Adriana Gomez-Llerena, Pallavi Shekawat, Aishwarya Pradeep, Victoria L Clifton, Sherif A El Nashar, Aakriti R Carrubba
{"title":"The Impact of Targeted Endometriosis Treatment On Patients with Central Sensitization: Systematic Review and Meta Analysis.","authors":"Adriana Gomez-Llerena, Pallavi Shekawat, Aishwarya Pradeep, Victoria L Clifton, Sherif A El Nashar, Aakriti R Carrubba","doi":"10.1016/j.jmig.2025.07.020","DOIUrl":"10.1016/j.jmig.2025.07.020","url":null,"abstract":"<p><strong>Objective: </strong>Central sensitization (CSS), a condition where the central nervous system amplifies pain signals, may impact response to treatment of chronic pain conditions. The objective of this study is to determine if CSS affects outcomes after medical or surgical treatment for women with endometriosis via a systematic review and meta-analysis.</p><p><strong>Data sources: </strong>A systematic literature search using MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Review, Science Citation Index Expanded, and Emerging Sources Citation Index was conducted without language or date restrictions. The search strategy utilized MeSH and EMTREE terms to capture concepts related to central sensitization, endometriosis, and associated symptoms like dysmenorrhea. Interventions in the reviewed studies included medical treatment or surgery.</p><p><strong>Methods of study selection: </strong>Studies reporting on endometriosis outcomes in women with and wihout CSS were included in the review. We excluded studies which primarily focused on non-endometriosis pelvic pain syndromes. A total of 1821 abstracts were identified, and 259 full texts were reviewed for eligibility. Five studies met inclusion criteria encompassing a total of 1271 patients. Data for meta-analysis was not available for one study and another study was excluded as it was the only one describing medical treatment. The Newcastle-Ottawa scale was used to assess quality and risk of bias. Results were sythesized using random effect meta-anlayses to estimate the pooled risk ratio (RR) and 95% confience using the DerSimmonian and Laird methods.</p><p><strong>Tabulation, integration, and results: </strong>The percentage of patients with CSS ranged from 28.3% to 80.2%. Patients with CSS have smaller changes in pain scores after endometriosis surgery (RR 0.79, confidence interval 0.73-0.86) and significantly higher persistent pain (RR 2.27, confidence interval 1.40-3.68).</p><p><strong>Conclusion: </strong>Higher baseline catastrophization is associated with worse outcomes in women undergoing treatment for endometriosis. This is important to consider during counseling and decision-making.</p>","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Path Toward Earlier Recognition of Endometriosis: Can AI Bridge the Diagnostic Gap?","authors":"Aline Talhouk","doi":"10.1016/j.jmig.2025.07.016","DOIUrl":"10.1016/j.jmig.2025.07.016","url":null,"abstract":"","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":"32 9","pages":"Pages 749-750"},"PeriodicalIF":3.3,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Regarding \"Risk Factors and Prediction Nomogram of Local Regeneration After Ultrasound-Guided Microwave Ablation of Uterine Fibroids\".","authors":"Likun Wang","doi":"10.1016/j.jmig.2025.06.024","DOIUrl":"10.1016/j.jmig.2025.06.024","url":null,"abstract":"","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shweta Kanyal, Olivia Casas Diaz, Courtney Poston, Katrin Arnolds
{"title":"\"Hidden Behind the Cecum: When Acute Pain Reveals a Retrocecal Ovary\".","authors":"Shweta Kanyal, Olivia Casas Diaz, Courtney Poston, Katrin Arnolds","doi":"10.1016/j.jmig.2025.07.015","DOIUrl":"https://doi.org/10.1016/j.jmig.2025.07.015","url":null,"abstract":"","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Onabotulinumtoxin A Injections for patients with pelvic floor dysfunction.","authors":"Gabrielle T Whitmore, Jenny Tam, Megan Orlando","doi":"10.1016/j.jmig.2025.07.005","DOIUrl":"https://doi.org/10.1016/j.jmig.2025.07.005","url":null,"abstract":"<p><strong>Objective: </strong>To review the current literature surrounding onabotulinum toxin A injections for patients with pelvic floor dysfunction and to demonstrate how to perform these injections.</p><p><strong>Setting: </strong>Academic tertiary care hospital PARTICIPANTS: It is estimated that about 50-90% of patients with chronic pelvic pain have pain that originates from myofascial sources, including the pelvic floor muscles. In patients with pelvic floor dysfunction, management consists of pelvic floor physical therapy with the addition of pelvic floor trigger point injections with a local anesthetic as needed. We offer onabotulinum toxin A to individuals who require long-term repeat trigger point injections, have barriers to accessing monthly injections, or show no durable improvement.</p><p><strong>Intervention: </strong>We demonstrate a comprehensive pelvic floor exam and techniques for administration of onabotulinum toxin A into pelvic floor muscles in individuals with pelvic floor dysfunction, as well as a demonstration on a live patient. We perform an exam while the patient is awake, either in clinic or at the time of the procedure, and examine the pubococcygeus, iliococcygeus, and obturator internus muscles to assess for hypertonicity and tenderness to palpation. Once sedation is initiated, 200 units of onabotulinum toxin A is then reconstituted with 20 mL of normal saline. The pudendal nerve kit allows for 1cm depth of penetration with the needle. Approximately 1-2 mL of onabotulinumtoxin A are injected sequentially in multiple locations along the above-mentioned pelvic floor muscles. Medication effects may last up to 3-6 months, with a reduction in pain scores starting at 6 weeks and lasting through 12 weeks based on published literature. Adverse effects may include constipation, urinary incontinence, urinary tract infections, fecal incontinence, or urinary retention.</p><p><strong>Conclusions: </strong>Onabotulinumtoxin A may be helpful in patients with refractory pelvic floor dysfunction. We demonstrate how to perform these injections with a safe and reproducible technique.</p>","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144718032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wenling Wang, Ruirui Jin, Hongmei Cui, Yanxia Wang
{"title":"Regarding: Factors Associated With Spontaneous Conception Leading to Live Birth in Infertility Patients After Endometriosis Surgery.","authors":"Wenling Wang, Ruirui Jin, Hongmei Cui, Yanxia Wang","doi":"10.1016/j.jmig.2025.06.025","DOIUrl":"10.1016/j.jmig.2025.06.025","url":null,"abstract":"","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Total Laparoscopic Hysterectomy for OHVIRA Syndrome Variant in a Patient with Chronic Pelvic Pain and No Fertility Desire.","authors":"Stephanie L Kass, Rula V Kanj, Uchenna C Acholonu","doi":"10.1016/j.jmig.2025.07.014","DOIUrl":"https://doi.org/10.1016/j.jmig.2025.07.014","url":null,"abstract":"","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Tension-Releasing Appendage Suture-Loop for Adjustable Single-incision Sling Devices for Postoperative Voiding Dysfunction: A Simple Technique to Relieve Excessive Sling Tension.","authors":"Tsia-Shu Lo, Louiza Erika Rellora, Chia-Hsuan Yang, Eyal Rom, Lan-Sin Jhang, Wu-Chiao Hsieh","doi":"10.1016/j.jmig.2025.07.013","DOIUrl":"10.1016/j.jmig.2025.07.013","url":null,"abstract":"<p><strong>Study objective: </strong>To assess voiding dysfunction (VD) and restoration of normal voiding due to sling over-tension following tension-releasing suture-loop (TRS-loop) manipulation. Second, to evaluate cure rates, complications, and Quality of Life at 1-year post-operatively.</p><p><strong>Design: </strong>Retrospective study SETTING: Tertiary hospital in Taiwan PARTICIPANTS: Patients who underwent I-stop mini-procedures between March 2019 and January 2024 INTERVENTIONS: Patients with stress urinary incontinence (SUI/USI) who underwent I-stop-mini procedure were included. To improve voiding function in post-operative patients with urinary retention, TRS-loop manipulation was performed by pulling the appendagesuture-loop and adjusting the sling tension. Objective assessments included PVR measurement, urodynamic studies, and a 1-hour pad test. Subjective assessments included the Incontinence Impact Questionnaire-7 (IIQ-7) and Urogenital Distress Inventory-6 (UDI-6). Follow-ups were performed at 1 week, 1 month, 3 months, 6 months, and 1-year.</p><p><strong>Results: </strong>Objective and subjective cure rates were 91.3% and 89.6%, respectively. Ten patients required TRS-loop manipulation and one required a repeat adjustment. TRS-loop manipulation had a mean VAS score of 1.20, with an objective cure rate of 100% and subjective cure rate of 90%. Urodynamic improvements were observed in both groups, however, the differences were not statistically significant.</p><p><strong>Conclusion: </strong>TRS-loop manipulation is an effective method for addressing post-operative VD due to excessive sling tension without the need for additional invasive interventions. The high cure rates and improvements in QoL suggest their importance in SUI management. However, further research is needed to confirm the long-term outcomes.</p>","PeriodicalId":16397,"journal":{"name":"Journal of minimally invasive gynecology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}