Journal of Nanostructure in Chemistry最新文献

{"title":"Facile, fast, and green preparation of high-purity and quality silica nanoparticles using a handmade ball mill: comparison with the sol–gel method","authors":"Saeed Karimkhani, P. Derakhshi, P. Aberoomand Azar, S. Sheikh-Al-Eslamian","doi":"10.1007/s40097-022-00522-0","DOIUrl":"https://doi.org/10.1007/s40097-022-00522-0","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":"1 1","pages":"1-13"},"PeriodicalIF":10.1,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41458982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLGA microparticle formulations for tunable delivery of a nano-engineered filamentous bacteriophage-based vaccine: in vitro and in silico-supported approach.","authors":"Rezvan Jamaledin, Rossella Sartorius, Concetta Di Natale, Valentina Onesto, Roberta Manco, Valentina Mollo, Raffaele Vecchione, Piergiuseppe De Berardinis, Paolo Antonio Netti","doi":"10.1007/s40097-022-00519-9","DOIUrl":"10.1007/s40097-022-00519-9","url":null,"abstract":"<p><p>Bacteriophages have attracted great attention in the bioengineering field in diverse research areas from tissue engineering to therapeutic and clinical applications. Recombinant filamentous bacteriophage, carrying multiple copies of foreign peptides on protein capsid has been successfully used in the vaccine delivery setting, even if their plasma instability and degradation have limited their use on the pharmaceutical market. Encapsulation techniques in polymeric materials can be applied to preserve bacteriophage activity, extend its half-life, and finely regulate their release in the target environment. The main goal of this study was to provide tunable formulations of the bacteriophage encapsulated in polymeric microparticles (MPs). We used poly (lactic-co-glycolic-acid) as a biocompatible and biodegradable polymer with ammonium bicarbonate as a porogen to encapsulate bacteriophage expressing OVA (257-264) antigenic peptide. We demonstrate that nano-engineered fdOVA bacteriophages encapsulated in MPs preserve their structure and are immunologically active, inducing a strong immune response towards the delivered peptide. Moreover, MP encapsulation prolongs bacteriophage stability over time also at room temperature. Additionally, in this study, we show the ability of in silico-supported approach to predict and tune the release of bacteriophages. These results lay the framework for a versatile bacteriophage-based vaccine delivery system that could successfully generate robust immune responses in a sustained manner, to be used as a platform against cancer and new emerging diseases.</p><p><strong>Graphical abstract: </strong>Synopsis: administration of recombinant bacteriophage-loaded PLGA microparticles for antigen delivery. PLGA microparticles release the bacteriophages, inducing activation of dendritic cells and enhancing antigen presentation and specific T cell response. Bacteriophage-encapsulated microneedles potentially can be administered into human body and generate robust immune responses.</p>","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":" ","pages":"1-16"},"PeriodicalIF":10.1,"publicationDate":"2023-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9134250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-step construction of Co(OH)2-anchored g-C3N4 and rGO with phase junction for dopamine sensing and oxygen evolution reaction","authors":"Dexin Yu, Feng Zhang, Kai Yu, F. Qu","doi":"10.1007/s40097-022-00521-1","DOIUrl":"https://doi.org/10.1007/s40097-022-00521-1","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":"1 1","pages":"1-12"},"PeriodicalIF":10.1,"publicationDate":"2023-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42958160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymeric nanoparticles and nanomicelles of hydroxychloroquine co-loaded with azithromycin potentiate anti-SARS-CoV-2 effect.","authors":"Aline Oliveira da Siliva de Barros, Suyene Rocha Pinto, Sara Rhaissa Rezende Dos Reis, Eduardo Ricci-Junior, Luciana Magalhães Rebelo Alencar, Nancy Cristina Junqueira Bellei, Luiz Ramos Mário Janini, Juliana Terzi Maricato, Daniela Santoro Rosa, Ralph Santos-Oliveira","doi":"10.1007/s40097-022-00476-3","DOIUrl":"10.1007/s40097-022-00476-3","url":null,"abstract":"<p><p>The outbreak of coronavirus (COVID-19) has put the world in an unprecedented scenario. To reestablish the world routine as promote the effective treatment of this disease, the world is looking for new (and old) drug that can efficiently kill the virus. In this study, we have developed two nanosystems: polymeric nanoparticles and nanomicelles-based on hydroxychloroquine and azithromycin. The nanosystem was fully characterized by AFM and DLS techniques. Also, the nanosystems were radiolabeled with ^99mTc and pulmonary applied (installation) in vivo to evaluate the biological behavior. The toxicity of both nanosystem were evaluated in primary cells (FGH). Finally, both nanosystems were evaluated in vitro against the SARS-CoV-2. The results demonstrated that the methodology used to produce the nanomicelles and the nanoparticle was efficient, the characterization showed a nanoparticle with a spherical shape and a medium size of 390 nm and a nanomicelle also with a spherical shape and a medium size of 602 nm. The nanomicelles were more efficient (~ 70%) against SARS-CoV-2 than the nanoparticles. The radiolabeling process with ^99mTc was efficient (> 95%) in both nanosystems and the pulmonary application demonstrated to be a viable route for both nanosystems with a local retention time of approximately, 24 h. None of the nanosystems showed cytotoxic effect on FGH cells, even in high doses, corroborating the safety of both nanosystems. Thus, claiming the benefits of the nanotechnology, especially with regard the reduced adverse we believe that the use of nanosystems for COVID-19 treatment can be an optimized choice.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40097-022-00476-3.</p>","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":"13 2","pages":"263-281"},"PeriodicalIF":8.6,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8881703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9409626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advancements in adsorptive removal of organophosphate pesticides from aqueous phase using nanomaterials","authors":"Jyotsana Mehta, R. Dhaka, N. Dilbaghi, Dong-Kwon Lim, A. A. Hassan, Ki-Hyun Kim, Sandeep Kumar","doi":"10.1007/s40097-022-00516-y","DOIUrl":"https://doi.org/10.1007/s40097-022-00516-y","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":"1 1","pages":""},"PeriodicalIF":10.1,"publicationDate":"2022-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43602526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoinduced electron transfer in host–guest complexes of double nanohoops","authors":"O. Stasyuk, A. Stasyuk, M. Solà, A. A. Voityuk","doi":"10.1007/s40097-022-00518-w","DOIUrl":"https://doi.org/10.1007/s40097-022-00518-w","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47389007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-functional cobalt phosphide nanoparticles for performance enhancement of lithium-sulfur battery","authors":"Hai-xin Liu, Xiaofei Wang, Qian Wang, Chenchen Pei, Hui Wang, Shouwu Guo","doi":"10.1007/s40097-022-00517-x","DOIUrl":"https://doi.org/10.1007/s40097-022-00517-x","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47936713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermoresponsive and antibacterial two-dimensional polyglycerol-<i>interlocked</i>-polynipam for targeted drug delivery.","authors":"Nasim Khosravani, Vahid Ahmadi, Ali Kakanejadifard, Mohsen Adeli","doi":"10.1007/s40097-022-00514-0","DOIUrl":"10.1007/s40097-022-00514-0","url":null,"abstract":"<p><p>Two-dimensional polymeric networks are a new class of polymers with interesting physicochemical and biological properties. They promise a wide range of future biomedical applications including pathogen interactions, drug delivery, bioimaging, photothermal, and photodynamic therapy, owing to their unique features, such as high surface area and multivalent interactions at nano-biointerfaces. In this work, a thermosensitive two-dimensional polymeric network consisting poly(<i>N</i>-isopropylacrylamide) (pNIPAM) chains that are mechanically interlocked by a polyglycerol platform was synthesized and used for bacteria incapacitation. Two-dimensional hyperbranched polyglycerol (2D-hPG) was synthesized by a graphene-assisted strategy and used for encapsulation of azobisisobutyronitrile (AIBN). Radical polymerization of <i>N</i>-isopropylacrylamide by encapsulated AIBN resulted in thermoresponsive platforms with ~ 500 nm lateral size and 20-50 nm thickness. Due to its porous structure, 2D-PNPG was able to efficiently load antibiotics, such as tetracycline (TC) and amoxicillin (AMX). The rate of release of antibiotics from 2D-PNPG and the antibacterial activity of the system correlated with the variation of temperature as a result of the thermosensitivity of 2D-PNPG. This study shows that two-dimensional polymers are efficient platforms for future biomedical applications including drug delivery and bacteria incapacitation.</p><p><strong>Graphical abstract: </strong>Thermoresponsive two-dimensional nanomaterials with the ability of loading therapeutic agents and antibacterial activity are synthesized and characterized.</p>","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":" ","pages":"1-11"},"PeriodicalIF":10.1,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9523184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33489055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitosan conjugated-ordered mesoporous silica: a biocompatible dissolution enhancer for promoting the antidiabetic effect of a poorly water-soluble drug of repaglinide","authors":"A. Maleki, Shayesteh Bochani, Mehraneh Kermanian, Pooyan Makvandi, M. Hosseini, M. Hamidi, Ali Kalantari-Hesari, H. Kheiri, M. Eskandari, Maryam Rosta, V. Mattoli, S. H. Hosseini","doi":"10.1007/s40097-022-00515-z","DOIUrl":"https://doi.org/10.1007/s40097-022-00515-z","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48984967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effect of melanin nanoparticles created from squid ink against irradiation on human keratinocytes","authors":"Le Na Nguyen Thi, S. Le Duc, Van Khanh Bui Thi, Thanh Tam Dinh Thi, Hai Do Xuan, My-Nhung Hoang Thi, Thang Nguyen Dinh","doi":"10.1007/s40097-022-00513-1","DOIUrl":"https://doi.org/10.1007/s40097-022-00513-1","url":null,"abstract":"","PeriodicalId":16377,"journal":{"name":"Journal of Nanostructure in Chemistry","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2022-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45875383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}