Journal of Medical and Allied Sciences最新文献

{"title":"Evaluation of microbiological profile and antibiogram of aerobic bacteria isolated from pus samples","authors":"Pilli Hema Prakash Kumari, P. U. Rani, P. V. Lakshmi","doi":"10.5455/JMAS.284747","DOIUrl":"https://doi.org/10.5455/JMAS.284747","url":null,"abstract":"Purulent wound infections are quite complicated to manage because of multidrug resistant bacteria. The main purpose of the present study was to assess the prevalence, microbiological profile and antibiograms of aerobic bacteria isolated from pus samples. One hundred pus sam-ples sent to the microbiology laboratory from surgical departments over a period of six months were analyzed. Isolation and detection of culture isolates was done by using standard bacteriological techniques and antibiotic susceptibility testing was performed by disc diffusion method by following CLSI guidelines on Muller-Hinton (MH) agar. Highest number of pus samples were from incision and drainage (23.8%) followed by chronic non-healing ulcer (19.04%). Twenty one different bacterial isolates were obtained from one hundred pus samples. S. aureus was the predominant bacteria (28.5%) followed by coagulase-negative Staphylococci (23.8%). The results of the antibiotics susceptibility testing illustrated that majority of the isolated organisms were MDR. S. aureus showed highest sensitivity to antibiotics like linezolid (83.3%) and teicoplanin (50%). Among the five isolated strains of coagulase-negative Staphylococci (CONS), three of them were MDR and the other two showed sensitivity to antibiotics cefaperazone, co-trimoxazole and ticarcillin/clavulanic acid (20%). Among the 9 isolates of Enterobacteriaceae, one isolate of E. coli (11.1%), two isolates of Klebsiella species (22.2%) showed ESBL pro-duction. The isolated four strains of P. aeruginosa showed ESBL pro-duction (44.4%) by CAZ/CA antibiotic susceptibility testing. These or-ganisms were screened for carbapenemase production through Modified Hodge test, 5 strains possess carbapenemase enzyme pro-duction (71.4%) and thus acquire resistance to carbapenem antibiotics. Carbapenemase production was not detected in the 2 isolates of P. aeruginosa among the 4 tested strains. The overall results showed that 85% of the isolated strains showed MDR to certain classes of antibiotics.","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"8 1","pages":"26-35"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cyto-histo pathological correlation of bladder tumors in relation to smoking as a risk factor","authors":"Tanushree Satpathy, B. Satpathy, S. Chakraborty, P. K. Satpathy, P. Vijayalakshmi","doi":"10.5455/jmas.293731","DOIUrl":"https://doi.org/10.5455/jmas.293731","url":null,"abstract":"73 Original article A cyto-histo pathological correlation of bladder tumors in relation to smoking as a risk factor Tanushree Satpathy, Binapani Satpathy, Sukumar Chakraborty, Prasanna Kumar Satpathy, Payala Vijayalakshmi 1 Department of Pathology and 4 Department of Microbiology, GITAM Institute of Medical Sciences and Research, GITAM University, Vishakhapatnam-530045, Andhra Pradesh, India. 2 Department of Obstetrics and Gynecology and 3 Department of Pathology, Hi-Tech Medical College, Pandara, Rasulgarh, Bhubaneswar-751025, Odisha, India. Article history: Abstract","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"8 1","pages":"73"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vaccine hesitancy - Issues and possible solutions","authors":"Dewesh Kumar, Nusrat Noor, V. Kashyap","doi":"10.5455/JMAS.290153","DOIUrl":"https://doi.org/10.5455/JMAS.290153","url":null,"abstract":"","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"8 1","pages":"55"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of tomato ( Lycopersicon esculentum ) extract on carbimazole-induced biochemical alterations in pancreas of albino rats","authors":"I. Uchendu, C. Agu, O. C. Orji","doi":"10.5455/JMAS.285861","DOIUrl":"https://doi.org/10.5455/JMAS.285861","url":null,"abstract":"","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"8 1","pages":"59"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic predisposition to COPD","authors":"A. Khan","doi":"10.5455/JMAS.5706","DOIUrl":"https://doi.org/10.5455/JMAS.5706","url":null,"abstract":"hronic obstructive pulmonary disease (COPD) is a major cause of global morbidity and mortality and categorized by irreversible airflow obstruction. COPD is presently the fourth leading cause of death and by 2030 COPD will be third leading cause of death according to the World Health Organization (WHO) reports. It was observe that minority of cigarette smokers have chance to develop COPD. But investigation suggests that subsequent to smoking other factors seems to be of play significant role for the development of the COPD. Epidemiological data demonstrated that genetics to be one of those factors, as COPD is known to aggregate in families and this provides evidence that genetic predisposition plays an important role in COPD. Related traits and genome wide association investigation of COPD have exposed multiple genetic loci association and risk of COPD. The heritability of COPD cannot be completely elucidated by identifying the genetic risk factors as achieving genome-wide significance. The mutual influence of genetic variation to COPD risk has not been completely understood.","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"8 1","pages":"53"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracranial carotid doppler correlation to multidetector CT angiography in ischemic stroke patients","authors":"J. Mohanty, Biswojeet Bisworanjan Sahoo, Mamata Singh","doi":"10.5455/jmas.275895","DOIUrl":"https://doi.org/10.5455/jmas.275895","url":null,"abstract":"The purpose of this study was to compare the diagnostic value of Color Doppler Ultrasound (CDUS), Computed Tomographic Angiography (CTA), and advantage of their combined use in defining the degree of stenosis and morphological character of atheromatous plaque in ischemic stroke patients. This was a cross-sectional study with a total of 60 patients having 120 carotid arteries were observed. The percentage of stenosis was measured at the narrowest point by modified NASCET criteria for both CDUS & CTA. Incidence of stroke was highest in the age group 50-70years with male population commonly affected. Frequency of carotid stenosis was more in male patients aged above 60 years. Hemiparesis was most common symptoms in stroke patients. The various risk factors of carotid atherosclerosis and stenosis included hypertension, diabetes mellitus, hyperlipidemia and cardiovascular disease. Atheromatous plaques with stenosis were most commonly found on right side. Carotid bifurcation was the common site for atheromatous plaque .There was significant correlation between Color Doppler Ultrasound and Computed Tomographic Angiography for detecting 70-100% stenosis. However CTA is more accurate in comparison to duplex ultrasonography in detecting 70-99% stenosis and total occlusion. There was no significant correlation between CDUS and CTA in detecting 20-49% stenosis. Duplex ultrasonography is more sensitive in detecting these lesions. Out of 49 plaques, in this study 11 were soft plaques, 26 were non-homogenous and 13 were ulcerative plaques. Color doppler has better role in plaque characterization. Besides degree of extracranial stenosis, length of the stenosis, site of intracranial stenosis and total number of stenotic sites are better assessed by CTA. Area of effected brain parenchyma and extent of collateral circulation are better assessed by CTA which aids in prognostic value. In conclusion, the advantage of the combined use of CDUS and the CTA in the identification and quantification of ICA stenosis is higher. However ultrasound had a better role in plaque characterization.","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"8 1","pages":"43-48"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrombocytopenia as a presenting manifestation of sarcoidosis","authors":"S. Reddy, A. Ravicharan, N. Narendrakumar, K. Bhaskar, G. Paramjyothi","doi":"10.5455/JMAS.296940","DOIUrl":"https://doi.org/10.5455/JMAS.296940","url":null,"abstract":"","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"8 1","pages":"94"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of two rare cases of Kindlers syndrome in siblings","authors":"Neha Koganti, N. Haneef, F. Razvi, B. Kumar, Nikhat Fatima, Mohammed Zubair, D. Chakraborty","doi":"10.5455/JMAS.260417","DOIUrl":"https://doi.org/10.5455/JMAS.260417","url":null,"abstract":"Kindler’s syndrome is a rare autosomal recessive disorder. It is charac-terized by trauma-induced blistering, photosensitivity, poikiloderma and mucosal inflammation. It occurs due to mutation on chromosome 20p. This report describes two siblings with history of blistering and photosensitivity in childhood and later developed poikiloderma with histopathology of effected skin showing features of poikiloderma.","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of viral hepatitis E on maternal and fetal outcome","authors":"Naushaba Rizwan, Syed Farhan Uddin","doi":"10.5455/JMAS.249914","DOIUrl":"https://doi.org/10.5455/JMAS.249914","url":null,"abstract":"The outcome of Hepatitis during pregnancy has been observed to be broadly diverse by various researchers, ranging from the benign to fatal. A poor result has progressively been seen in pregnant women suffering Hepatitis in Pakistan. This study was planned to study the frequency, causative organisms and chief prognostic elements affecting the consequence of viral hepatitis in pregnant women. Sixty-eight pregnant ladies answering to the doctor's facilities with jaundice were enlisted and enrolled as cases and their hematological, biochemical and viral profiles were pondered. Sixteen non-pregnant women were chosen as controls and a comparable workup was carried out. A relationship was done between the two groups. We further separated the cases into two groups – survivors and nonsurvivors and attempted to discover the components anticipating mortality. The unpaired understudy t test and chi square test were utilized to figure out whether the distinctions were measurably noteworthy. All the information was entered and investigated utilizing SPSS form 20.0. Viral Hepatitis in pregnancy caused a very high maternal mortality (19.1%) and foetal wastage (42.6%). Hepatitis E virus was the commonest causative organism (77.9%) responsible for viral hepatitis during pregnancy. It also caused the highest maternal mortality due to fulminant hepatic failure. Maternal mortality was significantly higher in those women presenting with features of encephalopathy, SIRS, highbilirubin levels and prolonged prothrombin time. Vertical transmission was noted in Hepatitis B and E. Hepatitis E is the chief causative organism causing fulminant hepatic failure in pregnant women. It leads to very high rates of maternal mortality and foetal wastage.","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"7 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70824008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Report of three rare cases of Dowling Degos disease","authors":"Mohammed Zubair, N. Haneef, F. Razvi, B. Kumar, Neha Koganti","doi":"10.5455/JMAS.260932","DOIUrl":"https://doi.org/10.5455/JMAS.260932","url":null,"abstract":"Received 11 March 2017 Accepted 03 April 2017 Early online 23 June 2017 Print 31 July 2017 Dowling Dego’s disease is a rare autosomal dominant condition. It is caused by loss of function mutations in keratin 5 gene (kRT5) situated in keratin gene cluster on 12q13. We are reporting three cases of Dowling Dego’s disease out of which two belong to same family. The clinical manifestations and histopathology were analyzed. All the three patients of which two were mother and son had symmetric, reticulate hyperpigmentation, pitted scars and acneiform eruption over face (predominantly perioral area, nasolabial folds), pinnae, upper trunk, thighs were seen. Palms, soles and scalp were spared. Buccal mucosa also showed reticulate hyperpigmentation. In addition the female patient had vulval reticulate hyperpigmentation and hydradenitis suppurativa affecting axillae, groins and inframammary folds. Corresponding author","PeriodicalId":16176,"journal":{"name":"Journal of Medical and Allied Sciences","volume":"1 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70823977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}