{"title":"Inflammation in Schizophrenia? A review of alterations in patients","authors":"Reet Nandy","doi":"10.37506/dxfh2f92","DOIUrl":"https://doi.org/10.37506/dxfh2f92","url":null,"abstract":"Schizophrenia is a psychotic psychiatric disorder that significantly impacts the social life of the patient. A better understanding of pathogenesis of this disorder is of utmost importance to caregivers. Recent studies have shown evidence of inflammatory reactions involving the pathogenesis of Schizophrenia. Biochemical analysis of CSF has reported an increased count of IL-6 and IL-8 along with other inflammatory substances. Histopathological studies of brain of the affected individuals have presented microglial dysfunction along with several other changes, observed by different researchers. Also, mothers suffering from any particular condition that involved inflammation in the gestational period have been observed to lead to the development of Schizophrenia or related disorders in offspring. Gut-Brain Axis has recently acquired a huge interest among medical researchers. A lot of psychiatric conditions are nowadays being attributed to gut microbiota. Gut microbiota analysis among Schizophrenia patients has shown significant alteration of gut microflora, for example, an increased number of Lactobacillus sp. All these studies, when taken into consideration, can give a holistic approach towards the way the pathology of Schizophrenia being viewed, and thus allow professionals to provide better careto the patients.","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"10 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141265841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nnadi Ogechukwu Frances, Dr. Eyiuche Doris Ezigbo, Chijioke Noris Ezinwa
{"title":"The Effects of Different Forms of Contraceptives on the Coagulation Profile","authors":"Nnadi Ogechukwu Frances, Dr. Eyiuche Doris Ezigbo, Chijioke Noris Ezinwa","doi":"10.37506/5evcbf35","DOIUrl":"https://doi.org/10.37506/5evcbf35","url":null,"abstract":"Background: The association between combined oral contraceptive pills and increased risk of venous thromboembolism has been extensively researched but little has been reported on its effects on all haematological parameters and coagulation factors. This study aimed to evaluate the effects of different forms of oral contraceptives on the coagulation profile of female subjects in Enugu metropolis. This case-control study was conducted among women attending the Family planning unit of University of Nigera Teaching Hospital, Ituku Ozalla, Enugu State. \u0000Methods: The subjects were 36 women undergoing oral contraceptive medication and the control were 36 healthy women not taking this medication. ABO blood grouping and Full blood count (FBC) were carried out while prothrombin time (PT) and activated partial thromboplastin time (APTT) of test subjects were determined using test kits from Technoclone Austria. Most of the test subjects were found to be of the O + blood group. The haematological profile of test subjects showed a statistically significant increase in Red blood cell (RBC), packed cell volume (PCV), neutrophil, eosinophil, mean platelet volume (MPV) and plateletcrit while showing statisticallysignificant reductions in mean cell volume (MCV), mean cell haemoglobin (MCH), mean cell haemoglobin concentration (MCHC), lymphocyte, basophil, platelet volume distribution width (PDW) and red cell distribution widths in comparison to the control group. There was a significant decrease in the PT of test subjects (16.06±1.35 secs) in comparison to the control group (19.63±1.28 secs) while the slight increase in their APTT values was not significant. \u0000Conclusion: Thrombotic markers such as increased Red cell markers; RBC, haematocrit and platelet indices; MPV, PCT were increased along with decreased PT levels and prolonged APTT values though not significant can link oral contraceptives medication use to a hypercoagulable state in subjects thereby increasing their risk to venous thromboembolism.","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"2 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141387933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Comparative Study of Fine Needle Aspiration Cytology and Histopathology in Salivary Gland Lesions","authors":"D. Rathod, Bhavika Vaghela, H. Goswami","doi":"10.5958/2395-1184.2019.00024.X","DOIUrl":"https://doi.org/10.5958/2395-1184.2019.00024.X","url":null,"abstract":"","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124675166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Janaki, K. Srinivasulu, R. S. Rani, K. Bharani, K. S. Babu
{"title":"A Clinicopathological Study of Xanthogranulomatous Pyelonephritis","authors":"M. Janaki, K. Srinivasulu, R. S. Rani, K. Bharani, K. S. Babu","doi":"10.5958/2395-1184.2019.00015.9","DOIUrl":"https://doi.org/10.5958/2395-1184.2019.00015.9","url":null,"abstract":"","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133518862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinico-Histopathological Study of Tumours of Nasal & Paranasal Sinuses in a Tertiary Care Hospital","authors":"Naila Durrani, M. Ali","doi":"10.5958/2395-1184.2019.00027.5","DOIUrl":"https://doi.org/10.5958/2395-1184.2019.00027.5","url":null,"abstract":"","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127829471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic Accuracy of Fine Needle Aspiration Cytology (FNAC) and Histopathology in Salivary Gland Lesions","authors":"Payal Y. Malwiya, Mahesh Patel, H. Goswami","doi":"10.5958/2395-1184.2019.00008.1","DOIUrl":"https://doi.org/10.5958/2395-1184.2019.00008.1","url":null,"abstract":"","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"90 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116028557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Madhuvan, J. Mishra, A. Deshmukh, M. Bindra, Manoj Kumar Nandeolikar, Geeta Deshmukh
{"title":"Comparative Study of CBC based Indices in Microcytic Hypochromic Anemia to Detect Thalassemia Trait- An Experience at Tertiary Care Institute of Greater Noida","authors":"Madhuvan, J. Mishra, A. Deshmukh, M. Bindra, Manoj Kumar Nandeolikar, Geeta Deshmukh","doi":"10.5958/2395-1184.2019.00025.1","DOIUrl":"https://doi.org/10.5958/2395-1184.2019.00025.1","url":null,"abstract":"","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127912509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cytological and Histopathological Correlation of Breast Lump: A One Year Study at Tertiary Care Centre","authors":"D. Trivedi, V. Chaudhari, Neha A Jadhav","doi":"10.5958/2395-1184.2019.00030.5","DOIUrl":"https://doi.org/10.5958/2395-1184.2019.00030.5","url":null,"abstract":"","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117123853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective Study of Various Histopathological Lesions in Prostate Biopsy","authors":"Jaimin Manek, Ami Shah, H. Goswami","doi":"10.5958/2395-1184.2019.00009.3","DOIUrl":"https://doi.org/10.5958/2395-1184.2019.00009.3","url":null,"abstract":"","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117303289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Role of Novel Platelet Indices in Patients of Dengue Fever","authors":"Swati Singh, M. Tyagi","doi":"10.5958/2395-1184.2019.00029.9","DOIUrl":"https://doi.org/10.5958/2395-1184.2019.00029.9","url":null,"abstract":"","PeriodicalId":165727,"journal":{"name":"International Journal of Contemporary Pathology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122031837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}