Journal of Neuroimmune Pharmacology最新文献_第2页

Host-Immune Interactions in JC Virus Reactivation and Development of Progressive Multifocal Leukoencephalopathy (PML). JC病毒活化和进行性多灶性白质脑病（PML）发展过程中的宿主免疫相互作用

IF 5.2 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-12-01 Epub Date: 2019-08-27 DOI: 10.1007/s11481-019-09877-8

Amir Khalili, Michael Craigie, Martina Donadoni, Ilker Kudret Sariyer

{"title":"Host-Immune Interactions in JC Virus Reactivation and Development of Progressive Multifocal Leukoencephalopathy (PML).","authors":"Amir Khalili, Michael Craigie, Martina Donadoni, Ilker Kudret Sariyer","doi":"10.1007/s11481-019-09877-8","DOIUrl":"10.1007/s11481-019-09877-8","url":null,"abstract":"With the advent of immunomodulatory therapies and the HIV epidemic, the impact of JC Virus (JCV) on the public health system has grown significantly due to the increased incidence of Progressive Multifocal Leukoencephalopathy (PML). Currently, there are no pharmaceutical agents targeting JCV infection for the treatment and the prevention of viral reactivation leading to the development of PML. As JCV primarily reactivates in immunocompromised patients, it is proposed that the immune system (mainly the cellular-immunity component) plays a key role in the regulation of JCV to prevent productive infection and PML development. However, the exact mechanism of JCV immune regulation and reactivation is not well understood. Likewise, the impact of host factors on JCV regulation and reactivation is another understudied area. Here we discuss the current literature on host factor-mediated and immune factor-mediated regulation of JCV gene expression with the purpose of developing a model of the factors that are bypassed during JCV reactivation, and thus are potential targets for the development of therapeutic interventions to suppress PML initiation. Graphical Abstract.","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"14 1","pages":"649-660"},"PeriodicalIF":5.2,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6898772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42884718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Effects of Genistein in a SOD1-G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis. 染料木素在SOD1-G93A转基因肌萎缩性侧索硬化症小鼠模型中的神经保护作用

IF 6.1 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-12-01 Epub Date: 2019-07-18 DOI: 10.1007/s11481-019-09866-x

Zichun Zhao, Jinsheng Fu, Shiping Li, Zhenzhong Li

{"title":"Neuroprotective Effects of Genistein in a SOD1-G93A Transgenic Mouse Model of Amyotrophic Lateral Sclerosis.","authors":"Zichun Zhao, Jinsheng Fu, Shiping Li, Zhenzhong Li","doi":"10.1007/s11481-019-09866-x","DOIUrl":"10.1007/s11481-019-09866-x","url":null,"abstract":"Oxidant toxicity has been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS), an insidiously progressive neurodegenerative disorder involving upper and lower motor neurons. Here, we investigated the cellular and molecular mechanisms underlying the neuroprotective effects of an anti-oxidant genistein in SOD1-G93A transgenic mouse model of ALS. Rotarod test, hanging wire test and hindlimb clasping test were used to determined disease onset and assess motor performance. Immunostaining together with neuronal size measurement were used to count viable motor neurons. In addition, immunostaining procedure and ELISA kit were used to assess the inflammatory response in the spinal cord. Our results showed that Genistein administration suppressed the production of pro-inflammatory cytokines and alleviated gliosis in the spinal cord of SOD1-G93A mice. In addition, genistein administration induced autophagic processes and enhanced the viability of spinal motor neurons. As a result, genistein alleviated ALS-related symptoms and slightly prolonged the lifespan of SOD1-G93A mice. Taken together, our results indicate that genistein is neuroprotective in SOD1-G93A mice, suggesting genistein could be a promising treatment for human ALS. Graphical Abstract Genistein protects impariments in SOD1-G93A transgenic mouse model.","PeriodicalId":16500,"journal":{"name":"Journal of Neuroimmune Pharmacology","volume":"14 1","pages":"688-696"},"PeriodicalIF":6.1,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48188247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simvastatin Therapy in Multiple Sclerosis Patients with Respect to Gut Microbiome-Friend or Foe? 辛伐他汀治疗多发性硬化患者的肠道微生物组朋友还是朋友？

IF 6.1 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-12-01 Epub Date: 2019-10-18 DOI: 10.1007/s11481-019-09881-y

Mehdi Toghi, Sara Bitarafan

引用次数: 0

AGK2 Alleviates Lipopolysaccharide Induced Neuroinflammation through Regulation of Mitogen-Activated Protein Kinase Phosphatase-1 AGK2通过调节丝裂原活化蛋白激酶磷酸酶-1减轻脂多糖诱导的神经炎症

3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-11-30 DOI: 10.1007/s11481-019-09890-x

Fangzhou Jiao, Yao Wang, Wenbin Zhang, Haiyue Zhang, Qian Chen, Luwen Wang, Chunxia Shi, Zuojiong Gong

引用次数: 29

Protease Inhibitors, Saquinavir and Darunavir, Inhibit Oligodendrocyte Maturation: Implications for Lysosomal Stress 蛋白酶抑制剂沙奎那韦和达那韦抑制少突胶质细胞成熟:对溶酶体应激的影响

IF 6.2 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-11-28 DOI: 10.1007/s11481-019-09893-8

L. Festa, Lindsay M. Roth, Brigid K. Jensen, J. Geiger, K. Jordan-Sciutto, J. Grinspan

引用次数: 13

A Broad Application of CRISPR Cas9 in Infectious, Inflammatory and Neurodegenerative Diseases CRISPR Cas9在感染性、炎症性和神经退行性疾病中的广泛应用

IF 6.2 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-11-28 DOI: 10.1007/s11481-019-09889-4

K. Pahan

引用次数: 4

Beta1- and Beta2-Adrenoceptors Expression Patterns in Human Non-small Cell Lung Cancer: Relationship with Cancer Histology β 1-和β 2-肾上腺素受体在人非小细胞肺癌中的表达模式:与肿瘤组织学的关系

IF 6.2 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-10-16 DOI: 10.1007/s11481-019-09879-6

M. Coelho, A. Imperatori, A. Chiaravalli, F. Franzi, M. Castiglioni, E. Rasini, A. Luini, M. Legnaro, F. Marino, L. Ribeiro, M. Cosentino

引用次数: 6

A Broad Application of CRISPR Cas9 in Infectious Diseases of Central Nervous System CRISPR-Cas9在中枢神经系统传染病中的广泛应用

IF 6.2 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-09-11 DOI: 10.1007/s11481-019-09878-7

A. Bellizzi, Nicholas Ahye, Gauthami Jalagadugula, Hassen S Wollebo

引用次数: 4

HIV-1 Tat-Induced Astrocytic Extracellular Vesicle miR-7 Impairs Synaptic Architecture HIV-1诱导的星形细胞胞外泡miR-7损害突触结构

IF 6.2 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-08-10 DOI: 10.1007/s11481-019-09869-8

Guoku Hu, F. Niu, K. Liao, P. Periyasamy, S. Sil, Jinxu Liu, S. Dravid, S. Buch

引用次数: 33

The Association of Immune Markers with Cognitive Performance in South African HIV-Positive Patients 免疫标记物与南非hiv阳性患者认知能力的关系

IF 6.2 3区医学

Journal of Neuroimmune Pharmacology Pub Date : 2019-08-06 DOI: 10.1007/s11481-019-09870-1

M. E. Williams, J. Ipser, Dan J Stein, J. Joska, P. Naudé

引用次数: 11