Journal of Nanostructure in Chemistry最新文献

{"title":"Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications.","authors":"Tais Monteiro Magne, Thamires de Oliveira Vieira, Luciana Magalhães Rebelo Alencar, Francisco Franciné Maia Junior, Sara Gemini-Piperni, Samuel V Carneiro, Lillian M U D Fechine, Rafael M Freire, Kirill Golokhvast, Pierangelo Metrangolo, Pierre B A Fechine, Ralph Santos-Oliveira","doi":"10.1007/s40097-021-00444-3","DOIUrl":"10.1007/s40097-021-00444-3","url":null,"abstract":"<p><p>Over the past few years, there has been a growing potential use of graphene and its derivatives in several biomedical areas, such as drug delivery systems, biosensors, and imaging systems, especially for having excellent optical, electronic, thermal, and mechanical properties. Therefore, nanomaterials in the graphene family have shown promising results in several areas of science. The different physicochemical properties of graphene and its derivatives guide its biocompatibility and toxicity. Hence, further studies to explain the interactions of these nanomaterials with biological systems are fundamental. This review has shown the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic. This ability is derivative from the considerable number of forms that the graphene family can assume. The graphene-based materials biodistribution profile, clearance, toxicity, and cytotoxicity, interacting with biological systems, are discussed here, focusing on its synthesis methodology, physicochemical properties, and production quality. Despite the growing increase in the bioavailability and toxicity studies of graphene and its derivatives, there is still much to be unveiled to develop safe and effective formulations.</p><p><strong>Graphic abstract: </strong></p>","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8419677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39427946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium-based nanomaterials and their interrelation with chitosan: optimization for pCRISPR delivery.","authors":"Navid Rabiee,&nbsp;Mojtaba Bagherzadeh,&nbsp;Amir Mohammad Ghadiri,&nbsp;Mahsa Kiani,&nbsp;Sepideh Ahmadi,&nbsp;Vahid Jajarmi,&nbsp;Yousef Fatahi,&nbsp;Abdullah Aldhaher,&nbsp;Mohammadreza Tahriri,&nbsp;Thomas J Webster,&nbsp;Ebrahim Mostafavi","doi":"10.1007/s40097-021-00446-1","DOIUrl":"https://doi.org/10.1007/s40097-021-00446-1","url":null,"abstract":"<p><p>There have been numerous advancements in the early diagnosis, detection, and treatment of genetic diseases. In this regard, CRISPR technology is promising to treat some types of genetic issues. In this study, the relationship between calcium (due to its considerable physicochemical properties) and chitosan (as a natural linear polysaccharide) was investigated and optimized for pCRISPR delivery. To achieve this, different forms of calcium, such as calcium nanoparticles (CaNPs), calcium phosphate (CaP), a binary blend of calcium and chitosan including CaNPs/Chitosan and CaP/Chitosan, as well as their tertiary blend including CaNPs-CaP/Chitosan, were prepared via both routine and green procedures using <i>Salvia hispanica</i> to reduce toxicity and increase nanoparticle stability (with a yield of 85%). Such materials were also applied to the human embryonic kidney (HEK-293) cell line for pCRISPR delivery. The results were optimized using different characterization techniques demonstrating acceptable binding with DNA (for both CaNPs/Chitosan and CaNPs-CaP/Chitosan) significantly enhancing green fluorescent protein (EGFP) (about 25% for CaP/Chitosan and more than 14% for CaNPs-CaP/Chitosan).</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40097-021-00446-1.</p>","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10646080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring nano-enabled CRISPR-Cas-powered strategies for efficient diagnostics and treatment of infectious diseases.","authors":"Ankit Kumar Dubey, Vijai Kumar Gupta, Małgorzata Kujawska, Gorka Orive, Nam-Young Kim, Chen-Zhong Li, Yogendra Kumar Mishra, Ajeet Kaushik","doi":"10.1007/s40097-022-00472-7","DOIUrl":"10.1007/s40097-022-00472-7","url":null,"abstract":"<p><p>Biomedical researchers have subsequently been inspired the development of new approaches for precisely changing an organism's genomic DNA in order to investigate customized diagnostics and therapeutics utilizing genetic engineering techniques. Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR) is one such technique that has emerged as a safe, targeted, and effective pharmaceutical treatment against a wide range of disease-causing organisms, including bacteria, fungi, parasites, and viruses, as well as genetic abnormalities. The recent discovery of very flexible engineered nucleic acid binding proteins has changed the scientific area of genome editing in a revolutionary way. Since current genetic engineering technique relies on viral vectors, issues about immunogenicity, insertional oncogenesis, retention, and targeted delivery remain unanswered. The use of nanotechnology has the potential to improve the safety and efficacy of CRISPR/Cas9 component distribution by employing tailored polymeric nanoparticles. The combination of two (CRISPR/Cas9 and nanotechnology) offers the potential to open new therapeutic paths. Considering the benefits, demand, and constraints, the goal of this research is to acquire more about the biology of CRISPR technology, as well as aspects of selective and effective diagnostics and therapies for infectious illnesses and other metabolic disorders. This review advocated combining nanomedicine (nanomedicine) with a CRISPR/Cas enabled sensing system to perform early-stage diagnostics and selective therapy of specific infectious disorders. Such a Nano-CRISPR-powered nanomedicine and sensing system would allow for successful infectious illness control, even on a personal level. This comprehensive study also discusses the current obstacles and potential of the predicted technology.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40097-022-00472-7.</p>","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8853211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39820999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites.","authors":"Jaison Jeevanandam,&nbsp;Saravanan Krishnan,&nbsp;Yiik Siang Hii,&nbsp;Sharadwata Pan,&nbsp;Yen San Chan,&nbsp;Caleb Acquah,&nbsp;Michael K Danquah,&nbsp;João Rodrigues","doi":"10.1007/s40097-021-00465-y","DOIUrl":"https://doi.org/10.1007/s40097-021-00465-y","url":null,"abstract":"<p><p>Numerous viral infections are common among humans, and some can lead to death. Even though conventional antiviral agents are beneficial in eliminating viral infections, they may lead to side effects or physiological toxicity. Silver nanoparticles and nanocomposites have been demonstrated to possess inhibitory properties against several pathogenic microbes, including archaea, bacteria, fungi, algae, and viruses. Its pronounced antimicrobial activity against various microbe-mediated diseases potentiates its use in combating viral infections. Notably, the appropriated selection of the synthesis method to fabricate silver nanoparticles is a major factor for consideration as it directly impacts antiviral efficacy, level of toxicity, scalability, and environmental sustainability. Thus, this article presents and discusses various synthesis approaches to produce silver nanoparticles and nanocomposites, providing technological insights into selecting approaches to generate antiviral silver-based nanoparticles. The antiviral mechanism of various formulations of silver nanoparticles and the evaluation of its propensity to combat specific viral infections as a potential antiviral agent are also discussed.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8760111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10699078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced microplastic monitoring using Raman spectroscopy with a combination of nanostructure-based substrates.","authors":"Nguyễn Hoàng Ly, Moon-Kyung Kim, Hyewon Lee, Cheolmin Lee, Sang Jun Son, Kyung-Duk Zoh, Yasser Vasseghian, Sang-Woo Joo","doi":"10.1007/s40097-022-00506-0","DOIUrl":"10.1007/s40097-022-00506-0","url":null,"abstract":"<p><p>Micro(nano)plastic (MNP) pollutants have not only impacted human health directly, but are also associated with numerous chemical contaminants that increase toxicity in the natural environment. Most recent research about increasing plastic pollutants in natural environments have focused on the toxic effects of MNPs in water, the atmosphere, and soil. The methodologies of MNP identification have been extensively developed for actual applications, but they still require further study, including on-site detection. This review article provides a comprehensive update on the facile detection of MNPs by Raman spectroscopy, which aims at early diagnosis of potential risks and human health impacts. In particular, Raman imaging and nanostructure-enhanced Raman scattering have emerged as effective analytical technologies for identifying MNPs in an environment. Here, the authors give an update on the latest advances in plasmonic nanostructured materials-assisted SERS substrates utilized for the detection of MNP particles present in environmental samples. Moreover, this work describes different plasmonic materials-including pure noble metal nanostructured materials and hybrid nanomaterials-that have been used to fabricate and develop SERS platforms to obtain the identifying MNP particles at low concentrations. Plasmonic nanostructure-enhanced materials consisting of pure noble metals and hybrid nanomaterials can significantly enhance the surface-enhanced Raman scattering (SERS) spectra signals of pollutant analytes due to their localized hot spots. This concise topical review also provides updates on recent developments and trends in MNP detection by means of SERS using a variety of unique materials, along with three-dimensional (3D) SERS substrates, nanopipettes, and microfluidic chips. A novel material-assisted spectral Raman technique and its effective application are also introduced for selective monitoring and trace detection of MNPs in indoor and outdoor environments.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":8.6,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9206222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40401938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface modulation and structural engineering of graphitic carbon nitride for electrochemical sensing applications","authors":"Ann Mariella Babu, Rijo Rajeev, Ditto Abraham Thadathil, A. Varghese, G. Hegde","doi":"10.1007/s40097-021-00459-w","DOIUrl":"https://doi.org/10.1007/s40097-021-00459-w","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2021-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41334811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancement of organic solar cell efficiency by altering the zinc oxide photoanode nanostructure morphology","authors":"Zahra Samavati, A. Samavati, A. Ismail, T. Borhani, M. Velashjerdi, B. G. Eisaabadi, A. Rostami, M. Othman, A. Awang","doi":"10.1007/s40097-021-00453-2","DOIUrl":"https://doi.org/10.1007/s40097-021-00453-2","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41664039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equal contents of intrinsic defects and oxygen-containing defects promote carbon electrodes to achieve high sulfur loads","authors":"Caiwei Wang, Jianfeng Huang, Jiayin Li, Liyun Cao, Rong Lang, K. Kajiyoshi","doi":"10.1007/s40097-021-00454-1","DOIUrl":"https://doi.org/10.1007/s40097-021-00454-1","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42637882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioresorbable poly(lactic acid) and organic quantum dot-based nanocomposites: luminescent scaffolds for enhanced osteogenesis and real-time monitoring","authors":"K. Dave, V. Gomes","doi":"10.1007/s40097-021-00456-z","DOIUrl":"https://doi.org/10.1007/s40097-021-00456-z","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49170882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bimetallic Au–Ag nanocages extended TPP conjugate structure for self-enhancing therapy of tumors","authors":"Yilin Wen, Lu Chen, Feng Leng, Zhangyou Yang, Chao Yu","doi":"10.1007/s40097-021-00457-y","DOIUrl":"https://doi.org/10.1007/s40097-021-00457-y","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":null,"pages":null},"PeriodicalIF":10.1,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43896062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}