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Journal of lipid mediators最新文献

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Pathways in the biosynthesis of oxylipins in plants. 植物中氧化脂类生物合成的途径。
Journal of lipid mediators Pub Date : 1993-03-01
M Hamberg
{"title":"Pathways in the biosynthesis of oxylipins in plants.","authors":"M Hamberg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"375-84"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19095814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanism of prostaglandin F2 alpha action in the ovary. 前列腺素F2 α在卵巢中的作用机制。
Journal of lipid mediators Pub Date : 1993-03-01
G L Steele, P C Leung
{"title":"Mechanism of prostaglandin F2 alpha action in the ovary.","authors":"G L Steele, P C Leung","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"509-13"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19343503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lipid mediators of implantation and decidualization. 植入术和脱个体化的脂质介质。
Journal of lipid mediators Pub Date : 1993-03-01
G M Yee, P M Squires, S S Cejic, T G Kennedy
{"title":"Lipid mediators of implantation and decidualization.","authors":"G M Yee, P M Squires, S S Cejic, T G Kennedy","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"525-34"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19343505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PAF-induced amplification of mediator release in septic shock: prevention or downregulation by PAF antagonists. 败血性休克中PAF诱导的介质释放放大:PAF拮抗剂的预防或下调
Journal of lipid mediators Pub Date : 1993-03-01
M Koltai, D Hosford, P Braquet
{"title":"PAF-induced amplification of mediator release in septic shock: prevention or downregulation by PAF antagonists.","authors":"M Koltai, D Hosford, P Braquet","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"183-98"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19343772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are prostaglandins mediators of mifepristone (RU 486)-induced cervical softening in early pregnancy? 前列腺素是米非司酮(ru486)诱导妊娠早期宫颈软化的介质吗?
Journal of lipid mediators Pub Date : 1993-03-01
A Rådestad, M Bygdeman
{"title":"Are prostaglandins mediators of mifepristone (RU 486)-induced cervical softening in early pregnancy?","authors":"A Rådestad, M Bygdeman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"503-7"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19343502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Site-directed mutagenesis of leukotriene A4 hydrolase: distinction of leukotriene A4 hydrolase and aminopeptidase activities. 白三烯A4水解酶的定点诱变:白三烯A4水解酶和氨基肽酶活性的区别。
Journal of lipid mediators Pub Date : 1993-03-01
T Izumi, M Minami, N Ohishi, H Bito, T Shimizu
{"title":"Site-directed mutagenesis of leukotriene A4 hydrolase: distinction of leukotriene A4 hydrolase and aminopeptidase activities.","authors":"T Izumi,&nbsp;M Minami,&nbsp;N Ohishi,&nbsp;H Bito,&nbsp;T Shimizu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Leukotriene (LT) A4 hydrolase catalyzes enzymatic hydration of LTA4 to biologically active substance, LTB4. Biochemical and immuno-histochemical studies have shown that this enzyme is ubiquitously distributed in various cells and tissues. A sequence domain of LTA4 hydrolase was found to be homologous to those of several zinc metalloproteases. Both native and recombinant enzymes were shown to possess equimolar zinc ion and aminopeptidase activity. To examine the molecular mechanism of this enzyme reaction, site-directed mutagenesis experiments were carried out. Single amino acid substitutions at Glu-297 revealed a distinction of two enzyme activities, and suggest that the glutamic acid residue at 297 is essential for aminopeptidase, while the side chain of Glu or Gln is required for LTA4 hydrolase activity. The loss of two enzyme activities in a mutant E319K confirmed the proposal that the presence of a zinc ion in the enzyme is required for both enzyme activities.</p>","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"53-8"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19343506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intraocular pressure effects of selective prostanoid receptor agonists involve different receptor subtypes according to radioligand binding studies. 根据放射配体结合研究，选择性前列腺素受体激动剂对眼压的影响涉及不同的受体亚型。
Journal of lipid mediators Pub Date : 1993-03-01
D F Woodward, R A Lawrence, C E Fairbairn, T Shan, L S Williams
{"title":"Intraocular pressure effects of selective prostanoid receptor agonists involve different receptor subtypes according to radioligand binding studies.","authors":"D F Woodward,&nbsp;R A Lawrence,&nbsp;C E Fairbairn,&nbsp;T Shan,&nbsp;L S Williams","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The receptors involved in the ocular hypotensive activity of prostaglandins (PG) E2 and F2 alpha in dogs and monkeys was investigated by examining the effects of putative receptor selective agonists on intraocular pressure. A diverse variety of receptor selective agonists lowered intraocular pressure in these species. Thus, FP-receptor agonists (17-phenyl PGF2 alpha, fluprostenol), agonists with potent activity at the EP3 receptor (MB 28767, sulprostone) and a prostanoid with activity at the EP2 receptor (11-deoxy PGE1) were all potent ocular hypotensives when administered as a single dose to dogs and monkeys or b.i.d. for 5 days in monkeys. These findings were regarded as surprising and prompted us to re-examine some aspects of the current classification for prostanoid receptors. At present certain receptor subtypes, notably EP2, EP3 and FP receptors, are defined only according to the potency rank order for agonists. In these studies, we employed radioligand binding studies to determine the degree of competition between prostanoid agonists claimed to be selective on the basis of functional assays. Competition studies with a diverse variety of prostanoids at the binding site for PGE2 and sulprostone on the myometrial plasma membrane prepared from the rat uterus were consistent with the presence of an EP3 receptor. Thus, EP3-receptor agonists (MB 28767 and sulprostone) potently inhibited PGE2 and sulprostone binding, whereas FP agonists (17-phenyl PGF2 alpha, fluprostenol), a DP agonist (BW 245C), an EP1 antagonist (AH 6809), an EP2 agonist (AH 13205) and TP-receptor ligands (BM 13505, I-BOP) afforded little or no inhibition.(ABSTRACT TRUNCATED AT 250 WORDS)</p>","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"545-53"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19343507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E. coli. 肺和肾细胞色素P450的类二十烷羟基化的功能方面。cdna在哺乳动物细胞和大肠杆菌中的表达。
Journal of lipid mediators Pub Date : 1993-03-01
B S Masters, J E Clark, L J Roman, M Nishimoto, T J McCabe, P R Ortiz de Montellano, C G Plopper, D Gebremedhin, Y H Ma, D R Harder
{"title":"Functional aspects of eicosanoid hydroxylation by lung and kidney cytochromes P450. Expression of cDNAs in mammalian cells and E. coli.","authors":"B S Masters,&nbsp;J E Clark,&nbsp;L J Roman,&nbsp;M Nishimoto,&nbsp;T J McCabe,&nbsp;P R Ortiz de Montellano,&nbsp;C G Plopper,&nbsp;D Gebremedhin,&nbsp;Y H Ma,&nbsp;D R Harder","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A gene subfamily of cytochromes P450 with catalytic activity toward various eicosanoid substrates has been studied with a variety of techniques in this laboratory, including purification and characterization, localization at the tissue and subcellular levels, physiological function, and cloning and expression in prokaryotic and eukaryotic systems. This paper reports experiments directed toward determining the function of the cytochrome P4504A metabolite, 20-hydroxyarachidonic acid (20-hydroxyeicosatetraenoic acid; 20-HETE), in cellular ion flux, immunohistochemical localization in lung, the effects of a mechanism-based inhibitor, 12-hydroxy-16-heptadecynoic acid (12-HHDYA) on PGE1 omega-hydroxylation, and the structure-function determinants which govern the activities of the enzymes encoded by this gene subfamily.</p>","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"353-60"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19344408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
1,25-Dihydroxyvitamin D3 upregulates 5-lipoxygenase metabolism and 5-lipoxygenase activating protein in peripheral blood monocytes as they differentiate into mature macrophages. 1,25-二羟基维生素D3在外周血单核细胞分化为成熟巨噬细胞时上调5-脂氧合酶代谢和5-脂氧合酶激活蛋白。
Journal of lipid mediators Pub Date : 1993-03-01
M J Coffey, M Gyetko, M Peters-Golden
{"title":"1,25-Dihydroxyvitamin D3 upregulates 5-lipoxygenase metabolism and 5-lipoxygenase activating protein in peripheral blood monocytes as they differentiate into mature macrophages.","authors":"M J Coffey,&nbsp;M Gyetko,&nbsp;M Peters-Golden","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19344981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular origin of prostaglandins D2 and E2 in chick dorsal root ganglion: a biochemical and immunocytochemical study. 鸡背根神经节中前列腺素D2和E2的细胞起源:生化和免疫细胞化学研究。
Journal of lipid mediators Pub Date : 1993-03-01
M F Vesin, B Droz
{"title":"Cellular origin of prostaglandins D2 and E2 in chick dorsal root ganglion: a biochemical and immunocytochemical study.","authors":"M F Vesin,&nbsp;B Droz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":16323,"journal":{"name":"Journal of lipid mediators","volume":"6 1-3","pages":"453-6"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19344986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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