Journal of Neural Transmission-supplement最新文献_第4页

Birth, life and death of dopaminergic neurons in the substantia nigra. 黑质多巴胺能神经元的生、生、死。

Journal of Neural Transmission-supplement Pub Date : 2009-01-01

G Di Giovanni, V Di Matteo, E Esposito

引用次数: 0

Non-motor function of the midbrain dopaminergic neurons. 中脑多巴胺能神经元的非运动功能。

Journal of Neural Transmission-supplement Pub Date : 2009-01-01 DOI: 10.1007/978-3-211-92660-4_12

C. Da Cunha, E. Wietzikoski, M. Bortolanza, P. Dombrowski, Lucélia Mendes dos Santos, S. Boschen, E. Miyoshi, M. Vital, R. Boerngen-Lacerda, R. Andreatini

引用次数: 6

Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson's disease. 小鼠骨髓源性干细胞的窦腔内移植改善帕金森病小鼠模型的运动行为。

Journal of Neural Transmission-supplement Pub Date : 2007-01-01 DOI: 10.1007/978-3-211-73574-9_16

D Offen, Y Barhum, Y S Levy, A Burshtein, H Panet, T Cherlow, E Melamed

{"title":"Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson's disease.","authors":"D Offen, Y Barhum, Y S Levy, A Burshtein, H Panet, T Cherlow, E Melamed","doi":"10.1007/978-3-211-73574-9_16","DOIUrl":"https://doi.org/10.1007/978-3-211-73574-9_16","url":null,"abstract":"Strategies of cell therapy for the treatment of Parkinson's disease (PD) are focused on replacing damaged neurons with cells to restore or improve function that is impaired due to cell population damage. In our studies, we used mesenchymal stromal cells (MSCs) from mouse bone marrow. Following our novel neuronal differentiation method, we found that the basic cellular phenotype changed to cells with neural morphology that express specific markers including those characteristic for dopaminergic neurons, such as tyrosine hydroxylase (TH). Intrastriatal transplantation of the differentiated MSCs in 6-hydroxydopamine-lesioned mice led to marked reduction in the amphetamine-induced rotations. Immunohistological analysis of the mice brains four months post transplantation, demonstrated that most of the transplanted cells survived in the striatum and expressed TH. Some of the TH positive cells migrated toward the substantia nigra. In conclusion, transplantation of bone marrow derived stem cells differentiated to dopaminergic-like cells, successfully improved behavior in an animal model of PD suggesting an accessible source of cells that may be used for autotransplantation in patient with PD.","PeriodicalId":16395,"journal":{"name":"Journal of Neural Transmission-supplement","volume":" 72","pages":"133-43"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41014966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 61

The long-term effects of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on cognitive performance in rats. 神经毒素1-三氯甲基-1,2,3,4-四氢- β -碳碱(TaClo)对大鼠认知能力的长期影响。

Journal of Neural Transmission-supplement Pub Date : 2007-01-01 DOI: 10.1007/978-3-211-73574-9_18

T A Sontag, K W Lange, Ch Heim, W Kolasiewicz, O Tucha, K H Sontag

引用次数: 4

Neuronal differentiation and long-term culture of the human neuroblastoma line SH-SY5Y. 人神经母细胞瘤系SH-SY5Y的神经分化和长期培养。

Journal of Neural Transmission-supplement Pub Date : 2007-01-01 DOI: 10.1007/978-3-211-73574-9_3

R Constantinescu, A T Constantinescu, H Reichmann, B Janetzky

引用次数: 144

Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain. 内源性氧化吲哚在大鼠脑中对[3H]isatin结合具有抑制作用。

Journal of Neural Transmission-supplement Pub Date : 2007-01-01 DOI: 10.1007/978-3-211-73574-9_4

M Crumeyrolle-Arias, A Medvedev, A Cardona, M C Tournaire, V Glover

{"title":"Endogenous oxidized indoles share inhibitory potency against [3H]isatin binding in rat brain.","authors":"M Crumeyrolle-Arias, A Medvedev, A Cardona, M C Tournaire, V Glover","doi":"10.1007/978-3-211-73574-9_4","DOIUrl":"https://doi.org/10.1007/978-3-211-73574-9_4","url":null,"abstract":"Isatin is an endogenous oxidized indole that influences a range of processes in vivo and in vitro. It has a distinct and discontinuous distribution in the brain and [3H]isatin binding sites are widely distributed in rat brain sections. The highest labelling is found in hypothalamic nuclei and in the cortex, hippocampus, and cerebellum (Crumeyrolle-Arias et al., 2003). However, the properties of most isatin binding sites and their physiological ligands remain unknown. In the present study the effects of three endogenous oxidized indoles (oxindole, 5-hyxdoxyoxindole, and isatin) on [3H]isatin binding were investigated in rat brain sections. In most regions cold isatin (0.2 mM) significantly reduced [3H]isatin binding. In addition to isatin, the other endogenous oxidized indoles, 5-hydroxyoxindole and oxindole were effective in displacing [3H]isatin. Total irreversible inhibition of monoamine oxidases caused inhibition of specific [3H]isatin binding in 7 of 10 brain region studied. This was accompanied by altered sensitivity of [3H]isatin binding to these indoles, including regions where a decrease of specific binding was not detected. The combinations of the three oxidized indoles produced two clear effects: augmentation (potentiation) and attenuation (blockade) of inhibitory activity compared with the independent effects of these compounds. The different effects of oxidized indoles and their combinations (isatin + 5-hydroxyoxindole and isatin + oxindole) in various brain regions therefore suggest an interaction of [(3H]isatin with different and multiple isatin-binding sites, which exhibit different sensitivity to endogenous oxidizing indoles.","PeriodicalId":16395,"journal":{"name":"Journal of Neural Transmission-supplement","volume":" 72","pages":"29-34"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41015050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Hydrogen peroxide is a true first messenger. 过氧化氢是真正的第一信使。

Journal of Neural Transmission-supplement Pub Date : 2007-01-01 DOI: 10.1007/978-3-211-73574-9_6

L Holmquist, G Stuchbury, M Steele, G Münch

引用次数: 18

Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: an experimental approach. 中枢胰岛素抵抗作为散发性阿尔茨海默病样病理的触发因素:一种实验方法。

Journal of Neural Transmission-supplement Pub Date : 2007-01-01 DOI: 10.1007/978-3-211-73574-9_28

M Salkovic-Petrisic, S Hoyer

引用次数: 228

Observations on the cortical silent period in Parkinson's disease. 帕金森病皮层沉默期的观察。

Journal of Neural Transmission-supplement Pub Date : 2007-01-01 DOI: 10.1007/978-3-211-73574-9_19

Y D Van Der Werf, H W Berendse, E J W van Someren, D Stoffers, C J Stam, E Ch Wolters

{"title":"Observations on the cortical silent period in Parkinson's disease.","authors":"Y D Van Der Werf, H W Berendse, E J W van Someren, D Stoffers, C J Stam, E Ch Wolters","doi":"10.1007/978-3-211-73574-9_19","DOIUrl":"https://doi.org/10.1007/978-3-211-73574-9_19","url":null,"abstract":"Transcranial magnetic stimulation is a tool in the neurosciences to study motor functions and nervous disorders, amongst others. Single pulses of TMS applied over the primary motor cortex lead to a so-called cortical silent period in the recording from the corresponding muscle, i.e. a period of approximately 100ms with no muscle activity. We here show that in Parkinson's disease (PD), this cortical silent period in some cases is interrupted by short bursts of EMG activity. We describe in detail these interruptions in two patients with PD. These interruptions may number up to 3 per cortical silent period and show a consistent frequency across trials and hemispheres within a given patient; the two patients described here do differ, however, in the time-delay of the interruptions and hence the induced frequency. For one patient, the frequency of the interruptions proved to be around 13 Hz, the other patient showed a frequency of around 17 Hz. The results corroborate earlier findings of cortical oscillations elicited by pulses of TMS and may be related to abnormal oscillatory activity found in the cortical-subcortical motor system in PD.","PeriodicalId":16395,"journal":{"name":"Journal of Neural Transmission-supplement","volume":" 72","pages":"155-8"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/978-3-211-73574-9_19","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40736685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

VITA study: white matter hyperintensities of vascular and degenerative origin in the elderly. VITA研究:老年人血管和退行性起源的白质高信号。

Journal of Neural Transmission-supplement Pub Date : 2007-01-01 DOI: 10.1007/978-3-211-73574-9_23

P Fischer, W Krampla, N Mostafaie, S Zehetmayer, M Rainer, S Jungwirth, K Huber, K Bauer, W Hruby, P Riederer, K H Tragl

{"title":"VITA study: white matter hyperintensities of vascular and degenerative origin in the elderly.","authors":"P Fischer, W Krampla, N Mostafaie, S Zehetmayer, M Rainer, S Jungwirth, K Huber, K Bauer, W Hruby, P Riederer, K H Tragl","doi":"10.1007/978-3-211-73574-9_23","DOIUrl":"https://doi.org/10.1007/978-3-211-73574-9_23","url":null,"abstract":"The etiology of white matter hyperintensities (WMH) seen on T2-weighted cranial magnetic resonance images is a matter of debate. We investigated deep and periventricular WMH in the brains of a community-based cohort of 532 subjects aged 75-76 years. The objective of this study was to determine whether WMH at age of 75 years were associated rather with vascular factors than with degenerative factors. Arterial hypertension treated with antihypertensive drugs favored WMH, and WMH were found more frequently in subjects with focal vascular lesions. Additionally, we found significant associations between both, deep white matter and periventricular hyperintensities, and focal atrophy of medial temporal lobe structures. The odds ratio for deep WMH in subjects with more severe medial temporal atrophy was 4.4 (95%-CI: 1.9-9.8) that for periventricular hyperintensities was 3.9 (95%-CI: 1.7-8.8). These findings might indicate that not only vascular factors alone but also degenerative factors favor the occurrence of WMH after the age of 75 years.","PeriodicalId":16395,"journal":{"name":"Journal of Neural Transmission-supplement","volume":" 72","pages":"181-8"},"PeriodicalIF":0.0,"publicationDate":"2007-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40736689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13