Journal of Experimental and Integrative Medicine最新文献

{"title":"A comparative study of polyherbal Unani formulations in gestational Urinary tract infections","authors":"Azra Nishat, Shazadi Sultana, A. Sultana","doi":"10.5455/JEIM.290117.OR.166","DOIUrl":"https://doi.org/10.5455/JEIM.290117.OR.166","url":null,"abstract":"Introduction: To compare the efficacy of two polyherbal Unani formulations in gestational urinary tract infections (GUTIs). Materials and Methods: A prospective, randomized, comparative trial was conducted at Nizamia Tibbia College. Group A (n = 20) received mucilage of Althaea officinalis L. (5 ml) with 2.5 g powder of Sphaeranthus indicus L., Euphorbia hypericifolia L., Tribulus terrestris L., and Sharbat Anar shireen (Punica granatum) 10 ml, whereas Group B (n = 20) received 2.5 g powder of Citrullus vulgaris seeds L., Cucumis melo L. seed, and S. indicus L. orally twice daily after meals for 3 consecutive months. The primary outcome included cured measured as negative urine culture and alleviation of GUTIs symptoms. The secondary outcomes included the absence of pus cell in urine analysis, Apgar score, prevention of complication of GUTIs, and perinatal outcome. The results were analyzed with chi-square, Fisher exact test and student t-test with alpha 0.05. Results: The cure rate in Groups A and B was similar with 50% response. Both groups were equally effective in relieving the GUTIs symptoms (P < 0.001), Apgar score was >7, good perinatal outcome with no preterm labor, and intrauterine growth retardation. No maternal and fetal adverse effects were noted. Conclusion: Both groups were equally effective for the treatment of GUTIs without any maternal and fetal adverse effects.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"3 1","pages":"1"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82424042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated plexiform neurofibroma in a patient with Tuberous Sclerosis-a rare association -","authors":"Joyeeta Chowdhury, Loknath Ghoshal, Subhomay Neogi","doi":"10.5455/JEIM.080317.CR.008","DOIUrl":"https://doi.org/10.5455/JEIM.080317.CR.008","url":null,"abstract":"Plexiform neurofibroma is a rare tumour originating in peripheral nerve sheaths. It is mostly associated with Neurofibromatosis type1 and occasionally as an isolated entity. We report a case of isolated plexiform neurofibroma associated with Tuberous sclerosis.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"17 1","pages":"11-12"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84384484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation clinical, electrocardiographic and laboratory response of reperfusion therapy in patients with first acute myocardial infarction","authors":"B. Zamani, Manouchehr IranparvarAlamdari, M. Ashrafi","doi":"10.5455/jeim.130217.or.167","DOIUrl":"https://doi.org/10.5455/jeim.130217.or.167","url":null,"abstract":"Myocardial infarction (MI) is one of the most common causes of death and disability in various societies, especially in developed countries, and its complications are one of the main health problems in each country, especially in the big cities and among middle-aged and adult people [1,2]. Acute MI (AMI), which is the most common cause of acute attacks, is often caused due to obstructive coronary artery due to a blood clot, severe spasm of the arteries or atherosclerosis in the coronary arteries. In recent decades, despite of improving public health condition in many countries of the world, the incidence of cardiovascular diseases has become the most important health problem [1-3]. Returning of ST-segment is a good predictor of infarct artery patency and preserves myocardial perfusion in heart tissue level [4,5]. The successful resolution in ST-segment is as an electrocardiographic (ECG) signal of myocardial tissue repair which indicates the progression of infarction [6]. If the primary percutaneous coronary intervention (PCI) is not available, one of the initial treatment of AMI is the prescription of thrombolytic medication, which is considered the primary and preferred method of lifesaving [2,3]. Among thrombolytic medications, streptokinase (SK) due to the opening of the blocked artery by thrombosis and reduction of mortality without any potential hemorrhagic complications is more important [7-9]. Quick start of SK and other thrombolytic medications leads to adjacent of ischemic myocardial perfusion to the infarct region. The success of thrombolysis in clot lysis and creating second reperfusion in saving myocardial ischemic and in preserving of myocardial function plays a key role [8]. The effect of thrombolytic medications in creating myocardial perfusion can be measured by several factors, and angiography is considered as a delayed and invasive method in approaching the patients who received thrombolytic medications.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"31 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89978249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro anthelmintic activity of aqueous extract of Crassocephalum crepidioides (Benth.) S. Moore on Haemonchus contortus.","authors":"C. Z. Bogning, Abiodoun Pascal Oloulade, G. G. Alowanou, E. L. Nguemfo, A. Azébazé, A. Dongmo, S. Hounzangbé-Adoté","doi":"10.5455/JEIM.061215.OR.144","DOIUrl":"https://doi.org/10.5455/JEIM.061215.OR.144","url":null,"abstract":"Objectives: Gastrointestinal parasites are recognized as major constraint to livestock production throughout the tropics. The use of plants and plant extracts remain the most serious alternative to modern anthelmintic drugs. This study evaluates the in vitro anthelmintic activity of aqueous leaves extract of Crassocephalum crepidioides against Haemonchus contortus. \u0000Methods: Aqueous extract at concentrations of 75 to 2400 µg/ml was tested in vitro on three development stages of H. contortus using egg hatch assay (EHA), larval migration inhibition assay (LMIA) and adult worms motility inhibition assay (AMIA). \u0000Results: EHA showed significant reduction (P < 0.05) on H. contortus egg hatch. The inhibition of egg hatching was concentration dependent with the greatest inhibition (50.52%) at the highest concentration (2400 µg/ml) of the extract. Thiabendazole used as positive control showed significant inhibition (P < 0.001) with rate of 76.68 % at the highest concentration (500µg/ml). On LMIA the extract significantly (P < 0.05) inhibited larval migration of L3 in a concentration dependent manner compared to Phosphate Buffered Saline, but less than levamisole (P < 0.001). The highest inhibition rate was 35.30 % at the concentration of 1200 µg/ml. The addition of polyvinylpolyrrolidone to the aqueous extract slightly reduces (4.9%) the inhibition of the effect induced by the extract on larval migration. Effect of extract on AMIA was concentration-dependent with significant increase (P < 0.05) in percentage of inhibition after 12 h. Levamisole (500 µg/ml) kills 100% worms after 18 h post-exposure but by this time the plant exhibited only 16.67% inhibition at the highest concentration (2400 µg/ml). \u0000Conclusion: These finding indicate that C. crepidioides leaves have anthelmintic properties against H. contortus. This activity may be due to secondary metabolites such as saponins, flavonoids and tannins present in the extract. Further studies are needed to evaluate deeply the anthelmintic potential of this plant.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"6 1","pages":"31-37"},"PeriodicalIF":0.0,"publicationDate":"2016-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80185681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(D-Ser2)Oxm[Lys38-γ-glu-PAL] improves hippocampal gene expression and cognition in a mouse model of type 1 diabetes -","authors":"N. Pathak, N. Irwin, V. Pathak, V. Gault, P. Flatt","doi":"10.5455/JEIM.050216.BR.027","DOIUrl":"https://doi.org/10.5455/JEIM.050216.BR.027","url":null,"abstract":"Objective: Oxyntomodulin (Oxm) is a gastrointestinal hormone with recently noted therapeutic potential for type 1 diabetes mellitus (T1DM). The present study examined the effects of a stable Oxm analogue on anxiety, exploratory behavior, cognitive function, hippocampal gene expression and metabolic control in a mouse model of T1DM. Materials and Methods: Effects of twice daily administration of the stable Oxm analogue, (D-Ser2)Oxm[Lys38-γ-glu-PAL], was assessed in insulin-deficient streptozotocin (STZ)-induced T1DM mice. Results: Induction of diabetes by STZ injection significantly (P < 0.05) impaired learning and memory compared to normal control mice. However, (D-Ser2)Oxm[Lys38-γ-glu-PAL] treatment completely reversed this detrimental effect. Anxiety levels and exploratory behavior were not significantly different between all groups of mice. Hippocampal gene expression of MASH1, SYP and mTOR were reduced (P < 0.01 to P < 0.001) in T1DM mice, but significantly (P < 0.05 to P < 0.001) enhanced by twice daily (D-Ser2)Oxm[Lys38-γ-glu-PAL] intervention. Moreover, expression of SYP, mTOR and IRS-1 were significantly elevated (P < 0.05 to P < 0.001) in (D-Ser2)Oxm[Lys38-γ-glu-PAL] mice compared to both STZ and lean controls. These effects were accompanied by improved (P < 0.001) glucose tolerance and insulin sensitivity compared to STZ controls. Conclusion: The data highlight the potential of (D-Ser2)Oxm[Lys38-γ-glu-PAL] for the treatment of T1DM, and reveal the ability of this Oxm analogue to restore the deficits of learning and memory observed in STZ-induced T1DM.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"27 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2016-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84630935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Phyto-Pharmacological Potentials of Juniperus recurva -","authors":"A. Rashid, Raja A. H. Kuchay","doi":"10.5455/JEIM.260416.RW.015","DOIUrl":"https://doi.org/10.5455/JEIM.260416.RW.015","url":null,"abstract":"Juniperus recurva is a small tree or spreading shrub distributed from Afghanistan eastward through the Himalayas to southwest China. It is predominant in woodlands of the wetter areas of Himalayas (altitude of 1800 m to 3900 m), with moist and well-drained soils. It holds great potential as a medicinal plant. It has been traditionally used as anti-rheumatic, antiseptic, antispasmodic, antitoxic, aphrodisiac, astringent, carminative, rubificant and stomachic. However, very few authentic pharmacological studies on medicinal benefits of this plant have been conducted thus far. In a first of its kind, we review this plant for its chemical constituents, pharmacological activity and medicinal benefits. Keeping in view its success record as a traditional medicine to cure different ailments, it would be of interest to look for various bioactive natural products that might have therapeutic potential.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"61 1","pages":"93-97"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82111632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nephroprotective activity of Homalium Letestui stem extract against paracetamol induced kidney injury","authors":"J. Okokon, J. Simeon, E. Umoh","doi":"10.5455/JEIM.250216.OR.147","DOIUrl":"https://doi.org/10.5455/JEIM.250216.OR.147","url":null,"abstract":"","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"111 1","pages":"38-43"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76309330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Aerva lanata Extract Supresses Proliferation and Induce Mitochondria Mediated Apoptosis in Human Hepatocelluar carcinoma cell line","authors":"N. Govindan","doi":"10.5455/JEIM.270616.OR.153","DOIUrl":"https://doi.org/10.5455/JEIM.270616.OR.153","url":null,"abstract":"","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"16 1","pages":"71-81"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79789003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane Lipid Peroxidation and Redox Status in Erythrocytes of Sickle Cell Anaemia Patients Incubated in Leaf Extract of Gongronema latifolium","authors":"PAUL CHIDOKA CHIKEZIE","doi":"10.5455/JEIM.210616.OR.151","DOIUrl":"https://doi.org/10.5455/JEIM.210616.OR.151","url":null,"abstract":"","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"42 1","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88822849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of lactogenic activity of Triumfetta rhomboidea L. root: Validating its traditional usage -","authors":"H. Sahoo, P. Mandal, R. Sagar, S. Bhattamisra","doi":"10.5455/JEIM.160216.OR.146","DOIUrl":"https://doi.org/10.5455/JEIM.160216.OR.146","url":null,"abstract":"ABSTRACT Objectives: The aim of the study was to investigate the lactogenic activity of aqueous extract of Triumfetta rhomboidea L. on nursing rats. Materials and methods: Rats (200-250 g) with suckling pups were selected and were divided into five groups (n=6). Group I treated as control; Group II treated as standard (Domperidone) and Group III, IV and V were orally administered with aqueous extract of T. rhomboidea roots (ATRR) at 125, 250 and 500 mg/kg body wt. respectively and continued for l4th day of parturition. Milk yield, the weight of pups and mother were measured daily. On 15th day, the total protein/carbohydrate contents (mammary tissue) and serum prolactin/cortisol level were measured and compared with control. Results: Oral administration of ATRR increases the milk yield, body weight of pups as well as mother rat, glycogen and protein content of mammary gland tissue, as well as serum prolactin and cortisol, level as compared to the control animals. In addition, the lactogenic effect of ATRR was followed dose dependent manner as compared to standard. Conclusion: The present study reveals that the ATRR possesses significant lactogenic activity by enhancing milk production and prolactin concentration in nursing rats.","PeriodicalId":16091,"journal":{"name":"Journal of Experimental and Integrative Medicine","volume":"1 1","pages":"26-30"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90429280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}