Journal of interventional cardiology最新文献

{"title":"Gentamicin–Collagen Sponge Use in the Implant Pocket for the Prevention of Cardiac Implantable Electronic Device Infections","authors":"O. Azizy, A. Alwakaa, J. Trippe, M. Steinmetz, M. K. Oezcueruemez, A. Katsounas, A. Canbay, P. C. Patsalis","doi":"10.1155/joic/9922994","DOIUrl":"https://doi.org/10.1155/joic/9922994","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Cardiac implantable electronic device (CIED) infections remain a significant clinical challenge, particularly in high-risk populations. In view of their severity, a re-evaluation of preventive strategies is warranted. Real-world evidence on the procedural safety of a gentamicin-containing hemostatic collagen sponge (GS) for pocket prophylaxis is limited.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective single-center analysis of consecutive CIED implantations between October 2022 and October 2024 (<i>n</i> = 143). Perioperative prophylaxis consisted of intravenous ceftriaxone 2 g; in patients with documented <i>β</i>-lactam allergy, intravenous clindamycin was administered. In addition, a gentamicin-containing hemostatic collagen sponge was placed in the device pocket. Outcomes included procedural success, local and systemic complications, inflammatory markers, transesophageal echocardiography (TEE) for endocarditis, and CIED-related infection during the 12-month follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age was 74.5 years (SD ± 12), with males comprising 58% of the study population. Comorbidities were frequent (hypertension 81.1%, coronary artery disease 56%, heart failure 33%, diabetes mellitus 27%, renal failure 11%, and COPD 5.6%). Among patients, 5.6% were immunocompromised. Devices included dual-chamber pacemakers (74.8%), single-chamber pacemakers (10.5%), implantable cardioverter-defibrillators (10.5%), and event recorders (4.2%). Lead configuration was one lead in 17%, two leads in 74.5%, and three leads in 8.5%. Procedural success was 99.3%, with one lead dislodgement. Postoperative inflammatory markers remained within normal limits (CRP: 1.93 ± 3.82 mg/L; median: 0.51 mg/L; leukocytes: 7.87 ± 2.49 × 10^9/L; procalcitonin: 0.138 ± 0.11 ng/mL; <i>n</i> = 13), and no pathological fevers occurred. No clinically adjudicated CIED infections (major or minor) were observed during the 12-month follow-up. Clinical signs of pocket infection were absent in 142/143 patients (99.3%). One patient (0.7%) developed a pocket hematoma with localized tenderness while under intensive immunosuppression. Postprocedure TEE detected no endocarditis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In this exploratory cohort, adjunctive gentamicin–collagen sponge use demonstrated procedural feasibility without early safety signals. These findings are descriptive and hypothesis-generating. Given the retrospective design, absence of a control group, limited sample size, and zero-event out","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/9922994","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary Vein Isolation Suppresses Atrial Remodeling and Enhances Quality of Life in HFpEF Patients With Atrial Fibrillation: A Randomized Controlled Trial","authors":"Qun Tang, Yueqi Pan, Ling Liu, Yong Wang","doi":"10.1155/joic/3166864","DOIUrl":"https://doi.org/10.1155/joic/3166864","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Heart failure with preserved ejection fraction (HFpEF) is increasingly prevalent, accounting for nearly half of all heart failure cases, and is often complicated by atrial fibrillation (AF), which exacerbates symptoms and worsens prognosis. AF occurs in 40%–60% of HFpEF patients, contributing to structural remodeling, diastolic dysfunction, and elevated hospitalization rates. While pharmacological therapies including SGLT2 inhibitors, ACE inhibitors/ARBs/ARNI, beta-blockers, and mineralocorticoid receptor antagonists show broad benefits, rhythm control strategies such as radiofrequency ablation (RFA) remain underexplored in this population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This randomized, prospective, single-blinded trial enrolled 84 HFpEF patients with symptomatic AF. Participants were assigned to RFA (<i>n</i> = 39) or standard medical therapy (<i>n</i> = 45) and followed for 1 year. Key outcomes included changes in BNP levels, left atrial diameter (LAD), left ventricular ejection fraction (LVEF), AF recurrence, and quality of life (Minnesota Living with Heart Failure Questionnaire, MLHFQ). RFA involved pulmonary vein isolation (PVI) with irrigated catheters; patients with persistent AF also underwent posterior wall isolation (PWI). The medical group received optimized guideline-directed medical therapy (GDMT) including SGLT2 inhibitors, ACEi/ARB/ARNI, beta-blockers, and MRA as indicated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>RFA significantly reduced AF recurrence (<i>p</i> = 0.001) and attenuated left atrial enlargement (ΔLAD: −0.2 mm vs. +2.0 mm in the medical group, <i>p</i> < 0.001). While LVEF remained unchanged in both groups, RFA improved MLHFQ scores (<i>p</i> < 0.001), whereas medical therapy did not (<i>p</i> = 0.076). BNP levels declined in both groups (<i>p</i> < 0.001) but without intergroup differences. In patients with interpretable E/A ratio measurements, diastolic function appeared to improve in the ablation group compared to medical therapy (<i>p</i> < 0.001). Multivariate analysis identified PVI as an independent protective factor against AF recurrence (OR = 0.20) and a driver of MLHFQ improvement (<i>β</i> = −16.28).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In HFpEF patients with AF, RFA effectively suppresses atrial remodeling, reduces AF recurrence, and enhances the quality of life without altering LVEF. These benefits highlight the importance of targeting structural and symptomatic outcomes over traditional systolic function metrics. Future studies sho","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/3166864","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147715005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atrial Fibrillation Ablation Using Cryoballoon Versus Robotic Magnetic Navigation in Patients With Pulmonary Vein Variant","authors":"Xiao-Yu Liu,&nbsp;Xu Tang,&nbsp;Jie Zheng,&nbsp;Ku-Lin Li,&nbsp;Hua-Yan You,&nbsp;Shi-Peng Dang,&nbsp;Xiao-Xi Zhao,&nbsp;Yu-Fei Dai,&nbsp;Hai-Wei Geng,&nbsp;Ru-Xing Wang","doi":"10.1155/joic/1034508","DOIUrl":"https://doi.org/10.1155/joic/1034508","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>The outcomes of ablation for atrial fibrillation (AF) in patients with pulmonary vein (PV) variants remain controversial. The aim of this study was to compare procedure data and outcomes in paroxysmal AF patients with PV variant for cryoballoon (CRYO) ablation and robotic magnetic navigation (RMN) ablation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis assigned 256 patients underwent CRYO ablation and 254 patients underwent RMN ablation. They were divided into PV variant patients who underwent CRYO ablation (CRYO variant group, 58 cases); PV normal patients who underwent CRYO ablation (CRYO normal group, 198 cases); PV variant patients who underwent RMN ablation (RMN variant group, 49 cases); and the PV normal patients who underwent RMN ablation (RMN normal group, 205 cases).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with the RMN variant group, the procedure time (91.7 ± 14.8 min vs. 150.0 ± 16.4 min, <i>p</i> &lt; 0.001) was significantly decreased in the CRYO variant group, while the X-ray time (20.9 ± 6.3 min vs. 7.4 ± 3.1 min, <i>p</i> &lt; 0.001) and dose (574.0 ± 302.5 mGy vs. 206.5 ± 102.2 mGy, <i>p</i> &lt; 0.001) were significantly increased. The rates of maintaining sinus rhythm during 1 year of follow-up were similar in both groups (47/58 vs. 42/49, <i>p</i> = 0.497). Compared with the CRYO variant group, the procedure time, X-ray time, and dose were decreased in the CRYO normal group. However, there was no significant difference in procedure time, X-ray time, and dose between the RMN normal group and the RMN variant group. No matter which method was used, there was no significant difference in the 1-year follow-up recurrence rate between PV variant and PV normal patients. COX regression analysis showed that the ablation method is not a predictive factor for recurrence in PV variant ablation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CRYO and RMN have similar outcomes during a 1-year follow-up for patients with PV variants. Unlike RMN ablation, PV variants increase the procedure difficulty of CRYO ablation, manifested by increased procedure time, X-ray time, and dose.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/1034508","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147714968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heightened Mortality and Clinical Risks in Patients With Substance Use Disorder Undergoing Cardiac Catheterization","authors":"Joshua D. Greendyk,&nbsp;Afif Hossain,&nbsp;Julia DeLorenzo,&nbsp;Soyi Sarkar,&nbsp;Ashkan Hashemi,&nbsp;Benjamin Simmons,&nbsp;Vinesh Jonnala,&nbsp;Abhishek Sharma","doi":"10.1155/joic/3679178","DOIUrl":"https://doi.org/10.1155/joic/3679178","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Healthcare disparities significantly affect patients with substance use disorder (SUD), particularly in cardiovascular disease (CVD). Although SUD is linked to poorer outcomes, research comparing SUD patients’ clinical and procedural outcomes during cardiac catheterization to non-SUD controls is limited. This study aims to address this gap.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective 1:2 case-control study at University Hospital (UH) from 2008 to 2022 included 102 patients with SUD and 203 age- and sex-matched controls without SUD who underwent cardiac catheterization selected from the Cardiac Catheterization and Percutaneous Intervention (CAPIT) registry. Matching and exclusion criteria were applied, with additional data collected via chart review. The study was approved by the Rutgers Institutional Review Board.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>102 patients with SUD and 203 patients without SUD who underwent cardiac catheterization from 2008 to 2022 were compared. Of the SUD group, 52.4% used both heroin and cocaine and 23.8% had a history of intravenous drug use (IVDU). SUD patients were more likely to have an ejection fraction of less than 30% around 1 year or more after procedure (13.7% vs. 3.4%, <i>p</i> = 0.001), be designated as NYHA Class 3-4 (23.5% vs. 8.9%, <i>p</i> ≤ 0.001), have arrythmia (5.9% vs. 1.0%, <i>p</i> = 0.019), require mechanical ventilation (11.8% vs. 5.4%, <i>p</i> = 0.048), and have increased mortality (24.5% vs. 12.3%, <i>p</i> = 0.007) as shown in the tables. SUD was associated with significantly worse survival (estimated mean survival: 9.33 [95% CI 7.83–10.84] in the SUD group vs. 12.22 [95% CI 10.13–14.30] years, log rank <i>p</i> = 0.005 in the non-SUD group). SUD was an independent positive predictor of death (OR = 2.28, 95%, 1.09–4.76, <i>p</i> = 0.029).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Patients with SUD undergoing cardiac catheterization face heightened risks, including increased mortality, reduced ejection fraction, arrhythmias, mechanical ventilation, and shorter survival. These findings highlight the urgent need for targeted, multidisciplinary action to address disparities in this vulnerable population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/3679178","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147714883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of Transradial Access Through Chronically Occluded Radial Arteries","authors":"Sarah Komanapalli,&nbsp;Srikiran Dasari,&nbsp;Nathan Markus,&nbsp;Ricky Lemus,&nbsp;Saad Ali,&nbsp;Bistees Geroge,&nbsp;Alan Garcia,&nbsp;Sandeep Singh,&nbsp;Rolf P. Kreutz,&nbsp;Mohammad Thawabi","doi":"10.1155/joic/6845683","DOIUrl":"https://doi.org/10.1155/joic/6845683","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Radial artery occlusion (RAO) often precludes the use of transradial access (TRA) for coronary procedures. This study examines the feasibility and outcomes of TRA through chronically occluded radial arteries.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Access was obtained in the proximal or distal radial artery using ultrasound guidance by angiocath needle. Navigation through the occlusion was done using a GlideAdvantage 0.018″ wire. A 6Fr 16-cm Glidesheath Slender was advanced once the occlusion was crossed. The 5Fr catheters were utilized for coronary angiograms, and 6Fr guides were utilized for percutaneous coronary intervention (PCI). Aspirations were performed through the sheath and catheters up to the brachial artery. Outcomes were assessed predischarge and at 30-day follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirteen patients with chronic RAO were included. The median age was 59 (53, 65) years, with 69% (<i>n</i> = 9) being male. The last known radial patency was 17.5 (11.5–21.3) months prior to intervention. Proximal radial artery was utilized in 77% (<i>n</i> = 10) of the patients. Duration for TRA was 8 (6, 10) minutes, with a success rate of 100%. A total of 69% (<i>n</i> = 9) of the patients had a diagnostic coronary angiogram, while 31% (<i>n</i> = 4) of the patients underwent additional PCI. The intended procedure was successful in 12 out of 13 patients with no periprocedural complications. Severe pain and spasm occurred in 38% of the patients (<i>n</i> = 5). Duplex ultrasound revealed RAO in 12 patients predischarge and RAO in all patients at 30-day follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>TRA through chronically occluded radial arteries for coronary procedures was a feasible option in this cohort. This technique can offer an alternative for patients with no viable alternative access sites.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/6845683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Chronic Total Occlusion Percutaneous Coronary Intervention in Patients With Diabetes Mellitus","authors":"Chloe Kharsa,&nbsp;Gal Sella,&nbsp;Yasser M. Sammour,&nbsp;Rody G. Bou Chaaya,&nbsp;Mangesh Kritya,&nbsp;Jerrin Philip,&nbsp;Muhammad Haisum Maqsood,&nbsp;Neal S. Kleiman,&nbsp;Alpesh R. Shah","doi":"10.1155/joic/7566683","DOIUrl":"https://doi.org/10.1155/joic/7566683","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Diabetes mellitus is a well-established risk factor for coronary artery disease (CAD) and is associated with complex coronary anatomy. While percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) has evolved, outcomes in patients with diabetes remain poorly characterized.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;To evaluate procedural and clinical outcomes following CTO PCI in patients with and without diabetes mellitus using real-world data from a high-volume tertiary care center.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;We retrospectively analyzed data from 495 patients who underwent CTO PCI at the Houston Methodist DeBakey Heart and Vascular Center between January 2018 and December 2023. Patients were divided for analysis by diabetes status. The primary endpoints included procedural success, all-cause mortality at 1 year, and clinically driven target lesion revascularization (TLR). Secondary endpoints included target lesion failure (TLF) and in-hospital complications.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Among 495 patients undergoing CTO PCI, 246 (49.7%) had diabetes. Compared with nondiabetic patients, those with diabetes had significantly higher rates of chronic kidney disease (44.1% vs. 27.2%, &lt;i&gt;p&lt;/i&gt; &lt; 0.001), dialysis dependence (9.3% vs. 2.4%, &lt;i&gt;p&lt;/i&gt; = 0.001), and prior CABG (29.8% vs. 18.9%, &lt;i&gt;p&lt;/i&gt; = 0.005). Despite a higher prevalence of multivessel CTOs, reflecting greater anatomical complexity in patients with diabetes (43.8% vs. 23.9%, &lt;i&gt;p&lt;/i&gt; = 0.012), procedural success rates were similarly high in both groups (84.6% vs. 81.6%, &lt;i&gt;p&lt;/i&gt; = 0.37). At 1 year, all-cause mortality and TLF rates were significantly higher in diabetic patients (HR = 2.03; 95% CI, 1.07–3.88; &lt;i&gt;p&lt;/i&gt; = 0.03 and HR = 2.18; 95% CI, 1.31–3.62; &lt;i&gt;p&lt;/i&gt; = 0.003, respectively). Procedural complexity was not an independent predictor of mortality or TLR among diabetic patients.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this modern cohort, diabetes was associated with poorer long-term outcomes after CTO PCI despite high procedural success rates. These findings should be interpreted in light of the study’s single-center, retrospective design and potential residual confounding and appear to be largely driven by accompanying comorbidities, underscoring the need for individualized postprocedural management in this high-risk population.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 &lt;/di","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/7566683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147564129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Decade of Experience With Transcatheter VSD Closure: Outcomes From a Philanthropic-Based Center","authors":"Ahmad Amer,&nbsp;Hanita Shai,&nbsp;Avital Mitler,&nbsp;Alona Raucher Sternfeld,&nbsp;Sagi Assa","doi":"10.1155/joic/8890989","DOIUrl":"https://doi.org/10.1155/joic/8890989","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Ventricular septal defects (VSDs) are the most common congenital heart defects, with outcomes influenced by size and location. Transcatheter closure (TCC) has become a widely used option for repair. This study presents a decade-long institutional experience with TCC of VSDs, evaluating its safety and efficacy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study analyzed patients who underwent attempted TCC of VSDs between 2015 and 2024. Patients were selected based on clinical and hemodynamic significance, and indications for closure were heart-failure symptoms and a Qp:Qs ratio exceeding 1.5. Procedural success, complications, and ventricular remodeling were analyzed as primary outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 149 patients (51% male) were included; of these, 23 (15.4%) patients were local (Israeli) and 126 (84.6%) were foreign nationals. The mean age was 86.67 ± 57.13 months. Successful closure was achieved in 139 patients (93.3%). The mean defect diameter was 4.72 ± 1.82 mm. The majority had perimembranous defects (111 patients, 74.5%). ADO II devices (96 cases, 65%) and MFO devices (49 cases, 33%) were predominantly used. The retrograde approach was employed in 136 (92%) of cases. The most notable complication was a residual shunt adjacent to the device, detected in 21 patients (15.1%) at a 1-week follow-up; 19 patients (13.7%) had mild residual shunts and 2 patients (1.4%) had moderate residual shunts. In the long-term follow-up cohort, residual shunt persisted in 3 of 52 patients (5.8%), all of which were mild. No mortality or instances of complete heart block were reported. Overall, 10 procedures (6.7%) failed. Device embolization occurred in six cases (4%), five of which required surgical intervention. Univariable analysis showed significantly higher LVEDD Z-score, Qp:Qs ratio, defect diameter, and systolic pulmonary artery pressure in failed cases. In further analysis for pmVSD patients, device choice and subaortic rim were also significantly associated with failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This decade-long experience demonstrates TCC as a safe and effective treatment for VSDs, with high success rates and minimal complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/8890989","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Echocardiographic Parameters for Persistent Mitral Regurgitation Following Percutaneous Closure of Patent Ductus Arteriosus in Pediatric Population","authors":"Walaa Adem,&nbsp;Eun Young Bae,&nbsp;Gi Beom Kim,&nbsp;SangYun Lee,&nbsp;Susan Taejung Kim,&nbsp;Seung Min Baek,&nbsp;Mi Kyoung Song,&nbsp;Eun Jung Bae","doi":"10.1155/joic/1595586","DOIUrl":"https://doi.org/10.1155/joic/1595586","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hemodynamically significant patent ductus arteriosus (hsPDA) leads to left-sided chamber dilatation and mitral valve (MV) annular stretching, potentially resulting in mitral regurgitation (MR). While transcatheter PDA closure often improves MR, persistent MR may be associated with adverse outcomes. This study aimed to identify echocardiographic predictors of persistent MR following transcatheter PDA closure in pediatric patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We conducted a retrospective study of 183 pediatric patients (aged 1–18 years) who underwent transcatheter PDA closure at Seoul National University Hospital between 2004 and 2021. Echocardiographic parameters, including left ventricular internal diameter in diastole (LVIDd), MV annulus diameter, and MR severity were analyzed before and after the procedure. Cardiac catheterization data were also reviewed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The mean age at the time of the procedure was 1.92 years, and the average pulmonic end diameter of PDA was 2.91 mm. After transcatheter PDA closure, LVIDd (Z-score), LVIDd/BSA, and MV annulus (Z-score) significantly decreased. The prevalence of MR decreased from 22.4% (preclosure) to 8.2% (postclosure). Multivariate analysis identified preclosure LVIDd (Z-score), postclosure MV annulus diameter (mm), MV annulus (Z-score), and the presence of MV prolapse as independent predictors of persistent MR. ROC analysis demonstrated that a preclosure LVIDd (Z-score) ≥ 2.95 predicted persistent MR with a sensitivity of 66.7% and a specificity of 83.9%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Persistent MR after transcatheter PDA closure is predicted by preclosure LVIDd (Z-score), postclosure MV annulus diameter, and the presence of MV prolapse. Recognizing these factors may help guide clinical management and improve outcomes for patients at the risk of persistent MR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/1595586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146096404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Feasibility of Impella CP Decannulation With a Preclosure Technique in Myocardial Infarction With Cardiogenic Shock","authors":"Kosuke Muto,&nbsp;Takahide Arai,&nbsp;Hiroki Hoya,&nbsp;Shintaro Nakano","doi":"10.1155/joic/7630587","DOIUrl":"https://doi.org/10.1155/joic/7630587","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Impella CP is a widely used mechanical circulatory support device for patients with cardiogenic shock undergoing high-risk percutaneous coronary intervention. Hemostasis following Impella removal remains a clinical challenge. Although the preclosure technique using the Perclose ProGlide device is standard in elective procedures, its feasibility in emergency settings for cardiogenic shock has not been well established.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This single-center, retrospective study included 14 consecutive patients with myocardial infarction complicated by cardiogenic shock who underwent Impella CP insertion between January 2020 and December 2024. Patients requiring coronary artery bypass grafting or venoarterial extracorporeal membrane oxygenation were excluded. A single Perclose ProGlide device was deployed using the preclosure technique at the time of Impella insertion. For hemodynamically stable patients, the Impella was removed within 48 h at the bedside. Procedural endpoints comprised door-to-preclose, door-to-unloading (DTU), and door-to-balloon (DTB) times. Safety endpoints were also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>10 patients underwent Impella removal using the preclosure technique, and 4 patients underwent surgical cutdown. Comparing the preclose and surgical groups, the DTU time was not significantly different (median [interquartile range]: 89.5 [86.25–98.75] min vs. 92.0 [74.5–112.5] min, respectively; <i>p</i> = 0.811), nor was the DTB time (107.0 [104.25–119.75] min vs. 109.0 [88.5–131.0] min, respectively; <i>p</i> = 1.000). However, the time to Impella removal was significantly shorter in the preclose versus surgical groups (25.0 [22.0–27.75] h vs. 73.0 [59.0–91.5] h, respectively; <i>p</i> = 0.014). Technical success was achieved in all cases without major bleeding, surgical conversion, or infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study demonstrated the feasibility and safety of total percutaneous bedside Impella CP removal using a single Perclose ProGlide device in patients with cardiogenic shock. The preclosure technique did not prolong DTB or DTU times and may be a practical alternative to surgical Impella device removal in stable patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/7630587","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146058017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Percutaneous Intramyocardial Septal Pulsed Field Ablation in a Rabbit Model: Safety, Efficacy, and Feasibility","authors":"Xing-an Zhao,&nbsp;Hua-lei Dai,&nbsp;Si-ming Tao,&nbsp;Yi-jian Zhang,&nbsp;Ji Jia,&nbsp;Li-juan Song,&nbsp;Man Yang,&nbsp;Yun-na Ge,&nbsp;Xi-ya Wang,&nbsp;Juan Qing","doi":"10.1155/joic/5898802","DOIUrl":"https://doi.org/10.1155/joic/5898802","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Percutaneous intramyocardial (PIM) septal pulsed field ablation (SPFA) represents an innovative technique for the management of hypertrophic obstructive cardiomyopathy. However, the paucity of pertinent animal models has impeded comprehensive investigation. This study aimed to assess the safety, efficacy, and feasibility of PIM-SPFA, as well as to examine the pathological alterations in the interventricular septum (IVS) postablation, utilizing a healthy rabbit model.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Objective&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study aims to evaluate the efficacy, safety, and feasibility of PIM-SPFA in an animal model.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Method&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;In this study, percutaneous apical septal puncture under transthoracic echocardiography (TTE) guidance was employed to deliver a PFA catheter for treatment. The laboratory rabbits were allocated into a control group and an experimental group. Laboratory rabbits did not have hypertrophic obstructive cardiomyopathy. The experimental group was further subdivided into four cohorts based on varying PFA energies: 600, 800, 1000, and 1200 V, with the control group receiving 0 V. The experimental animals were monitored using electrocardiography, hemodynamic assessments, and cardiac enzymology. Histological analyses, encompassing triphenyl tetrazolium chloride (TTC) staining and Masson’s trichrome staining, were conducted 6 weeks postoperatively.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The maximum diameter of PFA-induced myocardial damage exhibited a positive correlation with increasing electric field strength (0 V: 0.49 ± 0.06 mm; 600 V: 1.52 ± 0.11 mm; 800 V: 2.78 ± 0.29 mm; 1000 V: 4.09 ± 0.49 mm; 1200 V: 5.03 ± 0.81 mm; &lt;i&gt;F&lt;/i&gt; = 51.11, &lt;i&gt;p&lt;/i&gt; &lt; 0.01). Postoperative monitoring at the 6-week mark demonstrated a significant reduction in the peak left ventricular outflow tract (LVOT) velocity (1000 V: 1.15 ± 0.21 to 0.75 ± 0.13 m/s; 1200 V: 1.12 ± 0.16 to 0.70 ± 0.13 m/s, &lt;i&gt;p&lt;/i&gt; &lt; 0.05). Intra-SPFA therapy did not precipitate severe malignant arrhythmias, and no atrioventricular block (AVB) was observed on perioperative electrocardiograms. Histological analysis revealed that the injury site was characterized primarily by myocardial necrosis, with preservation of microvessels and nerve fibers and was predominantly fibrotic in nature, with an absence of significant inflammatory cell infiltration.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusions&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A novel therapeutic","PeriodicalId":16329,"journal":{"name":"Journal of interventional cardiology","volume":"2026 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/joic/5898802","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145993873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}