxicity in PC-12 cells","authors":"H. Huseini, S. Andalib, E. Jasemi, F. Khalighi-Sigaroodi, Saeideh, Momtaz, R. M. Savadroodbari, Hadi Salehirad, Mojtaba Zn785iaee","doi":"10.52547/jmp.20.80.60","DOIUrl":"https://doi.org/10.52547/jmp.20.80.60","url":null,"abstract":"Abbreviations: MTT, 3-(4,5-Dimethylthiazol-2-Yl)-2,5-Diphenyltetrazolium Bromide; HPLC, High performance liquid chromatography; EDTA, Ethylenediamine tetraacetic acid *Corresponding author: ziaee.m@mrgums.ac.ir doi: 10.52547/jmp.20.80.60 Received 16 May 2021; Received in revised form 28 November 2021; Accepted 29 December 2021 © 2020. Open access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/) Research Article","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44969336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of adulteration in Lavandula angustifolia Mill. products using GC/MS combined with chemometric methods","authors":"Zahra Tarasoli, Hakim Faraji, F. Tajabadi, M. Shabani, H. Shahbazi","doi":"10.52547/jmp.20.80.34","DOIUrl":"https://doi.org/10.52547/jmp.20.80.34","url":null,"abstract":"Background: The essential oil of Lavandula angustifolia Mill. ( L. angustifolia ), a species from the Lamiaceae family, possesses several biological activities; therefore it is used in some herbal medicines. The lack of studies into identifying the essential oil of L. angustifolia and its similar appearance to Nepeta menthoides Boiss. & Buhse (N. menthoides) as “Ustukhuddoos” in Iranian traditional medicine, have caused misuse and adulteration in the product s . Objective: In this study, the chemical compositions of L. angustifolia and N. menthoides essential oils, and three commercial herbal medicines of L. angustifolia essential oil in Iranian markets were evaluated and investigated as adulteration with the help of GC/MS analysis and chemometric methods. Methods: The essential oils of L. angustifolia and N. menthoides , and commercial samples were extracted by different extraction methods. Furthermore, their chemical compositions were evaluated by GC/MS analysis. After identification of components by GC/MS, the obtained results were assessed by principal component analysis (PCA, Unscrambler X version 10.4) for clustering. Results: Results showed that all three commercial herbal preparations matched with the manufacturer's claim about using L. angustifolia essential oil in the products. PCA distinguished two groups which were characterized based on different types and amounts of the components. Conclusion: GC/MS analysis with the help of chemometric methods is a powerful method to evaluate and discriminate between the essential oils and their products. In general, the combination of instrumental analysis and clustering chemometric analysis can provide an accurate tool for identifying misuse between plant species.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43187001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical analysis and biological activities of essential oil and extract of Phlomis rigida Labill.","authors":"Fereshteh Heydari, R. Ghafarzadegan, Mansour Mofasseri, Seyed Vahid Ghasemi, M. Kashefi, R. Hajiaghaee, S. Tavakoli","doi":"10.52547/jmp.20.80.13","DOIUrl":"https://doi.org/10.52547/jmp.20.80.13","url":null,"abstract":"Background: The genus Phlomis is a member of Lamiaceae (Labiatae) family. About 10 species of this genus, among more than 100 species, are endemic to Iran. Phlomis rigida Labill. can be used as antimicrobial, anti-inflammatory, wound healing and antioxidant in drug investigations, based on literature. Objective: The aim of this study is to evaluate the composition, antioxidant, antibacterial and cytotoxic activity of essential oils and extract from leaves and flowers of P. rigida from Iran. The present study is the first research on P. rigida from Iran. Methods: Essential oils of leaves and flowers of P. rigida were studied by GC-MS and GC-FID to evaluate the chemical compositions. DPPH free radical scavenging method was used to evaluate the antioxidant effect of leaves and flowers extracts. Antimicrobial properties of the essential oils and extracts were investigated against various microorganisms in brain heart infusion agar to evaluate the minimum inhibitory concentration. A brine shrimp test (BST) was done to study the cytotoxicity of methanol extracts and essential oils from leaves and flowers in different concentrations. The growth inhibitory effects of the methanol extract from leaves and flowers were assessed against four cancer cell lines including MCF-7, MDBK, HT-29 and A-549. Results: Essential oils analysis showed 34 compounds and the main compounds were (Z)-β -ocimene (25.6 %), isobornyl acetate (16.6 %), trans -verbenol (12.6 %) and α -pinene (7.6 %). As a result of analysis of methanol extracts from leaves, luteolin, luteolin-7-O-glucoside and rosmarinic acid were isolated and identification for the first time from P. rigida growing in Iran. Investigation of antibacterial properties of the essential oil of flowers also showed 16 mm diameters of inhibition zone against Proteus vulgaris. Conclusion : The results of this study showed that the antibacterial effect of P. rigida essential oil could be due to the presence of its monoterpenes.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43222116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Halocnemum strobilaceum (Pall.) M.Bieb.: a review of its botany, phytochemistry, pharmacology and ethnobotany","authors":"F. Nasernakhaei, Mahyar Zahraei","doi":"10.52547/jmp.20.80.1","DOIUrl":"https://doi.org/10.52547/jmp.20.80.1","url":null,"abstract":"Abbreviations: TLC, Thin Layer Chromatography; PC, Paper Chromatography; UV, Ultraviolet; 1 H-NMR, Proton Nuclear Magnetic Resonance; MS, Mass Spectrometry; UPLC, Ultra Performance Liquid Chromatography; GC-MS, Gas Chromatography-Mass Spectrometry; GC-FID, Gas Chromatography-Flame Ionization Detection; TAC, Total Antioxidant Capacity; DPPH, 2,2-Diphenyl-1-Picrylhydrazyl; BCBT, β -Carotene Bleaching Test; GAE, Gallic Acid Equivalent; TGF, Transforming Growth Factor; IC 50 , Median Inhibitory Concentration; EC 50 , Median Effective Concentration; PC, Prostate Cancer; MTT, 3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide; ROS, Reactive Oxygen Species; MIC, Minimum Inhibitory Concentration Background: Halocnemum strobilaceum (Pall.) M.Bieb. (Amaranthaceae) is a halophyte commonly used in traditional medicine to treat fever, jaundice, hair loss, dysmenorrhea, and headache. Other uses of H. strobilaceum include using its aerial parts extract as probiotics in aquaculture feed and a preservative in the food and beverage industries. Objective: This review will summarize the current state of knowledge available on this plant's botany, phytochemistry, pharmacology, and ethnobotany. Methods: The databases of Google Scholar, Web of Science, PubMed, Scopus, and SID were searched systematically, with no date limitation for articles published in English. Results : H. strobilaceum extracts are a rich source of anthocyanins, saponins, caffeic acid, flavonoids, coumarins, phenolic compounds, alkaloids, and fatty acids. The bioactivities ascribed to H. strobilaceum extracts are anticancer, antimicrobial, and antioxidant activities. They also can be used as insecticides against pests of stored products. Conclusion: Considering the different activities and many properties of H. strobilaceum it seems to be a suitable option for further experimental and clinical trial research.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45171274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Allelopathic effect of herbal formulation containing Ferula assa-foetida L. essential oil and castor oil (Ricinus communis L.) as an herbicide on Amaranthus retroflexus L. seed germination","authors":"Zahra Tarassoli, M. Labbafi, Farzaneh Jokar Shoorijeh","doi":"10.52547/jmp.20.80.69","DOIUrl":"https://doi.org/10.52547/jmp.20.80.69","url":null,"abstract":"Background: Medicinal plant contain phytochemicals which have inhibitory effects on plant pathogens. Weeds compete with the main crops and reduce the growth, yield, and quality of agricultural products to some extent. One of the most common methods of reducing weed damage is the use of chemical herbicides. Due to the side effects that chemical herbicides on human health and the environment, there is a need to replace biocompatible and low-risk herbicides. Objective: In this study, the allelopathic properties of the Ferula assa-foetida L. essential oil and castor oil ( Ricinus communis L.) have been investigated as a botanical herbicide to prevent germination of redroot pigweed seeds ( Amaranthus retroflexus L.). Methods: In this regard, an herbal formulation based on Ferula assa-foetida essential oil and castor oil was prepared and its effect on the germination of redroot pigweed seeds was studies in laboratory conditions. The chemical composition of the herbal formulation was analyzed by GC/MS. Results: The results showed that this herbal formulation in concentration 0.75 % and 1 % inhibits the germination of weed seeds about 70 %. The main constituents of Ferula assa-foetida and Ricinus communis were (E)-1-propenyl sec-butyl disulfide (43.9 %) and ricinoleic acid methyl ester (58.1 %), respectively. Conclusion : It was found that the studied botanical formulation has herbicidal properties. Therefore, more research is needed to achieve promising results in order to replace chemical herbicides with botanical herbicides.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44627494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical investigation among different populations of Papaver bracteatum Lindl. using ultrasonic - assisted extraction method followed by HPLC analysis","authors":"Alireza Habibzade, N. Moshtaghi, S. Malekzadeh-Shafaroudi","doi":"10.52547/jmp.20.80.23","DOIUrl":"https://doi.org/10.52547/jmp.20.80.23","url":null,"abstract":"Abbreviations: CE, Capillary Electrophoresis; EME, Electrode Membrane Extraction; GC, Gas Chromatography; HPLC, High Performance Liquid Chromatography; RSD, Relative Standard Deviation; SPE, Solid Phase Extraction; SFE, Super Critical Fluid Extraction; TFA, Triflouroacetic Acid; UAE, Ultrasonic-Assisted Extraction; UV, Ultraviolet Spectrophotometry ABSTRACT Background: Papaver bracteatum Lindl. (Persian poppy) has a very long history as the major source of natural alkaloids. Among Papaver species, Persian poppy can be considered as a rich source of thebaine. Objective: The purpose of this study was to evaluate the thebaine content in different organs and different populations of Persian poppy. Methods: Seven populations of Persian poppy were collected from five different geographical regions of Iran including Damavand (Rineh, Abask), Chalous (Yoush, Pol-e Zanguleh), Mahabad, Meshgin Shahr and Zanjan (Taham) and were screened for its thebaine content. Extraction of thebaine was performed using the ultrasonic-assisted extraction (UAE) method. The parameters including pH, amount of solvent, extraction temperature and time, the repetition of extraction cycles and also the particle size were investigated and optimal conditions were determined to reach the maximum efficiency. Also, the correlation between phenology of the plant and thebaine content was studied during the developmental stages of poppy from pre-flowering to lancing. The developed UAE method followed by high performance liquid chromatography (HPLC) was used for quantitative analysis. Results: Thebaine content was significantly different in various organs and populations grew at different regions. The thebaine content was in the range of 0.9-1.4 % and 0.1-0.45 % in capsules and stems, respectively. The highest thebaine content was obtained in the capsules of Mahabad population. Conclusion: Extraction led to a high purity thebaine from Persian poppy. Eventually, a comprehensive profile of thebaine in different Persian poppy populations from different geographical regions in Iran was released.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41376325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of isoflavonoids in antioxidant effective fraction of Arum rupicola Boiss. leaves","authors":"Z. Tofighi, Y. Shahpar, Arian Taheri, S. Tavakoli, R. Asatouri, M. Eftekhari, M. Vazirian, M. S. Shams Ardekani, SN Sadati Lamardi","doi":"10.52547/jmp.20.79.14","DOIUrl":"https://doi.org/10.52547/jmp.20.79.14","url":null,"abstract":"Abbreviations: FRAP, Ferric Reducing Ability of Plasma; DPPH, 2,2-Diphenyl-1-picrylhydrazyl; MTT, 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide Antioxidant activity total methanol extract n chloroform, ethyl acetate and water residue evaluated using FRAP and DPPH methods. Total phenol content measured using Folin-Ciocalteu method.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42062666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The differences between Froriepia subpinnata (Ledeb.) Baill. and Pimpinella anisum L. commonly named as anarijeh based on major components of the essential oil; a marker for resolve ambiguities","authors":"Pooyan Mehrabanjoubani, M. Ghorbani Nohooji, E. Karimi, A. Abdolzadeh","doi":"10.52547/jmp.20.79.59","DOIUrl":"https://doi.org/10.52547/jmp.20.79.59","url":null,"abstract":"Background: Froriepia subpinnata (Ledeb.) Baill. and Pimpinella anisum L. are two important medicinal plants belong to the Apiaceae family. Due to the similar Persian name in ethnobotanical studies, namely “anarijeh”, these two medicinal plants are mistakenly used instead of each other in the Iranian medicinal plants market and even in scientific reports. Objective: In this study, the correct morphological description of studied species were introduced and the chemical composition of their essential oils and their using DPPH and FRAP Results: p -Cymen-8-ol (51.13 (7.69 (6.83 (85.65 carvone anisum EO. The results antioxidant activities in DPPH and FRAP assays at 250 μg/ml were 53.03 and 62.72 % for F. subpinnata 50.27 and 59.91 P. anisum , respectively. results of antioxidant activity DPPH FRAP almost similar potential.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49172821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}