Trends in Bioinformatics最新文献

筛选
英文 中文
Validation of Isolate Stability Status and in silico Characterization of SARS-COV 2 Partial CdsRdRP Gene Sequences 分离物稳定性状态验证及SARS-COV 2部分CdsRdRP基因序列的计算机表征
Trends in Bioinformatics Pub Date : 2021-01-15 DOI: 10.3923/tb.2021.13.27
Godwin Michael Ub, J. Ebigwai, N. E. Edu, P. Ekpo, Solomon I. Ofem, Imaobong S. Essien
{"title":"Validation of Isolate Stability Status and in silico Characterization of SARS-COV 2 Partial CdsRdRP Gene Sequences","authors":"Godwin Michael Ub, J. Ebigwai, N. E. Edu, P. Ekpo, Solomon I. Ofem, Imaobong S. Essien","doi":"10.3923/tb.2021.13.27","DOIUrl":"https://doi.org/10.3923/tb.2021.13.27","url":null,"abstract":"Background and Objective: In December 2019, patients diagnosed with viral pneumonia due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was subsequently identified as the causative pathogen, provisionally named 2019 novel coronavirus (COVID 19). The article aimed to unmask the genetic stability and nature of the viruses and validated the safety guidelines adopted for the coronaviruses currently causing the global pandemic. Materials and Methods: This study uses in silico approach and bioinformatics tools to validate the stability status and characteristics of the novel SARS-COV 2 coronaviruses by retrieving nucleotide sequences isolated and deposited in the NCBI. Results: The results have revealed that 11 out of 12 isolates studied are genetically and thermally unstable. The aliphatic index ranged from 52.98-112.07 in MT187977.1-MT127116.1, respectively. The instability index among the sequences ranged from 39.58-73.65 in MT187977.1-MT152900.1 isolate, respectively. The G-C contents range from 37.28-49.26% in MN938385.1-MT187977.1, respectively. Phylogenetically, isolates MT127116.1, MT159778.1, MT050414.1 and MT042777.1 showed the same genetic and mutation pathway with an evolutionary distance of 0.4 and 0.8 divergence times relative to the last common ancestor. Conclusion: There is a need for concerted effort in studying and understanding the genetic and thermal stability status and other characteristics of the viruses to be able to find a suitable therapy and drug design for the pandemic and biosecurity of humans against the virus now and in the future.","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125822292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptional Patterns of High-Risk Human Papillomavirus Types 16, 18, 45, 68b Genes 高危人乳头瘤病毒16、18、45、68b基因的转录模式
Trends in Bioinformatics Pub Date : 2020-12-15 DOI: 10.3923/TB.2021.1.12
Arkom Chaiwongko, Masahide Seki, Yutaka Suzuki, Teerasit Techawiwat, Parvapan Bhattarako
{"title":"Transcriptional Patterns of High-Risk Human Papillomavirus Types 16, 18, 45, 68b Genes","authors":"Arkom Chaiwongko, Masahide Seki, Yutaka Suzuki, Teerasit Techawiwat, Parvapan Bhattarako","doi":"10.3923/TB.2021.1.12","DOIUrl":"https://doi.org/10.3923/TB.2021.1.12","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131560358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Study on Role of Homology in Prediction of Protein Structure and Challenges of Homology 同源性在蛋白质结构预测中的作用及其挑战研究
Trends in Bioinformatics Pub Date : 2019-12-15 DOI: 10.3923/tb.2020.10.17
Bhaludra Chandra Sekhar Sin
{"title":"Study on Role of Homology in Prediction of Protein Structure and Challenges of Homology","authors":"Bhaludra Chandra Sekhar Sin","doi":"10.3923/tb.2020.10.17","DOIUrl":"https://doi.org/10.3923/tb.2020.10.17","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124333577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In silico Modelling and Molecular Docking Insight of Bacterial Peptide for Anti-tubercular and Anticancer Drug Designing 抗结核和抗癌药物设计中细菌肽的计算机建模和分子对接
Trends in Bioinformatics Pub Date : 2019-12-15 DOI: 10.3923/tb.2020.1.9
A. Khusro, C. Aarti, P. Agastian
{"title":"In silico Modelling and Molecular Docking Insight of Bacterial Peptide for Anti-tubercular and Anticancer Drug Designing","authors":"A. Khusro, C. Aarti, P. Agastian","doi":"10.3923/tb.2020.1.9","DOIUrl":"https://doi.org/10.3923/tb.2020.1.9","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116176624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Drug Designing to Combat MDR Bacteria Using Potential Bioactive Compounds from Medicinal Plant 利用药用植物中潜在的生物活性化合物设计抗耐多药细菌的药物
Trends in Bioinformatics Pub Date : 2019-01-01 DOI: 10.3923/TB.2019.7.19
V. Saxena, Khushboo Arya, Roshani Gupta, Harshit Verma, Gaurav Kumar Pal
{"title":"Drug Designing to Combat MDR Bacteria Using Potential Bioactive Compounds from Medicinal Plant","authors":"V. Saxena, Khushboo Arya, Roshani Gupta, Harshit Verma, Gaurav Kumar Pal","doi":"10.3923/TB.2019.7.19","DOIUrl":"https://doi.org/10.3923/TB.2019.7.19","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125573080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Molecular Docking Study of 2, 3-Dimethylmaleic Anhydride (3, 4-Dimethyl-2, 5-Furandione) as Anti-inflammatory Agent 2,3 -二甲基马来酸酐(3,4 -二甲基- 2,5 -呋喃二酮)抗炎剂的分子对接研究
Trends in Bioinformatics Pub Date : 2018-02-01 DOI: 10.3923/tb.2018.56.63
M. Das, P. Basumatary, P. Barman, M. Choudhury
{"title":"Molecular Docking Study of 2, 3-Dimethylmaleic Anhydride (3, 4-Dimethyl-2, 5-Furandione) as Anti-inflammatory Agent","authors":"M. Das, P. Basumatary, P. Barman, M. Choudhury","doi":"10.3923/tb.2018.56.63","DOIUrl":"https://doi.org/10.3923/tb.2018.56.63","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"927 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133350071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
In silico Analysis of BRCA1 Gene and its Phylogenetic Relationship in some Selected Domestic Animal Species 部分家畜BRCA1基因的计算机分析及其系统发育关系
Trends in Bioinformatics Pub Date : 2016-12-15 DOI: 10.3923/TB.2017.1.10
E. Ikpeme, O. Udensi, M. Kooffreh, H. Etta, B. Ushie, E. Echea, M. Ozoje
{"title":"In silico Analysis of BRCA1 Gene and its Phylogenetic Relationship in some Selected Domestic Animal Species","authors":"E. Ikpeme, O. Udensi, M. Kooffreh, H. Etta, B. Ushie, E. Echea, M. Ozoje","doi":"10.3923/TB.2017.1.10","DOIUrl":"https://doi.org/10.3923/TB.2017.1.10","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122354611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Vision-based State Estimation of an Unmanned Aerial Vehicle 基于视觉的无人机状态估计
Trends in Bioinformatics Pub Date : 2016-12-15 DOI: 10.3923/TB.2017.11.19
L. K. Seng, M. Ovinis, Nagarajan, R. Seulin, O. Morel
{"title":"Vision-based State Estimation of an Unmanned Aerial Vehicle","authors":"L. K. Seng, M. Ovinis, Nagarajan, R. Seulin, O. Morel","doi":"10.3923/TB.2017.11.19","DOIUrl":"https://doi.org/10.3923/TB.2017.11.19","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123427266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Modelling the road transport for efficiency analysis 为效率分析建立道路运输模型
Trends in Bioinformatics Pub Date : 2016-09-15 DOI: 10.3923/TB.2016.65.69
Z. Zaid, M. Z. Shah, A. A. Rahim
{"title":"Modelling the road transport for efficiency analysis","authors":"Z. Zaid, M. Z. Shah, A. A. Rahim","doi":"10.3923/TB.2016.65.69","DOIUrl":"https://doi.org/10.3923/TB.2016.65.69","url":null,"abstract":"Road transportation system is a complex series of activities. However, this can be broken down into sub-activities for easier understanding to analysis its efficiencies. This study discusses a simple technique of process mapping to develop a simple model for efficiency analysis of road transport specifically container haulage system. Observation was made in the industry, processes are then mapped for model development. Basic variables are then identified after which the model are developed for further analysis of efficiency.","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114284286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
A Novel Wind Turbine Design for Electrical Power Generation 一种用于发电的新型风力涡轮机设计
Trends in Bioinformatics Pub Date : 2016-09-15 DOI: 10.3923/TB.2016.59.64
M. Miqdad, S. Abbas, S. Shahnawaz, S. Ahmed, S. Ali
{"title":"A Novel Wind Turbine Design for Electrical Power Generation","authors":"M. Miqdad, S. Abbas, S. Shahnawaz, S. Ahmed, S. Ali","doi":"10.3923/TB.2016.59.64","DOIUrl":"https://doi.org/10.3923/TB.2016.59.64","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131093658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信