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Abnormal protein SUMOylation in liver disease: novel target for therapy 肝病中的异常蛋白 SUMOylation：新的治疗靶点
Journal of Molecular Medicine Pub Date : 2024-04-03 DOI: 10.1007/s00109-024-02440-w
Yanfang Yang, Fuxun Yu
{"title":"Abnormal protein SUMOylation in liver disease: novel target for therapy","authors":"Yanfang Yang, Fuxun Yu","doi":"10.1007/s00109-024-02440-w","DOIUrl":"https://doi.org/10.1007/s00109-024-02440-w","url":null,"abstract":"<p>SUMOylation is an important protein post-translational modification (PTM) process, in which the small ubiquitin-like modifier (SUMO) protein covalently binds to the target protein and regulates stability, subcellular localization, and protein–protein interaction of the target protein. Protein SUMOylation exerts crucial regulatory function in the liver, and its abnormalities are associated with various liver-related disease processes. This review focuses on the biological functions of protein SUMOylation in liver-related diseases in recent years, summarizes the molecular mechanisms of SUMOylation in the replication of hepatitis viruses and the occurrence of hepatocellular carcinoma, and discusses the significance of SUMOylation in liver-related disorders, which is essential for understanding liver biological processes and formulating therapeutic strategies.</p>","PeriodicalId":16341,"journal":{"name":"Journal of Molecular Medicine","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140575156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging therapeutic targets in systemic sclerosis 系统性硬化症的新治疗靶点
Journal of Molecular Medicine Pub Date : 2024-02-22 DOI: 10.1007/s00109-024-02424-w
{"title":"Emerging therapeutic targets in systemic sclerosis","authors":"","doi":"10.1007/s00109-024-02424-w","DOIUrl":"https://doi.org/10.1007/s00109-024-02424-w","url":null,"abstract":"<h3>Abstract</h3> <p>Systemic sclerosis is an autoimmune connective tissue disease which is characterised by vascular perturbations, inflammation, and fibrosis. Although huge progress recently into the underlying molecular pathways that are perturbed in the disease, currently no therapy exists that targets the fibrosis element of the disease and consequently there is a huge unmet medical need. Emerging studies reveal new dimensions of complexity, and multiple aberrant pathways have been uncovered that have shed light on disturbed signalling in the disease, primarily in inflammatory pathways that can be targeted with repurposed drugs. Pre-clinical animal models using these inhibitors have yielded proof of concept for targeting these signalling systems and progressing to clinical trials. This review will examine the recent evidence of new perturbed pathways in SSc and how these can be targeted with new or repurposed drugs to target a currently intractable disease.</p>","PeriodicalId":16341,"journal":{"name":"Journal of Molecular Medicine","volume":"184 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139928032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review 药物性颌骨坏死的发病机制：综述
Journal of Molecular Medicine Pub Date : 2024-02-02 DOI: 10.1007/s00109-024-02425-9
{"title":"Etiopathogenesis of medication-related osteonecrosis of the jaws: a review","authors":"","doi":"10.1007/s00109-024-02425-9","DOIUrl":"https://doi.org/10.1007/s00109-024-02425-9","url":null,"abstract":"<h3>Abstract</h3> <p>This study compiles the main hypotheses involved in the etiopathogenesis of medication-related osteonecrosis of the jaw (MRONJ). A narrative review of the literature was performed. The etiopathogenesis of MRONJ is multifactorial and not fully understood. The main hypothesis considers the disturbance of bone turnover caused by anti-resorptive drugs. Bisphosphonates and denosumab inhibit osteoclast activity through different action mechanisms, accumulating bone microfracture. Other hypotheses also consider oral infection and inflammation, the antiangiogenic effect and soft tissue toxicity of bisphosphonates, and the inhibition of lymphangiogenesis. Knowledge of the current theories for MRONJ is necessary to define future studies and protocols to minimize the incidence of this severe condition.</p>","PeriodicalId":16341,"journal":{"name":"Journal of Molecular Medicine","volume":"68 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139664194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Liquid–liquid phase separation in Alzheimer’s disease 阿尔茨海默病中的液-液相分离技术
Journal of Molecular Medicine Pub Date : 2024-01-02 DOI: 10.1007/s00109-023-02407-3
Qinggang Fu, Bixiang Zhang, Xiaoping Chen, Liang Chu
{"title":"Liquid–liquid phase separation in Alzheimer’s disease","authors":"Qinggang Fu, Bixiang Zhang, Xiaoping Chen, Liang Chu","doi":"10.1007/s00109-023-02407-3","DOIUrl":"https://doi.org/10.1007/s00109-023-02407-3","url":null,"abstract":"<p>The pathological aggregation and misfolding of tau and amyloid-β play a key role in Alzheimer’s disease (AD). However, the underlying pathological mechanisms remain unclear. Emerging evidences indicate that liquid–liquid phase separation (LLPS) has great impacts on regulating human health and diseases, especially neurodegenerative diseases. A series of studies have revealed the significance of LLPS in AD. In this review, we summarize the latest progress of LLPS in AD, focusing on the impact of metal ions, small-molecule inhibitors, and proteinaceous partners on tau LLPS and aggregation, as well as toxic oligomerization, the role of LLPS on amyloid-β (Aβ) aggregation, and the cross-interactions between amyloidogenic proteins in AD. Eventually, the fundamental methods and techniques used in LLPS study are introduced. We expect to present readers a deeper understanding of the relationship between LLPS and AD.</p>","PeriodicalId":16341,"journal":{"name":"Journal of Molecular Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139079112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Estrogen receptors in normal human myometrium and leiomyoma. 正常人子宫肌层和平滑肌瘤中的雌激素受体。
Journal of Molecular Medicine Pub Date : 1977-01-01
K Pollow, M Schmidt-gollwitzer, E Boquoi, B Pollow
{"title":"Estrogen receptors in normal human myometrium and leiomyoma.","authors":"K Pollow,&nbsp;M Schmidt-gollwitzer,&nbsp;E Boquoi,&nbsp;B Pollow","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16341,"journal":{"name":"Journal of Molecular Medicine","volume":"2 1","pages":"61-8"},"PeriodicalIF":0.0,"publicationDate":"1977-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"22023437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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