Godwin Michael Ub, J. Ebigwai, N. E. Edu, P. Ekpo, Solomon I. Ofem, Imaobong S. Essien
{"title":"Validation of Isolate Stability Status and in silico Characterization of SARS-COV 2 Partial CdsRdRP Gene Sequences","authors":"Godwin Michael Ub, J. Ebigwai, N. E. Edu, P. Ekpo, Solomon I. Ofem, Imaobong S. Essien","doi":"10.3923/tb.2021.13.27","DOIUrl":"https://doi.org/10.3923/tb.2021.13.27","url":null,"abstract":"Background and Objective: In December 2019, patients diagnosed with viral pneumonia due to an unidentified microbial agent were reported in Wuhan, China. A novel coronavirus was subsequently identified as the causative pathogen, provisionally named 2019 novel coronavirus (COVID 19). The article aimed to unmask the genetic stability and nature of the viruses and validated the safety guidelines adopted for the coronaviruses currently causing the global pandemic. Materials and Methods: This study uses in silico approach and bioinformatics tools to validate the stability status and characteristics of the novel SARS-COV 2 coronaviruses by retrieving nucleotide sequences isolated and deposited in the NCBI. Results: The results have revealed that 11 out of 12 isolates studied are genetically and thermally unstable. The aliphatic index ranged from 52.98-112.07 in MT187977.1-MT127116.1, respectively. The instability index among the sequences ranged from 39.58-73.65 in MT187977.1-MT152900.1 isolate, respectively. The G-C contents range from 37.28-49.26% in MN938385.1-MT187977.1, respectively. Phylogenetically, isolates MT127116.1, MT159778.1, MT050414.1 and MT042777.1 showed the same genetic and mutation pathway with an evolutionary distance of 0.4 and 0.8 divergence times relative to the last common ancestor. Conclusion: There is a need for concerted effort in studying and understanding the genetic and thermal stability status and other characteristics of the viruses to be able to find a suitable therapy and drug design for the pandemic and biosecurity of humans against the virus now and in the future.","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125822292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Study on Role of Homology in Prediction of Protein Structure and Challenges of Homology","authors":"Bhaludra Chandra Sekhar Sin","doi":"10.3923/tb.2020.10.17","DOIUrl":"https://doi.org/10.3923/tb.2020.10.17","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124333577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"In silico Modelling and Molecular Docking Insight of Bacterial Peptide for Anti-tubercular and Anticancer Drug Designing","authors":"A. Khusro, C. Aarti, P. Agastian","doi":"10.3923/tb.2020.1.9","DOIUrl":"https://doi.org/10.3923/tb.2020.1.9","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116176624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Molecular Docking Study of 2, 3-Dimethylmaleic Anhydride (3, 4-Dimethyl-2, 5-Furandione) as Anti-inflammatory Agent","authors":"M. Das, P. Basumatary, P. Barman, M. Choudhury","doi":"10.3923/tb.2018.56.63","DOIUrl":"https://doi.org/10.3923/tb.2018.56.63","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"927 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133350071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. Ikpeme, O. Udensi, M. Kooffreh, H. Etta, B. Ushie, E. Echea, M. Ozoje
{"title":"In silico Analysis of BRCA1 Gene and its Phylogenetic Relationship in some Selected Domestic Animal Species","authors":"E. Ikpeme, O. Udensi, M. Kooffreh, H. Etta, B. Ushie, E. Echea, M. Ozoje","doi":"10.3923/TB.2017.1.10","DOIUrl":"https://doi.org/10.3923/TB.2017.1.10","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122354611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. K. Seng, M. Ovinis, Nagarajan, R. Seulin, O. Morel
{"title":"Vision-based State Estimation of an Unmanned Aerial Vehicle","authors":"L. K. Seng, M. Ovinis, Nagarajan, R. Seulin, O. Morel","doi":"10.3923/TB.2017.11.19","DOIUrl":"https://doi.org/10.3923/TB.2017.11.19","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123427266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Modelling the road transport for efficiency analysis","authors":"Z. Zaid, M. Z. Shah, A. A. Rahim","doi":"10.3923/TB.2016.65.69","DOIUrl":"https://doi.org/10.3923/TB.2016.65.69","url":null,"abstract":"Road transportation system is a complex series of activities. However, this can be broken down into sub-activities for easier understanding to analysis its efficiencies. This study discusses a simple technique of process mapping to develop a simple model for efficiency analysis of road transport specifically container haulage system. Observation was made in the industry, processes are then mapped for model development. Basic variables are then identified after which the model are developed for further analysis of efficiency.","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114284286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Miqdad, S. Abbas, S. Shahnawaz, S. Ahmed, S. Ali
{"title":"A Novel Wind Turbine Design for Electrical Power Generation","authors":"M. Miqdad, S. Abbas, S. Shahnawaz, S. Ahmed, S. Ali","doi":"10.3923/TB.2016.59.64","DOIUrl":"https://doi.org/10.3923/TB.2016.59.64","url":null,"abstract":"","PeriodicalId":164864,"journal":{"name":"Trends in Bioinformatics","volume":"133 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131093658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}