Journal of Integrative Oncology最新文献_第2页

Breast cancer risk factors, prevention and patients empowerment 乳腺癌风险因素、预防和患者赋权

Journal of Integrative Oncology Pub Date : 2020-01-01 DOI: 10.37421/JIO.2020.S1.009

M. Josa

引用次数: 0

Effect of Topical Anesthetic Cream on Pain During Periareolar Injection of Technetium Tc99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer: A Randomized Control Trial 局部麻醉乳膏对乳晕周围注射锝Tc99m硫胶体用于乳腺癌前哨淋巴结活检时疼痛的影响:一项随机对照试验

Journal of Integrative Oncology Pub Date : 2020-01-01 DOI: 10.37421/JIO.2020.S1.012

S. Canning

{"title":"Effect of Topical Anesthetic Cream on Pain During Periareolar Injection of Technetium Tc99m Sulfur Colloid for Sentinel Lymph Node Biopsy in Breast Cancer: A Randomized Control Trial","authors":"S. Canning","doi":"10.37421/JIO.2020.S1.012","DOIUrl":"https://doi.org/10.37421/JIO.2020.S1.012","url":null,"abstract":"Background: Injection of Tc99m to localize nodes for sentinel lymph node biopsy is reported by patients as very painful. The purpose of this study was to determine if anesthetic cream reduces pain associated with periareolar injection of Tc99m and to help elucidate conflicting literature regarding the efficacy of anesthetic cream for this procedure. Methods: A randomized, double-blind, placebo-controlled methodology was used for adult females with breast cancer undergoing periareolar injection of Tc99m for sentinel lymph node biopsy. Pain levels were compared using anesthetic cream (2.5% lidocaine/2.5% prilocaine) vs. placebo. Patient exclusion criteria included use of opioids or adjuvant pain medication or injecting Tc99m the day before surgery. The Numerical Rating Scale was used to assess pain levels immediately after the injections. Results: Comparing 23 experimental and 26 control pa tients, there was no significant difference between the experimental (median = 4) and the control group (median = 5) on level of pain experienced U=0.492, P > .05. Conclusions: The experimental group had a slightly lower median pain score; however, there was no statistically significant difference between those who used the cream compared with those who used a placebo, supporting the conclusion that anesthetic cream does not reduce pain during Tc99m injections. This study adds to the current literature to provide a stronger position that there is no benefit to using anesthetic cream for this procedure.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"1 1","pages":"12-12"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79482653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of predictors for behavioral intentions to adhere to cervical cancer treatment among aged 25-49 years in Botswana. 博茨瓦纳25-49岁人群坚持宫颈癌治疗的行为意向预测因素评估

Journal of Integrative Oncology Pub Date : 2020-01-01 DOI: 10.37421/JIO.2020.S1.007

Major, Koyabe, Ntsayagae, Molwane, Monare

引用次数: 0

Global Summit On Oncology and Breast Cancer | March 05-06, 2020 | Vienna, Austria 全球肿瘤与乳腺癌峰会| 2020年3月05-06日|奥地利维也纳

Journal of Integrative Oncology Pub Date : 2020-01-01 DOI: 10.37421/JIO.2020.S1.01

N. Senhou

引用次数: 0

Evaluation of endoscopic balloon dilatation as a treatment of eustachian tube dysfunction 内镜下球囊扩张术治疗咽鼓管功能障碍的疗效评价

Journal of Integrative Oncology Pub Date : 2019-01-25 DOI: 10.4172/2329-6771-c3-008

pFabio Fanfonip

引用次数: 2

The Correlation between Squamous Cell Abnormalities by Liquid based Cytology and Histopathology 鳞状细胞液基细胞学异常与组织病理学的关系

Journal of Integrative Oncology Pub Date : 2019-01-01 DOI: 10.4172/2329-6771.1000222

Wilasinee Areeruk, T. Manchana

{"title":"The Correlation between Squamous Cell Abnormalities by Liquid based Cytology and Histopathology","authors":"Wilasinee Areeruk, T. Manchana","doi":"10.4172/2329-6771.1000222","DOIUrl":"https://doi.org/10.4172/2329-6771.1000222","url":null,"abstract":"Objective: To evaluate the correlation between squamous cell abnormalities by liquid-based cytology and histopathology, and to evaluate the accuracy of liquid-based cytology in detecting cervical squamous cell abnormalities.Methods: A total of 943 patients with squamous cell abnormalities by liquid-based cytology underwent colposcopic examination from June 2014 until May 2017. The final histopathology was defined as the most severe lesion from colposcopic directed biopsy, excision procedure or hysterectomy.Results: A majority of abnormal cytology was LSIL (45.6%), followed by ASCUS, HSIL, ASC-H and SCC (29.6%, 13.5%, 9.7%, and 1.7%, respectively). LSIL/ASCUS cytology was confirmed to be CIN1 or less in approximately 90% of patients but coexisting high-grade lesions (CIN2/3) occurred in about 10% and invasive cancer was less than 1%. HSIL and ASC-H cytology yielded about 50% and 25% high-grade lesions, respectively; coexisting invasive cancer was diagnosed in 10.2% and 1.1%, respectively. Invasive cancers were diagnosed in 43.8% of patients with SCC cytology. The accuracy of liquid-based cytology for detecting cervical squamous cell abnormalities was 79.8%. There was a moderate correlation between cervical cytology and histopathology (Kappa=0.43, 95% CI=0.36-0.50).Conclusion: The correlation between cervical cytology and histopathology remained moderate. Despite, acceptable accuracy rate, it should only be used as a screening test. About 10% of the high-grade lesion was found in low-grade cytology and 10% of invasive lesion co-existed in high-grade cytology. Therefore, pathological confirmation should be made before definitive management especially in areas with high incidence of cervical cancers.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"48 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84368927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Pilot Screening Study of the Angiogenesis Factor Pleiotrophin (PTN) in Serum Samples from Patients of Various Disease Groups 不同疾病组患者血清中血管生成因子多营养因子(PTN)的初步筛选研究

Journal of Integrative Oncology Pub Date : 2018-04-24 DOI: 10.4172/2329-6771.1000208

G. Zugmaier, A. Karalis, C. Knabbe, A. Aigner

{"title":"Pilot Screening Study of the Angiogenesis Factor Pleiotrophin (PTN) in Serum Samples from Patients of Various Disease Groups","authors":"G. Zugmaier, A. Karalis, C. Knabbe, A. Aigner","doi":"10.4172/2329-6771.1000208","DOIUrl":"https://doi.org/10.4172/2329-6771.1000208","url":null,"abstract":"Introduction: The secreted growth factor pleiotrophin (PTN) belongs to the midkine family of heparin-binding growth factors and is tightly regulated during embryogenesis. In contrast to its very limited expression in normal adult tissues, PTN protein levels are markedly increased in different tumors, with PTN showing mitogenic, chemotactic, transforming, pro-angiogenic, pro-invasive and pro-metastatic activity. However, little is known about PTN upregulation in diseases other than cancer. The aim of this study was to investigate PTN serum levels in patients with various non-malignant chronic or acute disorders, and in pregant women, compared to healthy nonpregnant blood donors as negative control group.Materials and Methods: PTN serum levels were determined by a sandwich ELISA.Results: PTN serum levels were found to be significantly elevated with a p-value of <0.05 in patients with the acute non-malignant disorders, acute inflammation, acute vascular disease and acute trauma. In patients with chronic leukemia and solid tumors, and pregnancy, increased PTN serum levels were detected as well.Conclusion: Beyond its described functions in solid tumors and in the central nervous system, these data indicate that PTN is an acute phase protein in the adult organism and that, due to its upregulation under various non-cancer conditions, special caution must be taken when exploring PTN serum levels as potential tumor marker.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"8 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74300691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Comprehensive Yoga Program for Cervical Carcinoma 宫颈癌综合瑜伽项目的发展

Journal of Integrative Oncology Pub Date : 2018-03-25 DOI: 10.4172/2329-6771.1000206

H. Govardhan, N. Nelson, Khaleel, M. Roy

{"title":"Development of Comprehensive Yoga Program for Cervical Carcinoma","authors":"H. Govardhan, N. Nelson, Khaleel, M. Roy","doi":"10.4172/2329-6771.1000206","DOIUrl":"https://doi.org/10.4172/2329-6771.1000206","url":null,"abstract":"Background: Prior research reveal the benefits of yoga in managing fatigue, stress and psychosocial outcomes in cervical carcinoma; however, a definite structured yoga program is unavailable. In this study an effort is made to develop and validate a structured yoga program for cervical carcinoma. \u0000Methods: A detailed review of ancient and contemporary yoga literature was conducted to design a basic yoga program. Five yoga experts, who fulfilled the inclusion criteria validated the program. 27 practices were rated as (i) not essential, (ii) useful but not essential, and (iii) essential; Lawshe's content validity ratio (CVR) was calculated. \u0000Results: Eighteen practices exhibited significant content validity (cut-off value: 0.99, as calculated by applying Lawshe's formula for the CVR). One practice was added to the module by the experts, making a total of 19 practices including meditation. Yoga nidra was added as a special practice on days of high fatigue. \u0000Conclusions: The designed program received good content validity and thus is valid for cervical cancer. The program is to be applied on patients to assess its acceptability and feasibility.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"57 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80917175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Red Skin Nodule 红色皮肤结节

Journal of Integrative Oncology Pub Date : 2018-01-08 DOI: 10.4172/2329-6771.1000I101

Baroni Adone

引用次数: 1

SIPA1 Gene Polymorphisms And The Risk Of Breast Carcinoma Among The Egyptian Females: A Pilot Study SIPA1基因多态性与埃及女性乳腺癌风险:一项初步研究

Journal of Integrative Oncology Pub Date : 2018-01-03 DOI: 10.4172/2329-6771.1000202

A. Mackawy, O. Megahed

{"title":"SIPA1 Gene Polymorphisms And The Risk Of Breast Carcinoma Among The Egyptian Females: A Pilot Study","authors":"A. Mackawy, O. Megahed","doi":"10.4172/2329-6771.1000202","DOIUrl":"https://doi.org/10.4172/2329-6771.1000202","url":null,"abstract":"Background: Multiple genes are known to influence the cancer metastasis but the effect of the germline heritable genetic polymorphisms on the predisposition and metastasis is not yet well known. Signal-induced proliferation associated gene1 (SIPA1) was considered as a modifying factor in the breast carcinoma (BC) metastasis process. Molecular studies on Sipa 1 gene suggested its essential role as cell adhesion regulator and metastasis modulator. The present study relied on the hypothesis that Sipa1 gene may be contributed to the risk of breast cancer occurrence and aggressiveness as well.Objective: We aimed to examine the association of SIPA1 single nucleotide polymorphisms (SNPs) and human breast cancer incidence and prognosis in Egyptian female patients.Patient and Methods: Two common SNPs (rs3741378 C>T and rs746429 A>G) were genotyped in 80 Egyptian females; 50 patients with breast cancer and 30 breast carcinoma free females.Results: The rs3741378 TT genotype enhanced the incidence of breast carcinoma in comparison with the genotypes rs3741378 CC and TC (X2=7.08, P=0.029), Sipa 1 rs3741378 T allele had a high frequency in BC cases compared to controls (OR (95%)=2.593 (1.339-5.02), P=0.04). Sipa 1 rs3741378 TT genotype also displayed significant association with clinical stages, grades and lymph node metastasis (X2=12.73, P=0.013), (X2=10.88, P=0.028), (X2=6.534, P=0.010; OR (95%)=0.324 [0.134-0.781]), respectively. Pointing to those patients carrying the rs3741378 TT genotype had a higher tumor progression rate with advanced tumor grades. Oppositely, these associations could not be detected for rs746429 A>G.Conclusion: Our results suggest that the Sipa1 promoter rs3741378 C>T SNP was contributed to BC risk and progression, which may be considered as a foretelling biomarker of BC risk and progression.","PeriodicalId":16252,"journal":{"name":"Journal of Integrative Oncology","volume":"43 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88553722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0