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Advances in IgA nephropathy management, from pathological insights to personalized treatment IgA肾病管理的进展，从病理认识到个性化治疗
Journal of Nephropathology Pub Date : 2023-08-14 DOI: 10.34172/jnp.2023.21480
Mitra Shavakhi, A. Baqir
{"title":"Advances in IgA nephropathy management, from pathological insights to personalized treatment","authors":"Mitra Shavakhi, A. Baqir","doi":"10.34172/jnp.2023.21480","DOIUrl":"https://doi.org/10.34172/jnp.2023.21480","url":null,"abstract":"IgA nephropathy is a common glomerulonephritis with variable clinical outcomes. The optimal treatment for this condition remains uncertain, and corticosteroid therapy is reserved for patients unresponsive to supportive treatment. The histopathologic examination has a significant role in the diagnosis and prognosis of IgA nephropathy, but its role in the initiation of corticosteroid therapy is still under debate. Recently, targeted release formulation (TRF)-budesonide has emerged as a promising treatment due to its localized delivery to the gut and low systemic adverse effects. This brief review aims to assess recent advancements in IgA nephropathy management, focusing on applying Oxford classification in guiding corticosteroid therapy.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45205461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
End stage renal disease due to primary hyperoxaluria in a 7-month infant; a case report 7个月婴儿原发性高血氧血症致终末期肾病1例病例报告
Journal of Nephropathology Pub Date : 2023-07-04 DOI: 10.34172/jnp.2023.21475
Paniz Pourpashang, Arefeh Zahmatkesh, F. Nili, Zahra Pournasiri, Farzaneh Khosropour
{"title":"End stage renal disease due to primary hyperoxaluria in a 7-month infant; a case report","authors":"Paniz Pourpashang, Arefeh Zahmatkesh, F. Nili, Zahra Pournasiri, Farzaneh Khosropour","doi":"10.34172/jnp.2023.21475","DOIUrl":"https://doi.org/10.34172/jnp.2023.21475","url":null,"abstract":"Primary hyperoxaluria (PH) is a rare genetic metabolic disease presented severely in infants with end-stage renal disease (ESRD). Promoting diagnosis with aggressive management is essential in these patients. Here we presented a rare case of primary hyperoxaluria type 1 (PH1) in a seven-month infant girl who underwent dialysis with prospective kidney transplantation in the future.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":"125 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69815788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An unusual blend; IgA nephropathy and anti GBM disease 不寻常的混合;IgA肾病与抗GBM疾病
Journal of Nephropathology Pub Date : 2023-06-19 DOI: 10.34172/jnp.2023.17325
N. Jose, E. Indhumathi, M. Bindra, Selvin Sundar Raj, M. Jayakumar
{"title":"An unusual blend; IgA nephropathy and anti GBM disease","authors":"N. Jose, E. Indhumathi, M. Bindra, Selvin Sundar Raj, M. Jayakumar","doi":"10.34172/jnp.2023.17325","DOIUrl":"https://doi.org/10.34172/jnp.2023.17325","url":null,"abstract":"Anti-glomerular basement membrane (anti-GBM) disease is a rare illness with a wide spectrum of clinical manifestations. The typical presentation (90% of cases) of anti-GBM is with a rapidly progressive glomerulonephritis (RPGN) in conjunction with pulmonary disease in 25-60% of cases. In its atypical form – seen in 10% of cases, anti GBM disease takes on a chronic form, presenting with long standing renal dysfunction, proteinuria and better renal prognosis when compared to the typical form of the disease. The known associations of anti-GBM disease are with anti-neutrophil cytoplasmic antibody (ANCA)vasculitis and membranous nephropathy. In this case report, a young lady with atypical anti-GBM disease is described with a most unusual association with IgA nephropathy. This association is rare and only described in few case reports worldwide. The possible pathogenesis, clinical features, treatment and outcome of this disease are also elucidated.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48062170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extensive renal cortical necrosis in a postpartum patient after COVID-19 infection COVID-19感染后产后广泛肾皮质坏死1例
Journal of Nephropathology Pub Date : 2023-05-09 DOI: 10.34172/jnp.2023.18380
A. Abbasi, K. Makhdoomi, S. Babaei, Behzad Banaie, L. Mahmoudzadeh, Sepideh Rahimi, P. Porteghali
{"title":"Extensive renal cortical necrosis in a postpartum patient after COVID-19 infection","authors":"A. Abbasi, K. Makhdoomi, S. Babaei, Behzad Banaie, L. Mahmoudzadeh, Sepideh Rahimi, P. Porteghali","doi":"10.34172/jnp.2023.18380","DOIUrl":"https://doi.org/10.34172/jnp.2023.18380","url":null,"abstract":"It has been more than two years since the COVID-19 pandemic affects the world. COVID-19 affects other organs in addition to the respiratory system. Renal cortical necrosis is a severe kidney injury due to decreased renal arterial perfusion induced by vascular spasm, microvascular injury and endovascular thrombosis. Acute kidney injury is a common finding in COVID-19; however, renal cortical necrosis is rare. To the best of our knowledge, only one case of renal cortical necrosis has been reported in the literature.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47631897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The importance of screening for hypertension in children and adolescents 儿童和青少年高血压筛查的重要性
Journal of Nephropathology Pub Date : 2023-05-03 DOI: 10.34172/jnp.2023.21457
M. Alaei, Mohamad Ghazanfar Hashemi, Gelayol Chatrnour, Amirhossein Fakhre Yaseri
{"title":"The importance of screening for hypertension in children and adolescents","authors":"M. Alaei, Mohamad Ghazanfar Hashemi, Gelayol Chatrnour, Amirhossein Fakhre Yaseri","doi":"10.34172/jnp.2023.21457","DOIUrl":"https://doi.org/10.34172/jnp.2023.21457","url":null,"abstract":"Hypertension (HTN) is the most prevalent chronic non-infected disease and the greatest cause of adult premature mortality. Although in the past clinicians assumed that HTN in childhood and adolescents is uncommon, it is currently a significant public health issue and this narrative review aimed to assess the new finding regarding screening for HTN in Children and adolescents. Relevant English publications were extracted from Web of Science, PubMed, Scopus, and Google Scholar. As there are gaps regarding recommendations, guidelines, and screening for HTN in children and adolescents, this review tried to notice some important points.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48043902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An infant girl with bilateral multicystic dysplastic kidney: a case report 女婴双侧多囊肾发育不良1例
Journal of Nephropathology Pub Date : 2023-04-10 DOI: 10.34172/jnp.2023.21432
Paniz Pourpashang, Seyed Mohammad Taghi Hosseini Tabatabaei, M. Fallahi, L. Mohajerzadeh, Arefeh Zahmatkesh
{"title":"An infant girl with bilateral multicystic dysplastic kidney: a case report","authors":"Paniz Pourpashang, Seyed Mohammad Taghi Hosseini Tabatabaei, M. Fallahi, L. Mohajerzadeh, Arefeh Zahmatkesh","doi":"10.34172/jnp.2023.21432","DOIUrl":"https://doi.org/10.34172/jnp.2023.21432","url":null,"abstract":"Multicystic dysplastic kidney (MCDK) is a congenital kidney abnormality with an overall incidence rate of 1/4300 live births that is more prevalent in males than females. Here, we describe a rare case of bilateral MCDK complicated by hypertension, severe vesicoureteral reflux (VUR), and urinary tract infection (UTI), who stabilized during hospitalization with prospective kidney transplantation due to poor prognosis. Since bilateral MCDK is a rare disease with numerous complications and a poor prognosis, patient symptom management and treatment may be more challenging.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43218468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Disseminated tuberculosis presenting as a crescentic glomerulonephritis 呈新月体肾小球肾炎的播散性肺结核
Journal of Nephropathology Pub Date : 2023-04-10 DOI: 10.34172/jnp.2023.21434
Gerry George Mathew, Dinesh Babu
{"title":"Disseminated tuberculosis presenting as a crescentic glomerulonephritis","authors":"Gerry George Mathew, Dinesh Babu","doi":"10.34172/jnp.2023.21434","DOIUrl":"https://doi.org/10.34172/jnp.2023.21434","url":null,"abstract":"A 48-year-old male patient presented with dialysis dependent renal failure with biopsy showing crescentic glomerulonephritis and Positron emission tomography–computed tomography (PET-CT scan) revealing features of pericardial, pulmonary tuberculosis with positive urinary GeneXpert test for tuberculosis bacilli. Clinicians should keep in mind the atypical presentations of tuberculosis while managing rapidly progressive renal failure especially in tropical countries with high prevalence of tuberculosis.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49326856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Renal failure and pleural effusion; a diagnostic challenge 肾功能衰竭和胸腔积液;诊断上的挑战
Journal of Nephropathology Pub Date : 2023-04-10 DOI: 10.34172/jnp.2023.17309
Sara Cardoso Fernandes, Joana Marques, M. Pinto, M. Góis, H. Sousa, F. Nolasco
{"title":"Renal failure and pleural effusion; a diagnostic challenge","authors":"Sara Cardoso Fernandes, Joana Marques, M. Pinto, M. Góis, H. Sousa, F. Nolasco","doi":"10.34172/jnp.2023.17309","DOIUrl":"https://doi.org/10.34172/jnp.2023.17309","url":null,"abstract":"Sjögren’s syndrome is a chronic inflammatory disorder mostly involving the exocrine glands. Extraglandular disease may occur in up to one quarter of patients. Kidney involvement is rare, more often manifested by tubular dysfunction secondary to tubulointerstitial nephritis. Primary glomerular disease is uncommon. The authors present the case of a 73-year-old woman with xerostomia and positivity for anti-Ro and anti-La antibodies admitted for acute kidney injury and exudative pleural effusion. Biopsy of salivary glands was compatible with Sjögren’s syndrome. Extraglandular involvement was also confirmed by renal and pleural deposition of AA-amyloid. The patient was started on prednisolone followed by azathioprine with rapid improvement of lung disease. However, due to progressing renal disease and clinical deterioration, prognosis was guarded and the patient died. We describe a case of secondary amyloidosis with systemic involvement and infrequent clinical manifestations, briefly reviewing the key aspects of Sjögren’s syndrome and AA-amyloidosis.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48386247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case series of low dose rituximab for membranous nephropathy; a single centre experience 低剂量利妥昔单抗治疗膜性肾病病例系列；单中心体验
Journal of Nephropathology Pub Date : 2023-04-10 DOI: 10.34172/jnp.2023.21440
Gerry George Mathew, Jayaprakash Varadharajan, Sreedhar Sailapathy
{"title":"Case series of low dose rituximab for membranous nephropathy; a single centre experience","authors":"Gerry George Mathew, Jayaprakash Varadharajan, Sreedhar Sailapathy","doi":"10.34172/jnp.2023.21440","DOIUrl":"https://doi.org/10.34172/jnp.2023.21440","url":null,"abstract":"Introduction: Rituximab is the recent treatment of choice for primary membranous nephropathy However, dose of rituximab mentioned in literature is high and not economical in middle income countries. Low dose rituximab based on CD 19 cell count can be tried as an alternative for high dose rituximab for inducing clinical remission in appropriate clinical settings. Case Series: Four patients were administered low dose rituximab and initial CD 19 count was monitored for optimal rituximab response. Three males and one female are part of this case series. Renal biopsies showed membranous nephropathy with tissue phospholipase A2 receptor (PLA2R) positivity in two cases. Serum PLA2R was positive for the same two cases. Two patients completely remitted after one year, one male patient required additional rituximab dose based on CD19 count, one patient required single dose of rituximab for partial remission in the background of tacrolimus with steroids. One patient failed to remit on low dose rituximab protocol. Conclusion: Low dose Rituximab can be tried as a favorable alternative for high dose Rituximab in appropriate clinical settings.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42124925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rhabdomyolysis following Oxford/AstraZeneca COVID-19 vaccination; two case reports from Iran 牛津/阿斯利康新冠肺炎疫苗接种后的横纹肌溶解症；来自伊朗的两例病例报告
Journal of Nephropathology Pub Date : 2023-04-08 DOI: 10.34172/jnp.2023.18408
M. Hashemi, Ghazaleh Sajadi, Samaneh Pourajam
{"title":"Rhabdomyolysis following Oxford/AstraZeneca COVID-19 vaccination; two case reports from Iran","authors":"M. Hashemi, Ghazaleh Sajadi, Samaneh Pourajam","doi":"10.34172/jnp.2023.18408","DOIUrl":"https://doi.org/10.34172/jnp.2023.18408","url":null,"abstract":"Defined as the destruction of the skeletal muscle wall and the release of cellular contents into the bloodstream, rhabdomyolysis has been reported as a complication for some forms of vaccines. On the other hand, the COVID-19 pandemic has led to the extensive production and use of several vaccines against SARS-CoV-2, meanwhile, the side effects of these vaccines are gradually being reported. Up to now, few cases of rhabdomyolysis due to COVID-19 vaccination have been reported in the studies. The present study intended to report two cases of rhabdomyolysis due to vaccination with Oxford/AstraZeneca COVID-19 vaccines. The patients were two men aged 70 and 75 years old who presented to a healthcare facility with weakness, myalgia, nausea, and vomiting for about ten days after receiving their first dose of the Oxford/AstraZeneca COVID-19 vaccine. Patients had elevated levels of creatine phosphokinase (CPK), which were 5540 IU/L and 18760 IU/L in patients, respectively.","PeriodicalId":16515,"journal":{"name":"Journal of Nephropathology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46353344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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