Journal of Medicinal Plants最新文献_第2页

Optimization of Essential oils production in Mentha longifolia L. using plant growth promoting cyanobacteria 利用植物生长促进蓝藻优化长叶薄荷精油生产工艺

Journal of Medicinal Plants Pub Date : 2022-09-01 DOI: 10.52547/jmp.21.83.47

Zeinab Shariatmadari, Majid Ghorbani Nohooji, H. Riahi, A/Prof. Fatemeh Heidary MD, MPH, FAAO, FICO

引用次数: 0

Journal of Medicinal Plants Pub Date : 2022-09-01 DOI: 10.52547/jmp.21.83.1

Najmeh Dehparvar, F. Alijaniha, Seyyed Ali Mozaffarpur, A. Niasari-Naslaji, Zahra Bahaedin, A. Garshasbi, Mohammad Gholami-Fesharak, M. Naseri

引用次数: 0

Assessment of the antioxidant activity of the extrcat, cold press, and n-hexane oils and in vitro cytotoxic effects of Capparis spinosa L. seed on SH-SY5Y cancer cell lines 提取物、冷压油和正己烷油的抗氧化活性评估以及刺山柑种子对SH-SY5Y癌症细胞系的体外细胞毒性作用

Journal of Medicinal Plants Pub Date : 2022-09-01 DOI: 10.52547/jmp.21.83.87

Leila Ghassemifard, Saeed Sardari, H. Safari, H. Ramezanikhah, Narjes Khavasi

引用次数: 1

Isolation and purification of apigenin, quercetin and apigenin 7-O-glycoside from Apium graveolens L., Petroselinum crispum (Mill.) Fuss, Allium cepa L., respectively 芹菜素、槲皮素和芹菜素7-O-糖苷的分离纯化

Journal of Medicinal Plants Pub Date : 2022-09-01 DOI: 10.52547/jmp.21.83.72

S. Tavakoli, F. Khalighi-Sigaroodi, Nafiseh Khosravi Dehaghi, M. Yaghoobi, R. Hajiaghaee, A. Gholami, R. Ghafarzadegan

引用次数: 0

Fabrication and optimization of physicochemical properties of nano-phytosome from Punica granatum L. peel enriched polyphenol extract 石榴皮多酚提取物纳米植物体的制备及理化性质优化

Journal of Medicinal Plants Pub Date : 2022-09-01 DOI: 10.52547/jmp.21.83.60

D. Kazemi, S. Nejad Ebrahimi, Reza Mohsenian Kouchaksaraee

引用次数: 4

Chemical composition of the essential oils and antioxidant capacity evaluation of Echinophora platyloba DC. and Falcaria vulgaris Bernh. growing in Hamadan province of Iran 棘棘挥发油的化学成分及抗氧化能力评价。和寻常Falcaria Bernh。生长在伊朗哈马丹省

Journal of Medicinal Plants Pub Date : 2022-09-01 DOI: 10.52547/jmp.21.83.19

Mostafa Soleimani Shadvar, S. Moradkhani

引用次数: 1

Proapoptotic effect of nanoliposomes loaded with hydroalcoholic extract of Hypericum perforatum L. in combination with curcumin on SW48 and SW1116 colorectal cancer cell lines 载贯叶连翘水醇提取物纳米脂质体联合姜黄素对SW48和SW1116结直肠癌细胞株的促凋亡作用

Journal of Medicinal Plants Pub Date : 2022-05-01 DOI: 10.52547/jmp.21.82.28

F. Rezaeinejad, H. Bardania, Farideh ghalamfarsa, Sajad Hasanzadeh, F. Jadidi‐Niaragh, Ghasem Ghalamfarsa

{"title":"Proapoptotic effect of nanoliposomes loaded with hydroalcoholic extract of Hypericum perforatum L. in combination with curcumin on SW48 and SW1116 colorectal cancer cell lines","authors":"F. Rezaeinejad, H. Bardania, Farideh ghalamfarsa, Sajad Hasanzadeh, F. Jadidi‐Niaragh, Ghasem Ghalamfarsa","doi":"10.52547/jmp.21.82.28","DOIUrl":"https://doi.org/10.52547/jmp.21.82.28","url":null,"abstract":"Background: Colorectal cancer (CRC) continues to be a leading cause of cancer related death in the world and approximately 70 to 75 % of patients with metastatic colorectal cancer survive for up to 1 year after diagnosis. Curcumin (CUR) is a potential chemotherapeutic agent used to treat cancer. There is ample evidence of the inhibitory effects of Hypericum perforatum L. extract (HPE) on cell proliferation and its effects on the induction of apoptosis in various human cancer cell lines. Objective: The purpose of this study was to investigate the proapoptotic effect of HPE and its nanoliposomes (HPE-Lip) and to scrutinize the synergistic and therapeutic potential of HPE/CUR-loaded nanoliposome (HPE/CUR-Lip). Methods: In the present in vitro study, SW1116 and SW48 cell lines were cultured and then treated with different doses of HPE, CUR, bare liposome solely (Lip-Sol), and nanoliposomes loaded with HPE (HPE-Lip), CUR (CUR-Lip) and CUR/HPE (HPE/CUR-Lip) for 24, 48 and 72 hours. Cytotoxicity was measured by MTT assay and apoptosis rate by an annexin-V FITC/propidium iodide double-staining method using flow cytometry. Results: The results showed that cell viability was inhibited in a dose-dependent and time-dependent manner in all groups compared to the control group. The use of nanoliposomes improved the outcomes. HPE/CUR-Lip exhibited higher in vitro cytotoxic and proapoptotic activity against SW1116 and SW48 cell lines (P < 0.05). Conclusion: The findings of this study suggest that the HPE/CUR-Lip complex could provide a potential strategy to achieve a synergistic effect of HPE and CUR in the treatment of colorectal cancer.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47358888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of the anti-oxidative potential of Nepeta crispa Willd. (Lamiaceae) and its effects on oxidative stability of virgin sunflower oil under accelerated storage conditions 脆猪笼草抗氧化潜力的评估。（Lamiaceae）及其对加速贮藏条件下葵花油氧化稳定性的影响

Journal of Medicinal Plants Pub Date : 2022-05-01 DOI: 10.52547/jmp.21.82.13

Mohamadreza Motaghed, A. Nili-Ahmadabadi, S. Moradkhani

{"title":"Assessment of the anti-oxidative potential of Nepeta crispa Willd. (Lamiaceae) and its effects on oxidative stability of virgin sunflower oil under accelerated storage conditions","authors":"Mohamadreza Motaghed, A. Nili-Ahmadabadi, S. Moradkhani","doi":"10.52547/jmp.21.82.13","DOIUrl":"https://doi.org/10.52547/jmp.21.82.13","url":null,"abstract":"Acid Background: Nepeta crispa, is an annual plant native to certain regions of Hamadan province in Iran. Objective: This study aims to investigate the antioxidant potential of N. crispa. Methods: Hydro-distillated essential oil and methanol extract from aerial parts of N. crispa were obtained . They were subjected to several assays (DPPH, FRAP, TBARS, peroxide value and β -carotene-linoleic acid assay) in order to evaluate their antioxidant properties and their effect on prevention of oxidation in sunflower oil. Results: The extract consistently exhibited more activity than the essential oil in each and every one of the assays. The activity of the essential oil was not significant compared to positive controls or even the extract. The results from DPPH and FRAP assays correlated well with one another but those obtained from β -carotene-linoleic acid assay were to some extents inconsistent with the others. The results from TBARS and peroxide value assays revealed that certain concentrations of the extract effectively prevent the oxidation process in sunflower oil. Conclusion: Our data suggest that the methanol extract of N. crispa may be considered as novel bio-resource of natural antioxidants for using in pharmaceutical and food industries . Hopefully as the future research progress, new lights will be shed on characterization of components in the extract and the mechanisms through which they provide antioxidant activity.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49647539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Capparis spinosa L. tablet: from traditional to modern dosage form 枫香片:从传统剂型到现代剂型

Journal of Medicinal Plants Pub Date : 2022-05-01 DOI: 10.52547/jmp.21.82.56

S. Esmaeili, B. Keramatian, Haniye Kashafroodi, R. Choopani, H. Hajimehdipoor

{"title":"Capparis spinosa L. tablet: from traditional to modern dosage form","authors":"S. Esmaeili, B. Keramatian, Haniye Kashafroodi, R. Choopani, H. Hajimehdipoor","doi":"10.52547/jmp.21.82.56","DOIUrl":"https://doi.org/10.52547/jmp.21.82.56","url":null,"abstract":"Background: Capparis spinosa is used in Persian medicine for treatment of various diseases. In order to easier use, better patient’s acceptance and more stability, preparing a suitable dosage form is necessary. Objective: The aim of the study was preparing tablet form from caper fruits and quality assessment of the product. Methods: The fruit extraction was performed using ethanol 80% and maceration technique and the extract was dried by freeze dryer. Eight formulations were made using lactose, avicel PH-102, SiO 2 and magnesium stearate. The best formulation was failed during stability tests; therefore, the extract was dried by spray drying method along with maltodextrin and SiO 2 as excipients. Eight formulations were prepared using lactose, avicel PH-102, croscarmellose sodium, PVP K30 and magnesium stearate and the best one was selected. Physicochemical and microbial assessments were performed on the selected formulation and stability tests were done in 40°C and 75% humidity as well as 30°C. Results: Caper tablets with freeze dried extract were deformed and their color changed but tablets with spray dried extract were stable in 30°C. They were oblong, green-blue, biconvex, scored tablets with 20.3×9.9×6.7 mm dimensions. Weight, hardness, disintegration time, rutin assay and dissolution were 1115 mg ± 10%, 18.33 ± 1.52 kp, 15±3.5 min, 0.58 ± 0.02 mg/tab and 93.03 ± 3.61 % in 60 min, respectively. Conclusion: Caper tablets are good candidate for production in industrial scale after in vivo and clinical studies. Moreover stability assessment of the tablets should be performed in suitable packaging in long term study.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44055753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and evaluation of taste-masked pellets loaded with Matricaria chamomilla L. extract 苦菊提取物口味掩蔽微丸的研制与评价

Journal of Medicinal Plants Pub Date : 2022-05-01 DOI: 10.52547/jmp.21.82.80

N. Bolourchian, Sahel Shirvani, F. Mojab

{"title":"Development and evaluation of taste-masked pellets loaded with Matricaria chamomilla L. extract","authors":"N. Bolourchian, Sahel Shirvani, F. Mojab","doi":"10.52547/jmp.21.82.80","DOIUrl":"https://doi.org/10.52547/jmp.21.82.80","url":null,"abstract":"Abbreviations: Mch, Matricaria chamomilla L.; SLS, Sodium Lauryl Sulfate; MS, Magnesium Stearate; PVP, Polyvinyl Pyrrolidone; SSG, Sodium Starch Glycolate; DEx, Dry Extract; TPC, Total Phenol Content; TFC, Flavonoid Aspect CI, Carr’s Background: Remarkable properties of Matricaria chamomilla L. (Mch) have caused it to be considered widely in the treatment of different ailments including gastrointestinal disorders. Objective: In the present study, the Mch extract-loaded coated pellets were developed with the aim to mask its bitter taste and to improve its dosing flexibility and patient compliance, especially in children. Methods: The plant extract was obtained by maceration with ethanol 70 % and dried using rotary evaporating and freeze drying methods. Then it was used for pellet preparation along with different proportions of various additives such as Avicel, starch and lactose by extrusion-spheronization technique. The pellets were analyzed for their size, sphericity, aspect ratio and friability. The optimized formulation, subjected for coating by Eudragit E, was evaluated for taste-masking efficiency, dissolution and morphology. Results: The optimized pellets were produced with particle size, sphericity and aspect ratio equal to 1.13 mm, 0.924 and 1.172, respectively. Low friability, suitable flow properties (carr’s index = 3.01 %) as well as dissolution led this sample to be considered for taste-masking coating. Based on in vitro dissolution studies, although the coating layer significantly decreased the release of the components at higher pH compared to the uncoated particles, acceptable dissolution was observed at pH 1.2. Appropriate taste-masking of the product was also confirmed by in vivo analysis. Conclusion: The taste-masked Mch-loaded pellets with suitable characteristics could be an appropriate delivery system with improved patient compliance.","PeriodicalId":16582,"journal":{"name":"Journal of Medicinal Plants","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48404512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0