Journal of Kermanshah University of Medical Sciences最新文献

{"title":"The Effect of Vegetable and Volatile Oils on the Piroxicam Skin Permeability: A Mechanistic Study","authors":"A. Salimi, Behzad Sharif Makhmalzadeh, Ghazal Davood Baharvandi, Saeed Mohammad Soleymani","doi":"10.5812/jkums-126619","DOIUrl":"https://doi.org/10.5812/jkums-126619","url":null,"abstract":"Background: Piroxicam is a non-steroidal anti-inflammatory medication for treating fever, discomfort, and inflammation. In addition, Piroxicam inhibits cyclooxygenase and lowers prostaglandin synthesis, resulting in analgesic and anti-inflammatory effects. Objectives: This study used Franz diffusion cells made from rat skin primed with sesame, eucalyptus, olive, menthol, clove, and sunflower oils. Methods: Control was hydrated rat skin. Permeability measurements include steady-state flux (Jss), permeability coefficient (Kp), and diffusion coefficient (D). FT-IR was used to compare changes in peak position, DSC, mean transition temperature, and the permeability enhancement methods of the penetration enhancer (Tm). The skin acted as a barrier to Piroxicam permeability throughout the whole surface, indicating that drug flux was limited by diffusion into the skin. Results: The steady-state flux (Jss) of all penetration enhancers were not significantly different from control, except for clove and menthol oil (4 hours treated) and olive oil (2 and 4 hours treated). Conclusions: Penetration enhancers improved drug permeability through rat skin. Sesame oil, Menthol oil, and Sesame oil were found to have higher ERflux, ERD, and ERP ratios than water-hydrated skin due to lipid fluidization, lipid structure disruption, and irreversible keratin denaturation.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77239241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Quality of Life and Domestic Violence against Women During COVID-19 Quarantine Based on Resilience and Coping Styles","authors":"Zhaleh Koohboomi, M. Ghamari, S. Hosseinian","doi":"10.5812/jkums-120264","DOIUrl":"https://doi.org/10.5812/jkums-120264","url":null,"abstract":"Background: Restrictive measures caused by the COVID-19 have exposed the families' structure to some critical issues such as reduced quality of life and increased domestic violence. For this reason, the study of psychological factors are essential in this regard. Objectives: The study aimed to predict the quality of life and violence against women during COVID-19 quarantine based on resilience and coping styles. Methods: This descriptive correlation study was conducted on all married women in Karaj from October 1 to November 30, 2020. A total of 241 people were randomly selected as the sample and answered the questionnaires about coping styles, quality of life, violence against women, and resilience scale. The data were analysized by Pearson correlation test and regression analysis. Results: There was a significant positive relationship between resilience, efficient coping style, and quality of life, as well as a significant negative relationship between inefficient coping style and quality of life (P < 0.01). A significant negative relationship was observed between coping style with domestic violence, as well as a significant positive relationship between dysfunctional coping style and domestic violence (P < 0.01). Resilience and effective coping style predicted the quality of life, domestic violence, and ineffective coping style of domestic violence against women (P < 0.01). Conclusions: According to the results, individual and psychological factors of people could play a significant role in the occurrence of violence and thus reduce their quality of life. In educational-therapeutic sessions, counselors and family therapists increased the quality of life and reduced violence by examining coping styles and resilience to use educational strategies in this area.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86264821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Demographics Analysis of IgE- and Non-IgE-mediated Food Allergies in Children","authors":"Mohammad Norolahi, M. Hematyar, Rahman Pouyanfar, Seyed Karen Hashemitari, S. Darougar","doi":"10.5812/jkums-127184","DOIUrl":"https://doi.org/10.5812/jkums-127184","url":null,"abstract":"Background: There are three broad types of food allergies, including IgE-mediated reactions, non-IgE-mediated reactions, and mixed reactions. The onset of IgE-mediated food allergies is usually rapid and can sometimes lead to serious illness. Non-IgE-mediated and mixed types of food allergies can cause significant morbidity as a result of chronic disease. Objectives: This study aimed to compare various types of food allergies and discuss the basis of their different presentations. Methods: This study was conducted on children aged 2 - 12 years old with signs or symptoms of food allergy in the allergy clinics of Azad University Hospitals, Tehran, Iran, from January 2019 to January 2020. Food allergy was evaluated in these patients by careful history, physical exam, skin prick test, and atopy patch test. Results: A positive family history of atopy was detected in the first-degree relatives of 82 (63%) patients. All the children were exclusively breastfed at the beginning. A total of 61 patients had positive skin prick test (SPT), and 68 patients had positive atopy patch test (APT) results. Among food allergens, a significant correlation was detected between positive atopic patch test results and hypersensitivity reactions to cow’s milk (P value = 0.001), beef (0.002), and tomato (0.04). There was the same significant correlation between positive skin prick test results, allergens, and wheat (P value = 0.01). Conclusions: Although skin prick and atopy patch tests may help identify the culprit foods, oral food challenges are the mainstay of the diagnosis.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89957666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric Characteristics of Persian Version of Adult Hope Scale (AHS) in Iranian Females with Multiple Sclerosis (MS)","authors":"Roghieh Nooripour, Fradin Farmani, S. Brand, N. Ghanbari, Hossein Ilanloo, Joshua J. Matacotta, Dena Sadeghi-Bahmani","doi":"10.5812/jkums-123276","DOIUrl":"https://doi.org/10.5812/jkums-123276","url":null,"abstract":"Background: Hope is essential for MS patients to recognize favorable genetically challenging conditions and develop a positive outlook on life. Objectives: This study aimed to evaluate the psychometric characteristics of Snyder’s Adult Hope Scale (AHS) in Iranian females with multiple sclerosis (MS). Methods: This cross-sectional study was conducted on all female patient members of the Iran MS Society of Tehran Province from November 2017 to August 2019. This study was used a convenience sampling method used to select a sample of 321 Iranian females with MS (age: 40.61 years, SD = 9.89). A series of questionnaires was administered to the participants, including sociodemographic data, hope (Snyder's Adult Hope Scale; AHS), anxiety and depression (Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI-II), and self-efficacy (General Self-Efficacy Scale (GSE)). Through the analysis of psychometric features of the AHS, construct validity was determined via confirmatory factor analysis (CFA), reliability was determined via Cronbach's alpha, divergent validity was determined by examining the relationship between anxiety and depression, and convergent validity was determined using the General Self-Efficacy Scale. Results: The confirmatory factor analysis revealed that the data were well fit by a two-factor structure: sbX2 = 66.93 (P < 0.01); SRMR = 0.07; CFI = 0.91; NFI = 0.90; IFI = 0.92; PNFI = 0.61; GFI = 0.93; RMSEA = 0.079. The mean and standard deviation (SD) of the Adult Hope Scale (AHS) was calculated as much as 31.28 (4.58). There was a significant negative correlation between AHS with the Beck’s Depression Inventory (r = -0.51; P < 0.01) and Beck’s Anxiety Inventory (r = -0.42; P < 0.01). Additionally, it was observed that there was a positive correlation between self-efficacy and AHS (r = -0.41; P < 0.01). Conclusions: According to the results, the 12-item AHS indicated good psychometric characteristics in assessing hope among Iranian females with MS. The AHS is one of the primary scales in assessing hope, which can be applied in clinical and research settings.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83459583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Recombinant Erythropoietin on the Levels of Hemoglobin, Mean Corpuscular Volume, LDH, and Length of Stay at the Hospital in COVID-19 Patients","authors":"H. Samimagham, Mehdi Hassaniazad, D. Hooshyar, Maryam Haddad, M. Arabi, Mitra Kazemi Jahromi","doi":"10.5812/jkums-126623","DOIUrl":"https://doi.org/10.5812/jkums-126623","url":null,"abstract":"Background: Erythropoietin plays a significant role in the growth of red blood cells, hemoglobin levels, and tissue oxygenation in critically ill patients, as well as anti-inflammatory and neuroprotective effects. Objectives: This study aimed to evaluate the effect of recombinant erythropoietin on improving COVID-19 patients. Methods: This study was conducted on 20 COVID-19 participants with hemoglobin of ≥ 9. The inclusion criteria was at least one severe COVID-19 symptom/sign in this interventional study. The primary outcome was a combination of hospital stay length and paraclinical evaluation (LDH and hemoglobin level). The outcomes and side effects were evaluated on day 0 (before the intervention) and five (post-intervention). Results: The mean hemoglobin level was 10 ± 1.1 gr/dL in the intervention group and 8 ± 0.7 gr/dL in the control group post-treatment, indicating a significant difference between the groups (P = 0.04). The mean hospital stay length (6 ± 2 days) in the intervention group was significantly less than the control group (9 ± 4 days) (P = 0.001). At the end of the treatment, the mean LDH was significantly lower in the intervention group (503 ± 264 µ/L) than in the control group (725 ± 320 µ/L; P = 0.017). Conclusions: According to the results, this study provides the first solid evidence for the positive effects of recombinant erythropoietin on COVID-19.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85142114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Interactive Effect of Home-Based Aerobic Training and Turmeric Supplementation on the Quality of Life in Type 2 Diabetic Women","authors":"Mahsa Ahmadi Darmian, R. Hoseini, E. Amiri, S. Golshani","doi":"10.5812/jkums-115917","DOIUrl":"https://doi.org/10.5812/jkums-115917","url":null,"abstract":"Background: Type 2 diabetes is the most common health problem worldwide. Exercise and dietary interventions can help individuals with type 2 diabetes to improve their condition. Objectives: The purpose of this study was to determine the effects of aerobic training (AT) and turmeric supplement (TS) on the quality of life (QoL) of middle-aged hyperlipidemic women with type 2 diabetes. Methods: This study investigated 42 women with type 2 diabetes aged 45 to 60 years, who were volunteered and divided into four groups, including control + placebo (C; n = 11), AT + placebo (AT; n = 10), TS (n = 11), and AT + TS (n = 11). Aerobic training program was conducted for eight weeks (3 sessions per week for 20 to 40 minutes with 60 - 75% of maximum heart rate). The TS and AT + TS consumed 2100 mg per day of turmeric for eight weeks. The 26-item WHO QoL questionnaire (WHO QoL-BREF) was used to assess QoL. Finally, the data were statistically analyzed at a significant level of P < 0.05 using one-way analysis of variance (ANOVA), Tukey’s post hoc, and an independent t-test with SPSS. Results: AT + TS (P = 0.001), AT (P = 0.023), and TS (P = 0.039) significantly improved the average QoL after eight weeks. However, the improvement in AT + TS was more significant for the QoL of type 2 diabetic patients with hyperlipidemia compared to other groups. Conclusions: According to the results, exercise and turmeric supplementation can be used to improve the QoL of middle-aged women with type 2 hyperlipidemia during COVID-19 quarantine.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76060355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Prevalence of Intracerebral Hemorrhage and Related Factors in Patients with Acute Ischemic Stroke Receiving Tissue Plasminogen Activator","authors":"Payam Sariaslani, Royah Piran","doi":"10.5812/jkums-118448","DOIUrl":"https://doi.org/10.5812/jkums-118448","url":null,"abstract":"Background: Stroke is one of the most common causes of disability. Based on reports, recombinant tissue plasminogen activator (rtPA) remains the only drug approved for the treatment of ischemic stroke and reduction of associated disabilities. One of the most common complications of this treatment is intracerebral hemorrhage (ICH), which can lead to mortality and aggravate initial symptoms. Objectives: The present study aimed to evaluate the prevalence of hemogenic factors and the most important complication inhibiting the receiving of treatment (i.e., ICH). Methods: In total, 300 patients treated with rtPA, ICH was measured by using a CT scan, and the hemorrhage level was determined. Moreover, data analysis was performed in SPSS to compare the two groups in terms of demographic, clinical, and paraclinical findings, including age, gender, blood glucose level, the NIHSS score, early CT scores, history of diabetes, myocardial infarction and stroke, hypertension, aspirin use, and smoking status. Results: Intracerebral hemorrhage was detected in 35 out of 300 patients. The mean age of the ICH group was 74 ± 14 years and significantly higher than the non-ICH group (68 ± 14 years) (P = 0.007). The mean NIHSS score was estimated at 15 ± 5 and 12 ± 5 in the ICH and non-ICH groups, respectively (P = 0.001). More bleeding was observed in patients with the upper one-third lesion of the infarct in the MCA arterial territory (P = 0.027). Conclusions: The prevalence of cerebral hemorrhage was 11.7% with 7.6% symptomatic ICH.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"76 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86368803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Supportive Care Needs of Breast Cancer Patients and Its Related Factors: A Cross-Sectional Study","authors":"H. Okati-Aliabad, S. Kargar, Alireza Ansari-Moghadam, Mehdi Mohammadi","doi":"10.5812/jkums-121880","DOIUrl":"https://doi.org/10.5812/jkums-121880","url":null,"abstract":"Background: Planning cancer supportive care programs require assessing patients’ supportive needs. Objectives: This study aimed to investigate breast cancer patients’ supportive care needs and their related factors. Methods: This cross-sectional study was conducted this Zahedan, Iran, in 2020. Patients with breast cancer, who referred to the clinical oncology departments of Khatam-Al-Anbia hospital and Ali ibn Abi Talib hospital were selected by the census method. Standard questionnaires were distributed among the participants to obtain information and analyze data in SPSS software version 19.0. Results: This study examined 120 breast cancer patients with a mean age of 47.35 (SD 10.67) years. The patients’ highest and lowest need for help were related to health system/information (63.23 ± 20.80) and sexual needs (6.73 ± 19.66). Spearman’s correlation coefficient analysis indicated that social support and illness adjustment negatively correlated with many supportive care domains. Conclusions: Supportive care services, especially in the information and psychology domain, are needed for breast cancer patients in Zahedan, Iran. Patients can benefit from social support and positive coping strategies to help them cope with their disease.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72649543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Referral Pattern in a Central Hospital in Iran During the First COVID-19 Peak: The Role of Media and Health Planning","authors":"Z. Khazaeipour, A. Sheikhy, A. Fallahzadeh, Soroush Khojasteh-Kaffash, Ali Fanoodi, Z. Ahmadinejad, S. Hantoushzadeh, Enayat A. Shabani","doi":"10.5812/jkums-122601","DOIUrl":"https://doi.org/10.5812/jkums-122601","url":null,"abstract":"Background: A better understanding of the pattern of epidemic-related referrals to healthcare centers might allow the identification of vulnerabilities and the required changes that the healthcare management system should undergo. Objectives: This study aimed to investigate the COVID-19 referral pattern and the role of media and health management planning in changing the trends. Methods: Data extracted from the electronic medical database of Imam Khomeini Hospital Complex (IKHC), located in Tehran, Iran, from February 20 to June 4, 2020 were examined. Individuals were divided into two groups, COVID-19 positive and negative. We used Google Trends to evaluate Google Internet search queries and also available policy documents, programs, and official news related to COVID-19 in Iran during the mentioned period. Results: In this study, 8647 individuals aged 46.05 ± 16.5 years were referred to IKHC. Approximately 57% were male, and 70% were COVID-19 positive. The most clinical symptoms were dyspnea, fever, cough, and myalgia. Chronic kidney disease (CKD) and type 2 diabetes mellitus were the most common underlying health conditions. In the first two weeks, the percentage of negative cases was higher than positive cases and then the pattern was reversed, when people searched for information about COVID-19 in media. Conclusions: Proper and timely information and education to people through the media and health management measures can be effective in reducing unnecessary visits to health centers, preventing the exhaustion of medical staff, and controlling the disease during epidemics.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"126 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87033802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Meta-Analysis on The Comparison of The Sensitivity of Three Test Methods Used in the Diagnosis of COVID-19","authors":"Elmas Pınar Kahraman Kılbaş, Imdat Kilbas, I. Ciftci","doi":"10.5812/jkums-119539","DOIUrl":"https://doi.org/10.5812/jkums-119539","url":null,"abstract":"Background: Accurate detection of the global epidemic-causing coronavirus disease 2019 (COVID-19) is for disease surveillance. Additionally, RT-qPCR has been accepted as a reference test and is widely used for this purpose. However, RT-qPCR applications are not possible in all health centers. Therefore, the tests commonly used in the diagnosis of infectious disease should be evaluated from all angles to assess their potential role in the prognosis and management of COVID-19 patients. Objectives: The present study aimed to compare the diagnostic sensitivity of point of care (POC), enzyme-linked immunosorbent assay (ELISA), and computed tomography (CT) used in the diagnosis of COVID-19. Methods: This systematic review and meta-analysis was conducted via searching in databases such as NCBI, Google Scholar, and Medline in accordance with the preferred reporting items for systematic reviews and meta-analysis (PRISMA). Results: The pooled sensitivity of POC, ELISA, and CT was estimated at 68.62%, 88.05%, and 75.43%, respectively. In addition, the mean correct positivity rate of POC, ELISA, and CT was calculated to be 68.61%, 88.04%, and 79.25%, respectively. The sensitivity and true positivity rate of ELISA was observed to be the highest. Conclusions: According to the results, ELISA is a more accurate approach to the diagnosis of COVID-19 compared to POC and CT owing to its high sensitivity and true positivity rate, low false negative rate, short processing time, and simple study procedure. Although helpful in diagnosis, confirmation of ELISA results by polymerase chain reaction remains the ‘gold standard’.","PeriodicalId":16201,"journal":{"name":"Journal of Kermanshah University of Medical Sciences","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91201856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}