ACS Earth and Space Chemistry最新文献_第10页

Controlling Circular RNA Encapsulation within Extracellular Vesicles for Gene Editing and Protein Replacement 控制细胞外囊泡中的环形 RNA 封装，实现基因编辑和蛋白质置换

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-24 DOI: 10.1021/acsnano.4c0753010.1021/acsnano.4c07530

Liang Fang, Wenchao Gu, Ruoxin Li, Chaoxin Chen, Simian Cai, Sijin Luozhong, Michelle Chen, Annie Hsu, Yi-Chih Tsai, Ketaki Londhe and Shaoyi Jiang*,

{"title":"Controlling Circular RNA Encapsulation within Extracellular Vesicles for Gene Editing and Protein Replacement","authors":"Liang Fang, Wenchao Gu, Ruoxin Li, Chaoxin Chen, Simian Cai, Sijin Luozhong, Michelle Chen, Annie Hsu, Yi-Chih Tsai, Ketaki Londhe and Shaoyi Jiang*, ","doi":"10.1021/acsnano.4c0753010.1021/acsnano.4c07530","DOIUrl":"https://doi.org/10.1021/acsnano.4c07530https://doi.org/10.1021/acsnano.4c07530","url":null,"abstract":"Extracellular vesicles (EVs) are a population of vesicular bodies originating from cells, and EVs have been proven to have the potential to deliver different cargos, such as RNAs. However, conventional methods are not able to encapsulate long RNAs into EVs efficiently or may compromise the integrity of EVs. In this study, we have devised a strategy to encapsulate long circRNAs (>1000 nt) into EVs by harnessing the sorting mechanisms of cells. This strategy utilizes the inherent richness of circular RNAs in EVs and a genetic engineering method to increase the cytoplasmic concentration of target circRNAs, facilitating highly efficient RNA back-splicing to drive the circularization of RNAs. This allows target circRNAs to load into EVs with high efficiency. Furthermore, we demonstrate the practical applications of this strategy, showing that these circRNAs can be delivered by EVs to recipient cells for protein expression and to mice for gene editing.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30378–30387 30378–30387"},"PeriodicalIF":15.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Core–Shell Engineered Fillers Overcome the Electrical-Thermal Conductance Trade-Off 核壳工程填料克服了电导与热导之间的折衷关系

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-24 DOI: 10.1021/acsnano.4c0934610.1021/acsnano.4c09346

PeiChi Liao, Haichang Guo*, Hongyu Niu, Ruijie Li, Ge Yin, Lei Kang, Liuchen Ren, Ruicong Lv, Huifeng Tian, Shizhuo Liu, Zhixin Yao, Zhenjiang Li, Yihan Wang, Lina Yang Zhang, U Sasaki, Wenxi Li, Yijie Luo, Junjie Guo, Zhi Xu, Lifen Wang, Ruqiang Zou, Shulin Bai and Lei Liu*,

{"title":"Core–Shell Engineered Fillers Overcome the Electrical-Thermal Conductance Trade-Off","authors":"PeiChi Liao, Haichang Guo*, Hongyu Niu, Ruijie Li, Ge Yin, Lei Kang, Liuchen Ren, Ruicong Lv, Huifeng Tian, Shizhuo Liu, Zhixin Yao, Zhenjiang Li, Yihan Wang, Lina Yang Zhang, U Sasaki, Wenxi Li, Yijie Luo, Junjie Guo, Zhi Xu, Lifen Wang, Ruqiang Zou, Shulin Bai and Lei Liu*, ","doi":"10.1021/acsnano.4c0934610.1021/acsnano.4c09346","DOIUrl":"https://doi.org/10.1021/acsnano.4c09346https://doi.org/10.1021/acsnano.4c09346","url":null,"abstract":"The rapid development of modern electronic devices increasingly requires thermal management materials with controllable electrical properties, ranging from conductive and dielectric to insulating, to meet the needs of diverse applications. However, highly thermally conductive materials usually have a high electrical conductivity. Intrinsically highly thermally conductive, but electrically insulating materials are still limited to a few kinds of materials. To overcome the electrical-thermal conductance trade-off, here, we report a facile Pechini-based method to prepare multiple core (metal)/shell (metal oxide) engineered fillers, such as aluminum-oxide-coated and beryllium-oxide-coated Ag microspheres. In contrast to the previous in situ growth method which mainly focused on small-sized spheres with specific coating materials, our method combined with ultrafast joule heating treatment is more versatile and robust for varied-sized, especially large-sized core–shell fillers. Through size compounding, the as-synthesized core–shell-filled epoxy composites exhibit high isotropic thermal conductivity (∼3.8 W m–1 K–1) while maintaining high electrical resistivity (∼1012 Ω cm) and good flowability, showing better heat dissipation properties than commercial thermally conductive packaging materials. The successful preparation of these core–shell fillers endows thermally conductive composites with controlled electrical properties for emerging electronic package applications, as demonstrated in circuit board and battery thermal management.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30593–30604 30593–30604"},"PeriodicalIF":15.8,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PdSe2/2H–MoTe2 Heterojunction Self-Powered Photodetector: Broadband Photodetection and Linear/Circular Polarization Capability PdSe2/2H-MoTe2 异质结自供电光电探测器：宽带光电探测和线性/环形偏振能力

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-23 DOI: 10.1021/acsnano.4c1229810.1021/acsnano.4c12298

Mengqi Che, Bin Wang, Xingyu Zhao, Yahui Li, Chunlu Chang, Mingxiu Liu, Yu Du, Liujian Qi, Nan Zhang, Yuting Zou and Shaojuan Li*,

{"title":"PdSe2/2H–MoTe2 Heterojunction Self-Powered Photodetector: Broadband Photodetection and Linear/Circular Polarization Capability","authors":"Mengqi Che, Bin Wang, Xingyu Zhao, Yahui Li, Chunlu Chang, Mingxiu Liu, Yu Du, Liujian Qi, Nan Zhang, Yuting Zou and Shaojuan Li*, ","doi":"10.1021/acsnano.4c1229810.1021/acsnano.4c12298","DOIUrl":"https://doi.org/10.1021/acsnano.4c12298https://doi.org/10.1021/acsnano.4c12298","url":null,"abstract":"In this research, we introduce a PdSe2/2H–MoTe2 heterojunction photodetector that exhibits both broadband self-powered photodetection and linear/circular polarization detection capabilities. It has a broad spectral response range (covering 375–2200 nm) and reaches a peak sensitivity at 532 nm, exhibiting a notable responsivity of 7.3 × 103 A/W and a substantial specific detectivity of 8.5 × 1012 Jones. Even in the near-infrared region of 1310 nm, it still has a high responsivity of 20 A/W. The self-powered photodetection capabilities of the PdSe2/2H–MoTe2 heterojunction are equally impressive, covering a broad range from 375 to 1550 nm, with a responsivity of 243 mA/W, a specific detectivity of 6.46 × 1010 Jones, a fill factor of 0.8, and an external quantum efficiency of 56.73%. Finally, simultaneous implementation of linear/circular polarization detection on the PdSe2/2H–MoTe2 heterojunction provides a powerful solution for near-infrared full-Stokes polarization detectors with high integration, miniaturization, and portability.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30884–30895 30884–30895"},"PeriodicalIF":15.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facilitating Ion Storage and Transport Pathways by In Situ Constructing 1D Carbon Nanotube Electric Bridges between 2D MXene Interlayers 通过在二维 MXene 夹层间原位构建一维碳纳米管电桥促进离子存储和传输途径

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-23 DOI: 10.1021/acsnano.4c0947510.1021/acsnano.4c09475

Qi Fan, Kui Xu, Minghua Chen, Qing Tang, Ke Chen, Xiaofei Hu, Fuli Lan, Yueqi Wang, Hui Shao, Sicong Qiao, Ziwei Yan, Changda Wang, Li Song, Wencheng Hu, Michael Naguib, Patrice Simon, Qing Huang, Yao Xiao* and Kun Liang*,

{"title":"Facilitating Ion Storage and Transport Pathways by In Situ Constructing 1D Carbon Nanotube Electric Bridges between 2D MXene Interlayers","authors":"Qi Fan, Kui Xu, Minghua Chen, Qing Tang, Ke Chen, Xiaofei Hu, Fuli Lan, Yueqi Wang, Hui Shao, Sicong Qiao, Ziwei Yan, Changda Wang, Li Song, Wencheng Hu, Michael Naguib, Patrice Simon, Qing Huang, Yao Xiao* and Kun Liang*, ","doi":"10.1021/acsnano.4c0947510.1021/acsnano.4c09475","DOIUrl":"https://doi.org/10.1021/acsnano.4c09475https://doi.org/10.1021/acsnano.4c09475","url":null,"abstract":"Multiple van der Waals (vdW) gaps invoke abundant opportunities for contriving artificial architectures and tailoring desired properties via the intercalation route beyond the reach of conventional concepts. Intriguingly, the electrochemical intercalation strategy can precisely and reversibly tune the intercalation stage of charged functional species. This study presents a valid structural editing protocol facilitated by electrochemical intercalation to engineer MXene interlayers, ultimately incorporating in situ constructed carbon nanotube (CNT) electric bridges for enhanced ion storage and transport pathways. The method allows for the precise modulation of electrochemical forces to tailor materials for specific applications. Deep intercalation and in situ growth processes establish robust anchoring sites and connectivity hubs between MXenes and CNTs, ensuring structural homogeneity and stability in advanced electrode materials. The results demonstrate the effectiveness of electrochemistry-mediated interlayer nanoengineering in MXenes, offering a versatile approach to design vdW heterostructures with tailored functionalities for energy storage and conversion applications. This work highlights the potential of electrochemical modulation in advancing materials engineering strategies for next-generation energy storage technologies.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30638–30649 30638–30649"},"PeriodicalIF":15.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Template-Assisted Growth of High-Quality α-Phase FAPbI3 Crystals in Perovskite Solar Cells Using Thiol-Functionalized MoS2 Nanosheets 使用硫醇功能化 MoS2 纳米片在包光体太阳能电池中模板辅助生长高质量 α 相 FAPbI3 晶体

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-23 DOI: 10.1021/acsnano.4c1126810.1021/acsnano.4c11268

Yifan Yin, Yuchen Zhou, Shi Fu, Yu-Chung Lin, Xianghao Zuo, Aniket Raut, Yugang Zhang, Esther H. R. Tsai, Mingxing Li, Fang Lu, Chenyu Zhou, Tai-De Li, Kim Kisslinger, Mircea Cotlet, Chang-Yong Nam* and Miriam H. Rafailovich*,

{"title":"Template-Assisted Growth of High-Quality α-Phase FAPbI3 Crystals in Perovskite Solar Cells Using Thiol-Functionalized MoS2 Nanosheets","authors":"Yifan Yin, Yuchen Zhou, Shi Fu, Yu-Chung Lin, Xianghao Zuo, Aniket Raut, Yugang Zhang, Esther H. R. Tsai, Mingxing Li, Fang Lu, Chenyu Zhou, Tai-De Li, Kim Kisslinger, Mircea Cotlet, Chang-Yong Nam* and Miriam H. Rafailovich*, ","doi":"10.1021/acsnano.4c1126810.1021/acsnano.4c11268","DOIUrl":"https://doi.org/10.1021/acsnano.4c11268https://doi.org/10.1021/acsnano.4c11268","url":null,"abstract":"Formamidinium lead iodide (FAPI) has gained attention for hybrid perovskite solar cell (PSC) applications due to its enhanced stability and narrow bandgap. However, a significant challenge remains in inducing and stabilizing the elusive perovskite “black phase”─photoactive cubic α-FAPI─as the relatively bulky FA+ cations tend to favor the thermodynamically stable nonphotoactive “yellow phase”. In this study, we present a templated growth strategy employing thiol-functionalized MoS2 nanosheets as templates. By introduction of 3-mercaptopropionic acid (MPA)-functionalized MoS2 as a growth template, precise control over crystal formation was achieved, favoring the growth of high-quality α-FAPI films. These advanced templated films exhibited substantial improvements in charge transport properties, efficient light absorption, and enhanced charge extraction. As a result, the PSCs achieved a significantly enhanced power conversion efficiency (PCE) compared to the nontemplated control device, increasing from 20.6 to 22.5%. The MoS2-incorporated device also demonstrated excellent shelf stability, maintaining 91% of the initial PCE even after 1600 h of storage without device encapsulation.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30816–30828 30816–30828"},"PeriodicalIF":15.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated Bioelectronic and Optogenetic Methods to Study Brain–Body Circuits 综合生物电子学和光遗传学方法研究脑-体回路

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-23 DOI: 10.1021/acsnano.4c0725610.1021/acsnano.4c07256

Qiming R. Zhang, Styra Xicun Wang and Ritchie Chen*,

引用次数: 0

Water-Triboelectrification-Complemented Moisture Electric Generator 水-三电化-伴湿发电装置

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-23 DOI: 10.1021/acsnano.4c0958110.1021/acsnano.4c09581

Fangzhou Li, Jian Zhao*, Bin Li, Zechao Han, Linglan Guo, Peicheng Han, Hyun Ho Kim, Yanjie Su, Li-Min Zhu and Daozhi Shen*,

{"title":"Water-Triboelectrification-Complemented Moisture Electric Generator","authors":"Fangzhou Li, Jian Zhao*, Bin Li, Zechao Han, Linglan Guo, Peicheng Han, Hyun Ho Kim, Yanjie Su, Li-Min Zhu and Daozhi Shen*, ","doi":"10.1021/acsnano.4c0958110.1021/acsnano.4c09581","DOIUrl":"https://doi.org/10.1021/acsnano.4c09581https://doi.org/10.1021/acsnano.4c09581","url":null,"abstract":"Energy harvesting from ubiquitous natural water vapor based on moisture electric generator (MEG) technology holds great potential to power portable electronics, the Internet of Things, and wireless transmission. However, most devices still encounter challenges of low output, and a single MEG complemented with another form of energy harvesting for achieving high power has seldom been demonstrated. Herein, we report a flexible and efficient hybrid generator capable of harvesting moisture and tribo energies simultaneously, both from the source of water droplets. The moisture electric and triboelectric layers are based on a water-absorbent citric acid (CA)-mediated polyglutamic acid (PGA) hydrogel and porous electret expanded polytetrafluoroethylene (E-PTFE), respectively. Such a waterproof E-PTFE film not only enables efficient triboelectrification with water droplets' contact but also facilitates water vapor to be transferred into the hydrogel layer for moisture electricity generation. A single hybrid generator under water droplets' impact delivers a DC voltage of 0.55 V and a peak current density of 120 μA cm–2 from the MEG, together with a simultaneous AC output voltage of 300 V and a current of 400 μA from the complementary water-based triboelectric generator (TEG) side. Such a hybrid generator can work even under harsh wild environments with 5 °C cold and saltwater impacts. Significantly, an optical alarm and wireless communication system for wild, complex, and emergency scenarios is demonstrated with power from the hybrid generators. This work expands the applications of water-based electricity generation technologies and provides insight into harvesting multiple potential energies in the natural environment with high output.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30658–30667 30658–30667"},"PeriodicalIF":15.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Advances of Cellular Nanoparticles as Multiplex Countermeasures 作为多重对策的细胞纳米粒子的研究进展

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-23 DOI: 10.1021/acsnano.4c0983010.1021/acsnano.4c09830

Jiayuan Alex Zhang, Kailin Feng, Wei-Ting Shen, Weiwei Gao* and Liangfang Zhang*,

{"title":"Research Advances of Cellular Nanoparticles as Multiplex Countermeasures","authors":"Jiayuan Alex Zhang, Kailin Feng, Wei-Ting Shen, Weiwei Gao* and Liangfang Zhang*, ","doi":"10.1021/acsnano.4c0983010.1021/acsnano.4c09830","DOIUrl":"https://doi.org/10.1021/acsnano.4c09830https://doi.org/10.1021/acsnano.4c09830","url":null,"abstract":"Cellular nanoparticles (CNPs), fabricated by coating natural cell membranes onto nanoparticle cores, have been widely used to replicate cellular functions for various therapeutic applications. Specifically, CNPs act as cell decoys, binding harmful molecules or infectious pathogens and neutralizing their bioactivity. This neutralization strategy leverages the target’s functional properties rather than its structure, resulting in broad-spectrum efficacy. Since their inception, CNP platforms have undergone significant advancements to enhance their neutralizing capabilities and efficiency. This review traces the research advances of CNP technology as multiplex countermeasures across four categories with progressive functions: neutralization through cell membrane binding, simultaneous neutralization using both cell membrane and nanoparticle core, continuous neutralization via enzymatic degradation, and enhanced neutralization through membrane modification. The review highlights the structure–property relationship in CNP designs, showing the functional advances of each category of CNP. By providing an overview of CNPs in multiplex neutralization of a wide range of chemical and biological threat agents, this article aims to inspire the development of more advanced CNP nanoformulations and uncover innovative applications to address unresolved medical challenges.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30211–30223 30211–30223"},"PeriodicalIF":15.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.acs.org/doi/epdf/10.1021/acsnano.4c09830","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shortwave-Infrared Silver Chalcogenide Quantum Dots for Optoelectronic Devices 用于光电设备的短波-红外卤化银量子点

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-23 DOI: 10.1021/acsnano.4c1178710.1021/acsnano.4c11787

Hongchao Yang, Zhiwei Ma and Qiangbin Wang*,

{"title":"Shortwave-Infrared Silver Chalcogenide Quantum Dots for Optoelectronic Devices","authors":"Hongchao Yang, Zhiwei Ma and Qiangbin Wang*, ","doi":"10.1021/acsnano.4c1178710.1021/acsnano.4c11787","DOIUrl":"https://doi.org/10.1021/acsnano.4c11787https://doi.org/10.1021/acsnano.4c11787","url":null,"abstract":"Silver chalcogenide (Ag2X, X = S, Se, Te) semiconductor quantum dots (QDs) have been extensively studied owing to their short-wave infrared (SWIR, 900–2500 nm) excitation and emission along with lower solubility product constant and environmentally benign nature. However, their unsatisfactory photoluminescence quantum yields (PLQYs) make it difficult to obtain optoelectronic devices with high performances. To tackle this challenge, researchers have made great efforts to develop valid strategies to improve the PLQYs of SWIR Ag2X QDs by suppressing their nonradiative recombination of excitons. In this Perspective, we summarize the significant approaches of heteroatom doping and surface passivation to enhance the PLQYs of SWIR Ag2X QDs, and we conclude their application in high-efficiency optoelectronic devices. Finally, we examine the future trends and promising opportunities of Ag2X QDs with regard to their optical properties and optoelectronics. We believe that this Perspective will serve as a valuable reference for future advancement in the synthesis and application of SWIR Ag2X QDs.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30123–30131 30123–30131"},"PeriodicalIF":15.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthetic Nanoassemblies for Regulating Organelles: From Molecular Design to Precision Therapeutics 用于调节细胞器的合成纳米组件：从分子设计到精准治疗

IF 15.8 3区化学

ACS Earth and Space Chemistry Pub Date : 2024-10-23 DOI: 10.1021/acsnano.4c1019410.1021/acsnano.4c10194

Yanfei Guo, Peiran Li, Xiaocui Guo*, Chi Yao* and Dayong Yang*,

{"title":"Synthetic Nanoassemblies for Regulating Organelles: From Molecular Design to Precision Therapeutics","authors":"Yanfei Guo, Peiran Li, Xiaocui Guo*, Chi Yao* and Dayong Yang*, ","doi":"10.1021/acsnano.4c1019410.1021/acsnano.4c10194","DOIUrl":"https://doi.org/10.1021/acsnano.4c10194https://doi.org/10.1021/acsnano.4c10194","url":null,"abstract":"Each organelle referring to a complex multiorder architecture executes respective biological processes via its distinct spatial organization and internal microenvironment. As the assembly of biomolecules is the structural basis of living cells, creating synthetic nanoassemblies with specific physicochemical and morphological properties in living cells to interfere or couple with the natural organelle architectures has attracted great attention in precision therapeutics of cancers. In this review, we give an overview of the latest advances in the synthetic nanoassemblies for precise organelle regulation, including the formation mechanisms, triggering strategies, and biomedical applications in precision therapeutics. We summarize the emerging material systems, including polymers, peptides, and deoxyribonucleic acids (DNAs), and their respective intermolecular interactions for intercellular synthetic nanoassemblies, and highlight their design principles in constructing precursors that assemble into synthetic nanoassemblies targeting specific organelles in the complex cellular environment. We further showcase the developed intracellular synthetic nanoassemblies targeting specific organelles including mitochondria, the endoplasmic reticulum, lysosome, Golgi apparatus, and nucleus and describe their underlying mechanisms for organelle regulation and precision therapeutics for cancer. Last, the essential challenges in this field and prospects for future precision therapeutics of synthetic nanoassemblies are discussed. This review should facilitate the rational design of organelle-targeting synthetic nanoassemblies and the comprehensive recognition of organelles by materials and contribute to the deep understanding and application of the synthetic nanoassemblies for precision therapeutics.","PeriodicalId":15,"journal":{"name":"ACS Earth and Space Chemistry","volume":"18 44","pages":"30224–30246 30224–30246"},"PeriodicalIF":15.8,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142577735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0