Narra J Pub Date : 2023-11-13 DOI: 10.52225/narra.v3i3.437

Minarni ES. Aritonang, Pandiaman Pandia, Andika Pradana, Taufik Ashar

{"title":"Factors associated with small airway obstruction in COVID-19 survivors: A cross-sectional study among health-care providers","authors":"Minarni ES. Aritonang, Pandiaman Pandia, Andika Pradana, Taufik Ashar","doi":"10.52225/narra.v3i3.437","DOIUrl":"https://doi.org/10.52225/narra.v3i3.437","url":null,"abstract":"Coronavirus disease 2019 (COVID-19) has been identified for more than two years, yet studies assessing post-infection lung function are limited. Reports on lung function in COVID-19 patients indicate that patients have restrictive defects and small airway dysfunction that can persist and are not necessarily related to the severity of the disease. The aim of this study was to assess the incidence of small airway obstruction and its incidence-associated factors among COVID-19 survivors to better describe the long-term effects of COVID-19. A cross-sectional study was conducted among COVID-19 survivors who less than 50 years at Medan Adventist Hospital between 2020–2022. The data were collected through interview, direct assessment and respiratory examination. A total of 89 COVID-19 survivors were recruited of which the majority of them were female with a mean age of 32.6-year-old with the largest group was 19–30 years. The comorbidities found among the survivors were heart and thyroid disorders, with the most common symptom of post-COVID-19 was fatigue. Most of them had mild COVID-19. The mean forced mid-expiratory flow (FEF25–75%) was 96.3±20.22, with an incidence rate of small airway obstruction was 19.1%. Univariate and multivariate analyses indicated no significant association between age, gender, comorbidities, history of oxygenation during COVID-19 treatment, COVID-19 severity and the type of post COVID-19 syndrome symptoms with the incidence of small airway obstruction. In conclusion, among COVID-19 survivors who were less than 50 years old, those studied variables seems have less association with the incidence of small airway obstruction. Nevertheless, a further study with a bigger sample size is important to be conducted.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"60 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136349338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Proprotein convertase subtilisin/kexin type 9 (PCSK9) as a marker of coronary lesion severity in stable coronary artery disease (CAD) patients 枯草杆菌蛋白转化酶/可溶蛋白9型(PCSK9)作为稳定型冠心病(CAD)患者冠状动脉病变严重程度的标志

Narra J Pub Date : 2023-11-12 DOI: 10.52225/narra.v3i3.409

Cut A. Andra, Aldy S. Rambe, Refli Hasan, Rosita Sembiring, Doni Firman, Putri C. Eyanoer, Zulfikri Mukhtar, Taufik Sungkar, Muhammad Rusda, Mustafa M. Amin

{"title":"Proprotein convertase subtilisin/kexin type 9 (PCSK9) as a marker of coronary lesion severity in stable coronary artery disease (CAD) patients","authors":"Cut A. Andra, Aldy S. Rambe, Refli Hasan, Rosita Sembiring, Doni Firman, Putri C. Eyanoer, Zulfikri Mukhtar, Taufik Sungkar, Muhammad Rusda, Mustafa M. Amin","doi":"10.52225/narra.v3i3.409","DOIUrl":"https://doi.org/10.52225/narra.v3i3.409","url":null,"abstract":"Coronary artery disease (CAD) remains a significant global health concern with considerable high morbidity and mortality and its development is influenced by various genetic and environmental factors. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a vital regulator of low-density lipoprotein receptor (LDLR) metabolism, directly impacting serum cholesterol levels. However, its role in development of CAD is not fully understood. The aim of this study was to assess the association between the level of PCSK9 and coronary lesion severity in patients with CAD. A case-control study using consecutive sampling was conducted among CAD patients at H. Adam Malik General Hospital and Murni Teguh Memorial Hospital, Medan, Indonesia. A total of 200 CAD patients were divided into two groups based on the SYNTAX score: control (score ≤22, n=100) and case (score >22, n=100). Plasma PCSK9 levels were measured from venous blood using quantitative sandwich enzyme immunoassay. The Chi-squared test was used to analyze the data. Our data suggested that PCSK9 level was associated with coronary lesion severity (p<0.001) of which high PCSK9 level was associated with severe coronary lesion. We also found that hypertension (p<0.001), smoking (p=0.072), diabetes (p<0.001), dyslipidemia (p<0.001), obesity (p=0.023), and family history (p=0.001) were associated with lesion severity. Using the receiver operating characteristic (ROC) curve analysis, the cut-off 70.35 ng/mL of PCSK9 had sensitivity 75% and specificity 78% to predict severe coronary lesion. This study highlights that PCSK9 level has moderate sensitivity and specificity to predict the coronary lesion severity among CAD patients.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"37 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135036903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment acceptance and its associated determinants in cancer patients: A systematic review 癌症患者的治疗接受度及其相关决定因素:一项系统综述

Narra J Pub Date : 2023-11-11 DOI: 10.52225/narra.v3i3.197

Rima Novirianthy, Maimun Syukri, Soehartati Gondhowiardjo, Rachmad Suhanda, Marty Mawarpury, Agung Pranata, Teuku Renaldi

{"title":"Treatment acceptance and its associated determinants in cancer patients: A systematic review","authors":"Rima Novirianthy, Maimun Syukri, Soehartati Gondhowiardjo, Rachmad Suhanda, Marty Mawarpury, Agung Pranata, Teuku Renaldi","doi":"10.52225/narra.v3i3.197","DOIUrl":"https://doi.org/10.52225/narra.v3i3.197","url":null,"abstract":"Treatment recommendations for cancer patients are carried out according to clinical assessment, type and stage of cancer and treatment guidelines. However, many patients do not accept the recommendations. This raises obstacles in managing of cancers, which not only affects the patients, but also the family and people around the patients. This problem could increase morbidity, mortality and recurrence rate, which might result in lower quality of life. Since this condition is a complex problem, there is necessity to explore and determine various determinants from different levels. The aim of this systematic review was to explore the acceptances of cancer treatments among cancer patients and its associated determinants. Articles published from 2010 to 2023 were searched in four databases: ScienceDirect, Medline, Google Scholar and PubMed. Articles written in English and focussing on three main cancer treatments (surgery, chemotherapy and radiotherapy) were eligible. A narrative approach was used and the data were analysed into selected themes. Data suggest that several factors influence patient acceptance for cancer therapy including sociodemographic, economic and spiritual cultural backgrounds; patient knowledge and perceptions; community support, as well as policy and availability of health facilities. The determinants consist of individual, interpersonal, institutional, community and public policy level and interaction between levels are contributing to cancer treatment acceptance. In conclusion, cancer treatment acceptance remains a problem in particular in low middle income countries. In addition, the data on radiotherapy referral acceptance were limited and needed further study.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"17 20","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135043081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Etiopathogenesis of adolescent idiopathic scoliosis (AIS): Role of genetic and environmental factors 青少年特发性脊柱侧凸(AIS)的发病机制:遗传和环境因素的作用

Narra J Pub Date : 2023-11-06 DOI: 10.52225/narra.v3i3.217

Teuku N. Aulia, Djufri Djufri, Luthfi Gatam, Aman Yaman

引用次数: 0

Bicornis unicollis uterus as a risk factor of preterm birth: A case of young woman with multiple premature births 子宫独角双足是早产的危险因素:一例多胎早产的年轻妇女

Narra J Pub Date : 2023-11-06 DOI: 10.52225/narra.v3i3.229

Hasanuddin Hasanuddin, Cut R. Maharani, Hilwah Nora, Roziana Roziana, Rizka Aditya, Tgk. Puspa Dewi, Sofyan Qadri

{"title":"Bicornis unicollis uterus as a risk factor of preterm birth: A case of young woman with multiple premature births","authors":"Hasanuddin Hasanuddin, Cut R. Maharani, Hilwah Nora, Roziana Roziana, Rizka Aditya, Tgk. Puspa Dewi, Sofyan Qadri","doi":"10.52225/narra.v3i3.229","DOIUrl":"https://doi.org/10.52225/narra.v3i3.229","url":null,"abstract":"Bicornis unicollis uterus is a rare congenital uterine abnormality that occurs due to the failure of Mullerian duct fusion early in the development of the female internal genitalia system. In this case report, we present a woman with bicornis unicollis uterus who had preterm birth. A 30-year-old female patient with two caesarean sections history with premature babies was presented to the hospital with a complaint of regular contractions for twelve hours in her third preterm pregnancy. The patient has no particular symptoms besides acute abdominal pain. The ultrasonography examination indicated a uterus didelphys with breech presentation fetus. Due to the patient’s caesarean history and the fetal presentation, an emergency caesarean section was decided and performed. It was found that the gravid uterus was on the left and the baby was subsequently delivered with a complete placenta. Postoperative condition of the patient was shown to be stable while the baby underwent an intensive care at the neonatal intensive care unit. This case report highlights that early diagnosis in this rare case is critical since bicornis unicollis uterus are mostly asymptomatic. Caesarean section was chosen in the present case based on consideration of the fetal and maternal clinical conditions.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"12 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135678846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of umbilical cord mesenchymal stem cells on hypoxia-inducible factor-1 alpha (HIF-1α) production in arteriovenous fistula (AVF) animal model: A preliminary study 脐带间充质干细胞对动静脉瘘(AVF)动物模型缺氧诱导因子-1α (HIF-1α)产生影响的初步研究

Narra J Pub Date : 2023-11-04 DOI: 10.52225/narra.v3i3.225

Yopie A. Habibie, Dessy R. Emril, Azharuddin Azharuddin, Dedy Syahrizal

{"title":"Effect of umbilical cord mesenchymal stem cells on hypoxia-inducible factor-1 alpha (HIF-1α) production in arteriovenous fistula (AVF) animal model: A preliminary study","authors":"Yopie A. Habibie, Dessy R. Emril, Azharuddin Azharuddin, Dedy Syahrizal","doi":"10.52225/narra.v3i3.225","DOIUrl":"https://doi.org/10.52225/narra.v3i3.225","url":null,"abstract":"Hypoxia-inducible factor-1 alpha (HIF-1α) is a transcription factor that plays a crucial role in cellular responses to hypoxia, such as in the development of intimal hyperplasia, a common complication in arteriovenous fistula (AVF) creation. While the application of umbilical cord mesenchymal stem cells (UC-MSCs) has shown promise in various regenerative medicine applications, including tissue repair and angiogenesis, the effect of UC-MSCs on HIF-1α level in the AVF has not been tested. Therefore, the aim of this study was to evaluate the effect of UC-MSCs administration on HIF-1α levels in the AVF animal model. An experimental study was conducted on 28 local male rabbits (Lepus domestica) using a post-test-only design. The rabbits were divided randomly into four groups: normal rabbit group (negative control), placebo-treated AVF rabbit group (positive control), AVF rabbits treated with in-situ UC-MSCs injection (one dose, 106 UC-MSCs/kg body weight), and AVF rabbits treated with intravenous UC-MSCs (one dose, 106 UC-MSCs/kg body weight (BW). HIF-1α level was measured using ELISA method after 28 days post- treatment. All data were analyzed using the one-way analysis of variance (ANOVA) and continued with the Duncan’s post-hoc test. The data indicated that the levels of HIF-1α were different among all four groups (p<0.001). The post-hoc analysis revealed that the HIF-1α levels in both UC-MSC treated groups were significantly lower compared to untreated AVF rabbits(p<0.05). This study suggests that UC-MSCs could be a promising therapy to prevent and reduce intimal hyperplasia in AVF.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"36 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135775613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Single-nucleotide polymorphism of interleukin-10 promoter (IL-10 -819C/T) in leprosy patients with and without erythema nodosum leprosum, and household contacts 麻风结节性红斑患者和家庭接触者白细胞介素-10启动子(IL-10 -819C/T)的单核苷酸多态性

Narra J Pub Date : 2023-10-29 DOI: 10.52225/narra.v3i3.276

Sitti M. Arif, Nasrum Massi

{"title":"Single-nucleotide polymorphism of interleukin-10 promoter (IL-10 -819C/T) in leprosy patients with and without erythema nodosum leprosum, and household contacts","authors":"Sitti M. Arif, Nasrum Massi","doi":"10.52225/narra.v3i3.276","DOIUrl":"https://doi.org/10.52225/narra.v3i3.276","url":null,"abstract":"Leprosy, caused by Mycobacterium leprae, is a chronic infectious disease that impacts the skin and peripheral nerves, causing long-term disability. The invasion of M. leprae into the body triggers immunologic responses and single single-nucleotide polymorphisms in cytokine-encoding genes may influence predisposition and susceptibility, possibly predicting the incidence of leprosy reactions. The aim of this study was to assess the gene polymorphism of interleukin-10 promoter IL-10 −819C/T in leprosy patients, leprosy patients with erythema nodosum leprosum (ENL) reaction, and household contacts. A total of 54 individuals were included, with 18 in each group. Skin smear and histopathologic examinations were used to confirm the diagnosis of leprosy and ENL. The polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) technique was used to determine the polymorphism. The results confirmed the presence of polymorphism of which all TT, CT, and CC genotypes presented. The TT genotype was most prevalent in household contacts (94.4%) followed by ENL (50%), and leprosy patients (44.4%). The CT genotype was most frequently detected in leprosy patients (50%), followed by ENL cases (44.4%), and household contacts (5.56%). In contrast, CC was mostly presented in ENL cases (5.56%), only 1% in leprosy patients, and absent among household contacts. Although the most prevalent allele in all three groups was the T allele, the C allele presented in 27% and 30% of ENL and leprosy patients, respectively and only 5% in household contact individuals. This study suggests that the polymorphism variations of IL-10 −819C/T are higher in leprosy and ENL patients compared to household contacts. Since this data is preliminary, larger studies are needed.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136133680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Double fatal consequences of distance metastasis in nasopharyngeal carcinoma after a completed chemoradiation in pregnancy: A case report 妊娠期鼻咽癌完全放化疗后远处转移的双重致死后果:1例报告

Narra J Pub Date : 2023-10-29 DOI: 10.52225/narra.v3i3.221

Niken A. Utami, Liza Muknisa

{"title":"Double fatal consequences of distance metastasis in nasopharyngeal carcinoma after a completed chemoradiation in pregnancy: A case report","authors":"Niken A. Utami, Liza Muknisa","doi":"10.52225/narra.v3i3.221","DOIUrl":"https://doi.org/10.52225/narra.v3i3.221","url":null,"abstract":"Distant metastasis in nasopharyngeal carcinoma (NPC) patients is one of the reasons for the decreased life expectancy with the most common metastasis spreads are to the bone, liver, and lung. Hepatoma is the most frequent liver malignancy and is one of the highest causes of cancer death worldwide and this can be as a result of NPC metastasis. The aim of this case report was to present a patient with hepatoma in pregnancy as a result of NPC metastasis. A 34-year-old pregnant female at 24–25 weeks of gestation presented with a chief complaint of heartburn and unbearable pain radiating to the back. Previous medical history reported that the patient had a liver enlargement. The patient was G4P2A1 with a single living intrauterine fetus and active fetal movements. The patient has a history of NPC and received a completed chemoradiation one month prior to hospital admission. Physical examination showed bilateral rales and palpable diffuse multiple nodule masses in the upper right abdominal quadrant. Laboratory examination revealed anemia, thrombocytopenia, negative hepatitis B surface antigen (HBsAg), and elevated liver markers. Abdominal ultrasonography results showed multiple diffuse nodules in the liver. The patient was diagnosed with a metastatic hepatoma based on the clinical and imaging findings. During hospitalization, the patient repeatedly experienced pleural effusion with suspicion metastases. A few days later, the fetal movements stopped and the ultrasonography indicated negative fetal heart rate. After experiencing respiratory distress for hours, the patient expired the day after. This case highlights that due to the potential adverse effects of chemotherapy and radiotherapy, the initiation of these therapies should be carefully decided to avoid adverse effects to mother and fetus.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"56 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136157676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of SARS-CoV-2 spike protein exposure on ACE2 and interleukin 6 productions in human adipocytes: An in-vitro study SARS-CoV-2刺突蛋白暴露对人脂肪细胞中ACE2和白细胞介素6产生的影响:一项体外研究

Narra J Pub Date : 2023-10-29 DOI: 10.52225/narra.v3i3.284

Meity Ardiana, I GR. Suryawan, Hanestya O. Hermawan, Primasitha M. Harsono, Aisya A. Shafira, Faizal A. Anandita

{"title":"Effect of SARS-CoV-2 spike protein exposure on ACE2 and interleukin 6 productions in human adipocytes: An in-vitro study","authors":"Meity Ardiana, I GR. Suryawan, Hanestya O. Hermawan, Primasitha M. Harsono, Aisya A. Shafira, Faizal A. Anandita","doi":"10.52225/narra.v3i3.284","DOIUrl":"https://doi.org/10.52225/narra.v3i3.284","url":null,"abstract":"Since adipocytes play a crucial role in pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infection due to their interaction with angiotensin-converting enzyme 2 (ACE2) and interleukin 6 (IL-6), obesity is associated with an increased risk of coronavirus disease 2019 (COVID-19) mortality. Discovery of ACE2 as a SARS-CoV-2 receptor raises a controversy about whether to use ACE inhibitors (ACEIs) could be an optional therapy to prevent cytokine storms. Studies assessing the expressions of ACE2 and IL-6 upon exposure to SARS‑CoV‑2 is therefore important as a basis for therapeutical trials in the future. The aim of this study was to determine the effect of SARS-CoV-2 spike protein exposure on the production of ACE2 and IL-6 in adipocyte cells. Adipocytes were collected from abdominal adipose tissues of healthy and obese 45-year-old male donor having neither a history of SARS‑CoV‑2 infection nor COVID-19 vaccination. After being stained using the oil red O protocol, the viable adipocytes were then exposed to S1 subunit of SARS-CoV-2 spike protein. The levels of ACE2 and IL-6 were then examined using the enzyme-linked immunosorbent assay (ELISA). The results showed significant increase of ACE2 (90.22 µg/mL) and IL-6 level (60.01 µg/mL) in human adipocytes upon exposure compared to unexposed control cells (ACE2 13.33 µg/mL; IL-6 21.33 µg/mL), both comparisons had p<0.001). This study provides insight into the basic mechanism of severe COVID-19 symptoms in obese patients and provides a basic information of the potential of ACE inhibitors as an optional therapy for COVID-19 patients with obesity.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136157677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between caregiver burden in family and hemodialysis compliance of chronic kidney disease patients in Aceh, Indonesia 印度尼西亚亚齐省慢性肾病患者家庭照顾者负担与血液透析依从性之间的关系

Narra J Pub Date : 2023-10-24 DOI: 10.52225/narra.v3i3.255

Teuku AZ. Al-Muchtari, Maimun Syukri, Yusni Yusni

{"title":"Association between caregiver burden in family and hemodialysis compliance of chronic kidney disease patients in Aceh, Indonesia","authors":"Teuku AZ. Al-Muchtari, Maimun Syukri, Yusni Yusni","doi":"10.52225/narra.v3i3.255","DOIUrl":"https://doi.org/10.52225/narra.v3i3.255","url":null,"abstract":"Patient compliance toward undergoing treatment determines its success rate. Unfortunately, the compliance among hemodialysis patients is concerning. Supports from family has been suggested influence the patient compliance, especially from a family member who acts as a caregiver. The aim of this study was to determine the association between the level of caregiver burden and compliance in hemodialysis patients. A cross-sectional study was conducted at Dialysis Installation at Dr. Zainoel Abidin Hospital, Banda Aceh, Indonesia. The study sample was family members who accompanied hemodialysis patients. The minimal number of patients was determined of which 67 respondents were required and therefore recruited. Caregiver burden was collected using direct interview using Caregiver Burden Assessment questionnaire. The results revealed that twenty-four respondents (35.8%) had moderate caregiver burden, while there were only nine respondents (13.4%) had very low caregiver burden. The majority of the hemodialysis patients were non-compliant (n=38, 56.7%). A Chi-squared test indicated a significant association between the status of caregiver burden and the patient compliance to hemodialysis (p=0.011). These findings stress the importance of addressing caregiver burden in ensuring the compliance of patients receiving hemodialysis.","PeriodicalId":164668,"journal":{"name":"Narra J","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135266515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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