Journal of Medicinal Chemistry and Drug Design最新文献_第2页

Effect of PDCA Cycle Management Mode on Drug Loss in Inpatient Pharmacy PDCA循环管理模式对住院药房药品损失的影响

Journal of Medicinal Chemistry and Drug Design Pub Date : 2021-04-29 DOI: 10.11648/J.JDDMC.20210701.14

Xuliang Wu, Jufeng Li, Yanru Luo, Zhidong Zhang

{"title":"Effect of PDCA Cycle Management Mode on Drug Loss in Inpatient Pharmacy","authors":"Xuliang Wu, Jufeng Li, Yanru Luo, Zhidong Zhang","doi":"10.11648/J.JDDMC.20210701.14","DOIUrl":"https://doi.org/10.11648/J.JDDMC.20210701.14","url":null,"abstract":"Objective: To assess effect of PDCA cycle management mode on drug loss in inpatient pharmacy. Methods: From January 2019 to December 2020, we collected the data from hospital work record of inpatient pharmacy each season and data of total drug loss. The valid data of scrap drugs included item name, specification, packing, quantity, wholesale price, expiry date, and scrap reason. In scrap drugs record of hospital, the inpatient pharmacy managers often record drug data from actual situation of inpatient pharmacy and documents from the drug supplier. In addition, we also collected the change of for each season, and compare the result between 2019 and 2020. Result: The results showed that the number of damaged batches reported in 2019 was significantly higher than the number reported in 2020 (122 vs 77), with a difference of 68% between them. Among the drug loss amount, the loss amount increased with the increase of the number of batches reported to be damaged, and the result of loss amount differed by 54%. In quarter records, we observed that most of the losses occurred in the first quarter and the fourth quarter, with monetary losses of around RMB 2,000 in 2020 and about RMB 3,200 in 2019. Compared with 2019 group, there is a lower amount loss (RMB 10,157.88 vs RMB 5515.14) in the amount loss caused by drug loss in 2020, and the annual reported loss in 2020 group is 54% of the annual reported loss in 2019. Further, the dollar loss for each quarter in 2020 group was lower than for each quarter in 2019. Conclusion: PDCA cycle management mode effectively reduced drug broken event, that it provided continuous improvement as the inpatient pharmacy carried out this cycle management.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75000046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Analysis of Salvadora oleoides and Withania somnifera: An Insight into Their Antioxidant and Antimicrobial Capabilities 油萨尔瓦多和苦参的植物化学分析:对其抗氧化和抗菌能力的研究

Journal of Medicinal Chemistry and Drug Design Pub Date : 2021-03-10 DOI: 10.11648/J.JDDMC.20210701.12

Javed Ali Lakho, A. Taj, N. A. Rind, S. H. Naqvi

{"title":"Phytochemical Analysis of Salvadora oleoides and Withania somnifera: An Insight into Their Antioxidant and Antimicrobial Capabilities","authors":"Javed Ali Lakho, A. Taj, N. A. Rind, S. H. Naqvi","doi":"10.11648/J.JDDMC.20210701.12","DOIUrl":"https://doi.org/10.11648/J.JDDMC.20210701.12","url":null,"abstract":"Salvadora oleoides and Withania somnifera are the commonly found plants of Pakistan that are known to possess various medicinal properties. Present study was designed to evaluate the presence of various phytochemicals in these plants both qualitatively and quantitatively. This study was concluded with accessing the antioxidant and antimicrobial potentials of these phytochemicals against E. coli, Shigella Spp, Aspergillus terreus and Aspergillus niger. In addition qualitative analysis of phytochemical constituents i.e. alkaloids, glycosides, flavonoids, saponins, steroids, tannins and terpanoids and quantitative analysis of total proteins, sugars, reducing sugars, phenolics and flavonoids was performed. Plant extracts were also checked for the existence of antioxidant and antimicrobial activities. Results revealed the presence of a wide range of phytoconstituents including alkaloids, glycosides, flavonoids, saponins, steroids, tannins and terpenoids in both the plants. Quantification of few pharmaceutically important phytoconstituents showed the diversified response. Presence of antioxidants was confirmed in S. oleoides (2.14±SD mg/mL) in methanol extracts of leaves and water extract of leaves of W. somnifera (1.97±SD mg/mL). Methanolic extracts of leaves, bark and roots of both the medicinal plants showed inhibitory effects against both fungal and bacterial strains used. Our findings provide strong evidence that these medicinal plants possess phytoconstituents of pharmaceutical importance and thus may serve as an effective alternative to routine therapeutics.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79475612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient Tachypnea of the Newborn and the Use of Prophylactic Antibiotics 新生儿短暂性呼吸急促与预防性抗生素的应用

Journal of Medicinal Chemistry and Drug Design Pub Date : 2021-01-22 DOI: 10.11648/J.JDDMC.20210701.11

D. Saadoun, L. Doya, Adnan Dayoub, Oday Jouni

{"title":"Transient Tachypnea of the Newborn and the Use of Prophylactic Antibiotics","authors":"D. Saadoun, L. Doya, Adnan Dayoub, Oday Jouni","doi":"10.11648/J.JDDMC.20210701.11","DOIUrl":"https://doi.org/10.11648/J.JDDMC.20210701.11","url":null,"abstract":"Background: Transient tachypnea of the newborn (TTNB) is a common cause of respiratory distress in late preterm and full-term infants. It is caused by a delay in the clearance of fetal lung fluids. Although TTNB is a self-limited condition, prophylactic antibiotics usually administered for 48-72 hours until negative blood culture is reported. Objective: In this study, we aim to identify the relationship between using prophylactic antibiotics and the duration of tachypnea and hospitalization in neonates with TTNB. Materials and Methods: this was a cohort study design included 102 infants with TTNB. The infants were divided into two groups, one received supportive care, and the other received supportive care with intravenous antibiotics. The clinical signs and laboratory results were examined in the two groups. Results: Of total 102 infants who were included in this study, 41 (40.2%) were received supportive care with prophylactic intravenous antibiotics. There were no significant differences between two groups in terms of gender, gestational age, birth weight, mode of delivery, and white blood cell. A significant relation was found between receiving prophylactic antibiotics with the duration of tachypnea and hospitalization. Conclusions: In the recent study, we found an increase in the hospitalization and tachypnea period in the group received antibiotics.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72663040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of in vitro and in vivo Antimicrobial Activity of an Isonitrosomalononitrile Silver(I) Salt 异硝基体单腈银(I)盐的体内外抗菌活性评价

Journal of Medicinal Chemistry and Drug Design Pub Date : 2021-01-01 DOI: 10.16966/2578-9589.117

Colmont M, Brunel Jm

引用次数: 0

Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, Acinetobacter Baumannii 新型无毒性两亲性α-螺旋抗菌肽抗耐药革兰氏阴性细菌鲍曼不动杆菌的设计

Journal of Medicinal Chemistry and Drug Design Pub Date : 2021-01-01 DOI: 10.16966/2578-9589.114

Mant Ct, J. Z, G. L, D. T, Hodges Rs

{"title":"Design of Novel Amphipathic α-Helical Antimicrobial Peptides with No Toxicity as Therapeutics against the Antibiotic-Resistant Gram-Negative Bacterial Pathogen, Acinetobacter Baumannii","authors":"Mant Ct, J. Z, G. L, D. T, Hodges Rs","doi":"10.16966/2578-9589.114","DOIUrl":"https://doi.org/10.16966/2578-9589.114","url":null,"abstract":"We designed de novo and synthesized two series of five 26-residue amphipathic α-helical cationic antimicrobial peptides (AMPs) with five or six positively charged residues (D-Lys, L-Dab (2,4-diaminobutyric acid) or L-Dap (2,3-diaminopropionic acid)) on the polar face where all other residues are in the D-conformation. Hemolytic activity against human red blood cells was determined using the most stringent conditions for the hemolysis assay, 18h at 37°C, 1% human erythrocytes and peptide concentrations up to 1000 μg/mL (~380 μM). Antimicrobial activity was determined against 7 Acinetobacter baumannii strains, resistant to polymyxin B and colistin (antibiotics of last resort) to show the effect of positively charged residues in two different locations on the polar face (positions 3, 7, 11, 18, 22 and 26 versus positions 3, 7, 14, 15, 22 and 26). All 10 peptides had two D-Lys residues in the center of the non-polar face as “specificity determinants” at positions 13 and 16 which provide specificity for prokaryotic cells over eukaryotic cells. Specificity determinants also maintain excellent antimicrobial activity in the presence of human sera. This study shows that the location and type of positively charged residue (Dab and Dap) on the polar face are critical to obtain the best therapeutic indices.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"146 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77719360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Docking Analysis of A-type Proanthocyanidins to α-Glucosidase Constructed by Correlation with in Vitro Bioassay a型原花青素与α-葡萄糖苷酶的硅对接分析

Journal of Medicinal Chemistry and Drug Design Pub Date : 2019-12-23 DOI: 10.11648/J.JDDMC.20190504.11

S. Ho, Yili Lin, Sheng-Fa Tsai, Shoei‐Sheng Lee

{"title":"In Silico Docking Analysis of A-type Proanthocyanidins to α-Glucosidase Constructed by Correlation with in Vitro Bioassay","authors":"S. Ho, Yili Lin, Sheng-Fa Tsai, Shoei‐Sheng Lee","doi":"10.11648/J.JDDMC.20190504.11","DOIUrl":"https://doi.org/10.11648/J.JDDMC.20190504.11","url":null,"abstract":"The type A proanthocyanidins (2−8) with (2β→O→7, 4β→8) interflavane linkage, isolated from Machilus philippinensis, have been found to possess inhibitory activity against α-glucosidase (EC 3.2.1.20 from Bacillus stearothermophilus). To rationalize such activity, computer assisted docking of these compounds and the positive control, acarbose, on the conformation model of α-glucosidase (AG), built by using human intestinal maltase glucoamylase as a template, was undertaken in this study. The result showed good correlation between IC50 values and docking scores, expressed as binding energy (ΔG), obtained from London (trimatch)-refinement (forcefield AffinityΔG) mode. Among these isolates, the most potent aesculitannin B (2) (IC50 3.5μM) showed the best docking score (ΔG -21.48 kcal/mol). Being interested in clarification of structure and activity relationship, virtual screening on the related compounds, including the de-unit III homologs of 2−8 (i.e., nor- series) and additional 13 stereoisomers of the trimeric 2 at the C-2 and C-3 positions of units II and III, was further carried out. This docking study indicated the de-unit III homologs of 2−8 did not have better binding energies than 2. As for the trimers, 3-entC, 3C-entE, 3ent-C, 3C, and 3ent, showed comparable docking score to 2. The verification of this virtual screening was partially done by evaluating the inhibitory activity of the dimeric 2-nor-ent, 3-nor, 3-nor-ent, and iso-2-nor-ent, isolated from peanut skins, against α-glucosidase. Of these, iso-2-nor-ent, the only proanthocyanidin with (2β→O→7, 4β→6) interflavane linkage, showed the best activity (IC50 9.72 μM). Their simulation profiles of docking score also displayed a reasonable qualitative consistency with the overall trend of the bioassay results. This study demonstrates that virtual screening using this built model to search α-glucosidase inhibitors is facile and feasible and peanut skin might be used as a hypoglycemic food.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78520050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Rational Computational Study for New Kinase Inhibitors 新型激酶抑制剂的理性计算研究

Journal of Medicinal Chemistry and Drug Design Pub Date : 2019-09-02 DOI: 10.11648/J.JDDMC.20190503.12

João Antunes, Michelle Bueno de Moura Pereira

{"title":"Rational Computational Study for New Kinase Inhibitors","authors":"João Antunes, Michelle Bueno de Moura Pereira","doi":"10.11648/J.JDDMC.20190503.12","DOIUrl":"https://doi.org/10.11648/J.JDDMC.20190503.12","url":null,"abstract":"The development of new drugs can present several problems, it is a important obstacle the ability to adapt a molecule that is a potent pharmacological inhibitor and that is also possible to execute its synthesis. Quinazolines are known to be capable of inhibiting kinases. Thus, a detailed study was carried out to propose new quinazolines with already known synthetic routes, and that were promising for the ability to inhibit kinases. A drug candidate molecule shall be proposed to have a good absorption, an extensive distribution so it’s capable of reaching the desired therapeutic targets. Lipinski's Rule of 5 in computational studies has been applied to select more promising molecules. In this study, the molecules proposed for the synthesis were systematically designed in appropriate computational programs to test several substituents of the quinazoline nucleus on the capacity of these molecules to be considered inhibitors of kinases. Six molecules were selected with the best results to inhibit kinases. In the study to evaluate the variation of substituents, the result obtained for the 8-position of the quinazoline ring and with the -Cl substituent at that ring position presented 60% of the 10 best molecules capable of inhibiting kinases. The molecular docking study confirmed that the two most promising molecules to inhibit kinase also obtained the best results to inhibit AKT kinase. Therefore, through this study it was possible to select six more promising molecules to be synthesized and available in large screening tests for several therapeutic targets known as High-Throughput Screening.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73392533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New ACE Inhibitor Designed from Nicotianamine and Its Docking Pose Prediction Using the Gold Program 由烟碱胺设计的新型ACE抑制剂及其对接位预测

Journal of Medicinal Chemistry and Drug Design Pub Date : 2019-08-23 DOI: 10.11648/J.JDDMC.20190503.11

N. Takada, T. Okada, E. Kogawa, Y. Sanada, A. Ishidoya

{"title":"New ACE Inhibitor Designed from Nicotianamine and Its Docking Pose Prediction Using the Gold Program","authors":"N. Takada, T. Okada, E. Kogawa, Y. Sanada, A. Ishidoya","doi":"10.11648/J.JDDMC.20190503.11","DOIUrl":"https://doi.org/10.11648/J.JDDMC.20190503.11","url":null,"abstract":"Hypertension is currently one of the most serious health issues worldwide. Nicotianamine, a non-peptide-type amino acid trimer, is ubiquitously present in higher plants and plays a role as an internal metal transporter. It is known that nicotianamine inhibits ACE activity and that oral treatment with the compound improves hypertension. However the mode of action remains unclear, due to lack of crystallographic data. Although a structure-activity relationship study of nicotianamine has the potential to uncover the details of the inhibition profile, the azetidine-2-carboxylic acid moiety in nicotianamine has become a critical barrier for further biochemical research due to limited commercial supply and difficulties with structural modification. In this paper, ten nicotianamine analogs without azetidine-2-carboxylic acid moiety were prepared and their inhibition of angiotensin I-converting enzyme was investigated. Among these analogs, a phenylalanine analog, (2S,3′S,3″S)-N-{3′-(3″-amino-3″-carboxypropylamino)-3′-carboxypropyl}phenylalanine, displayed the most potent activity. The inhibition activity of the compound corresponded to that of captopril. These results suggested a possibility of structural modification of nicotianamie to develop antihypertensive drugs. Molecular docking studies with Gold were also performed to predict the binding poses of nicotianamine and its analog, suggesting that nicotianamine and its analogs combine a plausible allosteric site in an area away from the catalytic site in ACE.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76292252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Development of Co-processed Paracetamol with Hydroxypropyl Methylcellulose (HPMC) and Maltodextrin by Wet Granulation Process 羟丙基甲基纤维素与麦芽糖糊精湿法制备对乙酰氨基酚的研究

Journal of Medicinal Chemistry and Drug Design Pub Date : 2019-08-07 DOI: 10.11648/J.JDDMC.20190502.12

Ortega Leticia, G. Martin, D. Rodríguez

{"title":"Development of Co-processed Paracetamol with Hydroxypropyl Methylcellulose (HPMC) and Maltodextrin by Wet Granulation Process","authors":"Ortega Leticia, G. Martin, D. Rodríguez","doi":"10.11648/J.JDDMC.20190502.12","DOIUrl":"https://doi.org/10.11648/J.JDDMC.20190502.12","url":null,"abstract":"The purpose of this work is to improve one of the important physicochemical properties of an active pharmaceutical ingredient (API), as is the water solubility of paracetamol. To improve the physicochemical properties of this API, two pharmaceutical excipients such as the HPMC and maltodextrin were used, which help to improve the solubility, and this helps to the manufacturing process of a pharmaceutical product. Different granule formulations were manufactured by applying a matrix design of experiment where the wet granulation process was performed, combining Paracetamol with the excipients to obtain a uniform particle size and subsequently evaluate the properties of interest. The solubility was evaluated using a method (Mexican pharmacopoeia - FEUM) based on UV / VIS method, performing the calibration curve only for the API to evaluate the granule and calculate the percentage of solubility of these. Favorable results were obtained for two of the seven granule formulations manufactured, the mixture of granule F and G: 25 g of paracetamol, 1.5; 1.75 g of HPMC and 23.5 g; 23.25 of the maltodextrin has a solubility of 104.17% and 101.48% of the G, which shows that the process by wet granulation can improve its solubility. This type of co-processed granule also fulfills the function of masking the bitter taste of paracetamol in one oral pharmaceutical form, as in the case of a syrup and it could be an advantage in the market. The flavor was evaluated by a panel of 20 people and the taste of the syrups that were prepared with the granule with better solubility was compared with the syrups containing only the API dissolved. It is shown that the granules F have improvement in the solubility of paracetamol and can mask the unpleasant (bitter) taste of the active ingredient.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76962746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug 橡树瘿中单宁的提取及其抗氧化活性和单宁铁螯合作用与去铁胺药物的比较

Journal of Medicinal Chemistry and Drug Design Pub Date : 2019-08-07 DOI: 10.11648/J.JDDMC.20190502.11

Meghdad Payab, M. Chaichi, Omeleila Nazari, F. Maleki

{"title":"Tannin Extraction from Oak Gall and Evaluation of Anti-Oxidant Activity and Tannin Iron Chelation Compared with Deferoxamine Drug","authors":"Meghdad Payab, M. Chaichi, Omeleila Nazari, F. Maleki","doi":"10.11648/J.JDDMC.20190502.11","DOIUrl":"https://doi.org/10.11648/J.JDDMC.20190502.11","url":null,"abstract":"In this study, tannins were extracted by two methods (soaking and Soxhlet) with three different solvents (water, methanol and aqueous methanol 50%) and the three kind plant (walnut shell, gall oak and walnut leaves), that the highest extraction efficiency (82.08%) was related to extraction with aqueous methanol by Soxhlet method from the oak galls. Although the results of soaking were nearly to the Soxhlet. One oak Gall extract was evaluated by Lowenthal method that the result was showed that reducing materials such as tannins are 26.14%. The extracted was evaluated by Folin-Ciocalteu method that suggests phenolic compounds in the extract was 15.27, (61.07± 7.12 mg compared to gallic acid). Result of evaluation of antioxidant activity of the extracted showed the high antioxidant properties of tannins compared to ascorbic acid at less than 100 ppm concentrations, but these properties comparable to ascorbic acid of the higher concentrations, so a lower dose of the extract was may be helpful. The chelation properties of the iron ions at low concentrations of iron (III), oak was showed better performance compared to Deferoxamine but Deferoxamine due to complex formation with higher stoichiometry (1: 6) at high concentrations of Fe (III), has performed better than the oak.","PeriodicalId":16581,"journal":{"name":"Journal of Medicinal Chemistry and Drug Design","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90773902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2