K. Sen, Rashmirekha Pati, Atimukta Jha, G. Mishra, Subhasish Prusty, Shweta Chaudhary, Swati Swetalika, S. Podder, Aishwarya Sen, Mamuni Swain, R. Nanda, S. Raghav
{"title":"Nuclear Receptor Co-repressor NCoR1 governs immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation","authors":"K. Sen, Rashmirekha Pati, Atimukta Jha, G. Mishra, Subhasish Prusty, Shweta Chaudhary, Swati Swetalika, S. Podder, Aishwarya Sen, Mamuni Swain, R. Nanda, S. Raghav","doi":"10.15305/ijir.v7i1.372","DOIUrl":"https://doi.org/10.15305/ijir.v7i1.372","url":null,"abstract":"","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133448946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanusha Pathak, R. Parashar, Pragati Raghuwanshi, D. Joshi, A. Joshi, R. Joshi, R. Shrivastava
{"title":"Analysis of complete blood count parameters throughout disease severity in COVID-19 survivors","authors":"Tanusha Pathak, R. Parashar, Pragati Raghuwanshi, D. Joshi, A. Joshi, R. Joshi, R. Shrivastava","doi":"10.15305/ijir.v7i1.373","DOIUrl":"https://doi.org/10.15305/ijir.v7i1.373","url":null,"abstract":"","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"3 3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124429192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pragati Raghuwanshi, R. Parashar, S. Mukherjee, Ankur Joshi, R. Joshi, Himadri Singh
{"title":"Inflammation status in COVID-19 survivors in the recovery phase","authors":"Pragati Raghuwanshi, R. Parashar, S. Mukherjee, Ankur Joshi, R. Joshi, Himadri Singh","doi":"10.15305/ijir.v7i1.374","DOIUrl":"https://doi.org/10.15305/ijir.v7i1.374","url":null,"abstract":"","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"130 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115773300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mitra Sabetghadam Moghadam, N. A. Fard, A. Mirshafiey
{"title":"The association of NLRP3 p.Q705K and CARD8 p.C10X genetic polymorphisms with rheumatoid arthritis: A review of the literature","authors":"Mitra Sabetghadam Moghadam, N. A. Fard, A. Mirshafiey","doi":"10.15305/IJIR/V5I1/341","DOIUrl":"https://doi.org/10.15305/IJIR/V5I1/341","url":null,"abstract":"Many genetic factors are involved in the pathogenesis of rheumatoid arthritis (RA). This study is aimed to summarize the literature regarding the relationship between variation in the genes encoding NLRP3/CARD8 and RA, using a candidate polymorphism approach. Several investigations have been conducted on the association of the genetic alterations of the NLRP3 p.Q705K and CARD8 p.C10X with the inflammatory diseases. Although there are variable results, the role of inflammatory pathways and genes involved is undeniable. The genetic context of the NLRP3 p.Q705K and CARD8 p.C10X gene variants in the pathogenesis of RA is still unclear to confirm that these variations show a pivotal role in the pathophysiology of RA. More comprehensive studies in this area seem to be needed.","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133341234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Is Eales’ disease due to tuberculosis?","authors":"Prasad Gupta, J. Biswas","doi":"10.15305/ijir/v4i1/328","DOIUrl":"https://doi.org/10.15305/ijir/v4i1/328","url":null,"abstract":"Eales’ disease, first described by the British ophthalmologist Henry Eales, is characterized by stages of vasculitis, occlusion, and retinal neovascularization. It results in recurrent vitreous hemorrhage leading to vision loss. Multifactorial causes like Mycobacterium tuberculosis (TB), human leukocyte antigen, retinal autoimmunity and free radical-mediated damage, have been hypothesized in the etiopathogenesis of this disease.","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"377 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122776435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Multi-cellular and multi-molecular immune interactions in the transplantation tolerance and rejection","authors":"G. Lal, Shilpi Giri","doi":"10.15305/ijir/v3i1/318","DOIUrl":"https://doi.org/10.15305/ijir/v3i1/318","url":null,"abstract":"Transplantation tolerance remains the paramount goal for achieving long-term allograft survival. Several chemotherapeutic drugs are in use to prolong allograft survival, but its side effects and toxicity limits its clinic application. Transplantation tolerance requires complex cellular and molecular interaction between immune cells and stromal cells in the secondary lymphoid tissues. Early interaction of these cells decides the fate of generation and maintenance of tolerance. The role of adaptive immunity (T cells and B cells) in the inflammation and tolerance are well established, and new cellular and molecular interactions are evolving with time. In this review, we discussed the importance of innate and adaptive immune cells and how their interactions contribute to transplantation tolerance or rejection. We also discussed how these cellular and molecular interactions had been explored to control the inflammatory reactions and promote the survival of allogenic grafts in the various transplantation setting.","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114144585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Biologics in uveitis: An update","authors":"Kowsigan Magesan, Amravi Shah, J. Biswas","doi":"10.15305/IJIR/V3I1/312","DOIUrl":"https://doi.org/10.15305/IJIR/V3I1/312","url":null,"abstract":"‘Uveitis is’ the term used to describe inflammation of the uvea. It can be due to infective or non-infective agents. Most of the non-infectious uveitides are autoimmune or auto-inflammatory in nature, and the management of non-infective uveitis is often crucial. Advancements in biotechnology and understanding the pathophysiologies of autoimmune diseases have enabled the development of the new class of drugs named ‘biologics’. These drugs act at cellular level inhibiting the actions of pro-inflammatory cytokines including tumor necrosis factor-α (TNF-α), interleukin-1, and IL-6, and B and T lymphocytes. Biologics have been proven to be less toxic and can be used in uveitic cases that are refractory to conventional therapy. Though the efficacy of biologics is based on insufficient clinical trials, majority of them indicate preferable outcomes on refractory uveitis, with remarkable promise to increase the possibility of long-term remission. In this review, we aimed to outline the ideal characteristics of each biologic drug and review the data to support the use of current and emerging biological therapies.","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127767358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factors affecting the pathophysiology of sepsis, an inflammatory disorder: Key roles of oxidative and nitrosative stress","authors":"S. Yadav, Taru Verma, D. Nandi","doi":"10.15305/ijir/v3i1/303","DOIUrl":"https://doi.org/10.15305/ijir/v3i1/303","url":null,"abstract":"Sepsis, one of the primary causes of mortality in the intensive care units, occurs due to the host’s dysregulated immune responses to an infection. Consequently, persistent systemic inflammation along with suppressed adaptive immunity ensues, resulting in deranged metabolism, recurrent infections, tissue damage and multi-organ failure. The uncontrolled oxidative stress mediated by the imbalance between the generation of reactive oxygen species and their neutralization by the host’s antioxidant system is involved in inflammation-induced damage. The profound deleterious effects in the host range from mitochondrial dysfunction and endothelial damage to reduced cardiac output. Therefore, antioxidant therapy was actively considered to have therapeutic benefits in sepsis patients. Although some success has been obtained with the use of antioxidants in sepsis patients, considerable ambiguity persists that prevents their routine use. Another key molecule that may dictate the outcome and prognosis during sepsis is nitric oxide (NO). This pleiotropic molecule plays a central role in inflammation and in leukocyte recruitment at the site of inflammation. NO is synthesized by three different isoforms of nitric oxide synthases (NOS) and significantly high and sustained levels of NOS2 have been reported in sepsis. Abundant literature supports the protective roles of NO during sepsis; however, there is uncertainty in various reports. The administration of NO donors in clinical trials for sepsis treatment has encountered limited success. NO, during sepsis, acts like a double-edged sword: increased NO levels can result in hypotension, whereas reduced levels contribute to poor organ perfusion and an elevated susceptibility to infection. Therefore, several parameters need to be evaluated, while considering the potential of antioxidant and NO-based therapy during sepsis.","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"37 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130157625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nanotherapy that prevents trained immunity and promotes tolerance","authors":"W. Mulder","doi":"10.15305/IJIR/V3I1/287","DOIUrl":"https://doi.org/10.15305/IJIR/V3I1/287","url":null,"abstract":"Investigators at the Icahn School of Medicine at Mount Sinai in New York, USA reported a novel nanoimmunotherapy that targets myeloid cells in vivo in the November 2018 issue of the journal Immunity. Senior authors Drs. Jordi Ochando and Willem Mulder spearheaded an extensive effort in which this nanoimmunotherapy was applied to an experimental mouse model of organ transplantation.","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128010527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acute inflammation and influenza: Innovative nanoparticle vaccination studies in a pig model","authors":"Renukaradhya J. Gourapura","doi":"10.15305/IJIR/V3I1/279","DOIUrl":"https://doi.org/10.15305/IJIR/V3I1/279","url":null,"abstract":"According to the reports of World Health Organization (WHO), around three to five million people are infected with seasonal influenza annually and approximately 250,000 to 500,000 people die worldwide. The risk of influenza associated complications are due to severe inflammatory reactions in the respiratory tract, and it is common in children <5 years, pregnant women, elderly individuals and people with chronic medical conditions. Influenza A virus (IAV) subtypes H1N1 and H3N2 are the major currently circulating viruses among humans. Vaccination is the most effective way to prevent influenza in humans. Influenza virus primarily infects epithelial cells lining the respiratory tract mucosa, and nasal virus shedding forms the means of viral transmission. Hence, induction of strong mucosal antibody and cell-mediated immune responses are beneficial for efficient protection during influenza epidemics and pandemics. But protection from currently used influenza vaccines varies from 10 to 60%, and it induces poor mucosal immune responses. Since inflammation associated with IAV infection is a ‘double edge sword’, control of infection-associated morbidity is essential. It is possible only through the use of potent intranasal influenza vaccines, which induce robust mucosal immune response and alleviates inflammation in the respiratory tract. This review article summarizes inflammatory responses triggered by IAV infection causing severe pulmonary disease, and the novel mucosal vaccination strategies, tested in a pig model, that have been showing promise to mitigate influenza-induced immunopathology.","PeriodicalId":163153,"journal":{"name":"Indian Journal of Inflammation Research","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123581188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}